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Clinical Pharmacokinetics, ISSN 0312-5963, 3/2016, Volume 55, Issue 3, pp. 359 - 367
Journal Article
Circulation, ISSN 0009-7322, 2018, Volume 137, Issue 3, pp. 307 - 309
Journal Article
European Heart Journal, ISSN 0195-668X, 08/2015, Volume 36, Issue 29, pp. 1901 - 1912a
Journal Article
European Journal of Clinical Pharmacology, ISSN 0031-6970, 6/2018, Volume 74, Issue 6, pp. 745 - 754
Ticagrelor, the first reversible P2Y12 receptor antagonist, exhibits faster onset and offset of antiplatelet effects and more consistent platelet inhibition... 
Biomedicine | Maximal platelet inhibition | Simulation | CYP3A53 | CYP3A41G | AR-C124910XX | Pharmacology/Toxicology | Ticagrelor | Population pharmacokinetics and pharmacodynamics | Turnover model | AZD6140 | ANTAGONIST | SAFETY | GENOTYPE | OPEN-LABEL | CLOPIDOGREL | INHIBITION | STANDARD-DOSE TICAGRELOR | TOLERABILITY | PHARMACOLOGY & PHARMACY | P2Y RECEPTOR | Purinergic P2Y Receptor Antagonists - pharmacology | Adenosine - pharmacokinetics | Purinergic P2Y Receptor Antagonists - administration & dosage | Humans | Asian Continental Ancestry Group - genetics | Purinergic P2Y Receptor Antagonists - pharmacokinetics | Male | Purinergic P2Y Receptor Antagonists - blood | Adenosine - pharmacology | Adenosine - administration & dosage | Healthy Volunteers | Dose-Response Relationship, Drug | Young Adult | Adenosine - blood | Cytochrome P-450 CYP3A - genetics | Models, Biological | Adenosine - analogs & derivatives | Adult | Platelet Aggregation - drug effects | Polymorphism, Single Nucleotide | Blood Platelets - drug effects | Single nucleotide polymorphisms | Coronary heart disease | Analysis | Cardiac patients | Cytochrome P-450 | Pharmacodynamics | Computer simulation | Coronary artery | Cardiovascular disease | Population studies | Pharmacology | Single-nucleotide polymorphism | Dosage | Coronary artery disease | Optimization | Mens health | Blood platelets | Biotransformation | Clopidogrel | Inhibition | Pharmacokinetics | Platelets | Heart diseases | Asians
Journal Article
Journal Article
European Journal of Clinical Pharmacology, ISSN 0031-6970, 4/2013, Volume 69, Issue 4, pp. 877 - 883
Journal Article
Clinical Research in Cardiology, ISSN 1861-0684, 4/2016, Volume 105, Issue 4, pp. 349 - 355
Morphine decreases the concentrations and effects of clopidogrel, which could lead to treatment failure in myocardial infarction.To clarify whether more potent... 
Prasugrel | Medicine & Public Health | Drug interactions | Morphine | Platelet function tests | Cardiology | Vasodilator-stimulated phosphoprotein | MORTALITY | PATHWAYS | CARDIAC & CARDIOVASCULAR SYSTEMS | PHOSPHORYLATION | REPERFUSION | ACUTE CORONARY SYNDROMES | CLOPIDOGREL | PLATELET INHIBITION | ACUTE MYOCARDIAL-INFARCTION | INTERVENTION | ACTIVE METABOLITE | Purinergic P2Y Receptor Antagonists - administration & dosage | Humans | Male | Purinergic P2Y Receptor Antagonists - blood | Drug Monitoring - methods | Healthy Volunteers | Platelet Aggregation Inhibitors - blood | Young Adult | Purinergic P2Y Receptor Antagonists - adverse effects | Tandem Mass Spectrometry | Austria | Analgesics, Opioid - adverse effects | Drug Interactions | Biotransformation | Platelet Aggregation Inhibitors - administration & dosage | Platelet Function Tests | Chromatography, Liquid | Adult | Female | Platelet Aggregation - drug effects | Platelet Aggregation Inhibitors - pharmacokinetics | Prasugrel Hydrochloride - administration & dosage | Prasugrel Hydrochloride - pharmacokinetics | Platelet Aggregation Inhibitors - adverse effects | Double-Blind Method | Risk Assessment | Purinergic P2Y Receptor Antagonists - pharmacokinetics | Prasugrel Hydrochloride - adverse effects | Cross-Over Studies | Analgesics, Opioid - administration & dosage | Morphine - administration & dosage | Morphine - adverse effects | Prasugrel Hydrochloride - blood | Medical colleges | Metabolites | Vasodilators | Clinical trials | Liquid chromatography | Mass spectrometry | Original Paper
Journal Article
International Journal of Clinical Pharmacology and Therapeutics, ISSN 0946-1965, 2014, Volume 52, Issue 6, pp. 478 - 491
Journal Article
Journal Article
World Neurosurgery, ISSN 1878-8750, 02/2019, Volume 122, pp. e961 - e968
Hemorrhagic complications reported from external ventricular drain (EVD) placement range from 10% to 44%. There remains limited literature investigating the... 
Catheter-induced hemorrhage (CIH) | External ventriculostomy | Platelet inhibition assay | VerifyNow assay | External ventricular drain (EVD) | SURGERY | INSERTION | ANTIPLATELET AGENTS | PLATELET TRANSFUSION | REACTIVITY | BLOOD-PRESSURE | CLINICAL NEUROLOGY | DRAIN PLACEMENT | RATES | INHIBITION | ANTICOAGULANT-THERAPY | INTRACEREBRAL HEMORRHAGE | Platelet Transfusion - methods | Humans | Middle Aged | Male | Purinergic P2Y Receptor Antagonists - blood | Anti-Inflammatory Agents, Non-Steroidal - blood | Cerebral Hemorrhage - diagnosis | Cerebral Hemorrhage - blood | Platelet Aggregation Inhibitors - blood | Platelet Transfusion - trends | Young Adult | Purinergic P2Y Receptor Antagonists - adverse effects | Aspirin - adverse effects | Aged, 80 and over | Adult | Female | Aspirin - therapeutic use | Retrospective Studies | Platelet Aggregation Inhibitors - therapeutic use | Purinergic P2Y Receptor Antagonists - therapeutic use | Platelet Aggregation Inhibitors - adverse effects | Cerebral Hemorrhage - chemically induced | Aspirin - blood | Ventriculostomy - trends | Anti-Inflammatory Agents, Non-Steroidal - adverse effects | Anti-Inflammatory Agents, Non-Steroidal - therapeutic use | Adolescent | Aged | Ventriculostomy - methods | Cohort Studies | Complications and side effects | Brain | Medical research | Aspirin | Transfusion | Blood platelets | Medicine, Experimental | Injuries | Risk factors
Journal Article
The Journal of Clinical Pharmacology, ISSN 0091-2700, 6/2012, Volume 52, Issue 6, pp. 789 - 797
In TRITON-TIMI 38, levels of the prasugrel active metabolite (pras-AM) were measured in a population pharmacokinetic substudy that characterized the intrinsic... 
prasugrel | post hoc analysis | low body weight and elderly | active metabolite exposure | substudy | ACHIEVES GREATER | ANTAGONIST | CS-747 | ASPIRIN-TREATED PATIENTS | ACUTE CORONARY SYNDROMES | ANTIPLATELET AGENT | CLOPIDOGREL | POLYMORPHISMS | PLATELET INHIBITION | PHARMACOLOGY & PHARMACY | ARTERY-DISEASE | Piperazines - administration & dosage | Prodrugs - administration & dosage | Prasugrel Hydrochloride | Body Weight | Purinergic P2Y Receptor Antagonists - administration & dosage | Age Factors | Thiophenes - adverse effects | Humans | Acute Coronary Syndrome - physiopathology | Male | Purinergic P2Y Receptor Antagonists - blood | Thiophenes - administration & dosage | Thiophenes - blood | Incidence | Dose-Response Relationship, Drug | Platelet Aggregation Inhibitors - blood | Purinergic P2Y Receptor Antagonists - adverse effects | Biotransformation | Platelet Aggregation Inhibitors - administration & dosage | Platelet Aggregation Inhibitors - pharmacokinetics | Piperazines - pharmacokinetics | Thrombosis - prevention & control | Piperazines - blood | Platelet Aggregation Inhibitors - adverse effects | Severity of Illness Index | Double-Blind Method | Hemorrhage - epidemiology | Hemorrhage - physiopathology | Purinergic P2Y Receptor Antagonists - pharmacokinetics | Piperazines - adverse effects | Acute Coronary Syndrome - drug therapy | Receptors, Purinergic P2Y12 - chemistry | Prodrugs - adverse effects | Thiophenes - pharmacokinetics | Prodrugs - pharmacokinetics | Acute Coronary Syndrome - metabolism | Models, Biological | Thrombosis - etiology | Aged | Hemorrhage - chemically induced | Methylene compounds | Research | Clinical outcomes
Journal Article