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Molecular cell, ISSN 1097-2765, 2009, Volume 35, Issue 5, pp. 563 - 573
The target of rapamycin complex 1 (TORC1) is a central regulator of eukaryotic cell growth that is activated by a variety of hormones (e.g., insulin) and... 
CELLBIO | PROTEINS | SIGNALING | YEAST SACCHAROMYCES-CEREVISIAE | CELL-GROWTH CONTROL | SIGNALING PATHWAYS | FUNCTIONAL HOMOLOG | RAG GTPASES | VACUOLE FUSION | BIOCHEMISTRY & MOLECULAR BIOLOGY | AMINO-ACID PERMEASE | COMPONENT | GTP-BINDING PROTEINS | GAP1 PERMEASE | CELL BIOLOGY | Vacuoles - enzymology | Intracellular Membranes - enzymology | Saccharomyces cerevisiae - genetics | Multiprotein Complexes | Adaptor Proteins, Vesicular Transport - genetics | Saccharomyces cerevisiae - drug effects | Guanosine Triphosphate - metabolism | Adaptor Proteins, Vesicular Transport - metabolism | Vacuoles - drug effects | DNA-Binding Proteins - metabolism | Amino Acids - metabolism | Time Factors | Guanine Nucleotide Exchange Factors - metabolism | Protein-Serine-Threonine Kinases - antagonists & inhibitors | Guanosine Diphosphate - metabolism | Protein Synthesis Inhibitors - pharmacology | Protein-Serine-Threonine Kinases - metabolism | Guanine Nucleotide Exchange Factors - genetics | Signal Transduction | Saccharomyces cerevisiae Proteins - antagonists & inhibitors | Monomeric GTP-Binding Proteins - genetics | Saccharomyces cerevisiae Proteins - genetics | Amino Acid Transport Systems - metabolism | Sirolimus - pharmacology | Cycloheximide - pharmacology | Protein Transport | Transcription Factors - metabolism | Monomeric GTP-Binding Proteins - metabolism | Saccharomyces cerevisiae Proteins - metabolism | Protein Binding | Saccharomyces cerevisiae - enzymology | Endosomes - enzymology | Intracellular Membranes - drug effects | Mutation | Saccharomyces cerevisiae - growth & development | Proteins | Purines | Amino acids | Gross domestic product | Guanosine
Journal Article
Nature (London), ISSN 1476-4687, 2014, Volume 515, Issue 7527, pp. 431 - 435
Journal Article
Journal Article
Nature (London), ISSN 1476-4687, 2010, Volume 468, Issue 7324, pp. 696 - 700
Journal Article
Nature (London), ISSN 1476-4687, 2013, Volume 497, Issue 7448, pp. 217 - 223
The mammalian target of rapamycin (mTOR), a phosphoinositide 3-kinase-related protein kinase, controls cell growth in response to nutrients and growth factors... 
MAMMALIAN TARGET | RAPAMYCIN | RAPTOR | BINDING PARTNER | RAG GTPASES | RHEB | PATHWAY | TOR | MULTIDISCIPLINARY SCIENCES | CELL-GROWTH | P70 S6 KINASE | Adaptor Proteins, Signal Transducing - chemistry | Catalytic Domain - drug effects | TOR Serine-Threonine Kinases - metabolism | Pyridines - chemistry | Furans - pharmacology | Humans | Crystallography, X-Ray | Structure-Activity Relationship | Pyrimidines - chemistry | TOR Serine-Threonine Kinases - antagonists & inhibitors | Indoles - metabolism | Furans - chemistry | Adenosine Triphosphate - metabolism | Indoles - pharmacology | Tacrolimus Binding Protein 1A - pharmacology | Naphthyridines - chemistry | Ribosomal Protein S6 Kinases, 70-kDa - metabolism | Purines - metabolism | Purines - pharmacology | MTOR Associated Protein, LST8 Homolog | Tacrolimus Binding Protein 1A - chemistry | Models, Molecular | Magnesium - metabolism | Pyrimidines - pharmacology | Sirolimus - metabolism | Sirolimus - pharmacology | Magnesium - chemistry | Purines - chemistry | TOR Serine-Threonine Kinases - chemistry | Tacrolimus Binding Protein 1A - metabolism | Pyridines - pharmacology | Sirolimus - chemistry | Adaptor Proteins, Signal Transducing - metabolism | Adenosine Triphosphate - chemistry | Indoles - chemistry | Naphthyridines - pharmacology | Naphthyridines - metabolism | Protein Structure, Tertiary - drug effects | Proteins | Enzymes | Kinases | Crystal structure
Journal Article
Neurobiology of aging, ISSN 0197-4580, 2015, Volume 36, Issue 1, pp. 68 - 80
Journal Article
Arteriosclerosis, thrombosis, and vascular biology, ISSN 1079-5642, 04/2010, Volume 30, Issue 4, pp. 758 - 765
OBJECTIVE—Diet-induced obesity (DIO) in mice causes vascular inflammation and insulin resistance that are accompanied by decreased endothelial-derived NO... 
ENOS | Nitric oxide | Vascular inflammation | nitric oxide | eNOS | ACTIVATED PROTEIN-KINASE | SILDENAFIL | ATHEROSCLEROSIS | ALPHA | ADHESION MOLECULES | ENDOTHELIAL FUNCTION | OVEREXPRESSION | NITRIC-OXIDE PRODUCTION | INHIBITION | vascular inflammation | PERIPHERAL VASCULAR DISEASE | HEMATOLOGY | EXPRESSION | Humans | Phosphodiesterase 5 Inhibitors | Male | NF-kappa B - metabolism | Insulin Receptor Substrate Proteins - metabolism | Aortic Diseases - metabolism | Sildenafil Citrate | Inflammation - metabolism | Proto-Oncogene Proteins c-akt - metabolism | Disease Models, Animal | Endothelial Cells - metabolism | Down-Regulation | Enzyme Inhibitors - pharmacology | Aorta, Thoracic - metabolism | Cell Adhesion Molecules - metabolism | Inflammation - etiology | Nitric Oxide Synthase Type III - genetics | Piperazines - pharmacology | Mice, Knockout | Nitric Oxide Synthase Type III - antagonists & inhibitors | Insulin - metabolism | Cyclic GMP - metabolism | Signal Transduction - drug effects | Inflammation - prevention & control | Mice | Endothelial Cells - enzymology | Palmitic Acid - metabolism | Phosphorylation | Phosphatidylinositol 3-Kinases - metabolism | Sulfones - pharmacology | I-kappa B Kinase - metabolism | Dietary Fats | Inflammation Mediators - metabolism | Aorta, Thoracic - drug effects | Nitric Oxide Donors - pharmacology | Nitric Oxide Synthase Type III - metabolism | Cyclic Nucleotide Phosphodiesterases, Type 5 - metabolism | Purines - pharmacology | Mice, Inbred C57BL | Cells, Cultured | Insulin Resistance | Phosphodiesterase Inhibitors - pharmacology | Aorta, Thoracic - physiopathology | Aortic Diseases - physiopathology | Animals | Nitric Oxide - metabolism | Aortic Diseases - etiology | Endothelial Cells - drug effects | Inflammation - physiopathology
Journal Article
Gastroenterology (New York, N.Y. 1943), ISSN 0016-5085, 2014, Volume 146, Issue 3, pp. 801 - 811
Journal Article