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1. Full Text Salt and Cocrystals of Sildenafil with Dicarboxylic Acids: Solubility and Pharmacokinetic Advantage of the Glutarate Salt
by Sanphui, Palash and Tothadi, Srinu and Ganguly, Somnath and Desiraju, Gautam R
Molecular pharmaceutics, ISSN 1543-8384, 12/2013, Volume 10, Issue 12, pp. 4687 - 4697
X-ray crystallography | bioavailability | crystal engineering | dissolution | hydrogen bond | Pharmacology & Pharmacy | Life Sciences & Biomedicine | Medicine, Research & Experimental | Science & Technology | Research & Experimental Medicine | Dicarboxylic Acids - pharmacokinetics | Area Under Curve | Biological Availability | Male | Piperazines - chemistry | Pimelic Acids - pharmacokinetics | Salts - chemistry | Sildenafil Citrate | Glutarates - pharmacokinetics | Sulfones - chemistry | Oxalic Acid - pharmacokinetics | Water - chemistry | Salts - pharmacokinetics | Glutarates - chemistry | Pimelic Acids - chemistry | Piperazines - pharmacokinetics | Oxalic Acid - chemistry | Purines - pharmacokinetics | Crystallization | Solubility | Fumarates - chemistry | Rats | Succinic Acid - pharmacokinetics | Permeability | Sulfones - pharmacokinetics | Rats, Sprague-Dawley | Dicarboxylic Acids - chemistry | Animals | Purines - chemistry | Fumarates - pharmacokinetics | Succinic Acid - chemistry | Index Medicus
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2. Full Text Changes in Individual Drug-Independent System Parameters during Virtual Paediatric Pharmacokinetic Trials: Introducing Time-Varying Physiology into a Paediatric PBPK Model
by Abduljalil, Khaled and Jamei, Masoud and Rostami-Hodjegan, Amin and Johnson, Trevor N
The AAPS journal, ISSN 1550-7416, 5/2014, Volume 16, Issue 3, pp. 568 - 576
Biochemistry, general | developmental pharmacokinetics | paediatrics | Biotechnology | Biomedicine | Pharmacy | time varying | metabolism | Pharmacology/Toxicology | Life Sciences & Biomedicine | Pharmacology & Pharmacy | Science & Technology | Pediatrics | Anticonvulsants - pharmacokinetics | Reproducibility of Results | Vasodilator Agents - pharmacokinetics | Humans | Purines - pharmacokinetics | Child, Preschool | Infant | Sulfones - pharmacokinetics | Sildenafil Citrate | Pharmaceutical Preparations - metabolism | Theophylline - pharmacokinetics | Models, Biological | Bronchodilator Agents - pharmacokinetics | Clinical Trials as Topic - methods | Piperazines - pharmacokinetics | Pharmacokinetics | Child | Infant, Newborn | Phenytoin - pharmacokinetics | Aging - metabolism | Physiological aspects | Models | Cytochrome P-450 | Index Medicus
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3. Full Text Clinical Pharmacokinetics and Pharmacodynamics of Linagliptin
by Graefe-Mody, Ulrike and Retlich, Silke and Friedrich, Christian
Clinical pharmacokinetics, ISSN 0312-5963, 7/2012, Volume 51, Issue 7, pp. 411 - 427
Pharmacotherapy | Internal Medicine | Medicine & Public Health | Pharmacology/Toxicology | pharmacokinetics | type-2-diabetes-mellitus | linagliptin | drug-interactions | pharmacology | Life Sciences & Biomedicine | Pharmacology & Pharmacy | Science & Technology | Biological and medical sciences | Medical sciences | General pharmacology | Pharmacology. Drug treatments | Pharmacokinetics. Pharmacogenetics. Drug-receptor interactions | Animals | Drug Interactions | Dipeptidyl-Peptidase IV Inhibitors - pharmacokinetics | Purines - pharmacology | Humans | Purines - pharmacokinetics | Quinazolines - pharmacokinetics | Linagliptin | Diabetes Mellitus, Type 2 - metabolism | Quinazolines - pharmacology | Dipeptidyl-Peptidase IV Inhibitors - pharmacology | Index Medicus
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4. Full Text Review article: recent advances in pharmacogenetics and pharmacokinetics for safe and effective thiopurine therapy in inflammatory bowel disease
by Moon, W and Loftus, E. V
Alimentary pharmacology & therapeutics, ISSN 0269-2813, 04/2016, Volume 43, Issue 8, pp. 863 - 883
Inflammatory Bowel Diseases - drug therapy | Azathioprine - therapeutic use | Pharmacogenetics | Thionucleotides - metabolism | Thioinosine - metabolism | Mercaptopurine - therapeutic use | Humans | Methyltransferases - metabolism | Thioinosine - analogs & derivatives | Mercaptopurine - analogs & derivatives | Oxidases | Purines | Metabolites | Molybdenum compounds | Glutathione transferase | Gastrointestinal diseases | Physiological aspects | Nucleosides | Nucleotides | Mercaptopurine | Index Medicus
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5. Clinical Pharmacokinetic and Pharmacodynamic Profile of Idelalisib
by Ramanathan, Srinivasan and Jin, Feng and Sharma, Shringi and Kearney, Brian P
Clinical pharmacokinetics, ISSN 0312-5963, 01/2016, Volume 55, Issue 1, pp. 33 - 45
Life Sciences & Biomedicine | Pharmacology & Pharmacy | Science & Technology | Administration, Oral | Humans | Purines - pharmacokinetics | Quinazolinones - administration & dosage | Antineoplastic Agents - administration & dosage | Purines - administration & dosage | Dose-Response Relationship, Drug | Drug Interactions | Leukemia, Lymphocytic, Chronic, B-Cell - metabolism | Lymphoma, Non-Hodgkin - metabolism | Antineoplastic Agents - pharmacokinetics | Leukemia, Lymphocytic, Chronic, B-Cell - drug therapy | Lymphoma, Non-Hodgkin - drug therapy | Quinazolinones - pharmacokinetics | Index Medicus
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6. Pharmacokinetics and pharmacodynamics of single rising intravenous doses (0.5mg-10mg) and determination of absolute bioavailability of the dipeptidyl peptidase-4 inhibitor linagliptin (BI 1356) in healthy male subjects
by Retlich, Silke and Duval, Vincent and Ring, Arne and Staab, Alexander and Httner, Silke and Jungnik, Arvid and Jaehde, Ulrich and Dugi, Klaus A and Graefe-Mody, Ulrike
Clinical pharmacokinetics, ISSN 0312-5963, 2010, Volume 49, Issue 12, pp. 829 - 840
Research-and-development | Population-pharmacokinetics | Antihyperglycaemics, pharmacokinetics | Linagliptin, pharmacokinetics | Bioavailability | Dipeptidyl-peptidase-inhibitors, pharmacodynamics | Pharmacokinetic-pharmacodynamic-relationships | Linagliptin, pharmacodynamics | Pharmacokinetic-modelling | Dipeptidyl-peptidase-inhibitors, pharmacokinetics | Antihyperglycaemics, pharmacodynamics | Life Sciences & Biomedicine | Pharmacology & Pharmacy | Science & Technology | Single-Blind Method | Dipeptidyl Peptidase 4 - metabolism | Tablets | Area Under Curve | Humans | Middle Aged | Half-Life | Quinazolines - pharmacokinetics | Biological Availability | Male | Purines - administration & dosage | Dose-Response Relationship, Drug | Tissue Distribution | Young Adult | Quinazolines - metabolism | Adult | Dipeptidyl-Peptidase IV Inhibitors - metabolism | Quinazolines - administration & dosage | Linagliptin | Purines - metabolism | Purines - pharmacokinetics | Dipeptidyl-Peptidase IV Inhibitors - administration & dosage | Cross-Over Studies | Dipeptidyl-Peptidase IV Inhibitors - pharmacokinetics | Models, Biological | Adolescent | Protein Binding | Infusions, Intravenous
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7. Full Text Pharmacokinetics, Pharmacodynamics, Safety, and Tolerability of Nebulized Sodium Nitrite (AIR001) Following Repeat-Dose Inhalation in Healthy Subjects
by Rix, Peter J and Rix, Peter J and Vick, Andrew and Vick, Andrew and Attkins, Neil J and Attkins, Neil J and Barker, Geoffrey E and Barker, Geoffrey E and Bott, Adrian W and Bott, Adrian W and Alcorn Jr, Harry and Alcorn Jr, Harry and Gladwin, Mark T and Gladwin, Mark T and Shiva, Sruti and Shiva, Sruti and Bradley, Stephen and Bradley, Stephen and Hussaini, Azra and Hussaini, Azra and Hoye, William L and Hoye, William L and Parsley, Ed L and Parsley, Ed L and Masamune, Hiroko and Masamune, Hiroko
Clinical pharmacokinetics, ISSN 0312-5963, 3/2015, Volume 54, Issue 3, pp. 261 - 272
Pharmacotherapy | Internal Medicine | Medicine & Public Health | Pharmacology/Toxicology | Life Sciences & Biomedicine | Pharmacology & Pharmacy | Science & Technology | Biomarkers - metabolism | Piperazines - administration & dosage | Sodium Nitrite - administration & dosage | Humans | Middle Aged | Administration, Inhalation | Male | Hypertension, Pulmonary - metabolism | Purines - administration & dosage | Hypoxia - metabolism | Sildenafil Citrate | Young Adult | Sodium Nitrite - pharmacology | Drug Interactions | Sodium Nitrite - adverse effects | Adolescent | Adult | Female | Hypertension, Pulmonary - drug therapy | Nitric Oxide - metabolism | Sulfonamides - administration & dosage | Cohort Studies | Index Medicus
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8. Ebola Virus Infection: Review of the Pharmacokinetic and Pharmacodynamic Properties of Drugs Considered for Testing in Human Efficacy Trials
by Madelain, Vincent and Nguyen, Thi Huyen Tram and Olivo, Anaelle and de Lamballerie, Xavier and Guedj, Jérémie and Taburet, Anne-Marie and Mentré, France
Clinical pharmacokinetics, ISSN 0312-5963, 08/2016, Volume 55, Issue 8, pp. 907 - 923
Life Sciences & Biomedicine | Pharmacology & Pharmacy | Science & Technology | Amides - pharmacology | Antiviral Agents - pharmacology | Antiviral Agents - pharmacokinetics | Hemorrhagic Fever, Ebola - prevention & control | Antiviral Agents - therapeutic use | Purine Nucleosides - pharmacology | Humans | Amides - therapeutic use | Pyrazines - therapeutic use | Healthy Volunteers | Hemorrhagic Fever, Ebola - epidemiology | Purine Nucleosides - pharmacokinetics | Ebolavirus - drug effects | Animals | Pyrazines - pharmacokinetics | Amides - pharmacokinetics | Purine Nucleosides - therapeutic use | Disease Outbreaks - prevention & control | Models, Animal | Pyrazines - pharmacology | Hemorrhagic Fever, Ebola - drug therapy
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