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Nature communications, ISSN 2041-1723, 2019, Volume 10, Issue 1, pp. 1373 - 14
Using an ORF kinome screen in MCF-7 cells treated with the CDK4/6 inhibitor ribociclib plus fulvestrant, we identified FGFR1 as a mechanism of drug resistance.... 
Cyclin-Dependent Kinase 6 - antagonists & inhibitors | Cyclin D1 - metabolism | Receptors, Estrogen - metabolism | Circulating Tumor DNA - genetics | Humans | Purines - administration & dosage | Fulvestrant - pharmacology | Receptor, Fibroblast Growth Factor, Type 1 - genetics | Quinolines - pharmacology | Breast Neoplasms - metabolism | Quinoxalines - pharmacology | MCF-7 Cells | Fulvestrant - administration & dosage | Female | Receptor, Fibroblast Growth Factor, Type 2 - antagonists & inhibitors | Cyclin-Dependent Kinase 4 - antagonists & inhibitors | Pyrazoles - pharmacology | Aminopyridines - administration & dosage | Antineoplastic Agents, Hormonal - pharmacology | Signal Transduction | Purines - pharmacology | Antineoplastic Agents, Hormonal - administration & dosage | Proportional Hazards Models | Breast Neoplasms - drug therapy | Piperazines - pharmacology | Receptor, Fibroblast Growth Factor, Type 1 - antagonists & inhibitors | Naphthalenes - pharmacology | Xenograft Model Antitumor Assays | Protein Kinase Inhibitors - administration & dosage | Drug Resistance, Neoplasm - genetics | Animals | Breast Neoplasms - genetics | Antineoplastic Combined Chemotherapy Protocols - therapeutic use | Aminopyridines - pharmacology | Progression-Free Survival | High-Throughput Nucleotide Sequencing | Mice | Protein Kinase Inhibitors - pharmacology | Pyridines - pharmacology | Mutation | Receptor, Fibroblast Growth Factor, Type 2 - genetics | Drug Resistance, Neoplasm - drug effects | Tyrosine | Xenotransplantation | Clinical trials | Antagonists | Breast cancer | Drug resistance | Patients | Cyclin-dependent kinase 4 | Fulvestrant | Gene sequencing | Amplification | Next-generation sequencing | Inhibitors | Xenografts | Open reading frames | Fibroblast growth factor receptor 1 | Protein-tyrosine kinase | Deoxyribonucleic acid--DNA | DNA sequencing | Cancer | Fibroblast growth factor receptors
Journal Article
Journal of Urology, The, ISSN 0022-5347, 2013, Volume 190, Issue 2, pp. 746 - 756
Journal Article
Nature (London), ISSN 1476-4687, 2013, Volume 497, Issue 7448, pp. 217 - 223
The mammalian target of rapamycin (mTOR), a phosphoinositide 3-kinase-related protein kinase, controls cell growth in response to nutrients and growth factors... 
MAMMALIAN TARGET | RAPAMYCIN | RAPTOR | BINDING PARTNER | RAG GTPASES | RHEB | PATHWAY | TOR | MULTIDISCIPLINARY SCIENCES | CELL-GROWTH | P70 S6 KINASE | Adaptor Proteins, Signal Transducing - chemistry | Catalytic Domain - drug effects | TOR Serine-Threonine Kinases - metabolism | Pyridines - chemistry | Furans - pharmacology | Humans | Crystallography, X-Ray | Structure-Activity Relationship | Pyrimidines - chemistry | TOR Serine-Threonine Kinases - antagonists & inhibitors | Indoles - metabolism | Furans - chemistry | Adenosine Triphosphate - metabolism | Indoles - pharmacology | Tacrolimus Binding Protein 1A - pharmacology | Naphthyridines - chemistry | Ribosomal Protein S6 Kinases, 70-kDa - metabolism | Purines - metabolism | Purines - pharmacology | MTOR Associated Protein, LST8 Homolog | Tacrolimus Binding Protein 1A - chemistry | Models, Molecular | Magnesium - metabolism | Pyrimidines - pharmacology | Sirolimus - metabolism | Sirolimus - pharmacology | Magnesium - chemistry | Purines - chemistry | TOR Serine-Threonine Kinases - chemistry | Tacrolimus Binding Protein 1A - metabolism | Pyridines - pharmacology | Sirolimus - chemistry | Adaptor Proteins, Signal Transducing - metabolism | Adenosine Triphosphate - chemistry | Indoles - chemistry | Naphthyridines - pharmacology | Naphthyridines - metabolism | Protein Structure, Tertiary - drug effects | Proteins | Enzymes | Kinases | Crystal structure
Journal Article
Free radical biology & medicine, ISSN 0891-5849, 2012, Volume 53, Issue 4, pp. 817 - 827
The Keap1-Nrf2 system plays a critical role in cellular defense against electrophiles and reactive oxygen species. Keap1 possesses a number of cysteine... 
Keap1 | Reactive cysteine | Stress response | Nrf2 | OXIDATIVE STRESS | ACTIVATION | BIOCHEMISTRY & MOLECULAR BIOLOGY | CDDO-IM | PHASE-2 RESPONSE | ANTIOXIDANT | COVALENT MODIFICATION | ENDOCRINOLOGY & METABOLISM | GENE-EXPRESSION | NITRIC-OXIDE | CYSTEINE RESIDUES | Oxidants - pharmacology | Maleates - pharmacology | Cytoskeletal Proteins - genetics | Humans | Oleanolic Acid - analogs & derivatives | Transcriptional Activation - drug effects | Oleanolic Acid - pharmacology | NAD(P)H Dehydrogenase (Quinone) - genetics | Hydroquinones - pharmacology | Organoselenium Compounds - pharmacology | HEK293 Cells | Cytoskeletal Proteins - metabolism | NF-E2-Related Factor 2 - genetics | Glutamate-Cysteine Ligase - metabolism | Dimethyl Fumarate | Kelch-Like ECH-Associated Protein 1 | Macrophages, Peritoneal - drug effects | Isothiocyanates - pharmacology | Gene Expression | Mice, Transgenic | Imidazoles - pharmacology | Antioxidants - pharmacology | Azoles - pharmacology | Gene Expression Regulation - drug effects | Animals | Fumarates - pharmacology | NF-E2-Related Factor 2 - metabolism | Adaptor Proteins, Signal Transducing - genetics | NAD(P)H Dehydrogenase (Quinone) - metabolism | Glutamate-Cysteine Ligase - genetics | Mice | Oxidative Stress - drug effects | Adaptor Proteins, Signal Transducing - metabolism | Macrophages, Peritoneal - metabolism | Amino Acid Substitution | Purines | Cysteine | Dimethylformamide | Ligases | Quinone | Transplantation of organs, tissues, etc | Universities and colleges | Macrophages | Cystine | stress response | reactive cysteine
Journal Article
Nature communications, ISSN 2041-1723, 2019, Volume 10, Issue 1, pp. 5065 - 15
Journal Article
Journal Article
Journal of sexual medicine, ISSN 1743-6095, 04/2013, Volume 10, Issue 4, pp. 960 - 971
Prevalence of erectile dysfunction (ED) increases progressively with aging, but the ED pathophysiology at its early stages is still poorly investigated. This... 
Erectile Dysfunction | Antioxidant Therapy | Oxidative Stress | Corpus Cavernosum | Apocynin | Superoxide Dismutase | STIMULATOR BAY 41-2272 | HUMAN CORPUS CAVERNOSUM | RELAXATION | DIABETIC-RATS | PHOSPHODIESTERASE TYPE-5 INHIBITORS | SOLUBLE GUANYLATE-CYCLASE | SMOOTH-MUSCLE | CARDIOVASCULAR-DISEASE | UROLOGY & NEPHROLOGY | ENDOGENOUS NITRIC-OXIDE | Blood Pressure | Free Radical Scavengers - pharmacology | Cyclic GMP - pharmacology | Up-Regulation | Electric Stimulation | Membrane Glycoproteins - metabolism | NADPH Oxidases - metabolism | Male | Nitroprusside - pharmacology | RNA, Messenger - metabolism | Sulfones - pharmacology | Penile Erection | Sildenafil Citrate | Cyclic GMP - analogs & derivatives | Acetophenones - pharmacology | NADPH Oxidases - genetics | Phosphodiesterase 5 Inhibitors - pharmacology | Superoxide Dismutase - metabolism | Pyrazoles - pharmacology | Superoxide Dismutase - pharmacology | Vasodilator Agents - pharmacology | Acetylcholine - pharmacology | Purines - pharmacology | Down-Regulation | Enzyme Inhibitors - pharmacology | Rats | Muscle Relaxation | NADPH Oxidase 2 | Piperazines - pharmacology | Erectile Dysfunction - metabolism | Membrane Glycoproteins - genetics | Animals | Aging - physiology | Cyclic GMP - metabolism | Endothelium, Vascular - metabolism | Nitric Oxide Synthase - metabolism | Pyridines - pharmacology | Superoxide Dismutase-1 | Prevention | Oxidases | Antioxidants | Impotence | Nitric oxide | Sodium nitroferricyanide | Superoxide
Journal Article
Respiratory Research, ISSN 1465-9921, 12/2011, Volume 12, Issue 1, pp. 1 - 8
The development of bronchial hyperreactivity (BHR) subsequent to precapillary pulmonary hypertension (PHT) was prevented by acting on the major signalling... 
Medicine & Public Health | Pneumology/Respiratory System | PARENCHYMAL MECHANICS | LUNG | METHACHOLINE-INDUCED BRONCHOCONSTRICTION | AIRWAY | THERAPY | VASOACTIVE-INTESTINAL-PEPTIDE | RESPIRATORY SYSTEM | ARTERIAL-HYPERTENSION | INHALATION | NITRIC-OXIDE | VIP | Antihypertensive Agents - pharmacology | Tetrazoles - pharmacology | Airway Resistance - drug effects | Iloprost - pharmacology | Bronchial Provocation Tests | Antihypertensive Agents - administration & dosage | Hypertension, Pulmonary - physiopathology | Male | Endothelins - metabolism | Sulfones - pharmacology | Lung Volume Measurements | Sildenafil Citrate | Time Factors | Vasoactive Intestinal Peptide - pharmacology | Bronchoconstriction - drug effects | Bronchial Hyperreactivity - physiopathology | Bronchial Hyperreactivity - metabolism | Blood Pressure - drug effects | Hypertension, Pulmonary - drug therapy | Lung - metabolism | Phosphodiesterase 5 Inhibitors - pharmacology | Endothelin Receptor Antagonists | Disease Models, Animal | Bronchial Hyperreactivity - etiology | Prostaglandins I - metabolism | Bronchial Hyperreactivity - therapy | Infusion Pumps, Implantable | Vasodilator Agents - pharmacology | Administration, Oral | Purines - pharmacology | Receptors, Endothelin - metabolism | Infusions, Parenteral | Rats | Hypertension, Pulmonary - metabolism | Lung - physiopathology | Piperazines - pharmacology | Rats, Sprague-Dawley | Animals | Analysis of Variance | Signal Transduction - drug effects | Lung - drug effects | Pyridines - pharmacology | Lung - blood supply | Nitric Oxide - metabolism | Vasodilator Agents - administration & dosage | Hypertension, Pulmonary - complications | Bronchi | Physiological aspects | Development and progression | Respiratory agents | Research | Drug therapy | Health aspects | Pulmonary hypertension | Prevention | Nitric oxide
Journal Article
Journal Article
British Journal of Pharmacology, ISSN 0007-1188, 12/2014, Volume 171, Issue 24, pp. 5757 - 5773
Journal Article