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Journal Article
Neuron, ISSN 0896-6273, 2006, Volume 51, Issue 1, pp. 113 - 123
Behavioral and computational studies predict that synaptic plasticity of excitatory mossy fiber inputs to cerebellar nuclear neurons is required for... 
MOLNEURO | PURKINJE-CELLS | MUTANT MICE | CORTEX | UNCONDITIONED STIMULUS | INFERIOR OLIVE | CONDITIONED EYELID RESPONSES | LONG-TERM DEPRESSION | HIPPOCAMPAL-NEURONS | CALCIUM CURRENTS | NEUROSCIENCES | PLASTICITY | Synaptic Transmission - physiology | Excitatory Postsynaptic Potentials - drug effects | Purkinje Cells - physiology | Excitatory Postsynaptic Potentials - physiology | Neural Inhibition - physiology | Nerve Fibers - physiology | Neuronal Plasticity - physiology | Synaptic Transmission - drug effects | Cerebellar Nuclei - physiology | Electric Stimulation - methods | Action Potentials - drug effects | Organ Culture Techniques | Receptors, N-Methyl-D-Aspartate - drug effects | Presynaptic Terminals - drug effects | Mice, Inbred C57BL | Nerve Fibers - drug effects | Excitatory Amino Acid Agonists - pharmacology | Excitatory Amino Acid Antagonists - pharmacology | Presynaptic Terminals - physiology | Chelating Agents - pharmacology | Receptors, N-Methyl-D-Aspartate - physiology | Association Learning - physiology | Cerebellar Nuclei - drug effects | Action Potentials - physiology | Conditioning, Eyelid - physiology | Patch-Clamp Techniques | Animals | Mice | Neural Inhibition - drug effects | Physiological aspects | Methyl aspartate | Neurosciences | Neurons | Action potentials (Electrophysiology) | Brain | Software | Protocol | Acquisitions & mergers | Index Medicus
Journal Article
Journal Article
American Journal of Physiology - Regulatory Integrative and Comparative Physiology, ISSN 0363-6119, 05/2013, Volume 305, Issue 4, pp. R343 - R350
We have previously found that modest chronic increases in maternal cortisol result in an enlarged fetal heart. To explore the mechanisms of this effect, we... 
Sheep | Purkinje fiber | Caspase-3 | Cardiomyocyte | Stress | stress | ACTIVATION | PHYSIOLOGY | ENLARGEMENT | EPICARDIUM-DERIVED CELLS | PURKINJE-FIBERS | CYCLE ACTIVITY | HYPERTROPHIC CARDIOMYOPATHY | INHIBITION | cardiomyocyte | ALDOSTERONE | EXPRESSION | sheep | MATERNAL CORTISOL | caspase-3 | Hydrocortisone - toxicity | Apoptosis - drug effects | Receptors, Mineralocorticoid - metabolism | Caspase 3 - metabolism | Cardiomegaly - pathology | Ki-67 Antigen - metabolism | Receptors, Glucocorticoid - metabolism | Proto-Oncogene Proteins c-kit - metabolism | Stem Cells - metabolism | Hydrocortisone - administration & dosage | Receptors, Mineralocorticoid - drug effects | Purkinje Fibers - drug effects | Mineralocorticoid Receptor Antagonists - pharmacology | Female | Receptors, Glucocorticoid - drug effects | Fetal Heart - metabolism | Canrenoic Acid - pharmacology | Purkinje Fibers - metabolism | Gestational Age | Fetal Heart - pathology | Pregnancy | Purkinje Fibers - pathology | Animals | Fetal Heart - drug effects | Cardiomegaly - chemically induced | Stem Cells - drug effects | Stem Cells - pathology | Cell Proliferation - drug effects | Hydrocortisone - pharmacology | Infusions, Intravenous | Mifepristone - pharmacology | Cardiomegaly - metabolism | Heart | Enzymes | Stem cells | Prenatal development | T cell receptors | Hormones | Apoptosis | Index Medicus | Cardiovascular and Renal Integration
Journal Article
Circulation Research, ISSN 0009-7330, 02/2010, Volume 106, Issue 2, pp. 399 - 408
RATIONALE:Recurrent ventricular arrhythmias after initial successful defibrillation are associated with poor clinical outcome. OBJECTIVE:We tested the... 
Electric defibrillation | Delayed afterdepolarization | Purkinje fiber | Inward rectifying K current | Intracellular Ca | FIBRILLATION | ARRHYTHMOGENESIS | POLYMORPHIC VENTRICULAR-TACHYCARDIA | CARDIAC & CARDIOVASCULAR SYSTEMS | ANDERSEN-TAWIL-SYNDROME | POTASSIUM CURRENT | delayed afterdepolarization | intracellular Ca | electric defibrillation | inward rectifying K current | TORSADE-DE-POINTES | EARLY AFTERDEPOLARIZATIONS | CA2 | ELECTRICAL STORM | PERIPHERAL VASCULAR DISEASE | HEMATOLOGY | RABBIT HEARTS | Diastole | Calcium - metabolism | Electrophysiology | Male | Pericardium - metabolism | Arrhythmias, Cardiac - physiopathology | Endocardium - metabolism | Purkinje Fibers - physiopathology | Purkinje Fibers - drug effects | Pericardium - physiopathology | Myocardium - metabolism | Female | Arrhythmias, Cardiac - metabolism | Heart - physiopathology | Rabbits | Chlorides - pharmacology | Myocardium - pathology | Cardiotonic Agents - pharmacology | Purkinje Fibers - metabolism | Potassium - pharmacology | Barium Compounds - pharmacology | Endocardium - physiopathology | Myocytes, Cardiac - pathology | Cesium - pharmacology | Animals | Membrane Potentials | Epicardial Mapping | Isoproterenol - pharmacology | Heart - drug effects | Myocytes, Cardiac - metabolism | In Vitro Techniques | Index Medicus | electrical defibrillation
Journal Article
Journal Article
British Journal of Pharmacology, ISSN 0007-1188, 10/2013, Volume 170, Issue 4, pp. 768 - 778
Journal Article
Journal Article
British Journal of Pharmacology, ISSN 0007-1188, 05/2010, Volume 160, Issue 1, pp. 60 - 76
Background and purpose:  The regulatory guidelines (ICHS7B) for the identification of only drug-induced long QT and pro-arrhythmias have certain limitations.... 
ventricular fibrillation (VF) | conduction time | INa | ventricular tachycardia (VT) | drug | I | Na | Drug | Conduction time | Ventricular fibrillation (VF) | Ventricular tachycardia (VT) | FIBRILLATION | FLECAINIDE | VENTRICULAR-TACHYCARDIA | MECHANISMS | PROLONGATION | SUDDEN UNEXPECTED DEATH | BRUGADA-SYNDROME | I-Na | LIDOCAINE | ACUTE MYOCARDIAL-INFARCTION | PHARMACOLOGY & PHARMACY | CHANNELS | Lidocaine - pharmacology | Lidocaine - adverse effects | Arrhythmias, Cardiac - chemically induced | Cricetulus | Myocardial Reperfusion Injury - chemically induced | Anti-Arrhythmia Agents - pharmacology | Tachycardia, Ventricular - chemically induced | Electric Conductivity | Sodium Channels - physiology | Purkinje Fibers - drug effects | Sodium Channel Blockers - adverse effects | Ventricular Fibrillation - physiopathology | Ether-A-Go-Go Potassium Channels - physiology | CHO Cells | Drug Evaluation, Preclinical - methods | Rabbits | Cricetinae | Sodium Channel Blockers - pharmacology | Flecainide - pharmacology | Heart Conduction System - drug effects | Myocardial Reperfusion Injury - physiopathology | Flecainide - adverse effects | Patch-Clamp Techniques | Tachycardia, Ventricular - physiopathology | Animals | Anti-Arrhythmia Agents - adverse effects | Ventricular Fibrillation - chemically induced | In Vitro Techniques | Purkinje Fibers - physiology | Sodium | Cardiac arrhythmia | Index Medicus | Research Papers | I Na
Journal Article