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1. Full Text Multifunctional organoboron compounds for scalable natural product synthesis
by Meng, Fanke and Meng, Fanke and McGrath, Kevin P and McGrath, Kevin P and Hoveyda, Amir H and Hoveyda, Amir H
Nature, ISSN 0028-0836, 2014, Volume 513, Issue 7518, pp. 367 - 374
Efficient catalytic reactions that can generate C-C bonds enantioselectively, and ones that can produce trisubstituted alkenes diastereoselectively, are... 
ORGANIC-SYNTHESIS | CYCLIC ENONES | REAGENTS | ENANTIOSELECTIVE SYNTHESIS | FUMARATE REDUCTASE INHIBITOR | MULTIDISCIPLINARY SCIENCES | CU-CATALYZED HYDROBORATION | NHC LIGANDS | CONJUGATE ADDITIONS | EFFICIENT | CARBON STEREOGENIC CENTERS | Monosaccharides - chemical synthesis | Pyrans - chemical synthesis | Boron - chemistry | Stereoisomerism | Antineoplastic Agents - chemical synthesis | Fatty Alcohols - chemical synthesis | Fatty Alcohols - chemistry | Alkenes - chemical synthesis | Antineoplastic Agents - chemistry | Anti-Bacterial Agents - chemical synthesis | Alkenes - chemistry | Biological Products - chemical synthesis | Biological Products - chemistry | Animals | Copper - chemistry | Pyrans - chemistry | Anti-Bacterial Agents - chemistry | Catalysis | Porifera - chemistry | Monosaccharides - chemistry | Usage | Natural products | Chemical properties | Chemical synthesis | Organoboron compounds | Methods | Production processes | Phosphates | Boron
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2. Full Text Synthesis of carbocyclic and heterocyclic β-aminocarboxylic acids
by Kiss, Loránd and Fülöp, Ferenc
Chemical Reviews, ISSN 0009-2665, 01/2014, Volume 114, Issue 2, pp. 1116 - 1169
HIGH-YIELDING SYNTHESIS | CONVERTING-ENZYME TACE | L-IDURONIC ACID | PYRAN CARBOXYLIC-ACIDS | ORALLY BIOAVAILABLE INHIBITORS | OSELTAMIVIR PHOSPHATE TAMIFLU | PARALLEL KINETIC RESOLUTION | EFFICIENT S(N)2 REACTIONS | CHEMISTRY, MULTIDISCIPLINARY | SUGAR AMINO-ACID | INFLUENZA NEURAMINIDASE INHIBITORS | Heterocyclic Compounds - chemistry | Carboxylic Acids - chemical synthesis | Carboxylic Acids - chemistry | Amino Acids - chemistry | Heterocyclic Compounds - chemical synthesis | Molecular Structure | Amino Acids - chemical synthesis | Carboxylic acids | Chemical properties | Research | Amino compounds
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3. Full Text Meldrum's acid and related compounds in the synthesis of natural products and analogs
by Ivanov, Andrey S
Chemical Society Reviews, ISSN 0306-0012, 2008, Volume 37, Issue 4, pp. 789 - 811
This critical review focuses on applications of Meldrum's acid and its derivatives to the synthesis of natural products and analogs. It covers all relevant... 
ORGANIC-SYNTHESIS | EFFICIENT TOTAL-SYNTHESIS | WESTERDYKELLA-MULTISPORA F50733 | TYROSINE-PHOSPHATASE INHIBITOR | SOLID-PHASE SYNTHESIS | ONE-POT SYNTHESIS | SPONGE DYSIDEA-HERBACEA | FORMAL TOTAL-SYNTHESIS | BETA-KETO-ESTERS | ANTI-JUVENILE-HORMONE | CHEMISTRY, MULTIDISCIPLINARY | Biological Products - chemical synthesis | Pyrans - chemical synthesis | Pyrrolidinones - chemical synthesis | Models, Chemical | Alkaloids - chemical synthesis | Furans - chemical synthesis | Terpenes - chemical synthesis | Dioxanes - chemistry
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4. Full Text Total synthesis of bryostatin 1
by Keck, Gary E and Poudel, Yam B and Cummins, Thomas J and Rudra, Arnab and Covel, Jonathan A
Journal of the American Chemical Society, ISSN 0002-7863, 02/2011, Volume 133, Issue 4, pp. 744 - 747
Bryostatin 1 is a marine natural product that is a very promising lead compound because of the potent biological activity it displays against a variety of... 
ANTITUMOR MACROLIDES | CELLS | PROTEIN-KINASE-C | ANALOGS | ALZHEIMERS-DISEASE | PYRAN ANNULATION | PHORBOL ESTERS | CANCER | CHEMISTRY, MULTIDISCIPLINARY | Biological Products - chemical synthesis | Biological Products - chemistry | Pyrans - chemistry | Stereoisomerism | Bryostatins - chemical synthesis | Bryostatins - chemistry | Chemical synthesis | Analysis
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5. Full Text Synthesis of natural products containing spiroketals via intramolecular hydrogen abstraction
by Sperry, Jonathan and Liu, Yen-Cheng William and Brimble, Margaret A
Organic & biomolecular chemistry, ISSN 1477-0520, 01/2010, Volume 8, Issue 1, pp. 29 - 38
Although known for over a quarter of a century, the oxidative radical cyclisation route to spiroketals has found limited use in natural product synthesis in... 
Ethers - chemical synthesis | Antineoplastic Agents - chemical synthesis | Ivermectin - chemical synthesis | Anthelmintics - chemical synthesis | Ethers - chemistry | Ivermectin - chemistry | Hydrogen - chemistry | Oxazoles - chemistry | Benzofurans - chemistry | Ethers, Cyclic - chemistry | Bridged-Ring Compounds - chemistry | Phenazines - chemistry | Furans - chemistry | Pyrans - chemistry | Anti-Bacterial Agents - chemistry | Spiro Compounds - chemical synthesis | Ivermectin - analogs & derivatives | Molecular Structure | Ciguatoxins - chemical synthesis | Spiro Compounds - chemistry | Pyrans - chemical synthesis | Ethers, Cyclic - chemical synthesis | Oxidation-Reduction | Ciguatoxins - chemistry | Benzofurans - chemical synthesis | Anthelmintics - chemistry | Antineoplastic Agents - chemistry | Phosphoprotein Phosphatases - chemical synthesis | Anti-Bacterial Agents - chemical synthesis | Biological Products - chemical synthesis | Biological Products - chemistry | Oxazoles - chemical synthesis | Cyclization | Furans - chemical synthesis | Phenazines - chemical synthesis | Bridged-Ring Compounds - chemical synthesis | Phosphoprotein Phosphatases - chemistry
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6. Full Text Multicomponent Hetero-[4 + 2] Cycloaddition/Allylboration Reaction: From Natural Product Synthesis to Drug Discovery
by Hall, Dennis G and Rybak, Taras and Verdelet, Tristan
Accounts of Chemical Research, ISSN 0001-4842, 11/2016, Volume 49, Issue 11, pp. 2489 - 2500
CONSPECTUS: Multicomponent reactions (MCR), transformations employing three or more simple substrates in a single and highly atom-economical operation, are... 
ALDER/ALLYLBORATION SEQUENCE | DIVERSITY-ORIENTED SYNTHESIS | ASYMMETRIC-SYNTHESIS | DIELS-ALDER REACTIONS | TANDEM | 3-COMPONENT REACTION | REGIODIVERGENT | OPTIMIZATION | DERIVATIVES | CHEMISTRY, MULTIDISCIPLINARY | POLYSUBSTITUTED PIPERIDINES | Pyrans - chemical synthesis | Humans | Enzyme Inhibitors - pharmacology | Biological Products - pharmacology | Enzyme Inhibitors - chemical synthesis | Piperidines - chemical synthesis | Cycloaddition Reaction | Drug Discovery | Chemistry Techniques, Synthetic - methods | Anti-Bacterial Agents - chemical synthesis | Biological Products - chemical synthesis | Piperidines - pharmacology | Anti-Bacterial Agents - pharmacology | Pyrans - pharmacology
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7. Full Text Total Synthesis of Thailanstatin A
by Nicolaou, K.C and Rhoades, Derek and Lamani, Manjunath and Pattanayak, Manas R and Kumar, S. Mothish
Journal of the American Chemical Society, ISSN 0002-7863, 06/2016, Volume 138, Issue 24, pp. 7532 - 7535
The total synthesis of the spliceosome inhibitor thailanstatin A has been achieved in a longest linear sequence of nine steps from readily available starting... 
MICHAEL REACTION | SPLICEOSTATIN | CATALYSIS | U4/U6.U5 TRI-SNRNP | FR901464 | MECHANISM | BURKHOLDERIA SP | ALDEHYDES | INHIBITORS | CHEMISTRY, MULTIDISCIPLINARY | PRE-MESSENGER-RNA | Pyrans - chemical synthesis | Pyrans - chemistry | Antineoplastic Agents - chemical synthesis | Antineoplastic Agents - pharmacology | Molecular Structure | Antineoplastic Agents - chemistry | Drug Discovery | Hydrogenation | Pyrans - pharmacology | Chemistry Techniques, Synthetic - methods | Spliceosomes - drug effects | Research | Chemical properties | Chemical synthesis | Statins
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8. Full Text Prins-type macrocyclizations as an efficient ring-closing strategy in natural product synthesis
by Crane, Erika A and Scheidt, Karl A
Angewandte Chemie - International Edition, ISSN 1433-7851, 11/2010, Volume 49, Issue 45, pp. 8316 - 8326
Prins-type macrocyclizations have recently emerged as a successful strategy in the synthesis of polyketide-derived natural products. This reaction provides a... 
Polyketides | Synthesis design | Cyclization | Macrocycles | Total synthesis | POLYCAVERNOSIDE | NITROGEN-HETEROCYCLES | MACROLIDE | OLEFIN METATHESIS | polyketides | cyclization | CHEMISTRY, MULTIDISCIPLINARY | VANCOMYCIN | KENDOMYCIN | macrocycles | CYCLIZATION REACTIONS | NEOPELTOLIDE | total synthesis | synthesis design | MANZAMINE-A | OXONIA-COPE REARRANGEMENT | Rifabutin - chemistry | Macrocyclic Compounds - chemistry | Stereoisomerism | Rifabutin - analogs & derivatives | Disaccharides - chemistry | Bryostatins - chemistry | Disaccharides - chemical synthesis | Biological Products - chemical synthesis | Biological Products - chemistry | Macrolides - chemistry | Macrolides - chemical synthesis | Pyrans - chemistry | Rifabutin - chemical synthesis | Bryostatins - chemical synthesis
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9. Full Text Efficient Construction of Pyrano[3,2‐a]carbazoles: Application to a Biomimetic Total Synthesis of Cyclized Monoterpenoid Pyrano[3,2‐a]carbazole Alkaloids
by Hesse, Ronny and Gruner, Konstanze K and Kataeva, Olga and Schmidt, Arndt W and Knölker, Hans‐Joachim
Chemistry – A European Journal, ISSN 0947-6539, 10/2013, Volume 19, Issue 42, pp. 14098 - 14111
We have developed a highly efficient route to 2‐hydroxy‐3‐methylcarbazole ( 1 ) via a palladium‐catalyzed construction of the carbazole skeleton. Using 1 as... 
natural products | palladium | CH bond activation | cyclization | crystal‐structure determination | alkaloids | C-H bond activation | Alkaloids | Palladium | Cyclization | Natural products | Crystal-structure determination | crystal-structure determination | MURRAYA-KOENIGII | ORGANIC-SYNTHESIS | CHEMICAL TAXONOMY | TRANSITION-METAL-COMPLEXES | CARBAZOLE ALKALOIDS | CATALYZED TOTAL-SYNTHESIS | CHEMISTRY, MULTIDISCIPLINARY | MEDIATED TOTAL-SYNTHESIS | CH bond activation | DIENE COMPLEXES | 1ST TOTAL-SYNTHESIS | CLAUSINE-L | Pyrans - chemical synthesis | Carbazoles - chemistry | Oxidation-Reduction | Crystallography, X-Ray | Carbazoles - chemical synthesis | Monoterpenes - chemical synthesis | Lewis Acids - chemistry | Biomimetics | Pyrans - chemistry | Monoterpenes - chemistry | Molecular Structure | Palladium - chemistry | Synthesis | Transition metal compounds | Organic compounds | Crystal structure | Lewis acid | Organic chemistry | Construction | Chemical reactions | Citral
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10. Full Text Phosphine-catalyzed enantioselective synthesis of oxygen heterocycles
by Chung, Ying Kit and Fu, Gregory C
Angewandte Chemie - International Edition, ISSN 1433-7851, 03/2009, Volume 48, Issue 12, pp. 2225 - 2227
Chiral phosphepine 1 catalyzes the transformation of an array of hydroxy-2-alkynoates into saturated oxygen heterocycles with good enantioselectivity. Phenols... 
Phosphanes | Cyclization | Oxygen heterocycles | Asymmetric catalysis | Isomerization | oxygen heterocycles | PHOSPHORUS LIGANDS | isomerization | IMINES | OLEFINS | asymmetric catalysis | phosphanes | ALLENES | cyclization | DERIVATIVES | CHEMISTRY, MULTIDISCIPLINARY | CHIRAL PHOSPHINES | Pyrans - chemical synthesis | Stereoisomerism | Heterocyclic Compounds - chemical synthesis | Phosphines - chemistry | Heterocyclic Compounds - chemistry | Furans - chemistry | Pyrans - chemistry | Oxygen - chemistry | Chromans - chemical synthesis | Catalysis | Furans - chemical synthesis | Chromans - chemistry
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11. Full Text Multi-stimuli sensitive amphiphilic block copolymer assemblies
by Klaikherd, Akamol and Nagamani, Chikkannagari and Thayumanavan, S
Journal of the American Chemical Society, ISSN 0002-7863, 04/2009, Volume 131, Issue 13, pp. 4830 - 4838
Stimuli-responsive polymers are arguably the most widely considered systems for a variety of applications in biomedical arena. We report here a novel triple... 
TRIGGERED RELEASE | DIBLOCK COPOLYMERS | N-ISOPROPYLACRYLAMIDE | REDUCIBLE POLYCATIONS | BIOENGINEERING APPLICATIONS | NONIONIC SURFACTANT | SUPRAMOLECULAR ASSEMBLIES | INTRACELLULAR DRUG-DELIVERY | POLYMERIC MICELLES | RESPONSIVE POLYMERS | CHEMISTRY, MULTIDISCIPLINARY | Temperature | Methacrylates - chemistry | Drug Carriers - chemistry | Oxazines - metabolism | Pyrans - chemistry | Micelles | Water - chemistry | Acrylamides - metabolism | Acrylic Resins | Methacrylates - chemical synthesis | Pyrans - chemical synthesis | Drug Carriers - metabolism | Magnetic Resonance Spectroscopy | Oxidation-Reduction | Polymers - chemical synthesis | Acids - chemistry | Methacrylates - metabolism | Drug Carriers - chemical synthesis | Acrylamides - chemistry | Hydrophobic and Hydrophilic Interactions | Polymers - chemistry | Kinetics | Acrylamides - chemical synthesis | Polymers - metabolism | Hydrogen-Ion Concentration | Chemical reaction, Rate of | Oxidation-reduction reaction | Analysis
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12. Full Text Stereoselective construction of 2,6- cis -disubstituted tetrahydropyrans via intramolecular amide enolate alkylation: Total synthesis of (-)-centrolobine
by Latif, Muhammad and Yun, Jeong In and Seshadri, Kalapati and Kim, Hyoung Rae and Park, Chi Hoon and Park, Haeil and Kim, Hyoungsu and Lee, Jongkook
Journal of Organic Chemistry, ISSN 0022-3263, 03/2015, Volume 80, Issue 6, pp. 3315 - 3320
A highly stereoselective construction of 2,6-cis-disubstituted tetrahydropyrans was achieved by using an intramolecular amide enolate alkylation with KHMDS.... 
Amides - chemistry | Pyrans - chemical synthesis | Molecular Structure | Pyrans - chemistry | Stereoisomerism | Alkylation | Research | Chemical properties | Chemical synthesis | Organic compounds
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13. Full Text Design, synthesis, and biological evaluation of platensimycin analogues with varying degrees of molecular complexity
by Nicolaou, K.C and Stepan, Antonia F and Lister, Troy and Li, Ang and Montero, Ana and Tria, G. Scott and Turner, Craig I and Tang, Yefeng and Wang, Jianhua and Denton, Ross M and Edmonds, David J
Journal of the American Chemical Society, ISSN 0002-7863, 10/2008, Volume 130, Issue 39, pp. 13110 - 13119
The molecular design, chemical synthesis, and biological evaluation of two distinct series of platensimycin analogues with varying degrees of complexity are... 
METAL CARBENE TRANSFORMATIONS | INTRAMOLECULAR CYCLOPROPANATION | OXIDATION | STREPTOMYCES-PLATENSIS | DIRHODIUM(II) | FORMAL SYNTHESIS | ANTIBIOTIC PROPERTIES | METATHESIS CATALYSTS | ENANTIOSELECTIVE ROUTE | INHIBITOR | CHEMISTRY, MULTIDISCIPLINARY | Anti-Infective Agents - pharmacology | Benzoates - chemistry | Cyclohexenes - chemistry | Anilides - chemistry | Structure-Activity Relationship | Anilides - chemical synthesis | Microbial Sensitivity Tests | Epoxy Compounds - chemical synthesis | Pyrans - chemistry | Anti-Infective Agents - chemistry | Drug Design | Benzodioxoles - chemistry | Methicillin Resistance | Adamantane - analogs & derivatives | Pyrans - chemical synthesis | Adamantane - pharmacology | Benzaldehydes - chemistry | Cyclohexenes - chemical synthesis | Benzoates - chemical synthesis | Aminobenzoates - chemical synthesis | Anti-Infective Agents - chemical synthesis | Adamantane - chemical synthesis | Aminobenzoates - chemistry | Epoxy Compounds - chemistry | Anilides - pharmacology | Aminobenzoates - pharmacology | Benzoates - pharmacology | Adamantane - chemistry | Aniline Compounds - chemistry | Staphylococcus aureus - drug effects | Aniline Compounds - chemical synthesis | Benzoic acid | Substitution reactions | Chemical properties | Antibiotics | Structure | Analysis
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14. Full Text A facile one-pot green synthesis and antibacterial activity of 2-amino-4H-pyrans and 2-amino-5-oxo-5,6,7,8-tetrahydro-4H-chromenes
by Kumar, Dalip and Reddy, V. Buchi and Sharad, Shashwat and Dube, Urvashi and Kapur, Suman
European Journal of Medicinal Chemistry, ISSN 0223-5234, 09/2009, Volume 44, Issue 9, pp. 3805 - 3809
A facile one-pot expeditious synthesis of 2-amino-4H-pyrans and 2-amino-5-oxo-5,6,7,8-tetrahydro-4H-chromenes has been described under solvent-free conditions... 
2-Amino-4H-pyrans | Antibacterial activity | Tetrahydro-4H-chromenes | Magnesium oxide | Multi-component reaction | MAGNESIUM-OXIDE | CHEMISTRY, MEDICINAL | KNOEVENAGEL | REAGENTS | SOLID-STATE | SOLVENT-FREE | NITRILES | DERIVATIVES | Pyrans - chemical synthesis | Escherichia coli - drug effects | Structure-Activity Relationship | Pseudomonas aeruginosa - drug effects | Anti-Bacterial Agents - chemical synthesis | Benzopyrans - chemistry | Microbial Sensitivity Tests | Benzopyrans - chemical synthesis | Pyrans - chemistry | Anti-Bacterial Agents - chemistry | Pseudomonas putida - drug effects | Anti-Bacterial Agents - pharmacology | Catalysis | Benzopyrans - pharmacology | Staphylococcus aureus - drug effects | Pyrans - pharmacology | Magnesium compounds | Antibacterial agents
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15. Full Text Organocatalytic asymmetric synthesis of α,α-disubstituted α-amino acids and derivatives
by Cabrera, Silvia and Reyes, Efraim and Alemán, José and Milelli, Andrea and Kobbelgaard, Sara and Jørgensen, Karl Anker
Journal of the American Chemical Society, ISSN 0002-7863, 09/2008, Volume 130, Issue 36, pp. 12031 - 12037
It is shown that racemic oxazolones are excellent reagents for the synthesis of chiral quaternary amino acids and its derivatives by the diastereo- and... 
MICHAEL REACTION | MANNICH REACTION | CATALYSIS | ALPHA,BETA-UNSATURATED ALDEHYDES | CHEMISTRY | CARBONYL-COMPOUNDS | ANTI-MANNICH | GENERAL ORGANOCATALYST | CHEMISTRY, MULTIDISCIPLINARY | SYN-ALDOL REACTIONS | CONJUGATE ADDITION | Pyrans - chemical synthesis | Proline - analogs & derivatives | Amino Alcohols - chemical synthesis | Stereoisomerism | Amino Acids - chemistry | Lactams - chemical synthesis | Models, Molecular | Crystallography, X-Ray | Oxazolone - chemistry | Proline - chemical synthesis | Amino Acids - chemical synthesis | Hydrogen Bonding | Catalysis | Aldehydes - chemistry
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16. Full Text Total synthesis of bryostatin 7 via C-C bond-forming hydrogenation
by Lu, Yu and Woo, Sang Kook and Krische, Michael J
Journal of the American Chemical Society, ISSN 0002-7863, 09/2011, Volume 133, Issue 35, pp. 13876 - 13879
The marine macrolide bryostatin 7 is prepared in 20 steps (longest linear sequence) and 36 total steps with five C-C bonds formed using hydrogenative methods.... 
CATALYZED CARBONYL ALLYLATION | DESIGN | POTENT | ASYMMETRIC-SYNTHESIS | ANALOGS | A-RING | BIOLOGICAL EVALUATION | FRAGMENT | ALDEHYDE OXIDATION LEVEL | PYRAN ANNULATION | CHEMISTRY, MULTIDISCIPLINARY | Biological Products - chemical synthesis | Animals | Chemistry Techniques, Synthetic | Hydrogenation | Bryostatins - chemical synthesis | Bryozoa - chemistry | Chemical bonds | Analysis
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17. Full Text Total synthesis of bryostatin 9
by Wender, Paul A and Schrier, Adam J
Journal of the American Chemical Society, ISSN 0002-7863, 06/2011, Volume 133, Issue 24, pp. 9228 - 9231
The total synthesis of bryostatin 9 was accomplished using a uniquely step-economical and convergent Prins-driven macrocyclization strategy. At 25 linear and... 
ANTITUMOR MACROLIDES | PROTEIN-KINASE-C | POTENT | ASYMMETRIC-SYNTHESIS | PRINS MACROCYCLIZATION | A-RING | ANTINEOPLASTIC AGENTS | PHASE-II | PKC | PYRAN ANNULATION | CHEMISTRY, MULTIDISCIPLINARY | Cyclization | Bryostatins - metabolism | Protein Kinase C - metabolism | Bryostatins - chemical synthesis | Bryostatins - chemistry | Ring formation (Chemistry) | Chemical synthesis | Analysis | Methods
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18. Full Text Strategies for the construction of tetrahydropyran rings in the synthesis of natural products
by Nasir, Nadiah Mad and Ermanis, Kristaps and Clarke, Paul A
Organic & biomolecular chemistry, ISSN 1477-0520, 06/2014, Volume 12, Issue 21, pp. 3323 - 3335
This review focuses on the methodology used for the construction of tetrahydropyran (THP) rings in the synthesis of natural products over the last seven years.... 
Chemistry, Organic - methods | Biological Products - chemical synthesis | Pyrans - chemical synthesis | Biological Products - chemistry | Oxidation-Reduction | Pyrans - chemistry | Kinetics | Cycloaddition Reaction
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