X
Search Filters
Format Format
Subjects Subjects
Subjects Subjects
X
Sort by Item Count (A-Z)
Filter by Count
index medicus (2165) 2165
animals (1225) 1225
pyrans - pharmacology (1081) 1081
humans (811) 811
pyrans - chemistry (512) 512
male (480) 480
rats (454) 454
pharmacology & pharmacy (420) 420
pyrans - metabolism (410) 410
mice (376) 376
biochemistry & molecular biology (331) 331
female (284) 284
chemistry, medicinal (269) 269
pyrans (232) 232
cell line, tumor (222) 222
iridoids (213) 213
dose-response relationship, drug (206) 206
molecular structure (191) 191
apoptosis (187) 187
structure-activity relationship (173) 173
pyrans - isolation & purification (165) 165
analysis (158) 158
enzyme inhibitors - pharmacology (157) 157
pyrans - chemical synthesis (148) 148
antineoplastic agents - pharmacology (142) 142
salinomycin (142) 142
apoptosis - drug effects (139) 139
in vitro techniques (135) 135
toxicology (135) 135
kinetics (129) 129
chemistry, organic (127) 127
cancer (125) 125
in-vitro (125) 125
expression (123) 123
cells, cultured (118) 118
rats, sprague-dawley (118) 118
okadaic acid (117) 117
time factors (116) 116
pyrans - administration & dosage (112) 112
magnetic resonance spectroscopy (110) 110
phosphorylation (110) 110
cell proliferation - drug effects (107) 107
cell line (106) 106
pyrans - therapeutic use (106) 106
anti-bacterial agents - pharmacology (105) 105
activation (104) 104
research (103) 103
pyrans - toxicity (102) 102
cell survival - drug effects (101) 101
inhibition (101) 101
proteins (101) 101
article (100) 100
cell biology (99) 99
oncology (99) 99
pyrans - analysis (98) 98
biotechnology & applied microbiology (96) 96
cells (93) 93
plant sciences (93) 93
chemistry (92) 92
pyrans - biosynthesis (86) 86
rabbits (86) 86
enzymes (85) 85
microbiology (85) 85
chemistry, multidisciplinary (84) 84
identification (83) 83
mass spectrometry (82) 82
models, molecular (81) 81
oleuropein (81) 81
physiological aspects (81) 81
antifungal agents - pharmacology (79) 79
metabolism (79) 79
growth (78) 78
oxidative stress (78) 78
spiro compounds - pharmacology (77) 77
rats, wistar (76) 76
biosynthesis (74) 74
chromatography, high pressure liquid (74) 74
stereoisomerism (74) 74
gene expression (73) 73
protein binding (72) 72
cytotoxicity (70) 70
spiro compounds (70) 70
fermentation (69) 69
disease models, animal (68) 68
plant extracts - pharmacology (68) 68
zanamivir (68) 68
signal transduction - drug effects (67) 67
chemistry, applied (65) 65
olive oil (65) 65
derivatives (64) 64
guanidines (64) 64
health aspects (64) 64
hydrogen-ion concentration (64) 64
pyrans - pharmacokinetics (64) 64
dogs (63) 63
food science & technology (63) 63
protein (63) 63
streptomyces - metabolism (63) 63
picolines - pharmacology (62) 62
antibiotics (61) 61
more...
Library Location Library Location
Language Language
Language Language
X
Sort by Item Count (A-Z)
Filter by Count
English (2192) 2192
German (18) 18
Chinese (16) 16
French (14) 14
Japanese (10) 10
Russian (9) 9
Bulgarian (2) 2
Polish (2) 2
Italian (1) 1
Spanish (1) 1
Ukrainian (1) 1
more...
Publication Date Publication Date
Click on a bar to filter by decade
Slide to change publication date range


Nature Chemical Biology, ISSN 1552-4450, 09/2015, Volume 11, Issue 9, pp. 705 - 712
Actin-targeting macrolides comprise a large, structurally diverse group of cytotoxins isolated from remarkably dissimilar micro- and macroorganisms. In spite... 
BACTERIAL SYMBIONT | GENE-CLUSTER | CYTOTOXIC MACROLIDES | NATURAL-PRODUCT DISCOVERY | CYANOBACTERIA | BIOCHEMISTRY & MOLECULAR BIOLOGY | SYNTHASES | IN-SITU HYBRIDIZATION | SPONGE THEONELLA-SWINHOEI | IDENTIFICATION | ANTIFUNGAL MACROLIDE | Cyanobacteria - genetics | Deltaproteobacteria - metabolism | Multigene Family | Peptides | Actins - metabolism | Bacterial Proteins - chemistry | Cyanobacteria - metabolism | Molecular Sequence Data | Polyketides - chemistry | Small Molecule Libraries - metabolism | Polyketides - metabolism | Polyketide Synthases - metabolism | Macrolides - chemistry | Pyrans - chemistry | Pyrans - metabolism | Base Sequence | Actins - chemistry | Symbiosis | Gene Expression | Bacterial Proteins - genetics | Macrolides - metabolism | Biological Evolution | Small Molecule Libraries - chemistry | Polyketide Synthases - chemistry | Animals | Deltaproteobacteria - genetics | Theonella - microbiology | Protein Binding | Bacterial Proteins - metabolism | Polyketide Synthases - genetics | Enzymes | Bacteria | Biosynthesis | Metabolism | Index Medicus | Polyketide Synthases/metabolism | Actins/metabolism | Macrolides/chemistry | Polyketide Synthases/chemistry | Life Sciences | Cyanobacteria/metabolism | Deltaproteobacteria/genetics | Bacterial Proteins/chemistry | Macrolides/metabolism | Actins/chemistry | Polyketide Synthases/genetics | Deltaproteobacteria/metabolism | Small Molecule Libraries/metabolism | Theonella/microbiology | Cyanobacteria/genetics | Pyrans/metabolism | Small Molecule Libraries/chemistry | Microbiology and Parasitology | Bacterial Proteins/metabolism | Polyketides/chemistry | Polyketides/metabolism | Bacterial Proteins/genetics | Pyrans/chemistry
Journal Article
Journal Article
BMC Plant Biology, ISSN 1471-2229, 09/2012, Volume 12, Issue 1, pp. 162 - 162
Background: Olive (Olea europaea L.) fruits contain numerous secondary metabolites, primarily phenolics, terpenes and sterols, some of which are particularly... 
Secoiridoids | Olea europaea | Phenolics | RT-qPCR | Secondary metabolism | Transcriptome | OLEA-EUROPAEA FRUITS | CATHARANTHUS-ROSEUS | CULTIVAR HARDYS MAMMOTH | TERPENOID BIOSYNTHESIS | BIOCHEMICAL-CHARACTERIZATION | AROGENATE DEHYDROGENASE | INDOLE ALKALOID BIOSYNTHESIS | PLANT SCIENCES | PERFORMANCE LIQUID-CHROMATOGRAPHY | GERANIOL 10-HYDROXYLASE | MAGNETIC-RESONANCE CHARACTERIZATION | Species Specificity | Genes, Plant | Phenylethyl Alcohol - analogs & derivatives | Cytochrome P-450 Enzyme System - metabolism | Gene Expression Profiling | Olea - genetics | RNA, Messenger - metabolism | Glucosides - genetics | Iridoids | Pyrans - metabolism | Iridoid Glucosides - metabolism | Plant Proteins - metabolism | Fruit - metabolism | Plant Oils - analysis | Real-Time Polymerase Chain Reaction | Fruit - genetics | Prephenate Dehydrogenase - genetics | RNA, Messenger - genetics | Biosynthetic Pathways | Phenols - metabolism | Glucosides - metabolism | Metabolomics - methods | Phenylethyl Alcohol - metabolism | Fruit - growth & development | Plant Proteins - genetics | Olea - growth & development | Olea - metabolism | Plant Oils - metabolism | Cytochrome P-450 Enzyme System - genetics | Prephenate Dehydrogenase - metabolism | Amplified Fragment Length Polymorphism Analysis | Olive | Physiological aspects | Development | Genetic aspects | Research | Plants | Plant metabolites | Sterols | Fruit | Functional foods | Analysis | Genetic transcription | Acids | Metabolites | Olive oil | Gene expression | Manuscripts | Fruits | Cultivars | Environmental conditions | Index Medicus
Journal Article
Cell Metabolism, ISSN 1550-4131, 2006, Volume 3, Issue 6, pp. 417 - 427
Uncoupling protein 2 (UCP2) negatively regulates insulin secretion. UCP2 deficiency (by means of gene knockout) improves obesity- and high glucose-induced β... 
HUMDISEASE | REAGENT | SUPEROXIDE | PRODUCT | INSULIN-SECRETION | UCP2 | ENDOCRINOLOGY & METABOLISM | FATTY-ACIDS | POLYMORPHISM | PROMOTER | EXPRESSION | MITOCHONDRIAL UNCOUPLING PROTEINS | CELL BIOLOGY | Protons | Islets of Langerhans - drug effects | Ion Channels | Heterocyclic Compounds, 3-Ring - pharmacology | Molecular Conformation | Drugs, Chinese Herbal - pharmacology | Membrane Transport Proteins - drug effects | Male | Heterocyclic Compounds, 3-Ring - chemical synthesis | Aldehydes - metabolism | Aldehydes - antagonists & inhibitors | Mitochondrial Membranes - drug effects | Mitochondrial Proteins - drug effects | Potassium Channels - metabolism | Membrane Transport Proteins - deficiency | Iridoids | Islets of Langerhans - metabolism | Mitochondrial Proteins - metabolism | Pyrans - chemistry | Adenosine Triphosphate - metabolism | Islets of Langerhans - cytology | Membrane Transport Proteins - metabolism | Mitochondria - chemistry | Mitochondrial Proteins - deficiency | Insulin Secretion | Pyrans - pharmacology | Insulin-Secreting Cells - physiology | Glucose - pharmacology | Mitochondria - metabolism | Mitochondria - drug effects | Potassium Channels - drug effects | Glucose - antagonists & inhibitors | Mice, Knockout | Mitochondrial Membranes - metabolism | Obesity - metabolism | Insulin - metabolism | Animals | Insulin-Secreting Cells - drug effects | Heterocyclic Compounds, 3-Ring - chemistry | Iridoid Glycosides | Mice, Obese | Mice | Uncoupling Protein 2 | Index Medicus
Journal Article
Journal Article
Scientific Reports, ISSN 2045-2322, 08/2014, Volume 4, Issue 1, pp. 6098 - 6098
ABT-737 inhibits the anti-apoptotic proteins B-cell lymphoma 2 (BCL-2) and BCL-X-L. Meayamycin B switches the splicing pattern of myeloid cell leukemia factor... 
CIGARETTE-SMOKING | HUMAN-PAPILLOMAVIRUS TYPE-16 | MULTIDISCIPLINARY SCIENCES | BCL-X | CERVICAL-CANCER | CARCINOMA | SPLICING FACTOR | LINES | PRE-MESSENGER-RNA | P53 | Caspase 7 - metabolism | Head and Neck Neoplasms - virology | Apoptosis - drug effects | Humans | Caspase 3 - metabolism | Myeloid Cell Leukemia Sequence 1 Protein - metabolism | Piperazines - toxicity | Pyrans - toxicity | Phosphoproteins - antagonists & inhibitors | Phosphoproteins - metabolism | bcl-2 Homologous Antagonist-Killer Protein - metabolism | Head and Neck Neoplasms - metabolism | Biphenyl Compounds - toxicity | Ribonucleoprotein, U2 Small Nuclear - metabolism | RNA Interference | Ribonucleoprotein, U2 Small Nuclear - genetics | Oncogene Proteins, Viral - genetics | Repressor Proteins - metabolism | Oncogene Proteins, Viral - metabolism | RNA Splicing - drug effects | RNA Splicing Factors | bcl-2-Associated X Protein - metabolism | Repressor Proteins - genetics | Phosphoproteins - genetics | Human papillomavirus 16 - metabolism | Myeloid Cell Leukemia Sequence 1 Protein - genetics | Head and Neck Neoplasms - pathology | Nitrophenols - toxicity | Drug Synergism | Cell Line, Tumor | Ribonucleoprotein, U2 Small Nuclear - antagonists & inhibitors | Morpholines - toxicity | Sulfonamides - toxicity | HeLa Cells | bcl-X Protein - metabolism | RNA, Small Interfering - metabolism | Squamous cell carcinoma | Small cell lung carcinoma | Bax protein | Bcl-2 protein | Non-small cell lung carcinoma | Cytotoxicity | mRNA | Lung carcinoma | Tumor cell lines | Lymphoma | BAK protein | Mcl-1 protein | Western blotting | Polymerase chain reaction | Bcl-x protein | Lymphocytes B | Bcl protein | Head and neck cancer | Tumorigenesis | Neck | Splicing factors | Apoptosis | B-cell lymphoma | Index Medicus
Journal Article
Journal of Pharmacy and Pharmacology, ISSN 0022-3573, 11/2014, Volume 66, Issue 11, pp. 1606 - 1614
Journal Article
Journal Article
Clinical science (London, England : 1979), ISSN 0143-5221, 11/2015, Volume 129, Issue 9, pp. 809 - 822
BCSCs (breast cancer stem cells) have been shown to be resistant to chemotherapy. However, the mechanisms underlying BCSC-mediated chemoresistance remain... 
chemoresistance | Hedgehog signalling pathway | mammosphere | breast cancer tissues | MEDICINE, RESEARCH & EXPERIMENTAL | STEM-CELLS | CHEMOTHERAPY | PACLITAXEL | SUBPOPULATION | RESISTANCE | CARCINOMAS | EXPRESSION | ASSOCIATION | Paclitaxel - pharmacology | Receptors, G-Protein-Coupled - metabolism | Neoplastic Stem Cells - drug effects | CD24 Antigen - metabolism | Humans | Zinc Finger Protein Gli2 | Hedgehog Proteins - metabolism | Antineoplastic Agents - therapeutic use | Breast Neoplasms - metabolism | Proto-Oncogene Proteins c-bcl-2 - metabolism | MCF-7 Cells | Neoplastic Stem Cells - metabolism | Kruppel-Like Transcription Factors - metabolism | Smoothened Receptor | Hyaluronan Receptors - metabolism | Female | Antineoplastic Agents - pharmacology | Spheroids, Cellular - drug effects | Gene Expression Regulation, Neoplastic - drug effects | Nuclear Proteins - genetics | Pyrans - pharmacology | Pyrans - therapeutic use | Signal Transduction | Spheroids, Cellular - metabolism | Kaplan-Meier Estimate | Nuclear Proteins - metabolism | Transcription Factors - genetics | Breast Neoplasms - drug therapy | Paclitaxel - therapeutic use | Proto-Oncogene Proteins c-myc - metabolism | Transcription Factors - metabolism | Xenograft Model Antitumor Assays | Drug Resistance, Neoplasm - genetics | Animals | Breast Neoplasms - genetics | Mice, Nude | Mice, Inbred BALB C | Proto-Oncogene Proteins c-myc - genetics | Receptors, G-Protein-Coupled - genetics | Zinc Finger Protein GLI1 | Kruppel-Like Transcription Factors - genetics | Proto-Oncogene Proteins c-bcl-2 - genetics | Drug Resistance, Neoplasm - drug effects | Index Medicus
Journal Article
Journal of Cell Science, ISSN 0021-9533, 01/2006, Volume 119, Issue 1, pp. 96 - 103
Human enhancer of filamentation 1 (HEF1), a multifunctional docking protein of the Cas family, participates in integrin and growth factor signaling pathways... 
Protein phosphatase 2A (PP2A) | Actin cytoskeleton | Human enhancer of filamentation 1 (HEF1) | Cell adhesion | Proteasome | proteasome | SIGNALING PATHWAYS | TYROSINE PHOSPHORYLATION | CYTOSKELETON | DOCKING PROTEIN HEF1 | INTEGRIN | PHOSPHATASE | FAMILY-MEMBER HEF1 | HUMAN ENHANCER | P130(CAS) FAMILY | CELL BIOLOGY | actin cytoskeleton | CYCLIN-DEPENDENT KINASES | human enhancer of filamentation 1 (HEF1) | protein phosphatase 2A (PP2A) | cell adhesion | Nucleic Acid Synthesis Inhibitors - metabolism | Phosphorylation | Humans | Phosphoprotein Phosphatases - metabolism | Actins - metabolism | Okadaic Acid - metabolism | Cytochalasin D - metabolism | Intermediate Filaments - metabolism | Phosphoproteins - metabolism | Threonine - metabolism | Antineoplastic Agents - metabolism | Nocodazole | Microtubules - metabolism | Protein Isoforms - metabolism | Pyrans - metabolism | Tubulin Modulators - metabolism | Protein Phosphatase 2 | Cell Line | Oxazoles - metabolism | Actin Cytoskeleton - metabolism | Enzyme Inhibitors - metabolism | Colchicine - metabolism | Phosphoprotein Phosphatases - antagonists & inhibitors | Phosphoproteins - genetics | Serine - metabolism | Cell Adhesion - physiology | Adaptor Proteins, Signal Transducing - genetics | Signal Transduction - physiology | Proteasome Endopeptidase Complex - metabolism | Adaptor Proteins, Signal Transducing - metabolism | Proteasome Inhibitors | Protein Isoforms - genetics | Spiro Compounds - metabolism | Index Medicus
Journal Article
Chemosphere, ISSN 0045-6535, 09/2017, Volume 183, pp. 80 - 88
Journal Article