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Journal of Neuroscience, ISSN 0270-6474, 01/2009, Volume 29, Issue 2, pp. 393 - 401
Glucocorticoids exert an opposing rapid regulation of glutamate and GABA synaptic inputs to hypothalamic magnocellular neurons via the activation of... 
GABA | Magnocellular neuron | Endocannabinoid | Glucocorticoid | Nitric oxide | SUPRAOPTIC NUCLEUS | endocannabinoid | glucocorticoid | nitric oxide | ACTIVATION | magnocellular neuron | NITRIC-OXIDE SYNTHASE | NEUROSCIENCES | MEMBRANE ESTROGEN-RECEPTORS | ENDOCANNABINOID RELEASE | PARAVENTRICULAR NUCLEUS | G(alpha) | ADRENALECTOMIZED RATS | NEURONS | VASOPRESSIN | OXYTOCIN | G(beta)gamma | Cannabinoid Receptor Modulators - metabolism | Synaptic Transmission - physiology | gamma-Aminobutyric Acid - metabolism | GTP-Binding Proteins - antagonists & inhibitors | Male | Penicillamine - analogs & derivatives | Patch-Clamp Techniques - methods | Quinoxalines - pharmacology | Dexamethasone - pharmacology | Piperidines - pharmacology | Dronabinol - analogs & derivatives | Neurons - physiology | Nitric Oxide Donors - pharmacology | Dronabinol - pharmacology | Neurons - drug effects | Electric Stimulation - methods | Pyrans - pharmacology | Guanosine Diphosphate - pharmacology | Pyrazoles - pharmacology | Cyclic AMP-Dependent Protein Kinases - metabolism | Synapses - drug effects | Synapses - physiology | Penicillamine - pharmacology | Valine - analogs & derivatives | Enzyme Inhibitors - pharmacology | Rats | Excitatory Amino Acid Antagonists - pharmacology | Thionucleotides - pharmacology | Rats, Sprague-Dawley | Animals | Guanosine Diphosphate - analogs & derivatives | Hypothalamus - cytology | Signal Transduction - drug effects | Arginine - pharmacology | Cannabinoid Receptor Modulators - antagonists & inhibitors | Glucocorticoids - pharmacology | Glutamic Acid - metabolism | Valine - pharmacology | In Vitro Techniques | Nitric Oxide - metabolism | GTP-Binding Proteins - metabolism | Gβγ
Journal Article
Journal of Biological Chemistry, ISSN 0021-9258, 04/2012, Volume 287, Issue 15, pp. 11810 - 11819
gamma-Secretase-mediated cleavage of amyloid precursor protein (APP) results in the production of Alzheimer disease-related amyloid-beta (A beta) peptides. The... 
TARGET | PROTEIN | PATTERN | ALZHEIMERS-DISEASE | BIOCHEMISTRY & MOLECULAR BIOLOGY | TRANSMEMBRANE DOMAIN | INHIBITORS | BINDING-SITES | EXPRESSION | FAILURE | PRESENILIN-1 | Pyridines - chemistry | Receptors, Notch - metabolism | Humans | Receptor, EphA4 - metabolism | Pyrimidines - chemistry | Brain - metabolism | Alanine - analogs & derivatives | Dibenzazepines - pharmacology | Drug Interactions | Azepines - chemistry | Piperidines - pharmacology | Protein Processing, Post-Translational - drug effects | Pyrans - chemistry | Amyloid beta-Protein Precursor - metabolism | HEK293 Cells | Female | Pyrans - pharmacology | Alanine - pharmacology | Carbamates - pharmacology | Binding, Competitive | Guinea Pigs | Amyloid beta-Peptides - biosynthesis | Dipeptides - pharmacology | Mice, Inbred C57BL | Rats | Imidazoles - pharmacology | Pyrimidines - pharmacology | Receptor, EphB2 - metabolism | Sulfonamides - pharmacology | Azepines - pharmacology | Brain - drug effects | Sulindac - analogs & derivatives | Amyloid Precursor Protein Secretases - metabolism | Animals | Cell-Free System | Protein Binding | Mice | Pyridines - pharmacology | Amyloid Precursor Protein Secretases - antagonists & inhibitors | Flurbiprofen - pharmacology | Sulindac - pharmacology | Neurodegenerative Diseases | Secretases | Neurobiology | Intramembrane Proteolysis | Amyloid | Pharmacology | Alzheimer Disease
Journal Article
Journal Article
Phytochemistry, ISSN 0031-9422, 09/2015, Volume 117, pp. 317 - 324
Four alkaloids comprising two vallesamine, one strychnan, and pyranopyridine alkaloid were isolated from two Malayan species, and . Several of the isolated... 
Apocynaceae | NMR | Cytotoxicity | Alstonia rostrata | Vasorelaxation | Indole alkaloids | Alstonia pneumatophora | MACROPHYLLA | BIOCHEMISTRY & MOLECULAR BIOLOGY | BISINDOLE ALKALOIDS | MACROLINE-MACROLINE | PLANT SCIENCES | ANGUSTIFOLIA | A-D | SARPAGINE | ALSMAPHORAZINES | DERIVATIVES | Carbazoles - chemistry | Pyridines - chemistry | Humans | Crystallography, X-Ray | Cell Line, Tumor - drug effects | Alstonia - chemistry | Heterocyclic Compounds, 4 or More Rings - pharmacology | Phenylephrine - pharmacology | Pyrans - chemistry | Aldehydes - pharmacology | Lactams - pharmacology | Molecular Structure | Indole Alkaloids - chemistry | Pyrans - pharmacology | Drug Evaluation, Preclinical - methods | Alkaloids - pharmacology | Secologanin Tryptamine Alkaloids - chemistry | Secologanin Tryptamine Alkaloids - pharmacology | Vasodilator Agents - pharmacology | Aorta - drug effects | Heterocyclic Compounds, 4 or More Rings - chemistry | Rats | Antineoplastic Agents, Phytogenic - chemistry | Animals | Indolizines - chemistry | Indole Alkaloids - pharmacology | Vasodilator Agents - chemistry | Pyridines - pharmacology | Antineoplastic Agents, Phytogenic - pharmacology | Carbazoles - pharmacology | Alkaloids - chemistry | Indolizines - pharmacology | Aldehydes - chemistry | Lactams - chemistry | Alkaloids | Analysis | Nuclear nonproliferation
Journal Article
Antimicrobial Agents and Chemotherapy, ISSN 0066-4804, 02/2014, Volume 58, Issue 2, pp. 722 - 733
Journal Article
Scientific Reports, ISSN 2045-2322, 08/2016, Volume 6, Issue 1, p. 30857
Acute ethanol overdose can induce dysfunction of cerebellar motor regulation and cerebellar ataxia. In this study, we investigated the effect of ethanol on... 
PROTEIN-KINASE-A | GABAERGIC TRANSMISSION | MULTIDISCIPLINARY SCIENCES | LONG-TERM DEPRESSION | GABA RELEASE | SYNAPTIC-TRANSMISSION | ENDOCANNABINOID SYSTEM | NEURONS | CB1 CANNABINOID RECEPTOR | GAMMA-AMINOBUTYRIC-ACID | GRANULE CELL | Reflex - drug effects | Purkinje Cells - physiology | Central Nervous System Depressants - pharmacology | Isoquinolines - pharmacology | Receptor, Cannabinoid, CB1 - agonists | Cyclic AMP - analogs & derivatives | Piperidines - pharmacology | Dronabinol - analogs & derivatives | gamma-Aminobutyric Acid - secretion | Cyclic AMP-Dependent Protein Kinases - antagonists & inhibitors | Dronabinol - pharmacology | Purkinje Cells - drug effects | Pyrans - pharmacology | Action Potentials - drug effects | Pyrazoles - pharmacology | Membrane Potentials - drug effects | Morpholines - pharmacology | Thionucleotides - pharmacology | Sulfonamides - pharmacology | Mice, Inbred ICR | Naphthalenes - pharmacology | Physical Stimulation - methods | Cyclic AMP - pharmacology | Ethanol - pharmacology | Patch-Clamp Techniques | Animals | Signal Transduction - drug effects | Benzoxazines - pharmacology | Mice | Receptor, Cannabinoid, CB1 - antagonists & inhibitors | Protein kinase A | Cerebellum | Interneurons | Ethanol | Cerebellar ataxia | Cyclic AMP | Urethane | Cannabinoid CB1 receptors | Kinases | Motor task performance | Signal transduction | γ-Aminobutyric acid | Perfusion | Sensory integration | Purkinje cells | Rodents | Information processing | Overdose
Journal Article
Psychopharmacology, ISSN 0033-3158, 10/2014, Volume 231, Issue 20, pp. 3973 - 3985
Journal Article
Cell, ISSN 0092-8674, 06/2012, Volume 149, Issue 6, pp. 1284 - 1297
Journal Article
Stroke, ISSN 0039-2499, 09/2004, Volume 35, Issue 9, pp. 2200 - 2205
Background and Purpose - Premenopausal women are less susceptible to cardiovascular diseases than men or postmenopausal women. Such disease states are often... 
Cerebral arteries | Gender | Estrogens | Nitric oxide | cerebral arteries | nitric oxide | gender | PROTEIN-KINASE | estrogens | ATHEROSCLEROSIS | BASILAR ARTERY | CLINICAL NEUROLOGY | VASCULAR-TONE | SMOOTH-MUSCLE | CA2 | NITRIC-OXIDE | PERIPHERAL VASCULAR DISEASE | HYPERTENSION | GENDER-DIFFERENCES | MYOSIN PHOSPHATASE | Male | rhoA GTP-Binding Protein - metabolism | Nimodipine - pharmacology | Nitroprusside - pharmacology | Serotonin - pharmacology | Basilar Artery - ultrastructure | rho-Associated Kinases | Protein-Serine-Threonine Kinases - antagonists & inhibitors | Female | Nitric Oxide Donors - pharmacology | Pyrans - pharmacology | Estradiol - pharmacology | Amides - pharmacology | NG-Nitroarginine Methyl Ester - pharmacology | Vasoconstrictor Agents - pharmacology | Basilar Artery - enzymology | Basilar Artery - drug effects | Picolines - pharmacology | Vasodilator Agents - pharmacology | Ovariectomy | Acetylcholine - pharmacology | Cerebrovascular Circulation - drug effects | Protein-Serine-Threonine Kinases - physiology | Enzyme Inhibitors - pharmacology | Intracellular Signaling Peptides and Proteins | Rats | Calcium Channel Blockers - pharmacology | Enzyme Activation - drug effects | Rats, Sprague-Dawley | Animals | Potassium Channels - agonists | Pyridines - pharmacology | Vasodilation - drug effects | Nitric Oxide - metabolism
Journal Article