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Nature Immunology, ISSN 1529-2908, 07/2015, Volume 16, Issue 8, pp. 850 - 858
The success of antitumor immune responses depends on the infiltration of solid tumors by effector T cells, a process guided by chemokines. Here we show that in... 
Dipeptidyl Peptidase 4 - metabolism | Immunotherapy - methods | Male | Adoptive Transfer | Dipeptidyl-Peptidase IV Inhibitors - pharmacology | Cell Movement - immunology | Flow Cytometry | Lymphocytes - immunology | Neoplasms, Experimental - immunology | Chemokine CXCL10 - immunology | Neoplasms, Experimental - genetics | Female | Sitagliptin Phosphate | Dipeptidyl Peptidase 4 - immunology | Chemokines - immunology | Lymphocytes - metabolism | Receptors, CXCR3 - metabolism | Mice, Inbred C57BL | Neoplasms, Experimental - therapy | Dipeptidyl Peptidase 4 - genetics | Mice, Transgenic | Mice, Knockout | Triazoles - pharmacology | Cell Movement - drug effects | Animals | Receptors, CXCR3 - immunology | Cell Line, Tumor | Chemokines - metabolism | Mice, Inbred BALB C | Pyrazines - pharmacology | Chemokine CXCL10 - metabolism | CD26 EXPRESSION | CELLS | CXCL10 | CHEMOKINE ACTIVITY | IN-VIVO | RECEPTOR | IMMUNOLOGY | CD26/DIPEPTIDYL PEPTIDASE-IV | PROTEINS | CANCER | POSTTRANSLATIONAL MODIFICATION | Care and treatment | Usage | Immunotherapy | Development and progression | Inflammation | Health aspects | Chemokines | Tumors | Neoplasms, Experimental/genetics | Immunotherapy/methods | Cell Movement/drug effects | Neoplasms, Experimental/therapy | Lymphocytes/metabolism | Lymphocytes/immunology | Dipeptidyl Peptidase 4/genetics | Life Sciences | Chemokine CXCL10/immunology | Immunology | Pyrazines/pharmacology | Dipeptidyl Peptidase 4/immunology | Dipeptidyl-Peptidase IV Inhibitors/pharmacology | Chemokines/metabolism | Receptors, CXCR3/immunology | Receptors, CXCR3/metabolism | Neoplasms, Experimental/immunology | Triazoles/pharmacology | Cell Movement/immunology | Chemokines/immunology | Dipeptidyl Peptidase 4/metabolism | Chemokine CXCL10/metabolism
Journal Article
Arteriosclerosis, Thrombosis, and Vascular Biology, ISSN 1079-5642, 03/2012, Volume 32, Issue 3, pp. 669 - 676
OBJECTIVE—Nicotinic acid (NA) treatment has been associated with benefits in atherosclerosis that are usually attributed to effects on plasma lipoproteins. The... 
atherosclerosis | macrophages | vascular biology | receptors | cholesterol-lowering drugs | LONG-TERM | INTEGRIN VLA-4 | ACTIVATION | DENDRITIC CELLS | KAPPA-B | FOAM CELLS | ENDOTHELIAL-CELLS | PERIPHERAL VASCULAR DISEASE | MICE | HEMATOLOGY | EXTENDED-RELEASE NIACIN | Tumor Necrosis Factor-alpha - metabolism | Phosphorylation | Integrin alpha4beta1 - metabolism | Toll-Like Receptor 2 - agonists | Human Umbilical Vein Endothelial Cells - metabolism | Receptors, G-Protein-Coupled - metabolism | Humans | Human Umbilical Vein Endothelial Cells - immunology | Monocytes - metabolism | Monocytes - immunology | Niacin - pharmacology | Receptors, Prostaglandin - metabolism | Receptors, Immunologic - antagonists & inhibitors | Inflammation - metabolism | Transfection | Chemotaxis, Leukocyte - drug effects | I-kappa B Kinase - metabolism | RNA Interference | Inflammation Mediators - metabolism | Toll-Like Receptor 4 - agonists | Chemokine CCL2 - metabolism | Receptors, G-Protein-Coupled - drug effects | Interleukin-6 - metabolism | Receptors, Prostaglandin - antagonists & inhibitors | Receptors, Nicotinic - drug effects | Receptors, Nicotinic - metabolism | Human Umbilical Vein Endothelial Cells - drug effects | Cyclooxygenase 2 Inhibitors - pharmacology | Anti-Inflammatory Agents - pharmacology | Cells, Cultured | Inflammation - immunology | Toll-Like Receptor 2 - metabolism | Cell Adhesion - drug effects | Toll-Like Receptor 4 - metabolism | Monocytes - drug effects | Transcription Factor RelA - metabolism | Lipopolysaccharides - pharmacology | Inflammation - genetics | Receptors, G-Protein-Coupled - genetics | Pyrazines - pharmacology | Vascular Cell Adhesion Molecule-1 - metabolism | Receptors, Nicotinic - genetics | Receptors, Immunologic - metabolism
Journal Article
The Journal of Clinical Endocrinology & Metabolism, ISSN 0021-972X, 09/2012, Volume 97, Issue 9, pp. 3333 - 3341
Context: Sitagliptin is an inhibitor of the enzyme dipeptidyl peptidase-IV (DPP-IV), which degrades the incretins, glucagon-like peptide-1 and... 
IMMUNITY | DIPEPTIDYL-PEPTIDASE-IV | HEALTHY-SUBJECTS | INSULIN-RESISTANCE | INFLAMMATION | ENDOCRINOLOGY & METABOLISM | RECEPTOR | MICE | CD26 | INHIBITOR SITAGLIPTIN | Glycated Hemoglobin A - analysis | Tumor Necrosis Factor-alpha - metabolism | Interleukin-6 - analysis | Dipeptidyl Peptidase 4 - metabolism | Prospective Studies | Humans | Middle Aged | Male | Monocytes - metabolism | I-kappa B Kinase - analysis | Dipeptidyl-Peptidase IV Inhibitors - pharmacology | C-Reactive Protein - metabolism | MAP Kinase Kinase 4 - analysis | MAP Kinase Kinase 4 - metabolism | I-kappa B Kinase - metabolism | Glucagon-Like Peptide 1 - analysis | Adult | Female | Sitagliptin Phosphate | C-Reactive Protein - analysis | Interleukin-6 - metabolism | Toll-Like Receptor 4 - analysis | Dipeptidyl Peptidase 4 - analysis | Anti-Inflammatory Agents, Non-Steroidal | Blood Glucose - analysis | Double-Blind Method | Glucagon-Like Peptide 1 - metabolism | Cell Separation | Toll-Like Receptor 2 - metabolism | Receptors, CCR2 - analysis | Toll-Like Receptor 4 - metabolism | Blotting, Western | Tumor Necrosis Factor-alpha - analysis | Monocytes - drug effects | Triazoles - pharmacology | Receptors, CCR2 - metabolism | Diabetes Mellitus, Type 2 - physiopathology | Toll-Like Receptor 2 - analysis | Aged | Blood Glucose - metabolism | Diabetes Mellitus, Type 2 - drug therapy | Pyrazines - pharmacology | Endocrine Research
Journal Article
Cancer Cell, ISSN 1535-6108, 09/2013, Volume 24, Issue 3, pp. 289 - 304
Proteasome inhibitor (PI) resistance mechanisms in multiple myeloma (MM) remain controversial. We report the existence of a progenitor organization in primary... 
BORTEZOMIB RESISTANCE | OVEREXPRESSION | DEXAMETHASONE | BLIMP-1 | UNFOLDED PROTEIN RESPONSE | ONCOLOGY | FACTOR XBP-1 | MECHANISMS | DIFFERENTIATION | CANCER | GENOME | CELL BIOLOGY | eIF-2 Kinase - metabolism | Humans | Precursor Cells, B-Lymphoid - metabolism | Transcription Factors - deficiency | Pyrazines - therapeutic use | Boronic Acids - therapeutic use | DNA-Binding Proteins - deficiency | X-Box Binding Protein 1 | Plasma Cells - pathology | DNA-Binding Proteins - metabolism | Multiple Myeloma - drug therapy | Precursor Cells, B-Lymphoid - pathology | Plasma Cells - metabolism | Membrane Proteins - metabolism | Protein-Serine-Threonine Kinases - metabolism | Cell Survival - drug effects | Bortezomib | Endoribonucleases - metabolism | Proteasome Inhibitors - pharmacology | Signal Transduction | Immunophenotyping | Transcription Factors - genetics | DNA-Binding Proteins - genetics | Multiple Myeloma - metabolism | Regulatory Factor X Transcription Factors | Proteasome Inhibitors - therapeutic use | Transcription Factors - metabolism | Activating Transcription Factor 6 - metabolism | Drug Resistance, Neoplasm - genetics | Endoplasmic Reticulum Stress | Mutation | Pyrazines - pharmacology | Multiple Myeloma - genetics | Boronic Acids - pharmacology | Immunoglobulins | Care and treatment | Multiple myeloma | Genetic research | Health aspects | Tumors | Cancer
Journal Article
Journal Article
Science, ISSN 0036-8075, 01/2015, Volume 347, Issue 6219, pp. 273 - 277
Cancer cells rely on telomerase or the alternative lengthening of telomeres (ALT) pathway to overcome replicative mortality. ALT is mediated by recombination... 
GLIOBLASTOMA | REPEAT-CONTAINING RNA | PROTEIN-KINASE | MULTIDISCIPLINARY SCIENCES | POLYMERASE | CHROMOSOME ENDS | SINGLE-STRANDED-DNA | HOMOLOGOUS RECOMBINATION | MUTATIONS | TUMORS | DISCOVERY | Osteosarcoma - drug therapy | Ataxia Telangiectasia Mutated Proteins - metabolism | RNA, Untranslated - metabolism | Humans | Homologous Recombination | X-linked Nuclear Protein | Telomere - drug effects | Sulfones - pharmacology | RNA, Untranslated - genetics | Gene Knockdown Techniques | Glioma - genetics | Ataxia Telangiectasia Mutated Proteins - antagonists & inhibitors | Telomerase - metabolism | Antineoplastic Agents - pharmacology | Telomere - metabolism | Nuclear Proteins - genetics | DNA Helicases - genetics | Telomere - genetics | Tumor Suppressor Proteins - metabolism | Nuclear Proteins - metabolism | Replication Protein A - metabolism | Telomere Homeostasis | Transcription Factors - metabolism | DNA Helicases - metabolism | Cell Cycle | Cell Line, Tumor | Telomeric Repeat Binding Protein 2 - metabolism | HeLa Cells | Osteosarcoma - genetics | Pyrazines - pharmacology | Glioma - drug therapy | Promyelocytic Leukemia Protein | Apoptosis | Telomeres | Protein research | Cell research | Cancer cells | Cell cycle | Genetic aspects | Research | Health aspects | Enzymes | Deoxyribonucleic acid--DNA | Cancer | Index Medicus | Proteins | Inhibitors | Deoxyribonucleic acid | Kinases | Chromosomes | Telomerase | Tumors
Journal Article
Applied and Environmental Microbiology, ISSN 0099-2240, 03/2007, Volume 73, Issue 6, pp. 1809 - 1824
Journal Article
Journal of Molecular and Cellular Cardiology, ISSN 0022-2828, 2011, Volume 51, Issue 6, pp. 906 - 918
Abstract Type 2 diabetes is associated with an increased risk of cardiac complications. Inhibitors of dipeptidylpeptidase 4 (DPP-4) are novel drugs for the... 
Cardiovascular | Heart | AMPK | Sitagliptin | Diabetes | Metabolism | CARDIAC & CARDIOVASCULAR SYSTEMS | ACTIVATED PROTEIN-KINASE | DIPEPTIDYL-PEPTIDASE-IV | ACETYL-COA CARBOXYLASE | CELL BIOLOGY | PERFUSED HEARTS | TISSUE DISTRIBUTION | INSULIN-RESISTANCE | CARDIOVASCULAR-DISEASE | PRIOR MYOCARDIAL-INFARCTION | RAT-HEART | DIABETIC DB/DB MICE | Triazoles - administration & dosage | AMP-Activated Protein Kinases - metabolism | Dipeptidyl Peptidase 4 - metabolism | Glucose Transporter Type 4 - metabolism | Guanine - analogs & derivatives | Pyrazines - administration & dosage | Body Weight - drug effects | Male | Fibrosis - metabolism | Dipeptidyl-Peptidase IV Inhibitors - pharmacology | Guanine - metabolism | CD36 Antigens - metabolism | Cell Membrane - metabolism | Phosphorylation - drug effects | Sitagliptin Phosphate | Glucose Tolerance Test | Tumor Suppressor Proteins - metabolism | Mice, Inbred C57BL | Tumor Suppressor Protein p53 - metabolism | Myocardium - pathology | Dipeptidyl-Peptidase IV Inhibitors - administration & dosage | Mice, Knockout | Protein Transport | Triazoles - pharmacology | Insulin - metabolism | Myocardium - enzymology | Animals | Glycation End Products, Advanced - metabolism | Heart - drug effects | Mice | Pyrazines - pharmacology | Acetyl-CoA Carboxylase - metabolism | Type 2 diabetes | Analysis | Body weight | Physiological aspects | Glucose | Tumor proteins | Transforming growth factors | Fatty acids | Dextrose
Journal Article
PLoS ONE, ISSN 1932-6203, 09/2012, Volume 7, Issue 9, p. e46484
Journal Article
Journal Article
Blood, ISSN 0006-4971, 04/2013, Volume 121, Issue 15, pp. 2975 - 2987
Myeloid-derived suppressor cells (MDSCs) are a heterogeneous, immature myeloid cell population with the ability to suppress immune responses. MDSCs have been... 
CANCER-PATIENTS | SUBPOPULATIONS | DENDRITIC CELLS | T-REGULATORY CELLS | IMMUNOSUPPRESSION | MACROPHAGES | PERIPHERAL-BLOOD | DIFFERENTIATION | IDENTIFICATION | HEMATOLOGY | PROGRESSION | Cell Proliferation | Reactive Oxygen Species - metabolism | Coculture Techniques | Humans | Sialic Acid Binding Ig-like Lectin 3 - immunology | Multiple Myeloma - immunology | Thalidomide - pharmacology | Lewis X Antigen - metabolism | Lipopolysaccharides - immunology | Thalidomide - analogs & derivatives | Flow Cytometry | T-Lymphocytes - metabolism | Myeloid Cells - immunology | Reactive Oxygen Species - immunology | Myeloid Cells - drug effects | Antineoplastic Agents - pharmacology | HLA-DR Antigens - metabolism | Sialic Acid Binding Ig-like Lectin 3 - metabolism | Cytokines - immunology | Tumor Microenvironment - drug effects | Bortezomib | CD11b Antigen - immunology | Cytokines - metabolism | Cells, Cultured | Lewis X Antigen - immunology | Multiple Myeloma - metabolism | Tumor Microenvironment - immunology | Multiple Myeloma - pathology | Lipopolysaccharides - pharmacology | Cell Line, Tumor | Myeloid Cells - metabolism | T-Lymphocytes - immunology | HLA-DR Antigens - immunology | CD11b Antigen - metabolism | Pyrazines - pharmacology | Immunologic Factors - pharmacology | Boronic Acids - pharmacology | Tumor Burden - immunology | Lymphoid Neoplasia
Journal Article