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Journal Article
Chemical Physics Letters, ISSN 0009-2614, 05/2009, Volume 474, Issue 1-3, p. 13
First-principles calculations demonstrate that pyrazole decomposes to vinylcarbene+N.sub.2. 
Pyrazoles
Journal Article
Journal of Medicinal Chemistry, ISSN 0022-2623, 11/2007, Volume 50, Issue 22, pp. 5339 - 5356
Journal Article
European Journal of Medicinal Chemistry, ISSN 0223-5234, 03/2008, Volume 43, Issue 3, pp. 456 - 463
Journal Article
Journal Article
Drug Metabolism and Disposition, ISSN 0090-9556, 01/2015, Volume 43, Issue 2, pp. 289 - 297
Journal Article
Tetrahedron Letters, ISSN 0040-4039, 2009, Volume 50, Issue 19, pp. 2252 - 2255
Journal Article
The New England Journal of Medicine, ISSN 0028-4793, 07/2013, Volume 369, Issue 1, pp. 32 - 42
Ibrutinib inhibits Bruton's tyrosine kinase, a component of normal B-cell activation pathways. Ibrutinib produced responses in 71% of patients with refractory... 
MEDICINE, GENERAL & INTERNAL | BRUTONS TYROSINE KINASE | ACTIVATION | RITUXIMAB | B-CELL MALIGNANCIES | PCI-32765 | SURVIVAL SIGNALS | KAPPA-B | INHIBITOR | ANTIGEN RECEPTOR | FLUDARABINE | Recurrence | Pyrazoles - therapeutic use | Humans | Middle Aged | Male | Antineoplastic Agents - therapeutic use | Antineoplastic Agents - adverse effects | Aged, 80 and over | Adult | Female | Antineoplastic Agents - pharmacokinetics | Antineoplastic Agents - pharmacology | Pyrazoles - pharmacokinetics | Pyrazoles - adverse effects | Pyrazoles - pharmacology | Treatment Outcome | Pyrimidines - pharmacology | Remission Induction | Disease-Free Survival | Pyrimidines - therapeutic use | Pyrimidines - adverse effects | Pyrimidines - pharmacokinetics | Aged | Leukemia, Lymphocytic, Chronic, B-Cell - drug therapy | Protein-Tyrosine Kinases - antagonists & inhibitors | Antimitotic agents | Chronic lymphocytic leukemia | Care and treatment | Product development | Antineoplastic agents | Tyrosine | Cell proliferation | Pharmacodynamics | Chronic lymphatic leukemia | Cell survival | Risk groups | Leukemia | Diarrhea | Fatigue | Lymphatic leukemia | Kinases | Lymphoma | Bruton's tyrosine kinase | Patients | Risk factors | Cell adhesion & migration | Clonal deletion | Lymphocytes B | Respiratory tract diseases | Lymphomas | Pharmacokinetics | Lymphocytosis | Protein-tyrosine kinase | Index Medicus | Abridged Index Medicus
Journal Article
European Journal of Medicinal Chemistry, ISSN 0223-5234, 06/2015, Volume 97, Issue 1, pp. 732 - 746
In this review we report the recent advances in bioactive system containing pyrazole fused with a five membered heterocycle, covering the time span of the last... 
Pyrazole fused with a five membered heterocycle | Bioactive system | heterocycle | Pyrazole fused with a five membered | POTENT | DESIGN | CHEMISTRY, MEDICINAL | ASB16165 | BIOLOGICAL EVALUATION | INHIBITORS | DERIVATIVES | DISCOVERY | Drug Discovery - methods | Pyrazoles - chemistry | Animals | Humans | Pyrazoles - pharmacology | Sulfur compounds
Journal Article
Journal Article
The New England Journal of Medicine, ISSN 0028-4793, 12/2014, Volume 371, Issue 23, pp. 2167 - 2177