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Angewandte Chemie (International ed.), ISSN 1433-7851, 07/2017, Volume 56, Issue 31, pp. 9183 - 9187
The first syntheses of privileged [5,6]‐bicyclic heterocycles, with ring‐junction nitrogen atoms, by transition metal catalyzed C... 
C−H activation | homogeneous catalysis | cyclization | nitrogen heterocycles | rhodium | Physical Sciences | Chemistry | Chemistry, Multidisciplinary | Science & Technology | Rhodium | Nitrogen | Catalysis | Azoles | Synthesis | Triazoles | Heterocyclic compounds | Pyrazoles | Nitrogen atoms | Chemical reactions | Coupling | Alkynes | Index Medicus
Journal Article
Angewandte Chemie (International ed.), ISSN 1521-3773, 09/2018, Volume 57, Issue 36, pp. 11634 - 11639
Journal Article
Molecules (Basel, Switzerland), ISSN 1420-3049, 10/2018, Volume 23, Issue 10, p. 2548
Journal Article
Journal of medicinal chemistry, ISSN 0022-2623, 07/2011, Volume 54, Issue 13, pp. 4350 - 4364
The design, synthesis, docking, and biological evaluation of novel potent HDAC3 and HDAC8 isoxazole- and pyrazole-based diazide probes suitable for binding ensemble profiling with photoaffinity labeling (BEProFL... 
Pyrazoles - chemical synthesis | Antineoplastic Agents - chemical synthesis | Humans | Cell Membrane Permeability | Hydroxamic Acids - chemistry | Structure-Activity Relationship | Azides - chemistry | Isoxazoles - chemical synthesis | Histone Deacetylase Inhibitors - chemical synthesis | Pyrazoles - chemistry | Neuroprotective Agents - pharmacology | Drug Design | Antineoplastic Agents - pharmacology | Azides - pharmacology | Azides - chemical synthesis | Hydroxamic Acids - pharmacology | Repressor Proteins - metabolism | Pyrazoles - pharmacology | Repressor Proteins - chemistry | Neuroprotective Agents - chemistry | Histone Deacetylases - chemistry | Models, Molecular | Histone Deacetylases - metabolism | Isoxazoles - chemistry | Antineoplastic Agents - chemistry | Histone Deacetylase Inhibitors - chemistry | Photoaffinity Labels - chemical synthesis | Isoxazoles - pharmacology | Neuroprotective Agents - chemical synthesis | Photoaffinity Labels - pharmacology | Matrix Metalloproteinases - chemistry | Cell Line, Tumor | Matrix Metalloproteinase Inhibitors | Protein Binding | Histone Deacetylase Inhibitors - pharmacology | Hydroxamic Acids - chemical synthesis | Drug Screening Assays, Antitumor | Photoaffinity Labels - chemistry | Index Medicus | BEProFL | neuroprotection | diazide probes | histone deacetylases | Binding Ensemble Profiling with Photoaffinity Labeling | pyrazoles | isoxazoles | antiproliferative activity | HDAC
Journal Article
Journal of medicinal chemistry, ISSN 0022-2623, 06/2012, Volume 55, Issue 11, pp. 5188 - 5219
A highly selective series of inhibitors of the class I phosphatidylinositol 3-kinases (PI3Ks) has been designed and synthesized. Starting from the dual... 
Indazoles - chemical synthesis | Pyrazoles - chemical synthesis | Pyrimidines - chemical synthesis | Humans | Microsomes, Liver - metabolism | Pyridines - pharmacokinetics | Biological Availability | Crystallography, X-Ray | Structure-Activity Relationship | Sulfones - pharmacology | TOR Serine-Threonine Kinases - antagonists & inhibitors | Drug Design | Female | Piperazines - pharmacokinetics | Pyrazoles - pharmacokinetics | Pyrazoles - pharmacology | Sulfones - chemical synthesis | Purines - chemical synthesis | Triazines - pharmacology | Signal Transduction | Purines - pharmacology | Purines - pharmacokinetics | Pyridines - chemical synthesis | Models, Molecular | Rats | Proto-Oncogene Proteins c-akt - physiology | Pyrimidines - pharmacology | Sulfones - pharmacokinetics | Sulfonamides - pharmacology | Class I Phosphatidylinositol 3-Kinases - antagonists & inhibitors | Piperazines - pharmacology | Sulfonamides - pharmacokinetics | Indazoles - pharmacology | Xenograft Model Antitumor Assays | Sulfonamides - chemical synthesis | Animals | Class I Phosphatidylinositol 3-Kinases - physiology | Indazoles - pharmacokinetics | Mice, Nude | Triazines - chemical synthesis | Pyrimidines - pharmacokinetics | Piperazines - chemical synthesis | Mice | Pyridines - pharmacology | Triazines - pharmacokinetics | Index Medicus | DESIGN | NEOPLASMS | BASIC BIOLOGICAL SCIENCES | PHOSPHOTRANSFERASES | IN VIVO | PROTEINS | 60 APPLIED LIFE SCIENCES
Journal Article
Chemical communications (Cambridge, England), ISSN 1359-7345, 07/2014, Volume 50, Issue 57, pp. 7677 - 7679
.... A tandem conjugate addition, 1,2-addition, and N-N bond formation mechanism has been proposed for this diverse synthesis of pyrazoles based on mechanistic studies. 
Naphthalenes - chemical synthesis | Nitriles - chemical synthesis | Alkynes - chemical synthesis | Copper - chemistry | Amines - chemical synthesis | Pyrazoles - chemical synthesis | Index Medicus | Conjugates | Nitriles | Synthesis | Amines | Bonding | Pyrazole
Journal Article
ChemMedChem, ISSN 1860-7179, 04/2017, Volume 12, Issue 7, pp. 487 - 501
...‐relevant properties of sulfoximines. Herein we report the synthesis and in vitro characterization of a variety of sulfoximine analogues of marketed drugs and advanced... 
kinase inhibitors | pharmacophores | sulfoximines | drug design | medicinal chemistry | Estradiol - analogs & derivatives | Sulfoxides - chemical synthesis | Cyclin-Dependent Kinases - metabolism | Ataxia Telangiectasia Mutated Proteins - metabolism | Imatinib Mesylate - chemical synthesis | Pyrazoles - chemical synthesis | Pyridines - chemistry | Imatinib Mesylate - metabolism | Piperazines - metabolism | Piperazines - chemistry | Aminopyridines - metabolism | Fulvestrant | Aminopyridines - chemistry | Protein Kinase Inhibitors - chemistry | Pyrazoles - chemistry | Vardenafil Dihydrochloride - chemistry | Drug Design | Ataxia Telangiectasia Mutated Proteins - antagonists & inhibitors | Cyclin-Dependent Kinases - antagonists & inhibitors | Purines - chemical synthesis | Estradiol - metabolism | Protein Kinase Inhibitors - chemical synthesis | Piperidines - chemistry | Piperidines - metabolism | Purines - metabolism | Pyridines - chemical synthesis | Pyrazoles - metabolism | Piperidines - chemical synthesis | Imatinib Mesylate - chemistry | Vardenafil Dihydrochloride - metabolism | Aminopyridines - chemical synthesis | Sulfoxides - chemistry | Estradiol - chemistry | Purines - chemistry | Pyridines - metabolism | Vardenafil Dihydrochloride - chemical synthesis | Sulfoxides - metabolism | Piperazines - chemical synthesis | Estradiol - chemical synthesis | Protein Kinase Inhibitors - metabolism | Drug discovery | Chemical properties | Pharmaceutical industry | Index Medicus | Full Paper | Full Papers
Journal Article
Biochemical and biophysical research communications, ISSN 0006-291X, 11/2009, Volume 389, Issue 1, pp. 80 - 83
[125I]IodoDPA-713 [125I]1, which targets the translocator protein (TSPO, 18kDa), was synthesized in seven steps from methyl-4-methoxybenzoate as a tool for... 
Peripheral benzodiazepine receptor | Autoradiography | Small animal imaging | Pyrazolopyrimidine | Translocator protein | Biochemistry & Molecular Biology | Biophysics | Life Sciences & Biomedicine | Science & Technology | Brain - diagnostic imaging | Pyrazoles - chemical synthesis | Pyrimidines - chemical synthesis | Radiopharmaceuticals - chemical synthesis | Pyrimidines - chemistry | Acetamides - chemical synthesis | Pyrazoles - chemistry | Molecular Probes - pharmacokinetics | Female | Inflammation - diagnostic imaging | Pyrazoles - pharmacokinetics | Receptors, GABA - analysis | Radiopharmaceuticals - chemistry | Radiopharmaceuticals - pharmacokinetics | Acetamides - pharmacokinetics | Rats | Molecular Probes - chemical synthesis | Mice, Inbred Strains | Molecular Probes - chemistry | Acetamides - chemistry | Animals | Receptors, GABA - metabolism | Pyrimidines - pharmacokinetics | Mice | Pneumonia - diagnostic imaging | Tomography, Emission-Computed | Amides | Diagnostic imaging | Inflammation | Investigations | Benzodiazepines | Index Medicus | ACETAMIDE | LUNGS | RATS | IN VIVO | IMPURITIES | IODINE 125 | RADIATION, THERMAL, AND OTHER ENVIRONMENTAL POLLUTANT EFFECTS ON LIVING ORGANISMS AND BIOLOGICAL MATERIALS | RADIOPHARMACEUTICALS | RADIOCHEMISTRY | IN VITRO | INFLAMMATION | SYNTHESIS | RADIOLOGY AND NUCLEAR MEDICINE | RADIOACTIVITY | RECEPTORS | AUTORADIOGRAPHY | SINGLE PHOTON EMISSION COMPUTED TOMOGRAPHY | peripheral benzodiazepine receptor | small animal imaging | translocator protein | autoradiography | pyrazolopyrimidine
Journal Article
Angewandte Chemie (International ed.), ISSN 1433-7851, 07/2017, Volume 56, Issue 30, pp. 8823 - 8827
Journal Article