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Journal Article
Current medicinal chemistry, ISSN 0929-8673, 2017, Volume 24, Issue 16, pp. 1 - 16
The old-fashioned anticancer approaches, aiming at arresting cancer cell proliferation interfering with non-specific targets (e.g. DNA), have been replaced, in... 
Tumor microenvironment | Fda-Approved drugs | Multitargeted drugs | Anticancer agents | Polypharmacology | Tyrosine kinase receptors | Oncogene addiction | CHRONIC MYELOGENOUS LEUKEMIA | CHEMISTRY, MEDICINAL | GROWTH-FACTOR-RECEPTOR | TARGETED-THERAPY | TYROSINE KINASE | BIOCHEMISTRY & MOLECULAR BIOLOGY | REGORAFENIB BAY 73-4506 | BCR-ABL INHIBITOR | anticancer agents | FDA-approved drugs | CELL LUNG-CANCER | tyrosine kinase receptors | oncogene addiction | polypharmacology | PHILADELPHIA-CHROMOSOME | COLORECTAL-CANCER | PHARMACOLOGY & PHARMACY | tumor microenvironment | GASTROINTESTINAL STROMAL TUMORS | Neoplasms - metabolism | Niacinamide - analogs & derivatives | Anilides - therapeutic use | Pyrazoles - therapeutic use | Pyridines - chemistry | Humans | Anilides - chemistry | Imidazoles - chemistry | Imatinib Mesylate - therapeutic use | Protein Kinase Inhibitors - chemistry | Pyrazoles - chemistry | Niacinamide - chemistry | Phenylurea Compounds - chemistry | Receptor Protein-Tyrosine Kinases - antagonists & inhibitors | Imidazoles - therapeutic use | Pyrroles - therapeutic use | Quinazolines - chemistry | Pyridazines - therapeutic use | Pyridines - therapeutic use | Piperidines - chemistry | Niacinamide - therapeutic use | Phenylurea Compounds - therapeutic use | Receptor Protein-Tyrosine Kinases - metabolism | Imatinib Mesylate - chemistry | Neoplasms - drug therapy | Pyridazines - chemistry | Piperidines - therapeutic use | Protein Kinase Inhibitors - therapeutic use | Quinazolines - therapeutic use | Pyrroles - chemistry | Indoles - therapeutic use | Neoplasms - pathology | Indoles - chemistry | Tyrosine | Cell proliferation | Drugs | Medical research | Phenotypes | Clinical trials | Kinases | Proteins | Inhibitors | Modulation | Protein-tyrosine kinase | Deoxyribonucleic acid--DNA | Cancer
Journal Article
Angewandte Chemie (International ed.), ISSN 1433-7851, 2016, Volume 55, Issue 39, pp. 12073 - 12077
...Click chemistry and bioorthogonal reactions are exquisitely suited for tracking biomolecules in their native environment, and are therefore central to advance... 
click chemistry | fluorine-18 | radiolabeling | kinetics | electrophilic fluorination | CELLS | COMPLEX | REDUCTIVE ELIMINATION | CHEMISTRY, MULTIDISCIPLINARY | SYDNONE | CYCLOADDITION | FLUORINE | COPPER-FREE | Copper | Fluorides | Kinetics
Journal Article
Molecules (Basel, Switzerland), ISSN 1420-3049, 2018, Volume 23, Issue 10, p. 2548
Journal Article
Journal of medicinal chemistry, ISSN 0022-2623, 07/2011, Volume 54, Issue 13, pp. 4350 - 4364
The design, synthesis, docking, and biological evaluation of novel potent HDAC3 and HDAC8 isoxazole- and pyrazole-based diazide probes suitable for binding... 
CELLS | APOPTOSIS | CHEMISTRY, MEDICINAL | AZIDES | PATHWAY | CONVERSION | SUBSTRATE | INHIBITORS | BINDING | P53 | Pyrazoles - chemical synthesis | Antineoplastic Agents - chemical synthesis | Humans | Cell Membrane Permeability | Hydroxamic Acids - chemistry | Structure-Activity Relationship | Azides - chemistry | Isoxazoles - chemical synthesis | Histone Deacetylase Inhibitors - chemical synthesis | Pyrazoles - chemistry | Neuroprotective Agents - pharmacology | Drug Design | Antineoplastic Agents - pharmacology | Azides - pharmacology | Azides - chemical synthesis | Hydroxamic Acids - pharmacology | Repressor Proteins - metabolism | Pyrazoles - pharmacology | Repressor Proteins - chemistry | Neuroprotective Agents - chemistry | Histone Deacetylases - chemistry | Models, Molecular | Histone Deacetylases - metabolism | Isoxazoles - chemistry | Antineoplastic Agents - chemistry | Histone Deacetylase Inhibitors - chemistry | Photoaffinity Labels - chemical synthesis | Isoxazoles - pharmacology | Neuroprotective Agents - chemical synthesis | Photoaffinity Labels - pharmacology | Matrix Metalloproteinases - chemistry | Cell Line, Tumor | Matrix Metalloproteinase Inhibitors | Protein Binding | Histone Deacetylase Inhibitors - pharmacology | Hydroxamic Acids - chemical synthesis | Drug Screening Assays, Antitumor | Photoaffinity Labels - chemistry | BEProFL | neuroprotection | diazide probes | histone deacetylases | Binding Ensemble Profiling with Photoaffinity Labeling | pyrazoles | isoxazoles | antiproliferative activity | HDAC
Journal Article
Journal Article
Mini reviews in medicinal chemistry, ISSN 1389-5575, 2013, Volume 13, Issue 6, pp. 921 - 931
Journal Article
Journal Article
JNCI : Journal of the National Cancer Institute, ISSN 0027-8874, 01/2018, Volume 110, Issue 1, pp. 109 - 120
Background: Cancer-associated fibroblasts (CAFs) are tumor-promoting and correlate with poor survival in many cancers, which has led to their emergence as... 
CELL LUNG-CANCER | PHASE-II TRIAL | OXIDATIVE STRESS | ONCOLOGY | NAB-PACLITAXEL | ACTIVATION PROTEIN | DEPENDENT INVASION | PANCREATIC-CANCER | MONOCLONAL-ANTIBODY | DIFFERENTIATION | STROMAL CELLS | Lung Neoplasms - drug therapy | Up-Regulation | Pyrazoles - therapeutic use | Reactive Oxygen Species - metabolism | Cell Count | Humans | Middle Aged | Male | Oropharyngeal Neoplasms - pathology | Head and Neck Neoplasms - chemistry | RNA Interference | Cancer-Associated Fibroblasts - chemistry | Aged, 80 and over | NADPH Oxidases - genetics | Adenocarcinoma - chemistry | Esophageal Neoplasms - chemistry | Lung Neoplasms - chemistry | NADPH Oxidases - antagonists & inhibitors | Head and Neck Neoplasms - drug therapy | Carcinoma, Squamous Cell - chemistry | Survival Rate | Adenocarcinoma - drug therapy | Disease Progression | Phenotype | Carcinoma, Squamous Cell - drug therapy | Head and Neck Neoplasms - genetics | Mice | Neoplasm Transplantation | Carcinoma, Non-Small-Cell Lung - chemistry | Carcinoma, Squamous Cell - genetics | Colorectal Neoplasms - chemistry | Cell Transdifferentiation - genetics | Myofibroblasts - chemistry | Actins - analysis | Cell Transdifferentiation - drug effects | Adult | Female | Adenocarcinoma - genetics | Cancer-Associated Fibroblasts - physiology | Pyridines - therapeutic use | Lung Neoplasms - genetics | Myofibroblasts - pathology | Carcinoma, Non-Small-Cell Lung - genetics | NADPH Oxidases - analysis | Mouth Neoplasms - chemistry | NADPH Oxidase 4 | Cancer-Associated Fibroblasts - pathology | Animals | Esophageal Neoplasms - genetics | Mouth Neoplasms - pathology | Oropharyngeal Neoplasms - chemistry | Aged | Carcinoma, Non-Small-Cell Lung - drug therapy | Colorectal Neoplasms - pathology | Esophageal Neoplasms - drug therapy
Journal Article
Journal Article
Journal Article