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Antimicrobial Agents and Chemotherapy, ISSN 0066-4804, 05/2012, Volume 56, Issue 5, pp. 2643 - 2651
Journal Article
Free Radical Biology and Medicine, ISSN 0891-5849, 2006, Volume 40, Issue 4, pp. 632 - 640
Journal Article
Bioorganic Chemistry, ISSN 0045-2068, 08/2018, Volume 78, pp. 103 - 114
A series of newly synthesized 4-aryl-hydrazonopyrazolones were designed and their structures were confirmed by spectral and elemental analyses. All synthesized... 
Analgesic | Pyrazolone | COX-2 | Anti-inflammatory | 5-LOX | CELECOXIB ANALOGS | BIOCHEMISTRY & MOLECULAR BIOLOGY | CHEMISTRY, ORGANIC | LIPOXYGENASE INHIBITORS | IN-VITRO | CYCLOOXYGENASE-2 INHIBITORS | DRUGS | BIOLOGICAL EVALUATION | AGENTS | COX-2 INHIBITORS | DUAL INHIBITORS | DERIVATIVES | Analgesics - pharmacology | Rats, Wistar | Sulfhydryl Compounds - pharmacology | Anti-Inflammatory Agents, Non-Steroidal - chemistry | Male | Cyclooxygenase 2 Inhibitors - chemistry | Anti-Inflammatory Agents, Non-Steroidal - pharmacology | Lipoxygenase Inhibitors - chemical synthesis | Ulcer - pathology | Lipoxygenase Inhibitors - chemistry | Analgesics - chemical synthesis | Ulcer - drug therapy | Drug Design | Sulfhydryl Compounds - chemistry | Anti-Inflammatory Agents, Non-Steroidal - chemical synthesis | Stomach - drug effects | Ulcer - metabolism | Cyclooxygenase 2 Inhibitors - chemical synthesis | Pyrazolones - chemical synthesis | Pyrazolones - chemistry | Stomach - pathology | Arachidonate 5-Lipoxygenase - metabolism | Cyclooxygenase 2 Inhibitors - pharmacology | Rats | Edema - drug therapy | Animals | Analgesics - chemistry | Cyclooxygenase 2 - metabolism | Pyrazolones - pharmacology | Mice | Molecular Docking Simulation | Carrageenan | Edema - chemically induced | Lipoxygenase Inhibitors - pharmacology | Anti-inflammatory drugs | Liability (Law) | Analysis
Journal Article
Journal Article
Journal of Medicinal Chemistry, ISSN 0022-2623, 08/2012, Volume 55, Issue 16, pp. 7037 - 7053
Journal Article
Journal Article
Journal Article
ACS Chemical Neuroscience, ISSN 1948-7193, 11/2017, Volume 8, Issue 11, pp. 2522 - 2534
Discovery of multitarget-directed ligands (MTDLs), targeting different factors simultaneously to control the complicated pathogenesis of Alzheimer's disease... 
Phosphodiesterase 9 (PDE9) | multitarget-directed ligands | Alzheimer's disease | butyrylcholinesterase (BuChE) | CHOLINESTERASE | OXIDATIVE STRESS | DESIGN | CHEMISTRY, MEDICINAL | PDE9 INHIBITORS | BIOCHEMISTRY & MOLECULAR BIOLOGY | BETA AGGREGATION | SYNAPTIC PLASTICITY | NEUROSCIENCES | MEMORY | IN-VIVO | BIOLOGICAL EVALUATION | BAY 73-6691 | Antioxidants - chemistry | Oxidative Stress | Humans | Cholinesterase Inhibitors - chemistry | Cholinesterase Inhibitors - chemical synthesis | Pyrimidinones - chemistry | Rivastigmine - pharmacology | Protein Aggregation, Pathological - prevention & control | Drug Design | Butyrylcholinesterase - drug effects | Inhibitory Concentration 50 | Phosphodiesterase Inhibitors - chemical synthesis | Pyrimidinones - pharmacology | Molecular Structure | Phosphodiesterase Inhibitors - chemistry | Drug Evaluation, Preclinical | Pyrimidinones - chemical synthesis | Rivastigmine - chemistry | Pyrazolones - chemical synthesis | Rivastigmine - chemical synthesis | Pyrazolones - chemistry | Alzheimer Disease - drug therapy | Models, Molecular | Phosphodiesterase Inhibitors - pharmacology | Alzheimer Disease - enzymology | Antioxidants - chemical synthesis | Antioxidants - pharmacology | Peptide Fragments - chemistry | Cholinesterase Inhibitors - pharmacology | Cell Line, Tumor | Pyrazolones - pharmacology | Ligands | Protein Conformation | Molecular Docking Simulation | Amyloid beta-Peptides - chemistry | Index Medicus
Journal Article
Chemistry & Biology, ISSN 1074-5521, 2010, Volume 17, Issue 5, pp. 471 - 482
Journal Article
Journal of Medicinal Chemistry, ISSN 0022-2623, 10/2012, Volume 55, Issue 20, pp. 8745 - 8756
Journal Article