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PLoS ONE, ISSN 1932-6203, 01/2014, Volume 9, Issue 1, p. e87548
Background: Inhibition of the transporter-mediated hepatobiliary elimination of bile salts is a putative mechanism for liver toxicity observed with some... 
BILE-ACID TRANSPORT | IN-VITRO | RAT HEPATOCYTES | PULMONARY ARTERIAL-HYPERTENSION | SALT EXPORT PUMP | BILIARY-EXCRETION | MULTIDISCIPLINARY SCIENCES | HEPATIC-UPTAKE | KNOCKOUT MICE | FAMILIAL INTRAHEPATIC CHOLESTASIS | P-GLYCOPROTEIN | ATP Binding Cassette Transporter, Sub-Family G, Member 2 | Humans | Middle Aged | ATP-Binding Cassette, Sub-Family B, Member 1 - metabolism | Bile - metabolism | Male | Hepatocytes - metabolism | Pyridazines - pharmacology | Neoplasm Proteins - metabolism | Organic Anion Transporters - metabolism | Liver - drug effects | Organic Anion Transporters, Sodium-Independent - metabolism | ATP-Binding Cassette Transporters - metabolism | Adult | Female | Membrane Transport Proteins - metabolism | Endothelin Receptor Antagonists | Hepatocytes - drug effects | Solute Carrier Organic Anion Transporter Family Member 1B3 | Taurocholic Acid - pharmacology | Liver - metabolism | Receptors, Endothelin - metabolism | Thiophenes - pharmacology | Bile Acids and Salts - metabolism | Pyrimidines - pharmacology | Sulfonamides - pharmacology | Symporters - metabolism | Isoxazoles - pharmacology | Phenylpropionates - pharmacology | Bile - drug effects | Solute Carrier Organic Anion Transporter Family Member 1b1 | Multidrug Resistance-Associated Proteins - metabolism | Organic Anion Transporters, Sodium-Dependent - metabolism | Drug resistance in microorganisms | Endothelin | Bile acids | Research | Analysis | Salts | Transplants & implants | Toxicity | Pathogenesis | Liver | Gallbladder diseases | Accumulation | Bioaccumulation | Rodents | Protein transport | P-Glycoprotein | Efflux | Polypeptides | Mortality | Multidrug resistance | Glycoprotein | Substrate inhibition | Breast cancer | Substrates | Bile salts | Organic anion transporting polypeptide | Molecular modelling | Acids | Sodium | Hepatocytes | Transporter | Bile
Journal Article
Canadian Journal of Physiology and Pharmacology, ISSN 0008-4212, 06/2010, Volume 88, Issue 6, pp. 682 - 691
To evaluate potential mechanisms of clinical hepatotoxicity, 4 endothelin receptor antagonists (ERAs) were examined for substrate activity and inhibition of... 
Hepatic transport | BSEP | Endothelin | Transporter substrate | Pulmonary artery hypertension | Endothelin receptor antagonists | OATP | PHARMACOKINETIC INTERACTION | PHYSIOLOGY | pulmonary artery hypertension | RAT HEPATOCYTES | PULMONARY ARTERIAL-HYPERTENSION | SALT EXPORT PUMP | transporter substrate | HEPATIC-UPTAKE | endothelin receptor antagonists | CLINICAL-PRACTICE GUIDELINES | endothelin | CYCLOSPORINE-A | THERAPY | BILIARY-EXCRETION | KETOCONAZOLE | PHARMACOLOGY & PHARMACY | hepatic transport | Antihypertensive Agents - pharmacology | Estradiol - analogs & derivatives | Taurocholic Acid - metabolism | Humans | Middle Aged | ATP-Binding Cassette, Sub-Family B, Member 1 - metabolism | Male | Thiophenes - metabolism | Antihypertensive Agents - metabolism | Hepatocytes - metabolism | Pyridazines - pharmacology | ATP-Binding Cassette, Sub-Family B, Member 1 - antagonists & inhibitors | Organic Anion Transporters - metabolism | Pyrimidines - metabolism | Young Adult | Phenylpropionates - metabolism | Symporters - antagonists & inhibitors | ATP-Binding Cassette Transporters - metabolism | Adult | Female | Pyridazines - metabolism | Biological Transport - drug effects | Cell Culture Techniques | Endothelin Receptor Antagonists | Hepatocytes - drug effects | Estradiol - metabolism | Organic Anion Transporters - antagonists & inhibitors | Isoxazoles - metabolism | Organic Anion Transporters, Sodium-Dependent - antagonists & inhibitors | Cells, Cultured | Thiophenes - pharmacology | Multidrug Resistance-Associated Proteins - antagonists & inhibitors | Pyrimidines - pharmacology | Sulfonamides - pharmacology | Symporters - metabolism | Isoxazoles - pharmacology | Phenylpropionates - pharmacology | ATP Binding Cassette Subfamily B Member 11 | Enkephalin, D-Penicillamine (2,5)- - metabolism | Adolescent | Sulfonamides - metabolism | Aged | Multidrug Resistance-Associated Proteins - metabolism | Organic Anion Transporters, Sodium-Dependent - metabolism | ATP-Binding Cassette Transporters - antagonists & inhibitors | Cell receptors | Genetic aspects | Research | Diagnosis | Properties | Health aspects | Liver cells | Pulmonary hypertension
Journal Article
JOURNAL OF BIOLOGICAL CHEMISTRY, ISSN 0021-9258, 05/2010, Volume 285, Issue 19, pp. 14366 - 14376
Homeostatic scaling of glutamatergic and GABAergic transmission is triggered by prolonged alterations in synaptic neuronal activity . We have previously... 
ELECTROCONVULSIVE SEIZURE | RAT CEREBRAL-CORTEX | QUANTAL SIZE | NEUROTROPHIC FACTOR | BIOCHEMISTRY & MOLECULAR BIOLOGY | GYRUS IN-VIVO | VESICULAR ACETYLCHOLINE TRANSPORTER | GENE-EXPRESSION | LONG-TERM POTENTIATION | HIPPOCAMPAL-NEURONS | HOMEOSTATIC PLASTICITY | Synaptic Vesicles - metabolism | Calcium - metabolism | Neurons - cytology | Pyridazines - pharmacology | RNA, Messenger - metabolism | Immunoenzyme Techniques | Vesicular Glutamate Transport Protein 1 - genetics | C-Reactive Protein - metabolism | Gene Expression Regulation, Developmental | Transcription, Genetic | Brain-Derived Neurotrophic Factor - metabolism | Neurons - metabolism | Neurons - drug effects | Calcium Channels, L-Type - chemistry | Vesicular Glutamate Transport Protein 2 - genetics | Animals, Newborn | Calmodulin - metabolism | GABA-A Receptor Antagonists | Signal Transduction | Vesicular Glutamate Transport Protein 1 - metabolism | RNA, Messenger - genetics | Vesicular Glutamate Transport Protein 2 - metabolism | Cells, Cultured | Rats | Reverse Transcriptase Polymerase Chain Reaction | Blotting, Western | GABA Antagonists - pharmacology | Nerve Tissue Proteins - metabolism | Animals | Mitogen-Activated Protein Kinase 3 - metabolism | Receptor, trkA - metabolism | Neuronal Plasticity | Glutamate Decarboxylase - metabolism | Glutamic Acid - metabolism | Receptors, GABA-A - metabolism | Calcium Channels, L-Type - metabolism | Mitogen-Activated Protein Kinase 1 - metabolism | Quantal Size | Calcium | Subcellular Organelles | BDNF | Neurobiology | Homeostatic Synaptic Plasticity | Neurotransmitters | Vesicles | Gene | Inhibitory Feedback | Vesicular Transporter | Neurotransmitter | Regulation | Transport | Calmodulin
Journal Article
PLoS ONE, ISSN 1932-6203, 2012, Volume 7, Issue 8, p. e43054
Journal Article
Cancer Cell, ISSN 1535-6108, 08/2014, Volume 26, Issue 2, pp. 207 - 221
Journal Article
Journal Article
Journal Article
Molecular pharmacology, ISSN 0026-895X, 05/2016, Volume 89, Issue 5, pp. 541 - 551
N-methyl-d-aspartate receptors (NMDARs) are glutamate-gated ion channels that play key roles in brain physiology and pathology. Because numerous pathologic... 
Receptors, N-Methyl-D-Aspartate - antagonists & inhibitors | Membrane Transport Modulators - chemistry | Expert Systems | Humans | Molecular Conformation | Imidazoles - chemistry | Receptors, N-Methyl-D-Aspartate - metabolism | Pyrimidines - metabolism | Piperidines - pharmacology | Oxadiazoles - pharmacology | Receptors, N-Methyl-D-Aspartate - chemistry | Binding Sites | Imidazoles - metabolism | Protein Subunits - genetics | Piperidines - metabolism | Computational Biology | Models, Molecular | Imidazoles - pharmacology | Pyrimidines - pharmacology | Recombinant Fusion Proteins - chemistry | Pyridazines - chemistry | Adrenergic alpha-Antagonists - metabolism | Ligands | Molecular Docking Simulation | Protein Subunits - antagonists & inhibitors | Mutation | Oxadiazoles - metabolism | Drugs, Investigational - pharmacology | Xenopus Proteins - genetics | Adrenergic alpha-Antagonists - pharmacology | Drugs, Investigational - metabolism | Pyridazines - pharmacology | Recombinant Fusion Proteins - metabolism | Protein Subunits - metabolism | Pyrimidines - chemistry | Receptors, N-Methyl-D-Aspartate - genetics | Xenopus Proteins - chemistry | Drugs, Investigational - chemistry | Membrane Transport Modulators - pharmacology | Pyridazines - metabolism | Protein Interaction Domains and Motifs | Oxadiazoles - chemistry | Allosteric Regulation - drug effects | Piperidines - chemistry | Adrenergic alpha-Antagonists - chemistry | Xenopus Proteins - antagonists & inhibitors | Membrane Transport Modulators - metabolism | Animals | Xenopus Proteins - metabolism | Protein Subunits - chemistry | Amino Acid Substitution | Index Medicus
Journal Article
Science, ISSN 0036-8075, 01/2017, Volume 356, Issue 6342, pp. 1084 - 1087
A recent phase 1 trial of the fatty acid amide hydrolase (FAAH) inhibitor BIA 10-2474 led to the death of one volunteer and produced mild-to-severe... 
MOLECULAR CHARACTERIZATION | ENZYME | PAIN | ACID AMIDE HYDROLASE-1 | CLINICAL-TRIAL | MULTIDISCIPLINARY SCIENCES | ANANDAMIDE | RECEPTOR | BLOCKADE | ESTERASE | PF-04457845 | Anti-Anxiety Agents - metabolism | Analgesics - pharmacology | Pyridines - chemistry | Humans | Analgesics - metabolism | Pyridazines - pharmacology | Protein Interaction Maps | Pyridines - adverse effects | Cyclic N-Oxides - adverse effects | Cyclic N-Oxides - pharmacology | Urea - analogs & derivatives | Cyclic N-Oxides - metabolism | Anti-Anxiety Agents - adverse effects | Anti-Anxiety Agents - chemistry | Neurons - metabolism | Neurons - drug effects | Pyridazines - therapeutic use | Analgesics - adverse effects | Anti-Anxiety Agents - pharmacology | Amidohydrolases - antagonists & inhibitors | Cross Reactions | Cyclic N-Oxides - chemistry | Urea - therapeutic use | Pyridines - metabolism | Analgesics - chemistry | Cell Line, Tumor | Pyridines - pharmacology | Clinical Trials, Phase I as Topic | Urea - pharmacology | Amino acid sequence | Methods | Fatty-acid amide hydrolase | Brain | Profiling | Hydrolase | Neurons | Therapeutic applications | Cortex | Nervous system | Tissue analysis | Metabolism | Lipase | Tissues | Fatty acids | Proteins | Neurotoxicity | Pain | Inhibitors | Brain damage | Anxiety | Lipid metabolism | Brain injury | Index Medicus | Drugs | Networks | Proteomics | Amides
Journal Article
Science, ISSN 0036-8075, 5/2007, Volume 316, Issue 5825, pp. 715 - 719
Plastid-to-nucleus retrograde signaling coordinates nuclear gene expression with chloroplast function and is essential for the photoautotrophic life-style of... 
Proteins | Guns | Messenger RNA | Chloroplasts | Genes | Research Articles | Plants | Gene expression | Plastids | Seedlings | Plant cells | CHELATASE H-SUBUNIT | MESSENGER-RNA | MITOCHONDRIAL | MULTIDISCIPLINARY SCIENCES | IN-VIVO | TRANSCRIPTION | PENTATRICOPEPTIDE REPEAT PROTEIN | ARABIDOPSIS | ABSCISIC-ACID | BINDING PROTEIN | STRESS | Models | Cellular biology | Molecular biology | Botany
Journal Article
Biochemical Pharmacology, ISSN 0006-2952, 01/2013, Volume 85, Issue 2, pp. 265 - 273
The combinations of the endothelin-1 receptor antagonists bosentan or ambrisentan with the phosphodiesterase 5 inhibitors sildenafil or tadalafil are current... 
Tadalafil | Bosentan | Sildenafil | Induction | Ambrisentan | PULMONARY ARTERIAL-HYPERTENSION | P-GLYCOPROTEIN | RECEPTOR ANTAGONISTS AMBRISENTAN | IN-VITRO | MEDIATED CYP3A4 | PHARMACOKINETICS | PHARMACOLOGY & PHARMACY | INHIBITORS | EXPRESSION | POLYPEPTIDE | Antihypertensive Agents - pharmacology | Antihypertensive Agents - analysis | Humans | Intestinal Absorption - drug effects | Sulfones - adverse effects | Antihypertensive Agents - metabolism | Promoter Regions, Genetic - drug effects | RNA, Messenger - metabolism | Sildenafil Citrate | Drug Interactions | Biological Transport | Cytochrome P-450 CYP3A - genetics | Receptors, Cytoplasmic and Nuclear - genetics | Sulfonamides - pharmacology | Piperazines - adverse effects | Piperazines - pharmacology | ATP Binding Cassette Transporter, Subfamily B, Member 1 - genetics | Cytochrome P-450 CYP3A - metabolism | Peroxisome-Targeting Signal 1 Receptor | Cell Line, Tumor | Pregnane X Receptor | Intestines - enzymology | Receptors, Cytoplasmic and Nuclear - metabolism | Intestines - drug effects | Intestinal Mucosa - metabolism | Receptors, Steroid - metabolism | Pyridazines - pharmacology | Sulfones - pharmacology | Pyridazines - analysis | Phenylpropionates - metabolism | Endothelin A Receptor Antagonists | Pyridazines - metabolism | Purines - adverse effects | Phosphodiesterase 5 Inhibitors - pharmacology | Carbolines - adverse effects | Recombinant Proteins - metabolism | Sulfonamides - analysis | Purines - pharmacology | ATP Binding Cassette Transporter, Subfamily B | Gene Expression Regulation - drug effects | ATP Binding Cassette Transporter, Subfamily B, Member 1 - metabolism | Phenylpropionates - pharmacology | Receptors, Steroid - genetics | Sulfonamides - metabolism | Genes, Reporter - drug effects | Phenylpropionates - analysis | Carbolines - pharmacology | Enzymes | Endothelin
Journal Article