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1. Full Text Estradiol Acutely Suppresses Inhibition in the Hippocampus through a Sex-Specific Endocannabinoid and mGluR-Dependent Mechanism
by Huang, Guang Zhe and Woolley, Catherine S
Neuron (Cambridge, Mass.), ISSN 0896-6273, 06/2012, Volume 74, Issue 5, pp. 801 - 808
Neurosciences | Neurosciences & Neurology | Life Sciences & Biomedicine | Science & Technology | Cannabinoid Receptor Modulators - metabolism | CA1 Region, Hippocampal - cytology | Electric Stimulation | Estrogens - pharmacology | Male | Receptors, Metabotropic Glutamate - metabolism | Pyridazines - pharmacology | Lactones - pharmacology | Dose-Response Relationship, Drug | Drug Interactions | Castration | Piperidines - pharmacology | Excitatory Amino Acid Agents - pharmacology | Neurons - physiology | Female | Neurons - drug effects | Endocannabinoids | Estradiol - pharmacology | Pyrazoles - pharmacology | Enzyme Inhibitors - pharmacology | NAD - pharmacology | Cannabinoid Receptor Modulators - agonists | Morpholines - pharmacology | Rats | Biophysics | Rats, Sprague-Dawley | GABA Antagonists - pharmacology | Naphthalenes - pharmacology | Patch-Clamp Techniques | Animals | Benzoxazines - pharmacology | Cannabinoid Receptor Modulators - antagonists & inhibitors | Phenols | In Vitro Techniques | Neural Inhibition - drug effects | Benzodioxoles - pharmacology | Inhibitory Postsynaptic Potentials - drug effects | Brain | Epilepsy | Estrogen | GABA | Hormones, Sex | Estradiol | Studies | Rodents | Gender differences | Behavior | Males | Females | Index Medicus | Presynapse | Emotional behavior | gamma -Aminobutyric acid | Neurosteroids | Memory | Sex | Estrogen receptors | Cannabinoid CB1 receptors | Anandamide | Synaptic transmission | Hippocampus | Steroid hormones | Synapses
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2. Full Text Protein Tyrosine Phosphatase 1B Inhibitors: A Molecular Level Legitimate Approach for the Management of Diabetes Mellitus
by Thareja, Suresh and Aggarwal, Saurabh and Bhardwaj, T. R and Kumar, Manoj
Medicinal research reviews, ISSN 0198-6325, 05/2012, Volume 32, Issue 3, pp. 459 - 517
metabolism | insulin | diabetes | protein tyrosine phosphatase 1B (PTP 1B) | obesity | Obesity | Diabetes | Metabolism | Insulin | Protein Tyrosine Phosphatase 1B (PTP 1B) | Pharmacology & Pharmacy | Life Sciences & Biomedicine | Chemistry, Medicinal | Science & Technology | Catalytic Domain - drug effects | Humans | Benzofurans - pharmacology | Pyridazines - pharmacology | Biphenyl Compounds - pharmacology | Insulin Resistance - physiology | Janus Kinase 2 - metabolism | Acetophenones - pharmacology | Vanadium Compounds - pharmacology | Catechols - pharmacology | Chromones - pharmacology | Thiazolidinediones - pharmacology | Insulin Secretion | Phosphates - pharmacology | Amino Acid Sequence | Peptidomimetics - pharmacology | Protein Tyrosine Phosphatase, Non-Receptor Type 1 - antagonists & inhibitors | Models, Molecular | Thiophenes - pharmacology | Naphthoquinones - pharmacology | Enzyme Inhibitors - therapeutic use | Fluorides - pharmacology | Insulin - metabolism | Animals | STAT3 Transcription Factor - drug effects | Benzoates - pharmacology | Receptor, Insulin - drug effects | Receptor, Insulin - metabolism | Signal Transduction - physiology | Thiazoles - pharmacology | Blood Glucose - metabolism | Diabetes Mellitus, Type 2 - drug therapy | Index Medicus
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3. Full Text Inhibition of phosphodiesterase‐3 by levosimendan is sufficient to account for its inotropic effect in failing human heart
by Ørstavik, Ø and Ata, S H and Riise, J and Dahl, C P and Andersen, G Ø and Levy, F O and Skomedal, T and Osnes, J‐B and Qvigstad, E
British journal of pharmacology, ISSN 0007-1188, 12/2014, Volume 171, Issue 23, pp. 5169 - 5181
Life Sciences & Biomedicine | Pharmacology & Pharmacy | Science & Technology | Heart - physiopathology | Rats, Wistar | Phosphodiesterase 3 Inhibitors - pharmacology | Humans | Heart Failure - physiopathology | Adrenergic beta-Agonists - pharmacology | Myocardial Contraction - drug effects | Male | Quinolones - pharmacology | Cardiotonic Agents - pharmacology | Pyridazines - pharmacology | Phosphodiesterase 4 Inhibitors - pharmacology | Quinolines - pharmacology | Hydrazones - pharmacology | Animals | Calcium - physiology | Isoproterenol - pharmacology | In Vitro Techniques | Rolipram - pharmacology | Thiadiazines - pharmacology | Milrinone - pharmacology | Resveratrol | Rodents | Index Medicus | Research Papers
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4. Full Text Diacylglycerol Lipase Is Not Involved in Depolarization-Induced Suppression of Inhibition at Unitary Inhibitory Connections in Mouse Hippocampus
by Min, Rogier and Testa-Silva, Guilherme and Heistek, Tim S and Canto, Cathrin B and Lodder, Johannes C and Bisogno, Tiziana and Di Marzo, Vincenzo and Brussaard, Arjen B and Burnashev, Nail and Mansvelder, Huibert D
The Journal of neuroscience, ISSN 0270-6474, 02/2010, Volume 30, Issue 7, pp. 2710 - 2715
Neurosciences | Neurosciences & Neurology | Life Sciences & Biomedicine | Science & Technology | Lipoprotein Lipase - antagonists & inhibitors | Green Fluorescent Proteins - genetics | Pyridazines - pharmacology | Quinoxalines - pharmacology | Neural Inhibition - physiology | Receptor, Cannabinoid, CB1 - agonists | Neurons - physiology | Lysine - metabolism | Neurons - drug effects | Electric Stimulation - methods | Lipoprotein Lipase - metabolism | Animals, Newborn | Neural Inhibition - genetics | Lysine - analogs & derivatives | Mice, Inbred C57BL | Valine - analogs & derivatives | Enzyme Inhibitors - pharmacology | Inhibitory Postsynaptic Potentials - physiology | Morpholines - pharmacology | Excitatory Amino Acid Antagonists - pharmacology | Cyclohexanones - pharmacology | Hippocampus - cytology | GABA Antagonists - pharmacology | Mice, Knockout | Naphthalenes - pharmacology | Animals | Benzoxazines - pharmacology | Neocortex - cytology | Mice | Receptor, Cannabinoid, CB1 - deficiency | Valine - pharmacology | In Vitro Techniques | Neural Inhibition - drug effects | Inhibitory Postsynaptic Potentials - drug effects | Index Medicus | Brief Communications
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5. Full Text Similar patterns of mitochondrial vulnerability and rescue induced by genetic modification of α-synuclein, parkin, and DJ-1 in Caenorhabditis elegans
by Ved, Rina and Saha, Shamol and Westlund, Beth and Perier, Celine and Burnam, Lucinda and Sluder, Anne and Hoener, Marius and Rodrigues, Cecilia M. P and Alfonso, Aixa and Steer, Clifford and Liu, Leo and Przedborski, Serge and Wolozin, Benjamin
The Journal of biological chemistry, ISSN 0021-9258, 12/2005, Volume 280, Issue 52, pp. 42655 - 42668
Oncogene Proteins - genetics | Cholagogues and Choleretics - pharmacology | Humans | Molecular Sequence Data | Immunoblotting | Pyridazines - pharmacology | Probucol - pharmacology | Taurochenodeoxycholic Acid - pharmacology | Copper - chemistry | Time Factors | Gene Deletion | Rotenone - pharmacology | Neurons - metabolism | alpha-Synuclein - genetics | Paraquat - pharmacology | Transgenes | Disease Models, Animal | Pyrazoles - pharmacology | Amino Acid Sequence | Parkinson Disease - pathology | Caenorhabditis elegans - metabolism | Electron Transport Complex I - antagonists & inhibitors | Gene Library | Animals, Genetically Modified | Iron - chemistry | Polyenes - pharmacology | Gene Expression Regulation | Oxygen Consumption | Intracellular Signaling Peptides and Proteins | Bile Acids and Salts - metabolism | Ions | Mitochondria - metabolism | Antioxidants - pharmacology | Genetic Techniques | Sequence Homology, Amino Acid | Protein Deglycase DJ-1 | Animals | Mutagenesis | Benzoates - pharmacology | Thiazoles - pharmacology | Mutation | 3-Hydroxybutyric Acid - pharmacology | Ubiquitin-Protein Ligases - genetics | Sodium Azide - pharmacology | Apoptosis | Benzothiazoles | RNA, Small Interfering - metabolism | Index Medicus
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6. Full Text Network oscillations in rod-degenerated mouse retinas
by Menzler, Jacob and Zeck, Günther
The Journal of neuroscience, ISSN 0270-6474, 02/2011, Volume 31, Issue 6, pp. 2280 - 2291
Neurosciences | Neurosciences & Neurology | Life Sciences & Biomedicine | Science & Technology | Meclofenamic Acid - pharmacology | Age Factors | 2-Amino-5-phosphonovalerate - pharmacology | Male | Gap Junctions - genetics | Statistics as Topic | Nerve Net - drug effects | Pyridazines - pharmacology | Mice, Neurologic Mutants | Quinoxalines - pharmacology | Evoked Potentials, Visual - physiology | Light | Tetrodotoxin - pharmacology | Nerve Net - physiopathology | Retinal Rod Photoreceptor Cells - drug effects | Action Potentials - drug effects | Disease Models, Animal | Glutamic Acid - pharmacology | Retinal Degeneration - genetics | Mice, Inbred C57BL | Periodicity | gamma-Aminobutyric Acid - pharmacology | Sodium Channel Blockers - pharmacology | Excitatory Amino Acid Antagonists - pharmacology | Mice, Inbred C3H | Cyclooxygenase Inhibitors - pharmacology | GABA Antagonists - pharmacology | Action Potentials - physiology | Carbenoxolone - pharmacology | Animals | Evoked Potentials, Visual - drug effects | Glycine - pharmacology | Retinal Rod Photoreceptor Cells - physiology | 2-Amino-5-phosphonovalerate - analogs & derivatives | Mice | Gap Junctions - drug effects | In Vitro Techniques | Retinal Degeneration - pathology | Neural Inhibition - drug effects | Index Medicus
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7. Full Text Ponatinib inhibits polyclonal drug-resistant KIT oncoproteins and shows therapeutic potential in heavily pretreated gastrointestinal stromal tumor (GIST) patients
by Garner, Andrew P and Gozgit, Joseph M and Anjum, Rana and Vodala, Sadanand and Schrock, Alexa and Zhou, Tianjun and Serrano, Cesar and Eilers, Grant and Zhu, Meijun and Ketzer, Julia and Wardwell, Scott and Ning, Yaoyu and Song, Youngchul and Kohlmann, Anna and Wang, Frank and Clackson, Tim and Heinrich, Michael C and Fletcher, Jonathan A and Bauer, Sebastian and Rivera, Victor M
Clinical cancer research, ISSN 1078-0432, 11/2014, Volume 20, Issue 22, pp. 5745 - 5755
Life Sciences & Biomedicine | Oncology | Science & Technology | Exons | Humans | Molecular Conformation | Imidazoles - chemistry | Tomography, X-Ray Computed | Antineoplastic Agents - therapeutic use | Pyridazines - pharmacology | Proto-Oncogene Proteins c-kit - antagonists & inhibitors | Dose-Response Relationship, Drug | Protein Kinase Inhibitors - chemistry | Gastrointestinal Stromal Tumors - diagnosis | Gastrointestinal Stromal Tumors - pathology | Inhibitory Concentration 50 | Female | Indoles - pharmacology | Proto-Oncogene Proteins c-kit - genetics | Tumor Burden - genetics | Antineoplastic Agents - pharmacology | Benzamides - pharmacology | Imidazoles - therapeutic use | Gastrointestinal Stromal Tumors - genetics | Pyridazines - therapeutic use | Disease Models, Animal | Neoplasm Recurrence, Local | Models, Molecular | Imidazoles - pharmacology | Pyrimidines - pharmacology | Antineoplastic Agents - chemistry | Imatinib Mesylate | Piperazines - pharmacology | Pyridazines - chemistry | Xenograft Model Antitumor Assays | Drug Resistance, Neoplasm - genetics | Pyrroles - pharmacology | Animals | Tumor Burden - drug effects | Gastrointestinal Stromal Tumors - drug therapy | Protein Kinase Inhibitors - therapeutic use | Cell Line, Tumor | Protein Binding | Protein Kinase Inhibitors - pharmacology | Mutation | Proto-Oncogene Proteins c-kit - chemistry | Index Medicus | GIST | ponatinib | tyrosine kinase inhibitor | resistance | KIT
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8. Full Text Persistent GABAA/C responses to gabazine, taurine and beta-alanine in rat hypoglossal motoneurons
by Chesnoy-Marchais, D
Neuroscience, ISSN 0306-4522, 2016, Volume 330, pp. 191 - 204
Neurology | motoneuron | GABAC receptor | taurine | tonic inhibition | hybrid GABA receptor | gabazine | Taurine | receptor | Gabazine | GABA | Hybrid GABA receptor | Motoneuron | Tonic inhibition | Brain Stem - metabolism | Pentobarbital - pharmacology | Chlorine - metabolism | Pyridazines - pharmacology | Hypoglossal Nerve - metabolism | Brain Stem - drug effects | Hypoglossal Nerve - drug effects | Neuroprotective Agents - pharmacology | beta-Alanine - pharmacology | Motor Neurons - drug effects | Tissue Culture Techniques | Taurine - physiology | Strychnine - pharmacology | Bicuculline - pharmacology | Rats, Sprague-Dawley | Motor Neurons - metabolism | GABA Agents - pharmacology | Patch-Clamp Techniques | Animals | Pregnanolone - pharmacology | Phosphinic Acids - pharmacology | Central Nervous System Agents - pharmacology | Receptors, GABA - metabolism | Pyridines - pharmacology | Receptors, GABA-A - metabolism | Taurine - pharmacology | Midazolam - pharmacology | Index Medicus
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9. Full Text Rapid, activity-independent turnover of vesicular transmitter content at a mixed glycine/GABA synapse
by Apostolides, Pierre F and Trussell, Laurence O
The Journal of neuroscience, ISSN 0270-6474, 03/2013, Volume 33, Issue 11, pp. 4768 - 4781
Neurosciences | Neurosciences & Neurology | Life Sciences & Biomedicine | Science & Technology | Glycine - metabolism | Synaptic Vesicles - metabolism | Electric Stimulation | Synaptic Transmission - genetics | gamma-Aminobutyric Acid - metabolism | Channelrhodopsins | Male | Pyridazines - pharmacology | Glycine Agents - pharmacology | Synapses - metabolism | Inhibitory Postsynaptic Potentials - genetics | Time Factors | Mice, Inbred CBA | Female | Indoles - pharmacology | Synaptic Transmission - drug effects | Benzamides - pharmacology | Interneurons - cytology | Tetrodotoxin - pharmacology | Cochlear Nucleus - cytology | Synapses - drug effects | Mice, Inbred C57BL | Interneurons - drug effects | gamma-Aminobutyric Acid - pharmacology | Mice, Transgenic | Sodium Channel Blockers - pharmacology | Excitatory Amino Acid Antagonists - pharmacology | Strychnine - pharmacology | Biophysics | GABA Antagonists - pharmacology | Pregnancy | Glycine Plasma Membrane Transport Proteins - genetics | Patch-Clamp Techniques | Animals | Glycine - pharmacology | Glutamates - pharmacology | Glutamate Decarboxylase - metabolism | Mice | Models, Neurological | In Vitro Techniques | Neural Inhibition - drug effects | Inhibitory Postsynaptic Potentials - drug effects | Index Medicus
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10. Full Text Role of Ca2+ Ions in Nicotinic Facilitation of GABA Release in Mouse Thalamus
by Lena, Clement and Changeux, Jean-Pierre
The Journal of neuroscience, ISSN 0270-6474, 01/1997, Volume 17, Issue 2, pp. 576 - 585
GABA | calcium | facilitation | thalamus (sensory nuclei) | nicotinic acetylcholine receptors | presynaptic | Neurosciences | Neurosciences & Neurology | Life Sciences & Biomedicine | Science & Technology | Thalamic Nuclei - metabolism | Dihydro-beta-Erythroidine - pharmacology | Lobeline - pharmacology | Nicotinic Antagonists - pharmacology | Pyridazines - pharmacology | Cations, Divalent - pharmacology | Nicotine - pharmacology | Quinolizines | Calcium Channels - physiology | Calcium - physiology | Receptors, Nicotinic - chemistry | Receptors, GABA-A - drug effects | 6-Cyano-7-nitroquinoxaline-2,3-dione - pharmacology | Receptors, Nicotinic - deficiency | Dimethylphenylpiperazinium Iodide - pharmacology | Ion Transport | gamma-Aminobutyric Acid - secretion | Tetrodotoxin - pharmacology | Action Potentials - drug effects | Nicotinic Agonists - pharmacology | Microcystins | Alkaloids - pharmacology | Mice, Inbred C57BL | Atropine - pharmacology | Aconitine - analogs & derivatives | Marine Toxins - pharmacology | Aconitine - pharmacology | Calcium Channel Blockers - pharmacology | Potassium - pharmacology | Neurons, Afferent - physiology | GABA Antagonists - pharmacology | Mice, Knockout | Carbachol - pharmacology | Arousal - physiology | Bridged Bicyclo Compounds, Heterocyclic - pharmacology | Patch-Clamp Techniques | Animals | Azocines | Receptors, Nicotinic - physiology | Bacterial Toxins - pharmacology | Thalamic Nuclei - secretion | Mice | Pyridines - pharmacology | Receptors, Nicotinic - genetics | Index Medicus
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