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Nature cell biology, ISSN 1476-4679, 2014, Volume 16, Issue 4, pp. 357 - 366
.... However, how their biological properties intersect with cellular metabolism remains unexplained... 
ORGAN GROWTH | CHOLESTEROL | YAP/TAZ | TRANSCRIPTION | HIPPO PATHWAY | STATINS | CELL BIOLOGY | Phosphorylation - physiology | Cell Proliferation | Active Transport, Cell Nucleus - physiology | Humans | Intracellular Signaling Peptides and Proteins - metabolism | Drosophila Proteins - metabolism | Phosphoproteins - metabolism | Sterol Regulatory Element Binding Proteins - genetics | Breast Neoplasms - metabolism | Drosophila melanogaster - metabolism | RNA Interference | Tumor Suppressor Proteins - genetics | HEK293 Cells | Trans-Activators - genetics | Female | Transcription, Genetic | Hydroxymethylglutaryl-CoA Reductases, NAD-Dependent - metabolism | Nuclear Proteins - genetics | Protein-Serine-Threonine Kinases - metabolism | Signal Transduction | HCT116 Cells | Protein-Serine-Threonine Kinases - genetics | Nuclear Proteins - metabolism | Sterol Regulatory Element Binding Proteins - metabolism | Transcription Factors - genetics | Mevalonic Acid - metabolism | Polyisoprenyl Phosphates - metabolism | Transcription Factors - metabolism | Animals | Hydroxymethylglutaryl-CoA Reductase Inhibitors - pharmacology | rho GTP-Binding Proteins - metabolism | Trans-Activators - metabolism | Mice | Polyisoprenyl Phosphates - biosynthesis | Pyridines - pharmacology | RNA, Small Interfering | Drosophila Proteins - genetics | Adaptor Proteins, Signal Transducing - metabolism | Cell metabolism | Genetic research | Genetic aspects | Research | Cellular control mechanisms
Journal Article
The Journal of biological chemistry, ISSN 1083-351X, 2009, Volume 284, Issue 38, pp. 25984 - 25992
Obesity and type 2 diabetes are related metabolic disorders of high prevalence. The constitutive androstane receptor (CAR) was initially characterized as a... 
ALPHA-DEPENDENT INDUCTION | CROSS-TALK | TARGET GENES | ENHANCER MODULE | CAR | FREE FATTY-ACIDS | BIOCHEMISTRY & MOLECULAR BIOLOGY | PREGNANE-X-RECEPTOR | HEPATIC STEATOSIS | MEDIATED GLUCOSE-METABOLISM | DRUG-METABOLISM | Diabetes Mellitus, Type 2 - genetics | Gluconeogenesis - drug effects | Humans | Muscle, Skeletal - metabolism | Diabetes Mellitus, Type 2 - metabolism | Fatty Liver - chemically induced | Obesity - genetics | Adipose Tissue - metabolism | Fatty Acids - genetics | Lipoproteins, VLDL - secretion | Oxidation-Reduction - drug effects | Energy Metabolism - genetics | Fatty Acids - metabolism | Disease Models, Animal | Fatty Liver - genetics | Dietary Fats - adverse effects | Fatty Liver - metabolism | Obesity - chemically induced | Diabetes Mellitus, Type 2 - prevention & control | Fatty Liver - prevention & control | Insulin Resistance | PPAR alpha - genetics | Receptors, Cytoplasmic and Nuclear - agonists | Receptors, Cytoplasmic and Nuclear - genetics | Mice, Knockout | Obesity - metabolism | Triglycerides - metabolism | Animals | Gluconeogenesis - genetics | Diet | Obesity - prevention & control | Mice | Pyridines - pharmacology | Diabetes Mellitus, Type 2 - chemically induced | PPAR alpha - metabolism | Energy Metabolism - drug effects | Receptors, Cytoplasmic and Nuclear - metabolism | Index Medicus | Lipids and Lipoproteins | Metabolism, Regulation, and Signaling
Journal Article
PloS one, ISSN 1932-6203, 2013, Volume 8, Issue 1, p. e54001
Background: Histone deacetylase (HDAC) inhibitors are promising anti-fibrosis drugs; however, nonselective inhibition of class I and class II HDACs does not... 
GROWTH-FACTOR-BETA | SOLID TUMORS | OBSTRUCTIVE NEPHROPATHY | MULTIDISCIPLINARY SCIENCES | CARDIAC-HYPERTROPHY | INTERSTITIAL FIBROSIS | INJURY | ANGIOTENSIN-II | CHRONIC KIDNEY-DISEASE | FACTOR RECEPTOR | MOLECULAR-MECHANISMS | Kidney - pathology | Transforming Growth Factor beta1 - metabolism | Actins - metabolism | Smad3 Protein - metabolism | Ureteral Obstruction - metabolism | Leukocytes - immunology | Kidney - metabolism | Receptor, Epidermal Growth Factor - metabolism | Benzamides - therapeutic use | Benzamides - pharmacology | Phosphorylation - drug effects | Ureteral Obstruction - drug therapy | Protein-Serine-Threonine Kinases - metabolism | Transforming Growth Factor beta1 - biosynthesis | Fibroblasts - metabolism | Pyridines - therapeutic use | Collagen Type I - metabolism | Kidney - drug effects | Histone Deacetylases - metabolism | Fibroblasts - pathology | Fibronectins - metabolism | Ureteral Obstruction - immunology | Gene Expression Regulation - drug effects | Acetylation - drug effects | Animals | Receptors, Transforming Growth Factor beta - metabolism | Signal Transduction - drug effects | Cell Cycle Checkpoints - drug effects | Fibroblasts - drug effects | Ureteral Obstruction - pathology | Fibrosis | Histone Deacetylase Inhibitors - pharmacology | Leukocytes - drug effects | Cell Proliferation - drug effects | Histone Deacetylase Inhibitors - therapeutic use | Mice | Pyridines - pharmacology | Histones - metabolism | Fibronectins | Muscle proteins | Growth factors | Collagen | Analysis | Drugs | Histone deacetylase | Phosphorylation | Smad protein | Animal models | Collagen (type I) | Nephrology | Transcription | Syngeneic grafts | Transforming growth factor-b | Smooth muscle | Activation | Kinases | Fibronectin | Medical schools | Epidermal growth factor | Actin | Rodents | Cell cycle | Fibroblasts | Ureter | Inhibition | Kidneys | Transforming growth factor-b1 | Epidermal growth factor receptors | Pulmonary arteries | Fibrils | Muscles | Medicine | Signaling | Hospitals | Kidney diseases | Cancer
Journal Article
Journal Article
The EMBO journal, ISSN 0261-4189, 2011, Volume 30, Issue 20, pp. 4323 - 4335
Journal Article
Nature (London), ISSN 1476-4687, 2013, Volume 497, Issue 7448, pp. 217 - 223
The mammalian target of rapamycin (mTOR), a phosphoinositide 3-kinase-related protein kinase, controls cell growth in response to nutrients and growth factors... 
MAMMALIAN TARGET | RAPAMYCIN | RAPTOR | BINDING PARTNER | RAG GTPASES | RHEB | PATHWAY | TOR | MULTIDISCIPLINARY SCIENCES | CELL-GROWTH | P70 S6 KINASE | Adaptor Proteins, Signal Transducing - chemistry | Catalytic Domain - drug effects | TOR Serine-Threonine Kinases - metabolism | Pyridines - chemistry | Furans - pharmacology | Humans | Crystallography, X-Ray | Structure-Activity Relationship | Pyrimidines - chemistry | TOR Serine-Threonine Kinases - antagonists & inhibitors | Indoles - metabolism | Furans - chemistry | Adenosine Triphosphate - metabolism | Indoles - pharmacology | Tacrolimus Binding Protein 1A - pharmacology | Naphthyridines - chemistry | Ribosomal Protein S6 Kinases, 70-kDa - metabolism | Purines - metabolism | Purines - pharmacology | MTOR Associated Protein, LST8 Homolog | Tacrolimus Binding Protein 1A - chemistry | Models, Molecular | Magnesium - metabolism | Pyrimidines - pharmacology | Sirolimus - metabolism | Sirolimus - pharmacology | Magnesium - chemistry | Purines - chemistry | TOR Serine-Threonine Kinases - chemistry | Tacrolimus Binding Protein 1A - metabolism | Pyridines - pharmacology | Sirolimus - chemistry | Adaptor Proteins, Signal Transducing - metabolism | Adenosine Triphosphate - chemistry | Indoles - chemistry | Naphthyridines - pharmacology | Naphthyridines - metabolism | Protein Structure, Tertiary - drug effects | Proteins | Enzymes | Kinases | Crystal structure
Journal Article
Journal of Biological Chemistry, ISSN 0021-9258, 10/2004, Volume 279, Issue 41, pp. 42422 - 42430
Sphingosine 1-phosphate (S1P) is a lipid agonist that regulates smooth muscle cell (SMC) and endothelial cell functions by activating several members of the... 
MIGRATION | LYSOPHOSPHATIDIC ACID | PROTEIN-COUPLED RECEPTOR | BIOCHEMISTRY & MOLECULAR BIOLOGY | ALPHA-ACTIN EXPRESSION | ENDOTHELIAL-CELLS | SPHINGOSINE-1-PHOSPHATE | GENE-EXPRESSION | RHO-KINASE | VASCULAR MATURATION | CARG ELEMENTS | Lysophospholipids - metabolism | NIH 3T3 Cells | Up-Regulation | Phosphorylation | Transcription Factors - chemistry | Nitriles - pharmacology | rhoA GTP-Binding Protein - metabolism | Intracellular Signaling Peptides and Proteins - metabolism | Aorta - metabolism | RNA, Messenger - metabolism | Recombinant Fusion Proteins - metabolism | DNA-Binding Proteins - metabolism | Transfection | Genes, Dominant | Time Factors | Cell Division | Polymerase Chain Reaction | Cell Differentiation | Sphingosine - metabolism | Myocytes, Smooth Muscle - cytology | Genes, Reporter | Fibroblasts - metabolism | Amides - pharmacology | Proto-Oncogene Proteins - metabolism | Butadienes - pharmacology | Transcription Factors - physiology | ets-Domain Protein Elk-1 | Signal Transduction | Endothelial Cells - metabolism | Serum Response Factor - metabolism | Electrophoresis, Polyacrylamide Gel | Cells, Cultured | Enzyme Inhibitors - pharmacology | Glutathione Transferase - metabolism | Rats | Nuclear Proteins - metabolism | Muscle, Smooth - metabolism | Reverse Transcriptase Polymerase Chain Reaction | Blotting, Western | Transcription Factors - metabolism | Sphingosine - analogs & derivatives | Animals | Trans-Activators - metabolism | Mice | Pyridines - pharmacology | Mitogen-Activated Protein Kinases - metabolism
Journal Article
PloS one, ISSN 1932-6203, 2014, Volume 9, Issue 9, pp. e108789 - e108789
Alkaloids play a key role in higher plant defense against pathogens and herbivores. Following its biosynthesis in root tissues, nicotine, the major alkaloid of... 
SECONDARY METABOLISM | COPTIS-JAPONICA | MEDICAGO-TRUNCATULA | CATHARANTHUS-ROSEUS | MULTIDISCIPLINARY SCIENCES | PLANT-CELLS | ARABIDOPSIS | BINDING CASSETTE PROTEIN | MEMBRANE-TRANSPORT | ALKALOID METABOLISM | TOBACCO | Plant Cells - microbiology | Saccharomyces cerevisiae - drug effects | Gene Expression Profiling | Phylogeny | RNA, Messenger - metabolism | Nicotine - pharmacology | Saccharomyces cerevisiae - metabolism | Plant Proteins - classification | Alkaloids - metabolism | Cell Membrane - metabolism | Plant Proteins - metabolism | Plant Roots - metabolism | Tobacco - metabolism | Cyclopentanes - pharmacology | Up-Regulation - drug effects | Plant Proteins - genetics | Anabasine - metabolism | Nicotine - metabolism | Pyridines - metabolism | Plant Leaves - metabolism | Flavonoids - metabolism | Oxylipins - pharmacology | Plant Cells - drug effects | Vacuoles - metabolism | Acetates - pharmacology | Flavonoids | Flavones | RNA | Bioflavonoids | Analysis | Physiological aspects | Fluorescence | Nicotine | Yeast | Xylem | Laboratories | Amino acids | Biochemistry | Plants (organisms) | Biosynthesis | Tissues | Proteins | Alkaloids | Leaves | Metabolites | Cell cycle | Jasmonic acid | Pharmaceutical sciences | Translocation | Cloning | Dentistry | Metabolism | Gene expression | Methyl jasmonate | Tobacco | Extrusion | Herbivores | Transport | Transporter | Vacuoles | Index Medicus
Journal Article
Proceedings of the National Academy of Sciences - PNAS, ISSN 1091-6490, 2013, Volume 110, Issue 43, pp. 17253 - 17258
Phenotypic polarization of macrophages is regulated by a milieu of cues in the local tissue microenvironment. Although much is known about how soluble factors... 
Phenotypes | Cell growth | Cytokines | Stem cells | Cell lines | Actins | Physiological regulation | Macrophages | Endothelial cells | Cells | FIBER | MATRIX | ACTIVATION | ACTIN | MULTIDISCIPLINARY SCIENCES | IN-VIVO | DIFFERENTIATION | SCAFFOLDS | CULTURE | MESENCHYMAL STEM-CELLS | Mannose-Binding Lectins - metabolism | Arginase - metabolism | Lectins, C-Type - immunology | Cell Shape - immunology | Myosin-Light-Chain Kinase - antagonists & inhibitors | Cytochalasin D - pharmacology | Lectins, C-Type - metabolism | Arginase - immunology | Interleukin-4 - pharmacology | Flow Cytometry | Doxorubicin - analogs & derivatives | Inflammation Mediators - metabolism | Female | Immunophenotyping - methods | Cell Polarity - drug effects | Doxorubicin - metabolism | Macrophages - immunology | Cytokines - immunology | Amides - pharmacology | Biomarkers - metabolism | Inflammation Mediators - immunology | Cell Polarity - immunology | Cytokines - metabolism | Myosin-Light-Chain Kinase - metabolism | Mice, Inbred C57BL | Biomarkers - analysis | Cells, Cultured | Receptors, Cell Surface - metabolism | Macrophages - cytology | Interleukin-13 - pharmacology | Receptors, Cell Surface - immunology | Azepines - pharmacology | Cell Shape - drug effects | Macrophages - metabolism | Animals | Mannose-Binding Lectins - immunology | Lipopolysaccharides - pharmacology | Mice | Pyridines - pharmacology | Doxorubicin - immunology | Interferon-gamma - pharmacology | Microscopy, Fluorescence | Physiological aspects | Microbial genetics | Phenotype | Genetic aspects | Research | Biological Sciences | Physical Sciences
Journal Article
Proceedings of the National Academy of Sciences - PNAS, ISSN 1091-6490, 2015, Volume 112, Issue 40, pp. 12468 - 12473
Journal Article
Nature communications, ISSN 2041-1723, 2019, Volume 10, Issue 1, pp. 1897 - 17
The cellular decision regarding whether to undergo proliferation or death is made at the restriction (R)-point, which is disrupted in nearly all tumors. The... 
UBIQUITINATION | AML1-ETO | ACETYLATION | MULTIDISCIPLINARY SCIENCES | TRANSCRIPTION | PROTEINS | QUANTITATIVE-ANALYSIS | POLYCOMB | CANCER | KINASES | FAMILY | Chromatin - metabolism | RNA, Small Interfering - genetics | Myeloid-Lymphoid Leukemia Protein - metabolism | TOR Serine-Threonine Kinases - metabolism | Core Binding Factor Alpha 3 Subunit - antagonists & inhibitors | Humans | Polycomb-Group Proteins - metabolism | TOR Serine-Threonine Kinases - genetics | Cell Cycle Checkpoints - genetics | p38 Mitogen-Activated Protein Kinases - metabolism | Cyclin-Dependent Kinase 4 - antagonists & inhibitors | Chromatin - chemistry | MAP Kinase Kinase 1 - antagonists & inhibitors | Butadienes - pharmacology | Signal Transduction | Epithelial Cells - pathology | MAP Kinase Kinase 1 - metabolism | Imidazoles - pharmacology | Cyclin-Dependent Kinase 4 - metabolism | Piperazines - pharmacology | Cell Cycle Checkpoints - drug effects | Polycomb-Group Proteins - genetics | p38 Mitogen-Activated Protein Kinases - antagonists & inhibitors | Cell Line, Tumor | MAP Kinase Kinase 4 - genetics | RNA, Small Interfering - metabolism | ras Proteins - genetics | Core Binding Factor Alpha 3 Subunit - metabolism | Epithelial Cells - metabolism | Nitriles - pharmacology | Cyclin-Dependent Kinase 4 - genetics | Epithelial Cells - drug effects | ras Proteins - metabolism | Drosophila melanogaster - genetics | Chromatin Assembly and Disassembly - drug effects | Drosophila melanogaster - metabolism | MAP Kinase Kinase 1 - genetics | TOR Serine-Threonine Kinases - antagonists & inhibitors | MAP Kinase Kinase 4 - metabolism | HEK293 Cells | MAP Kinase Kinase 4 - antagonists & inhibitors | Chromatin - drug effects | Histone-Lysine N-Methyltransferase - genetics | Drosophila melanogaster - cytology | Gene Expression Regulation | p38 Mitogen-Activated Protein Kinases - genetics | Sirolimus - pharmacology |