X
Search Filters
Format Format
Format Format
X
Sort by Item Count (A-Z)
Filter by Count
Journal Article (4174) 4174
Book Review (399) 399
Publication (277) 277
Book Chapter (7) 7
Conference Proceeding (3) 3
Magazine Article (3) 3
Web Resource (2) 2
Book / eBook (1) 1
Dissertation (1) 1
more...
Subjects Subjects
Subjects Subjects
X
Sort by Item Count (A-Z)
Filter by Count
index medicus (3868) 3868
pyridones - pharmacology (2753) 2753
humans (2267) 2267
animals (1893) 1893
male (1214) 1214
pharmacology & pharmacy (1011) 1011
pyridones - therapeutic use (870) 870
female (847) 847
pyridones - chemistry (703) 703
rats (701) 701
mice (628) 628
chemistry, medicinal (543) 543
pyridones - administration & dosage (533) 533
milrinone (486) 486
pyridones - chemical synthesis (466) 466
structure-activity relationship (435) 435
dose-response relationship, drug (419) 419
biochemistry & molecular biology (389) 389
administration, oral (352) 352
middle aged (352) 352
cell line, tumor (344) 344
pyridones - pharmacokinetics (343) 343
adult (335) 335
pyridones - adverse effects (311) 311
molecular structure (290) 290
aged (283) 283
oncology (269) 269
in vitro techniques (261) 261
antineoplastic agents - pharmacology (255) 255
abridged index medicus (249) 249
analysis (249) 249
cardiotonic agents - pharmacology (242) 242
rivaroxaban (242) 242
pyrazoles - therapeutic use (234) 234
phosphodiesterase inhibitors - pharmacology (229) 229
anticoagulants (224) 224
chemistry, organic (216) 216
iron chelating agents - pharmacology (212) 212
dabigatran (210) 210
imidazoles - pharmacology (209) 209
cancer (208) 208
cell proliferation - drug effects (207) 207
models, molecular (203) 203
rats, sprague-dawley (200) 200
apixaban (199) 199
dogs (195) 195
research (194) 194
myocardial contraction - drug effects (192) 192
treatment outcome (192) 192
protein kinase inhibitors - pharmacology (190) 190
pyrazoles - pharmacology (190) 190
pyridones - metabolism (187) 187
pirfenidone (186) 186
pharmacokinetics (185) 185
anticoagulants - therapeutic use (184) 184
cells, cultured (184) 184
time factors (183) 183
expression (179) 179
disease models, animal (177) 177
mutation (176) 176
kinetics (175) 175
cell biology (172) 172
hematology (170) 170
pyrimidinones - pharmacology (170) 170
article (165) 165
anti-bacterial agents - pharmacology (164) 164
cardiac & cardiovascular systems (163) 163
microbial sensitivity tests (161) 161
hemodynamics - drug effects (160) 160
activation (157) 157
deferiprone (156) 156
inhibition (156) 156
therapy (156) 156
drug therapy (155) 155
warfarin (154) 154
enzyme inhibitors - pharmacology (150) 150
in-vitro (149) 149
pharmacology (147) 147
drug design (146) 146
pyrazoles - administration & dosage (145) 145
cell line (144) 144
antifungal agents - pharmacology (140) 140
apoptosis (137) 137
prevention (135) 135
apoptosis - drug effects (134) 134
pyrimidines - pharmacology (134) 134
guinea pigs (133) 133
rats, wistar (133) 133
toxicology (133) 133
care and treatment (132) 132
pyridones (132) 132
pyridines - pharmacology (129) 129
inhibitors (128) 128
pyrazoles - adverse effects (128) 128
iron - metabolism (127) 127
efficacy (125) 125
chemistry, multidisciplinary (123) 123
pyridones - blood (122) 122
adolescent (121) 121
medicine & public health (121) 121
more...
Library Location Library Location
Language Language
Language Language
X
Sort by Item Count (A-Z)
Filter by Count
English (3931) 3931
German (93) 93
Japanese (61) 61
Chinese (25) 25
French (22) 22
Polish (15) 15
Spanish (12) 12
Russian (9) 9
Italian (7) 7
Czech (3) 3
Hungarian (2) 2
Danish (1) 1
Hebrew (1) 1
Norwegian (1) 1
Romanian (1) 1
Swedish (1) 1
more...
Publication Date Publication Date
Click on a bar to filter by decade
Slide to change publication date range


Nature Communications, ISSN 2041-1723, 2014, Volume 5, Issue 1, pp. 5712 - 5712
Increased expression of the Microphthalmia-associated transcription factor (MITF) contributes to melanoma progression and resistance to BRAF pathway... 
BRAF INHIBITION | TYROSINE KINASE AXL | RAF INHIBITION | CELLS | BREAST-CANCER METASTASIS | MULTIDISCIPLINARY SCIENCES | ACQUIRED-RESISTANCE | IMPROVED SURVIVAL | MEK INHIBITORS | UP-REGULATION | CONFERS RESISTANCE | Prognosis | Skin Neoplasms - drug therapy | Humans | Gene Expression Regulation, Neoplastic | Extracellular Signal-Regulated MAP Kinases - metabolism | Extracellular Signal-Regulated MAP Kinases - genetics | Melanoma - genetics | Receptor Protein-Tyrosine Kinases - antagonists & inhibitors | Indoles - pharmacology | Pyrimidinones - pharmacology | Antineoplastic Agents - pharmacology | Benzamides - pharmacology | Proto-Oncogene Proteins B-raf - metabolism | Melanoma - metabolism | Proto-Oncogene Proteins - metabolism | Skin Neoplasms - pathology | Proto-Oncogene Proteins - antagonists & inhibitors | Microphthalmia-Associated Transcription Factor - metabolism | Signal Transduction | Proto-Oncogene Proteins - genetics | Imidazoles - pharmacology | Melanoma - pathology | Pyrimidines - pharmacology | Receptor Protein-Tyrosine Kinases - metabolism | Sulfonamides - pharmacology | Imatinib Mesylate | Piperazines - pharmacology | Skin Neoplasms - metabolism | Proto-Oncogene Proteins B-raf - antagonists & inhibitors | Xenograft Model Antitumor Assays | Drug Resistance, Neoplasm - genetics | Animals | Receptor Protein-Tyrosine Kinases - genetics | Proto-Oncogene Proteins B-raf - genetics | Aminopyridines - pharmacology | Melanoma - drug therapy | Skin Neoplasms - genetics | Cell Line, Tumor | Oximes - pharmacology | Mice | Protein Kinase Inhibitors - pharmacology | Microphthalmia-Associated Transcription Factor - genetics | Pyridones - pharmacology | Index Medicus
Journal Article
Neuropharmacology, ISSN 0028-3908, 03/2013, Volume 66, pp. 215 - 224
The functional role of presynaptic release-regulating metabotropic glutamate type 7 (mGlu7) receptors in hippocampal GABAergic terminals was investigated.... 
GABA | mGlu7 receptors | Hippocampal synaptosomes | GABAB receptors | AMN082 | MMPIP | receptors | GABA(B) receptors | ACTIVATION | PROTEIN | INHIBITORY SYNAPSES | SYNAPTOSOMES | DISORDERS | METABOTROPIC GLUTAMATE RECEPTORS | NEUROSCIENCES | ALLOSTERIC AGONIST AMN082 | SINGLE NERVE-TERMINALS | PHARMACOLOGY & PHARMACY | RAT HIPPOCAMPUS | GLUTAMATE-RECEPTOR-7 | Glycine - analogs & derivatives | Synaptosomes - drug effects | gamma-Aminobutyric Acid - metabolism | Receptors, Metabotropic Glutamate - physiology | Aminobutyrates - pharmacology | Hippocampus - drug effects | Synaptosomes - metabolism | Syntaxin 1 - metabolism | Exocytosis - physiology | Exocytosis - drug effects | Adenylyl Cyclase Inhibitors | Colforsin - antagonists & inhibitors | Dose-Response Relationship, Drug | Drug Interactions | Potassium Chloride - antagonists & inhibitors | Potassium Chloride - pharmacology | Baclofen - pharmacology | Colforsin - pharmacology | Excitatory Amino Acid Agonists - pharmacology | Excitatory Amino Acid Antagonists - pharmacology | Imines - pharmacology | GABA Antagonists - pharmacology | Hippocampus - metabolism | Animals | Vesicular Inhibitory Amino Acid Transport Proteins - metabolism | Glycine - pharmacology | Phosphinic Acids - pharmacology | Benzoates - pharmacology | Benzhydryl Compounds - pharmacology | Mice | Receptors, Metabotropic Glutamate - agonists | Benzylamines - pharmacology | Pyridones - pharmacology | Receptors, Metabotropic Glutamate - antagonists & inhibitors | Receptors, GABA-B - metabolism | Methane | Brain | Heterocyclic compounds | Analysis | Baclofen | Albumin | Glutamate decarboxylase | Glutamate | Index Medicus | Adenylate cyclase
Journal Article
Anti-Cancer Drugs, ISSN 0959-4973, 03/2013, Volume 24, Issue 3, pp. 251 - 259
Journal Article
Journal Article
PLOS ONE, ISSN 1932-6203, 05/2015, Volume 10, Issue 5, pp. e0125021 - e0125021
The aim of combination drug treatment in cancer therapy is to improve response rate and to decrease the probability of the development of drug resistance.... 
CANCER-CELLS | COLON-CANCER | MELANOMA | MEK INHIBITION | TYROSINE KINASE | MULTIDISCIPLINARY SCIENCES | SYNTHETIC LETHAL INTERACTION | RESISTANCE | BRAF | BETA-CATENIN | EGFR | Triazoles - administration & dosage | Proto-Oncogene Proteins p21(ras) - genetics | Humans | Oximes - administration & dosage | Imidazoles - administration & dosage | Aza Compounds - pharmacology | Cell Line, Tumor - drug effects | Indazoles - administration & dosage | Quinolines - administration & dosage | Indoles - administration & dosage | Quinolines - pharmacology | Antineoplastic Combined Chemotherapy Protocols - pharmacology | Pyridones - administration & dosage | Benzimidazoles - administration & dosage | Melanoma - genetics | Indoles - pharmacology | Pyrimidinones - pharmacology | Molecular Targeted Therapy - methods | Proto-Oncogene Proteins B-raf - metabolism | Proto-Oncogene Proteins p21(ras) - metabolism | Aza Compounds - administration & dosage | Imidazoles - pharmacology | Melanoma - pathology | Sulfonamides - pharmacology | Proto-Oncogene Proteins c-myc - metabolism | beta Catenin - metabolism | beta Catenin - genetics | Indazoles - pharmacology | Proto-Oncogene Proteins B-raf - antagonists & inhibitors | Triazoles - pharmacology | Proto-Oncogene Proteins B-raf - genetics | Melanoma - drug therapy | Oxazoles - administration & dosage | Oximes - pharmacology | Benzimidazoles - pharmacology | Cell Proliferation - drug effects | Oxazoles - pharmacology | Proto-Oncogene Proteins c-myc - genetics | Pyrimidinones - administration & dosage | Mutation | Pyridones - pharmacology | Sulfonamides - administration & dosage | Drug therapy, Combination | Drug resistance | Drug therapy | Health aspects | Analysis | Melanoma | Index Medicus
Journal Article
Toxicology and Applied Pharmacology, ISSN 0041-008X, 01/2014, Volume 274, Issue 2, pp. 328 - 338
Induction of fibrosis during prolonged culture of precision-cut liver slices (PCLS) was reported. In this study, the use of rat PCLS was investigated to... 
Early onset of fibrosis | Precision-cut liver slices | Antifibrotic drugs | Liver fibrosis | Ex vivo model | ROSMARINIC ACID | ANGIOTENSIN-II | ANTI-FIBROTIC DRUGS | IN-VITRO | INHIBITS ACTIVATION | HEPATIC STELLATE CELLS | PHARMACOLOGY & PHARMACY | ENDOPLASMIC-RETICULUM | DERMAL FIBROBLASTS | TOXICOLOGY | GROWTH-FACTOR | IMATINIB MESYLATE | Niacinamide - analogs & derivatives | Rats, Wistar | Transforming Growth Factor beta1 - antagonists & inhibitors | Transforming Growth Factor beta1 - metabolism | Male | Valproic Acid - pharmacology | Depsides - pharmacology | Perindopril - pharmacology | Collagen Type I - genetics | Liver - drug effects | Benzamides - pharmacology | Benzylisoquinolines - pharmacology | Organ Culture Techniques | Liver Cirrhosis - drug therapy | Gene Expression | Collagen Type I - metabolism | Proto-Oncogene Proteins c-sis - genetics | Proto-Oncogene Proteins c-sis - metabolism | Down-Regulation | Liver - metabolism | Rats | Transforming Growth Factor beta1 - genetics | Pyrimidines - pharmacology | Cinnamates - pharmacology | HSP47 Heat-Shock Proteins - genetics | Imatinib Mesylate | Piperazines - pharmacology | Animals | Models, Biological | HSP47 Heat-Shock Proteins - metabolism | Connective Tissue Growth Factor - genetics | Phenylurea Compounds - pharmacology | Niacinamide - pharmacology | Connective Tissue Growth Factor - metabolism | Pyridones - pharmacology | Proto-Oncogene Proteins c-sis - antagonists & inhibitors | Drugs | Liver diseases | Analysis | Liver | Fibrosis | Gene expression | Growth factors | Index Medicus | FIBROSIS | DRUGS | GENES | LIVER | RATS | 60 APPLIED LIFE SCIENCES | ATP
Journal Article
PLoS ONE, ISSN 1932-6203, 12/2014, Volume 9, Issue 12, pp. e111840 - e111840
Patients with non-Hodgkin lymphoma (NHL) are treated today with a cocktail of drugs referred to as CHOP (Cyclophosphamide, Hydroxyldaunorubicin, Oncovin, and... 
PROTEIN METHYLTRANSFERASES | SELECTIVE-INHIBITION | MOLECULAR SUBTYPES | APOPTOSIS | B-CELL LYMPHOMA | MULTIDISCIPLINARY SCIENCES | DRUG DISCOVERY | RESISTANCE | MECHANISMS | CANCER | SOMATIC MUTATIONS | Enhancer of Zeste Homolog 2 Protein - antagonists & inhibitors | Neoplasm Transplantation | Vincristine - pharmacology | Humans | Receptors, Glucocorticoid - metabolism | Antineoplastic Combined Chemotherapy Protocols - pharmacology | Receptors, Glucocorticoid - agonists | Dexamethasone - pharmacology | Female | Antineoplastic Agents - pharmacology | Benzamides - pharmacology | Gene Expression Regulation, Neoplastic - drug effects | Drug Evaluation, Preclinical | Lymphoma, Non-Hodgkin - drug therapy | Enhancer of Zeste Homolog 2 Protein - metabolism | Random Allocation | Mice, SCID | Prednisolone - pharmacology | Animals | Cyclophosphamide - pharmacology | Lymphoma, Non-Hodgkin - metabolism | Cell Line, Tumor | Glucocorticoids - pharmacology | Prednisone - pharmacology | Doxorubicin - pharmacology | Pyridones - pharmacology | Care and treatment | Corticosteroids | Fluocinolone acetonide | Central nervous system depressants | Analysis | Histones | Models | Non-Hodgkin's lymphomas | Immunosuppressive agents | Steroids | Cancer | Signal transduction | Enzymes | Cell growth | Glucocorticoids | Research & development--R&D | Lymphomas | Mutation | Gene expression | Apoptosis | Index Medicus | Research & development | R&D
Journal Article
Cancer Cell, ISSN 1535-6108, 05/2014, Volume 25, Issue 5, pp. 697 - 710
MEK inhibitors are clinically active in BRAF melanomas but only marginally so in KRAS mutant tumors. Here, we found that MEK inhibitors suppress ERK signaling... 
LUNG-CANCER | CELLS | MELANOMA | ONCOLOGY | KINASE | C-RAF | IMPROVED SURVIVAL | BRAF | B-RAF | MUTATIONS | FEEDBACK INHIBITION | CELL BIOLOGY | Surface Plasmon Resonance | ras Proteins - genetics | Proto-Oncogene Proteins p21(ras) | Diphenylamine - pharmacology | Humans | Extracellular Signal-Regulated MAP Kinases - antagonists & inhibitors | Melanoma - enzymology | Extracellular Signal-Regulated MAP Kinases - metabolism | raf Kinases - metabolism | MAP Kinase Kinase 1 - chemistry | MAP Kinase Kinase 1 - genetics | Diphenylamine - analogs & derivatives | RNA Interference | Melanoma - genetics | TNF Receptor-Associated Factor 3 - genetics | HEK293 Cells | Indoles - pharmacology | Pyrimidinones - pharmacology | Benzamides - pharmacology | Phosphorylation - drug effects | Cell Line | MAP Kinase Kinase 1 - antagonists & inhibitors | Proto-Oncogene Proteins - genetics | TNF Receptor-Associated Factor 3 - metabolism | Sulfonamides - pharmacology | Coumarins - pharmacology | Proto-Oncogene Proteins B-raf - antagonists & inhibitors | Drug Resistance, Neoplasm - genetics | Animals | MAP Kinase Signaling System - drug effects | Mice, Nude | Proto-Oncogene Proteins B-raf - genetics | Melanoma - drug therapy | Mice | Protein Kinase Inhibitors - pharmacology | RNA, Small Interfering | Pyridones - pharmacology | Analysis | Melanoma | Tumors | Index Medicus
Journal Article
Journal Article
Journal Article
Thrombosis and Haemostasis, ISSN 0340-6245, 08/2010, Volume 104, Issue 2, pp. 302 - 310
Journal Article
Nature Immunology, ISSN 1529-2908, 2014, Volume 15, Issue 8, pp. 717 - 726
Journal Article