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Journal Article
Antimicrobial Agents and Chemotherapy, ISSN 0066-4804, 2015, Volume 59, Issue 6, pp. 3018 - 3030
Journal Article
Journal Article
The Journal of Infectious Diseases, ISSN 0022-1899, 7/2013, Volume 208, Issue 1, pp. 139 - 148
Journal Article
The Journal of Infectious Diseases, ISSN 0022-1899, 10/2011, Volume 204, Issue 7, pp. 1120 - 1124
Journal Article
Malaria Journal, ISSN 1475-2875, 2010, Volume 9, Issue 1, pp. 136 - 136
BACKGROUND: There is renewed acknowledgement that targeting gametocytes is essential for malaria control and elimination efforts. Simple mathematical models... 
INFECTIOUS DISEASES | TRANSMISSION-BLOCKING VACCINES | COMBINATION THERAPY | TROPICAL MEDICINE | MALARIA TRANSMISSION | SEASONAL TRANSMISSION | ANTIMALARIAL-DRUGS | STAGE PARASITES | PRIMAQUINE | ARTEMISININ | SEQUENCE-BASED AMPLIFICATION | ARTESUNATE | PARASITOLOGY | Self-Sustained Sequence Replication - methods | Tanzania - epidemiology | Ethanolamines - pharmacology | Prevalence | Kenya - epidemiology | Germ Cells - drug effects | Humans | Fluorenes - therapeutic use | Child, Preschool | Infant | Male | Fluorenes - pharmacology | Parasitemia - drug therapy | Plasmodium falciparum - drug effects | Amodiaquine - pharmacology | Artemisinins - pharmacology | Time Factors | Sulfadoxine - therapeutic use | Plasmodium falciparum - isolation & purification | Malaria, Falciparum - epidemiology | Female | Amodiaquine - therapeutic use | Drug Therapy, Combination | Parasitemia - epidemiology | Child | Infant, Newborn | Pyrimethamine - therapeutic use | Malaria, Falciparum - drug therapy | Carrier State - parasitology | Treatment Outcome | Antimalarials - therapeutic use | Clinical Trials as Topic | Antimalarials - pharmacology | Malaria, Falciparum - parasitology | Artemisinins - therapeutic use | Models, Biological | Primaquine - therapeutic use | Adolescent | Parasitemia - parasitology | Ethanolamines - therapeutic use | Primaquine - pharmacology | Plasmodium falciparum - growth & development | Drug Combinations | Plasmodium falciparum | Control | Malaria | Physiological aspects | Gametocytes | Research | Drug therapy | Health aspects | Drugs | Therapy | Methodology | Primaquine | Artemisinin | Erythrocytes | Clinical trials | Infections | Parasites | Blood | Reduction | Artesunate | Peripheral blood | Mathematical models | Drug dosages | Sequencing | Public health | Vector-borne diseases | Medical research | Human diseases | Nucleotide sequence | Pyrimethamine | Duration | Nucleic acids | Studies | Mosquitoes | Amodiaquine | Artemether | Detection | Circulation
Journal Article
Journal Article
Malaria Journal, ISSN 1475-2875, 2010, Volume 9, Issue 1, pp. 338 - 338
Background: Anti-malarial drug resistance in Kenya prompted two drug policy changes within a decade: sulphadoxine-pyrimethamine (SP) replaced chloroquine (CQ)... 
POINT MUTATIONS | INTERMITTENT PREVENTIVE TREATMENT | SULFADOXINE-PYRIMETHAMINE | ARTEMETHER-LUMEFANTRINE | DIHYDROPTEROATE-SYNTHETASE GENES | DIHYDROFOLATE-REDUCTASE | STANDARD ANTIMALARIAL-DRUGS | PLACEBO-CONTROLLED TRIAL | PLASMODIUM-FALCIPARUM MALARIA | IN-VITRO ACTIVITY | PARASITOLOGY | TROPICAL MEDICINE | Ethanolamines - pharmacology | Parasitic Sensitivity Tests | Prevalence | Dihydropteroate Synthase - genetics | Humans | Fluorenes - therapeutic use | Fluorenes - pharmacology | Plasmodium - drug effects | Pyrimethamine - pharmacology | Quinolones - pharmacology | Mutation, Missense | Protozoan Proteins - genetics | Chloroquine - pharmacology | Artemisinins - pharmacology | Codon | Sulfadoxine - therapeutic use | Inhibitory Concentration 50 | Drug Resistance | Pyrimethamine - therapeutic use | Cross-Sectional Studies | Sulfadoxine - pharmacology | Plasmodium - genetics | Chloroquine - therapeutic use | Genotype | Kenya | Plasmodium - isolation & purification | Antimalarials - pharmacology | Artemisinins - therapeutic use | Malaria - parasitology | Ethanolamines - therapeutic use | Malaria - drug therapy | Folic Acid Antagonists - pharmacology | Drug Combinations | Tetrahydrofolate Dehydrogenase - genetics | Care and treatment | Malaria | Physiological aspects | Genetic aspects | Research | Drug resistance | Health aspects | Prevalence studies (Epidemiology) | Drugs | Haplotypes | Policies | Chloroquine | Materials | Erythrocytes | Parasites | Immunity | Blood | Quinolones | Dihydrofolate reductase | Failure | Public health | Genotypes | Vector-borne diseases | Mutations | Human diseases | Pyrimethamine | Pressure | Baseline studies | Womens health | Amodiaquine | Artemether | Mutation | Codons
Journal Article
Journal of Medicinal Chemistry, ISSN 0022-2623, 02/2011, Volume 54, Issue 3, pp. 734 - 750
Journal Article
Cancer Chemotherapy and Pharmacology, ISSN 0344-5704, 12/2006, Volume 58, Issue 6, pp. 826 - 834
Cellular uptake of hydrophilic antifolates proceeds via the reduced folate carrier whereas lipophilic antifolates enter cells by diffusion. Recently we have... 
Efflux | Chemotherapy | Lipophilic antifolates | Drug resistance | ABC transporter | TRANSPORTER | METHOTREXATE | efflux | CANCER CELL-LINE | chemotherapy | P-GLYCOPROTEIN | TRIMETREXATE | lipophilic antifolates | PROTEIN BCRP/ABCG2 | GENE | ONCOLOGY | DIHYDROFOLATE-REDUCTASE | PHARMACOLOGY & PHARMACY | drug resistance | MUTATIONS | MULTIDRUG-RESISTANCE | Folic Acid Antagonists - chemistry | Heterocyclic Compounds, 3-Ring - metabolism | Paclitaxel - pharmacology | Humans | Cell Survival - genetics | Neoplasm Proteins - antagonists & inhibitors | Doxorubicin - chemistry | Pyrimethamine - pharmacology | Neoplasm Proteins - metabolism | Pyrimidines - chemistry | Dose-Response Relationship, Drug | Paclitaxel - chemistry | Cisplatin - chemistry | Lipids - chemistry | Transfection | ATP-Binding Cassette Transporters - genetics | Pyrimethamine - analogs & derivatives | ATP-Binding Cassette Transporters - metabolism | Indoles - pharmacology | Antineoplastic Agents - pharmacology | Biological Transport - drug effects | Biological Transport - genetics | Molecular Structure | Neoplasm Proteins - genetics | Quinazolines - chemistry | Pyrimethamine - chemistry | ATP Binding Cassette Transporter, Subfamily G, Member 2 | Cell Line | Cell Survival - drug effects | Trimetrexate - chemistry | Cisplatin - pharmacology | Pyrimidines - pharmacology | Trimetrexate - pharmacology | Antineoplastic Agents - chemistry | Mutation - genetics | Drug Resistance, Neoplasm - genetics | Fluorouracil - chemistry | Cell Proliferation - drug effects | Fluorouracil - pharmacology | Quinazolines - pharmacology | Folic Acid Antagonists - pharmacology | Indoles - chemistry | Doxorubicin - pharmacology | ATP-Binding Cassette Transporters - antagonists & inhibitors
Journal Article