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Nature, ISSN 0028-0836, 11/2010, Volume 468, Issue 7323, pp. 557 - 561
Journal Article
Journal of Clinical Oncology, ISSN 0732-183X, 11/2012, Volume 30, Issue 32, pp. 4017 - 4025
Therapeutic drug monitoring (TDM) provides valuable guidance for dose adjustment of antibiotics, immunosuppressives, antiepileptics, and other drugs, but its... 
ANTI-CD20 MONOCLONAL-ANTIBODY | ONCOLOGY | FC-GAMMA-RIIIA | PROGRESSION-FREE SURVIVAL | MULTICENTER PHASE-II | SQUAMOUS-CELL CARCINOMA | TYROSINE KINASE INHIBITOR | ENDOTHELIAL GROWTH-FACTOR | SUNITINIB MALATE SU11248 | CHRONIC MYELOID-LEUKEMIA | IMATINIB PLASMA-LEVELS | Neoplasms - metabolism | Niacinamide - analogs & derivatives | Piperazines - administration & dosage | Thiazoles - blood | Injections, Intravenous | Area Under Curve | Pyrimidines - blood | Humans | Antibodies, Monoclonal, Murine-Derived - administration & dosage | Half-Life | Thiazoles - administration & dosage | Phenylurea Compounds | Antineoplastic Agents - administration & dosage | Benzenesulfonates - administration & dosage | Drug Monitoring - methods | Indoles - administration & dosage | Antibodies, Monoclonal - blood | Antibodies, Monoclonal, Humanized | Neoplasms - blood | Antineoplastic Agents - adverse effects | Pyrroles - administration & dosage | Benzenesulfonates - blood | Antineoplastic Agents - pharmacokinetics | Cetuximab | Piperazines - blood | Everolimus | Molecular Targeted Therapy - methods | Dasatinib | Sirolimus - analogs & derivatives | Pyridines - administration & dosage | Pyrimidines - administration & dosage | Indoles - blood | Rituximab | Pyrroles - blood | Sirolimus - blood | Evidence-Based Medicine | Imatinib Mesylate | Neoplasms - drug therapy | Sirolimus - administration & dosage | Antibodies, Monoclonal, Murine-Derived - blood | Pyridines - blood | Animals | Antibodies, Monoclonal - administration & dosage | Antineoplastic Agents - blood | Benzamides
Journal Article
Journal Article
Journal of Neurochemistry, ISSN 0022-3042, 09/2007, Volume 102, Issue 6, pp. 1749 - 1757
Imatinib, a protein tyrosine kinase inhibitor, may prevent the growth of glioblastoma cells. Unfortunately, its brain distribution is restricted by... 
CGP74588 | mouse | p‐glycoprotein | imatinib | blood–brain barrier | breast cancer resistance protein | Imatinib | Blood-brain barrier | Mouse | Breast cancer resistance protein | p-glycoproteinz | blood-brain barrier | CELLS | BIOCHEMISTRY & MOLECULAR BIOLOGY | p-glycoprotein | C-KIT | DRUG-RESISTANCE | DEFICIENT MICE | GF120918 | NEUROSCIENCES | REVERSAL | IN-VITRO | PHARMACOKINETICS | TYROSINE KINASE INHIBITOR | MULTIDRUG-RESISTANCE | Male | Piperazines - metabolism | Cyclosporins - pharmacology | Pyrimidines - metabolism | Quinolines - pharmacology | Antineoplastic Agents - metabolism | Brain - metabolism | Dose-Response Relationship, Drug | Brain - blood supply | ATP Binding Cassette Transporter, Subfamily B, Member 1 | ATP-Binding Cassette Transporters - genetics | Biological Transport, Active - physiology | ATP-Binding Cassette Transporters - metabolism | Dibenzocycloheptenes - pharmacology | ATP Binding Cassette Transporter, Subfamily B - genetics | Piperazines - pharmacokinetics | Immunosuppressive Agents - pharmacology | ATP Binding Cassette Transporter, Subfamily G, Member 2 | Tetrahydroisoquinolines - pharmacology | Biological Transport, Active - drug effects | Enzyme Inhibitors - pharmacology | Blood-Brain Barrier - drug effects | Imatinib Mesylate | ATP Binding Cassette Transporter, Subfamily B - metabolism | Blood-Brain Barrier - metabolism | Mice, Knockout | Brain - drug effects | Animals | ATP Binding Cassette Transporter, Subfamily B - antagonists & inhibitors | Acridines - pharmacology | Pyrimidines - pharmacokinetics | Mice | Benzamides | ATP-Binding Cassette Transporters - antagonists & inhibitors | Physiological aspects | Breast cancer | Proteins | Neurosciences | Inhibitor drugs | Rodents | Biochemistry | Glycoproteins
Journal Article
Lancet, The, ISSN 0140-6736, 2009, Volume 374, Issue 9699, pp. 1423 - 1431
Journal Article
Molecular Pharmaceutics, ISSN 1543-8384, 08/2012, Volume 9, Issue 8, pp. 2358 - 2363
The aims of this work were to study pharmacokinetics of randomly selected drugs in plasma and saliva samples in healthy human volunteers, and to introduce a... 
Salivary Excretion Classification System | effective permeability | pharmacokinetics | protein binding | bioequivalence | SimCYP | MEDICINE, RESEARCH & EXPERIMENTAL | RELATIVE BIOAVAILABILITY | PERMEABILITY | CLINICAL PHARMACOKINETICS | BIOLOGICAL FLUID | DRUGS | PHARMACOLOGY & PHARMACY | Quinolines - blood | Acetates - blood | Fluorobenzenes - pharmacokinetics | Hydrochlorothiazide - pharmacokinetics | Triazoles - blood | Piroxicam - blood | Azithromycin - blood | Humans | Losartan - blood | Saliva - secretion | Male | Naphthalenes - blood | Benzhydryl Compounds - blood | Fluorobenzenes - pharmacology | Quinolines - pharmacokinetics | Sulfonamides - blood | Azithromycin - pharmacokinetics | Tolterodine Tartrate | Female | Triazoles - pharmacokinetics | Naphthalenes - pharmacokinetics | Piroxicam - analogs & derivatives | Sitagliptin Phosphate | Hydrochlorothiazide - blood | Losartan - pharmacokinetics | Benzhydryl Compounds - pharmacokinetics | Metformin - blood | Cresols - blood | Phenylpropanolamine - blood | Metformin - pharmacokinetics | Rosuvastatin Calcium | Cloxacillin - pharmacokinetics | Pyrimidines - pharmacology | Sulfonamides - pharmacology | Sulfonamides - pharmacokinetics | Cinacalcet Hydrochloride | Cloxacillin - blood | Saliva - metabolism | Pyrazines - pharmacokinetics | Piroxicam - pharmacokinetics | Pyrimidines - pharmacokinetics | Cresols - pharmacokinetics | Anthraquinones - blood | Anthraquinones - pharmacokinetics | Phenylpropanolamine - pharmacokinetics | Pyrazines - blood | Acetates - pharmacokinetics
Journal Article
Journal of Ethnopharmacology, ISSN 0378-8741, 10/2011, Volume 137, Issue 3, pp. 1415 - 1424
The extract was hypoglycemic, positively affected the hemopoietic system and integrity/function (dose dependently) of the liver and kidney of the diabetic... 
Lipid profile | Ocular oxidative stress | Hypoglycemia | Apigenin | Acalypha wilkesiana | CHEMISTRY, MEDICINAL | CHOLESTEROL | ANTIOXIDANTS | CORONARY | PREVENTION | RISK | PLANT SCIENCES | INTEGRATIVE & COMPLEMENTARY MEDICINE | INSULIN-RESISTANCE | ADIPOCYTE DIFFERENTIATION | PHARMACOLOGY & PHARMACY | NUTRITION | GLUCOSE-UPTAKE | NUTRACEUTICALS | Plant Extracts - chemistry | Diabetes Mellitus, Experimental - drug therapy | Antioxidants - chemistry | Rats, Wistar | Plant Extracts - pharmacology | Solvents - chemistry | Blood Urea Nitrogen | Plant Leaves | Chromatography, Gas | Urea - blood | Diabetes Mellitus, Experimental - blood | Dose-Response Relationship, Drug | Calcium - blood | Kidney - metabolism | Liver - drug effects | Eye - drug effects | Blood Cells - drug effects | Eye - metabolism | Malondialdehyde - metabolism | Kidney - drug effects | Liver - metabolism | Metformin - pharmacology | Euphorbiaceae - chemistry | Rats | Plant Extracts - isolation & purification | Hypoglycemic Agents - chemistry | Antioxidants - pharmacology | Biomarkers - blood | Cholesterol, VLDL - blood | Blood Cell Count | Hypoglycemic Agents - pharmacology | Blood Glucose - drug effects | Hypoglycemic Agents - isolation & purification | Bilirubin - blood | Animals | Aspartate Aminotransferases - blood | Antioxidants - isolation & purification | Triglycerides - blood | Cholesterol, HDL - blood | Oxidative Stress - drug effects | Blood Glucose - metabolism | Plants, Medicinal | Oxidative stress | Pyrimidines | Medicine, Herbal | Biochemistry | Medicine, Botanic
Journal Article
Blood, ISSN 0006-4971, 08/2008, Volume 112, Issue 4, pp. 1005 - 1012
Journal Article