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1. Full Text Metabolism, Biochemical Actions, and Chemical Synthesis of Anticancer Nucleosides, Nucleotides, and Base Analogs
by Shelton, J and Lu, X and Hollenbaugh, JA and Cho, JH and Amblard, F and Schinazi, RF
CHEMICAL REVIEWS, ISSN 0009-2665, 12/2016, Volume 116, Issue 23, pp. 14379 - 14455
Nucleoside, nucleotide, and base analogs have been in the clinic for decades to treat both viral pathogens and neoplasms. More than 20% of patients on... 
CELL LUNG-CANCER | A ADENOSINE RECEPTOR | ACID RELATED-COMPOUNDS | ACUTE LYMPHOBLASTIC-LEUKEMIA | FLUORINATED PYRIMIDINE NUCLEOSIDES | DOUBLE-STRAND BREAKS | 6-METHYLENE-BRIDGED URACIL DERIVATIVES | NEDD8-ACTIVATING ENZYME-INHIBITOR | ACUTE MYELOID-LEUKEMIA | DNA METHYLTRANSFERASE INHIBITORS | CHEMISTRY, MULTIDISCIPLINARY
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2. Full Text Chemical syntheses of oligodeoxyribonucleotides containing spore photoproduct
by Jian, Yajun and Li, Lei
Journal of Organic Chemistry, ISSN 0022-3263, 04/2013, Volume 78, Issue 7, pp. 3021 - 3029
5-(alpha-Thyminyl)-5,6-dihydrothymine, also called spore photoproduct or SP, is commonly found in the genomic DNA of UV-irradiated bacterial endospores.... 
RADICAL SAM ENZYME | CIS-SYN | CYCLOBUTANE PYRIMIDINE DIMERS | DEWAR VALENCE ISOMER | DNA-REPAIR ENZYME | SOLID-PHASE SYNTHESIS | SYN THYMINE DIMER | SUPPORT OLIGONUCLEOTIDE SYNTHESIS | CHEMISTRY, ORGANIC | BACILLUS-SUBTILIS SPORES | ACID-SOLUBLE PROTEINS | Deoxyribonucleotides - chemical synthesis | Thymine - chemistry | Deoxyribonucleotides - chemistry | Molecular Structure | Thymine - analogs & derivatives | Photochemical Processes | Ribonucleotides | Usage | Spectrum analysis | Conformational analysis | Research | Nucleotide sequencing | Chemical properties | Structure | Methods | DNA sequencing
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3. Advances in chemical synthesis of structurally modified bioactive RNAs
by Li, Ziyuan and Zhou, Haipin and Wu, Xiaoming and Yao, Hequan
Current Medicinal Chemistry, ISSN 0929-8673, 2013, Volume 20, Issue 29, pp. 3641 - 3654
Methods for the chemical synthesis of RNA have been available for almost half century, and presently, RNA could be chemically synthesized by automated... 
Bioactive RNAs | Pseudobase | Conformational restriction | Structural modification | Ribose | Oligoribonucleotide | Nucleobase | Chemical synthesis | Internucleoside linkage | Small non-coding RNA | internucleoside linkage | THERMODYNAMIC PROPERTIES | CHEMISTRY, MEDICINAL | FORMACETAL INTERNUCLEOSIDE LINKAGES | OLIGORIBONUCLEOTIDE ANALOGS | nucleobase | SOLID-PHASE SYNTHESIS | oligoribonucleotide | CRYSTAL-STRUCTURE | BIOCHEMISTRY & MOLECULAR BIOLOGY | conformational restriction | ribose | SELECTIVE HYBRIDIZATION | structural modification | chemical synthesis | NUCLEIC-ACID RECOGNITION | pseudobase | PHARMACOLOGY & PHARMACY | small non-coding RNA | AMIDE-LINKED RNA | ANTISENSE OLIGONUCLEOTIDES | OLIGONUCLEOTIDE ANALOGS | Ribose - chemical synthesis | RNA - chemical synthesis | Pyrimidine Nucleosides - chemistry | Ribose - chemistry | Purine Nucleotides - chemical synthesis | Carbohydrate Conformation | Purine Nucleotides - chemistry | RNA - chemistry | Pyrimidine Nucleosides - chemical synthesis | Chemistry Techniques, Synthetic - methods | RNA - metabolism
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4. Full Text Thiaminylated adenine nucleotides. Chemical synthesis, structural characterization and natural occurrence
by Frédérich, Michel and Delvaux, David and Gigliobianco, Tiziana and Gangolf, Marjorie and Dive, Georges and Mazzucchelli, Gabriel and Elias, Benjamin and De Pauw, Edwin and Angenot, Luc and Wins, Pierre and Bettendorff, Lucien
The FEBS Journal, ISSN 1742-464X, 06/2009, Volume 276, Issue 12, pp. 3256 - 3268
Thiamine and its three phosphorylated derivatives (mono‐, di‐ and triphosphate) occur naturally in most cells. Recently, we reported the presence of a fourth... 
adenosine thiamine triphosphate | adenosine thiamine diphosphate | metabolism | nucleotides | cofactor | Adenosine hiamine riphosphate | Nucleotides | Metabolism | Adenosine thiamine diphosphate | Cofactor | DIPHOSPHATE | BIOCHEMISTRY & MOLECULAR BIOLOGY | PHOSPHATE-ESTERS | ESCHERICHIA-COLI | CYTOSOLIC ADENYLATE KINASE | PERFORMANCE LIQUID-CHROMATOGRAPHY | TRIPHOSPHATE | OLIGOPHOSPHATES | TISSUES | STRESS | Thiamine Pyrophosphate - analysis | Adenine - chemical synthesis | Myocardium - chemistry | Thiamine Pyrophosphate - chemistry | Adenosine Diphosphate - chemical synthesis | Humans | Adenine - analysis | Adenosine Diphosphate - chemistry | Thiamine Triphosphate - chemistry | Chromatography, High Pressure Liquid | Adenine - chemistry | Thiamine Triphosphate - analysis | Spectrometry, Mass, Electrospray Ionization | Adenosine Triphosphate - chemical synthesis | Muscle, Skeletal - chemistry | Thiamine Triphosphate - chemical synthesis | Molecular Structure | Fibroblasts - chemistry | Adenine - analogs & derivatives | Magnetic Resonance Spectroscopy | Adenosine Triphosphate - analysis | Models, Molecular | Spectrometry, Fluorescence | Thiamine Pyrophosphate - chemical synthesis | Escherichia coli - chemistry | Quail | Adenosine Diphosphate - analysis | Liver - chemistry | Animals | Cell Line, Tumor | Kidney - chemistry | Brain Chemistry | Mice | Adenosine Triphosphate - chemistry | 3T3 Cells | Purines | Pyrimidines | Analysis | Escherichia coli | Water quality | Chemical properties | Chemical synthesis | Enzymes | Biochemistry | Cellular biology | Molecular biology
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5. Full Text An Improved Protection-Free One-Pot Chemical Synthesis of 2′-Deoxynucleoside-5′-Triphosphates
by Kore, Anilkumar R and Shanmugasundaram, Muthian and Senthilvelan, Annamalai and Srinivasan, Balasubramanian
Nucleosides, Nucleotides and Nucleic Acids, ISSN 1525-7770, 05/2012, Volume 31, Issue 5, pp. 423 - 431
A facile, straightforward, reliable, and an efficient method for the gram-scale chemical synthesis of both purine deoxynucleotides such as... 
dNTP | Ludwig procedure | Deoxyribonucleotides | proton sponge | one-pot synthesis | One-pot synthesis | sNTP | Proton sponge | NUCLEOSIDE | CELLS | 5'-TRIPHOSPHATES | ANALOGS | BIOCHEMISTRY & MOLECULAR BIOLOGY | TRIPHOSPHATES | Purine Nucleotides - chemical synthesis | Purine Nucleotides - chemistry | Pyrimidine Nucleotides - chemical synthesis | Pyrimidine Nucleotides - chemistry | Chemistry Techniques, Synthetic - methods | Polyphosphates - chemistry
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6. Full Text A sustainable multicomponent pyrimidine synthesis
by Deibl, Nicklas and Ament, Kevin and Kempe, Rhett
Journal of the American Chemical Society, ISSN 0002-7863, 10/2015, Volume 137, Issue 40, pp. 12804 - 12807
Since alcohols are accessible from indigestible biomass (lignocellulose), the development of novel preferentially catalytic reactions in which alcohols are... 
MILD CONDITIONS | HETEROCYCLES | NITRILES | BORROWING HYDROGEN | ALKYLATION | QUINOLINES | RUTHENIUM | PYRROLES | OXIDATIVE SYNTHESIS | CHEMISTRY, MULTIDISCIPLINARY | PRIMARY ALCOHOLS | Biomass | Catalysis | Pyrimidines - chemical synthesis | Hydrogenation | Alkylation | Pyrimidines - chemistry | Amidines | Pyrimidines | Chemical properties | Research | Chemical synthesis
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7. Full Text Chemical Synthesis, Crystal Structure and Enzymatic Evaluation of a Dinucleotide Spore Photoproduct Analogue Containing a Formacetal Linker
by Lin, Gengjie and Chen, Chun‐Hsing and Pink, Maren and Pu, Jingzhi and Li, Lei
Chemistry – A European Journal, ISSN 0947-6539, 08/2011, Volume 17, Issue 35, pp. 9658 - 9668
Spore photoproduct (SP) is the exclusive DNA photodamage product found in bacterial endospores. Its photoformation and repair by a metalloenzyme spore... 
enzymes | UV irradiation | oligonucleotides | photochemistry | DNA damage | ACID | DNA-REPAIR ENZYME | THYMINE DIMERS | MOLECULAR-STRUCTURE | INTERNUCLEOSIDE LINKAGES | ULTRAVIOLET-LIGHT | CHEMISTRY, MULTIDISCIPLINARY | BACILLUS-SUBTILIS | CONFORMATIONAL-ANALYSIS | SUGAR RING | LYASE | Pyrimidine Dimers - metabolism | Oligonucleotides - chemistry | Thymine - chemistry | DNA, Bacterial - metabolism | Stereoisomerism | Thymine - analogs & derivatives | Crystallography, X-Ray | Bacillus subtilis - enzymology | DNA, Bacterial - chemistry | Bacillus subtilis - chemistry | DNA, Bacterial - radiation effects | Spores, Bacterial - metabolism | Oligonucleotides - chemical synthesis | Photochemical Processes | Proteins | Ultraviolet Rays | Spores, Bacterial - genetics | DNA Repair | Pyrimidine Dimers - chemistry | Pyrimidine Dimers - genetics | Catalysis | DNA Damage | Bacillus subtilis - metabolism | Thymine - metabolism | Crystallization | Crystal structure
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8. Full Text Synthesis of activated pyrimidine ribonucleotides in prebiotically plausible conditions
by Powner, Matthew W and Gerland, Béatrice and Sutherland, John D
Nature, ISSN 0028-0836, 05/2009, Volume 459, Issue 7244, pp. 239 - 242
At some stage in the origin of life, an informational polymer must have arisen by purely chemical means. According to one version of the 'RNA world'... 
PHOSPHATE | NUCLEOTIDES | PHOSPHORUS | EARLY EARTH | EVOLUTION | RNA | PHOSPHORYLATION | PRODUCTS | NUCLEOSIDES | MULTIDISCIPLINARY SCIENCES | CHEMISTRY | Acetaldehyde - chemistry | Arabinose - chemistry | Phosphorylation | Ribonucleotides - chemistry | Models, Chemical | Pyrimidines - chemical synthesis | Cyanamide - chemistry | Glyceraldehyde - chemistry | Phosphates - chemistry | Origin of Life | Oxazoles - chemistry | Pyrimidines - chemistry | Arabinose - analogs & derivatives | Oxazoles - chemical synthesis | Acetylene - chemistry | Ribonucleotides - chemical synthesis | Ribose | Nitriles - chemistry | Acetylene - analogs & derivatives | Catalysis | Buffers | Acetaldehyde - analogs & derivatives | Hydrogen-Ion Concentration | Ribonucleotides | Pyrimidines | Heterocyclic compounds | Protein biosynthesis | Biochemistry | Research | Properties | Aqueous solutions | Chemical synthesis | Chemistry
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9. Full Text Sustainable Synthesis of Quinolines and Pyrimidines Catalyzed by Manganese PNP Pincer Complexes
by Mastalir, Matthias and Glatz, Mathias and Pittenauer, Ernst and Allmaier, Günter and Kirchner, Karl
Journal of the American Chemical Society, ISSN 0002-7863, 12/2016, Volume 138, Issue 48, pp. 15543 - 15546
This study represents the first example an environmentally benign, sustainable, and practical synthesis of substituted quinolines and pyrimidines using... 
BORROWING HYDROGEN METHODOLOGY | SECONDARY ALCOHOLS | ALPHA-ALKYLATION | N-ALKYLATION | BOND FORMATION | RUTHENIUM | GAMMA-AMINO-ALCOHOLS | IRIDIUM COMPLEX | CHEMISTRY, MULTIDISCIPLINARY | AROMATIC-AMINES | C-H | Pyrimidines | Usage | Analysis | Chemical bonds | Amides | Chemical properties | Chemical synthesis
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10. Full Text Privileged structures: Efficient chemical "navigators" toward unexplored biologically relevant chemical spaces
by Kim, Jonghoon and Kim, Heejun and Park, Seung Bum
Journal of the American Chemical Society, ISSN 0002-7863, 11/2014, Volume 136, Issue 42, pp. 14629 - 14638
In the search for new therapeutic agents for currently incurable diseases, attention has turned to traditionally "undruggable" targets, and collections of... 
COMPOUND LIBRARIES | POLYHETEROCYCLIC BENZOPYRAN LIBRARY | DIVERSITY-ORIENTED SYNTHESIS | NATURAL-PRODUCTS | DRUG DISCOVERY | COMBINATORIAL LIBRARIES | TARGET IDENTIFICATION | PHASE PARALLEL SYNTHESIS | CHEMISTRY, MULTIDISCIPLINARY | MESENCHYMAL STEM-CELLS | SYNTHESIS PATHWAY | Small Molecule Libraries - pharmacology | Chemistry Techniques, Synthetic | Anti-Inflammatory Agents - pharmacology | Antineoplastic Agents - chemical synthesis | Humans | Small Molecule Libraries - chemical synthesis | Drug Discovery - methods | Antineoplastic Agents - chemistry | Small Molecule Libraries - chemistry | Animals | Anti-Inflammatory Agents - chemistry | Cell Differentiation - drug effects | Anti-Inflammatory Agents - chemical synthesis | Antineoplastic Agents - pharmacology
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11. Full Text Catalytic and highly regioselective cross-coupling of aromatic C-H substrates
by Hull, Kami L and Sanford, Melanie S
Journal of the American Chemical Society, ISSN 0002-7863, 10/2007, Volume 129, Issue 39, pp. 11904 - 11905
This communication describes a new Pd-catalyzed reaction for the highly chemo- and regioselective oxidative cross-coupling of aromatic C-H bonds. This... 
OXIDATION | MECHANISM | BOND FORMATION | DERIVATIVES | CHEMISTRY, MULTIDISCIPLINARY | SIMPLE ARENES | BORYLATION | Benzene Derivatives - chemical synthesis | Oxidation-Reduction | Pyrazoles - chemical synthesis | Pyridines - chemistry | Pyrimidines - chemical synthesis | Quinolines - chemistry | Pyridines - chemical synthesis | Heterocyclic Compounds - chemical synthesis | Pyrimidines - chemistry | Quinolines - chemical synthesis | Pyrazoles - chemistry | Heterocyclic Compounds - chemistry | Catalysis | Benzene Derivatives - chemistry | Palladium - chemistry | Palladium | Chemical properties | Hydrogen | Carbon compounds | Electric properties
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12. Full Text A general synthesis of ynones from aldehydes via oxidative C-C bond cleavage under aerobic conditions
by Wang, Zhaofeng and Li, Li and Huang, Yong
Journal of the American Chemical Society, ISSN 0002-7863, 09/2014, Volume 136, Issue 35, pp. 12233 - 12236
We describe a direct synthesis of various ynones from readily available aldehydes and hypervalent alkynyl iodides. In this method, a gold catalyst and a... 
DIOXYGEN ACTIVATION | 2,5-DISUBSTITUTED FURANS | REGIOSELECTIVE SYNTHESIS | EFFICIENT SYNTHESIS | TERMINAL ALKYNES | CARBON TRIPLE BOND | 3-COMPONENT PYRIMIDINE SYNTHESIS | DIRECT ALKYNYLATION | CHEMISTRY, MULTIDISCIPLINARY | MOLECULAR-OXYGEN | CARBOXYLIC-ACIDS | Amines - chemistry | Gold - chemistry | Alkynes - chemical synthesis | Oxidation-Reduction | Aldehydes - chemical synthesis | Alkynes - chemistry | Iodides - chemistry | Amines - chemical synthesis | Biological Products - chemical synthesis | Biological Products - chemistry | Oxygen - chemistry | Catalysis | Iodides - chemical synthesis | Aldehydes - chemistry | Chemical properties | Chemical synthesis | Carbon compounds | Analysis
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13. Full Text Microwave assisted synthesis of dihydrobenzo[4,5]imidazo[1,2-a]pyrimidin-4-ones; synthesis, in vitro antimicrobial and anticancer activities of novel coumarin substituted dihydrobenzo[4,5]imidazo[1,2-a]pyrimidin-4-ones
by Puttaraju, Kallimeledoddi B and Shivashankar, Kalegowda and Chandra and Mahendra, M and Rasal, Vijaykumar P and Venkata Vivek, Ponnuru N and Rai, Khushboo and Chanu, Maibam Beebina
European Journal of Medicinal Chemistry, ISSN 0223-5234, 11/2013, Volume 69, pp. 316 - 322
The present article describes the synthesis of dihydrobenzo[4,5]imidazo[1,2- ]pyrimidin-4-one ( – ) under microwave irradiation. The product was obtained in... 
Coumarins | 4-Bromomethylcoumarins | Benzimidazole | Pyrimidine | CHEMISTRY, MEDICINAL | DERIVATIVES | Antineoplastic Agents - chemical synthesis | Humans | Bacteria - drug effects | Coumarins - chemistry | Antifungal Agents - chemical synthesis | Antifungal Agents - chemistry | Benzimidazoles - chemistry | Pyrimidinones - chemistry | Microbial Sensitivity Tests | Anti-Bacterial Agents - chemistry | Pyrimidinones - pharmacology | Antineoplastic Agents - pharmacology | Molecular Structure | Pyrimidinones - chemical synthesis | Microwaves | Antifungal Agents - pharmacology | Fungi - drug effects | Benzimidazoles - chemical synthesis | Models, Molecular | Antineoplastic Agents - chemistry | Anti-Bacterial Agents - chemical synthesis | Cell Line, Tumor | Benzimidazoles - pharmacology | Anti-Bacterial Agents - pharmacology | Cell Proliferation - drug effects | Drug Screening Assays, Antitumor | Care and treatment | Pneumonia | Bacterial pneumonia | Bacteria | Lymphomas | Antibacterial agents | Cancer
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14. Full Text General and Efficient Copper‐Catalyzed Three‐Component Coupling Reaction towards Imidazoheterocycles: One‐Pot Synthesis of Alpidem and Zolpidem
by Chernyak, Natalia and Gevorgyan, Vladimir
Angewandte Chemie International Edition, ISSN 1433-7851, 04/2010, Volume 49, Issue 15, pp. 2743 - 2746
Three is not a crowd: A method for the construction of imidazopyridine, imidazoquinoline, and imidazoisoquinoline frameworks has been developed. The synthetic... 
multicomponent reactions | homogeneous catalysis | heterocycles | cyclization | imidazopyridines | Heterocycles | Multicomponent reactions | Cyclization | Imidazopyridines | Homogeneous catalysis | PROPARGYLAMINES | ALDEHYDES | ALKYNES | CHEMISTRY, MULTIDISCIPLINARY | LIGANDS | AFFINITY | AMINES | PERIPHERAL BENZODIAZEPINE-RECEPTOR | MULTICOMPONENT SYNTHESIS | BINDING | Pyridines - chemistry | Quinolines - chemistry | Imidazoles - chemistry | Pyridines - chemical synthesis | Heterocyclic Compounds - chemical synthesis | Pyrimidines - chemistry | Copper - chemistry | Anti-Anxiety Agents - chemical synthesis | Heterocyclic Compounds - chemistry | Anti-Anxiety Agents - chemistry | Catalysis | Imidazoles - chemical synthesis
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15. Full Text Discovery of 7-methyl-5-(1-{[3-(trifluoromethyl)phenyl]acetyl}-2,3-dihydro- 1H-indol-5-yl)-7H-pyrrolo[2,3-d]pyrimidin-4-amine (GSK2606414), a potent and selective first-in-class inhibitor of protein kinase R (PKR)-like endoplasmic reticulum kinase (PERK)
by Axten, Jeffrey M and Medina, Jesús R and Feng, Yanhong and Shu, Arthur and Romeril, Stuart P and Grant, Seth W and Li, William Hoi Hong and Heerding, Dirk A and Minthorn, Elisabeth and Mencken, Thomas and Atkins, Charity and Liu, Qi and Rabindran, Sridhar and Kumar, Rakesh and Hong, Xuan and Goetz, Aaron and Stanley, Thomas and Taylor, J. David and Sigethy, Scott D and Tomberlin, Ginger H and Hassell, Annie M and Kahler, Kirsten M and Shewchuk, Lisa M and Gampe, Robert T and Argonne National Lab. (ANL), Argonne, IL (United States). Advanced Photon Source (APS)
Journal of Medicinal Chemistry, ISSN 0022-2623, 08/2012, Volume 55, Issue 16, pp. 7193 - 7207
Protein kinase R (PKR)-like endoplasmic reticulum kinase (PERK) is activated in response to a variety of endoplasmic reticulum stresses implicated in numerous... 
PATHWAYS | CELLS | ACTIVATION | DESIGN | CHEMISTRY, MEDICINAL | PHOSPHORYLATION | STRESS-RESPONSE | HYPOXIC STRESS | PEK | CANCER | TRANSLATIONAL CONTROL | Neoplasm Transplantation | Phosphorylation | Adenine - chemical synthesis | Pyrimidines - chemical synthesis | Antineoplastic Agents - chemical synthesis | Humans | Indoles - chemical synthesis | Biological Availability | Crystallography, X-Ray | Male | Transplantation, Heterologous | Structure-Activity Relationship | Adenine - chemistry | Pyrimidines - chemistry | Female | Indoles - pharmacology | Antineoplastic Agents - pharmacology | Adenine - analogs & derivatives | Administration, Oral | Models, Molecular | Rats | Adenine - pharmacology | Pyrimidines - pharmacology | Antineoplastic Agents - chemistry | Rats, Sprague-Dawley | eIF-2 Kinase - antagonists & inhibitors | Pyrroles - pharmacology | Animals | Pyrroles - chemical synthesis | Mice, Nude | Dogs | Cell Line, Tumor | Pyrroles - chemistry | Protein Conformation | Mice | Indoles - chemistry | Drug Screening Assays, Antitumor
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16. Full Text Correction: An unprecedented tandem synthesis of fluorescent coumarin-fused pyrimidines via copper-catalyzed cross-dehydrogenative C(sp3)-N bond coupling
by Kumari, Santosh and Abdul Shakoor, S. M and Khullar, Sadhika and Mandal, Sanjay K and Sakhuja, Rajeev
Organic & biomolecular chemistry, ISSN 1477-0520, 11/2018, Volume 16, Issue 44, pp. 8647 - 8648
Correction for 'An unprecedented tandem synthesis of fluorescent coumarin-fused pyrimidines via copper-catalyzed cross-dehydrogenative C(sp 3 )-N bond... 
Pyrimidines | Dehydrogenation | Smog | Fluorescence | Coupling | Copper | Chemical synthesis | Coumarin
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17. Full Text A prebiotically plausible synthesis of pyrimidine β-ribonucleosides and their phosphate derivatives involving photoanomerization
by Xu, Jianfeng and Tsanakopoulou, Maria and Magnani, Christopher J and Szabla, Rafał and Šponer, Judit E and Šponer, Jiří and Góra, Robert W and Sutherland, John D
Nature Chemistry, ISSN 1755-4330, 04/2017, Volume 9, Issue 4, pp. 303 - 309
Previous research has identified ribose aminooxazoline as a potential intermediate in the prebiotic synthesis of the pyrimidine nucleotides with remarkable... 
NUCLEOTIDES | EXCITED-STATE | PICTURE | FORMAMIDE | NUCLEOSIDES | CHEMISTRY | 2-THIOURACIL | RELAXATION | PRECURSORS | CHEMISTRY, MULTIDISCIPLINARY | DEACTIVATION | Pyrimidines - chemical synthesis | Molecular Conformation | Ribonucleosides - chemistry | Phosphates - chemistry | Ribose - chemistry | Evolution, Chemical | Ribonucleosides - chemical synthesis | Oxazoles - chemistry | Phosphates - chemical synthesis | Pyrimidines - chemistry | Photochemical Processes
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18. Full Text Synthesis, Structure-Activity Relationships, and in Vivo Efficacy of the Novel Potent and Selective Anaplastic Lymphoma Kinase (ALK) Inhibitor 5-Chloro-N2-(2-isopropoxy-5-methyl-4-(piperidin-4-yl)phenyl)-N4-(2-(isopropylsulfonyl)phenyl)pyrimidine-2,4-diamine (LDK378) Currently in Phase 1 and Phase 2 Clinical Trials
by Marsilje, TH and Pei, W and Chen, B and Lu, WS and Uno, T and Jin, YH and Jiang, T and Kim, S and Li, NX and Warmuth, M and Sarkisova, Y and Sun, F and Steffy, A and Pferdekamper, AC and Li, AG and Joseph, SB and Kim, Y and Liu, B and Tuntland, T and Cui, XM and Gray, NS and Steensma, R and Wan, YQ and Jiang, JQ and Chopiuk, G and Li, J and Gordon, WP and Richmond, W and Johnson, K and Chang, J and Groessl, T and He, YQ and Phimister, A and Aycinena, A and Lee, CC and Bursulaya, B and Karanewsky, DS and Seidel, HM and Harris, JL and Michellys, PY
JOURNAL OF MEDICINAL CHEMISTRY, ISSN 0022-2623, 07/2013, Volume 56, Issue 14, pp. 5675 - 5690
The synthesis, preclinical profile, and in vivo efficacy in rat xenograft models of the novel and selective anaplastic lymphoma kinase inhibitor 15b (LDK378)... 
CELL LUNG-CANCER | CHEMISTRY, MEDICINAL | SOLID TUMORS | GENE | DRUG DISCOVERY | C-MET | NON-HODGKINS-LYMPHOMA | ANTITUMOR-ACTIVITY | IDENTIFICATION | RECEPTOR TYROSINE KINASE | EXPERIMENTAL-MODELS | Protein Kinase Inhibitors - pharmacokinetics | Protein Kinase Inhibitors - chemical synthesis | Sulfones - therapeutic use | Pyrimidines - chemical synthesis | Humans | Macaca fascicularis | Rats | Male | Structure-Activity Relationship |