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1. Full Text Unified prebiotically plausible synthesis of pyrimidine and purine RNA ribonucleotides
by Becker, Sidney and Feldmann, Jonas and Wiedemann, Stefan and Okamura, Hidenori and Schneider, Christina and Iwan, Katharina and Crisp, Antony and Rossa, Martin and Amatov, Tynchtyk and Carell, Thomas
Science (American Association for the Advancement of Science), ISSN 0036-8075, 10/2019, Volume 366, Issue 6461, pp. 76 - 82
Science & Technology - Other Topics | Multidisciplinary Sciences | Science & Technology | RNA - chemical synthesis | Pyrimidine Nucleosides - chemistry | Pyrimidine Nucleotides - chemical synthesis | Ribonucleotides - chemical synthesis | Chemical Phenomena | Purine Nucleosides - chemistry | Ribose - chemistry | Purine Nucleotides - chemical synthesis | Hydroxylamine - chemistry | Purine Nucleosides - chemical synthesis | Pyrimidine Nucleosides - chemical synthesis | Hydroxylamine | Catalysts | Biological evolution | Chemical reactions | Minerals | Ribonucleic acid--RNA | Metabolism | Substrates | Organic chemistry | Purines | Ribonucleotides | Pyrimidines | Atmospheric conditions | Pathways | Ribose | Information transfer | Nucleosides | Diphosphates | Index Medicus
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2. Full Text Biologically Driven Synthesis of Pyrazolo[3,4‑d]pyrimidines As Protein Kinase Inhibitors: An Old Scaffold As a New Tool for Medicinal Chemistry and Chemical Biology Studies
by Schenone, Silvia and Radi, Marco and Musumeci, Francesca and Brullo, Chiara and Botta, Maurizio
Chemical reviews, ISSN 0009-2665, 07/2014, Volume 114, Issue 14, pp. 7189 - 7238
Physical Sciences | Chemistry | Chemistry, Multidisciplinary | Science & Technology | Protein Kinase Inhibitors - chemical synthesis | Protein Kinase Inhibitors - chemistry | Protein Kinase Inhibitors - pharmacology | Pyrimidines - pharmacology | Pyrimidines - chemical synthesis | Pyrimidines - chemistry | Pyrimidines | Chemical properties | Research | Pharmaceutical chemistry | Proteins | Medicine | Biology | Chemical synthesis | Kinases | Index Medicus | Inhibitors | Synthesis | Tools | Scaffolds
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3. Full Text Carbon-Carbon Bond Cleavage Reaction: Synthesis of Multisubstituted Pyrazolo[1,5-a]pyrimidines
by Saikia, Pallabi and Gogoi, Sanjib and Boruah, Romesh C
Journal of organic chemistry, ISSN 0022-3263, 07/2015, Volume 80, Issue 13, pp. 6885 - 6889
Pyrazoles - chemistry | Pyrazoles - chemical synthesis | Pyrimidines - chemical synthesis | Ketones - chemistry | Molecular Structure | Carbon - chemistry | Pyrimidines - chemistry | Chemical bonds | Chemical reactions | Pyrimidines | Research | Chemical properties | Index Medicus
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4. Full Text Synthesis of activated pyrimidine ribonucleotides in prebiotically plausible conditions
by Gerland, Béatrice and Sutherland, John D and Powner, Matthew W
Nature (London), ISSN 0028-0836, 05/2009, Volume 459, Issue 7244, pp. 239 - 242
Fundamental and applied biological sciences. Psychology | Biological and medical sciences | Genetics of eukaryotes. Biological and molecular evolution | Biological evolution | Acetaldehyde - chemistry | Arabinose - chemistry | Phosphorylation | Ribonucleotides - chemistry | Models, Chemical | Pyrimidines - chemical synthesis | Cyanamide - chemistry | Glyceraldehyde - chemistry | Phosphates - chemistry | Origin of Life | Oxazoles - chemistry | Pyrimidines - chemistry | Arabinose - analogs & derivatives | Oxazoles - chemical synthesis | Acetylene - chemistry | Ribonucleotides - chemical synthesis | Ribose | Nitriles - chemistry | Acetylene - analogs & derivatives | Catalysis | Buffers | Acetaldehyde - analogs & derivatives | Hydrogen-Ion Concentration | Ribonucleotides | Pyrimidines | Heterocyclic compounds | Protein biosynthesis | Biochemistry | Research | Properties | Aqueous solutions | Chemical synthesis | Chemistry | Index Medicus
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5. Full Text Microwave assisted synthesis of dihydrobenzo[4,5]imidazo[1,2-a]pyrimidin-4-ones; synthesis, in vitro antimicrobial and anticancer activities of novel coumarin substituted dihydrobenzo[4,5]imidazo[1,2-a]pyrimidin-4-ones
by Puttaraju, Kallimeledoddi B and Shivashankar, Kalegowda and Chandra and Mahendra, M and Rasal, Vijaykumar P and Venkata Vivek, Ponnuru N and Rai, Khushboo and Chanu, Maibam Beebina
European journal of medicinal chemistry, ISSN 0223-5234, 11/2013, Volume 69, pp. 316 - 322
Coumarins | 4-Bromomethylcoumarins | Benzimidazole | Pyrimidine | Antineoplastic Agents - chemical synthesis | Humans | Bacteria - drug effects | Coumarins - chemistry | Antifungal Agents - chemical synthesis | Antifungal Agents - chemistry | Benzimidazoles - chemistry | Pyrimidinones - chemistry | Microbial Sensitivity Tests | Anti-Bacterial Agents - chemistry | Pyrimidinones - pharmacology | Antineoplastic Agents - pharmacology | Molecular Structure | Pyrimidinones - chemical synthesis | Microwaves | Antifungal Agents - pharmacology | Fungi - drug effects | Benzimidazoles - chemical synthesis | Models, Molecular | Antineoplastic Agents - chemistry | Anti-Bacterial Agents - chemical synthesis | Cell Line, Tumor | Benzimidazoles - pharmacology | Anti-Bacterial Agents - pharmacology | Cell Proliferation - drug effects | Drug Screening Assays, Antitumor | Care and treatment | Pneumonia | Bacterial pneumonia | Bacteria | Lymphomas | Antibacterial agents | Cancer | Index Medicus
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6. Full Text 6‑(Aryldiazenyl)pyrazolo[1,5‑a]pyrimidines as Strategic Intermediates for the Synthesis of Pyrazolo[5,1‑b]purines
by Castillo, Juan-Carlos and Estupiñan, Diego and Nogueras, Manuel and Cobo, Justo and Portilla, Jaime
Journal of organic chemistry, ISSN 0022-3263, 12/2016, Volume 81, Issue 24, pp. 12364 - 12373
Pyrimidines | Usage | Chemical properties | Chemical synthesis | Pyrazoles
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7. Full Text Synthesis of Azaheterocycles from Aryl Ketone O-Acetyl Oximes and Internal Alkynes by Cu–Rh Bimetallic Relay Catalysts
by Too, Pei Chui and Chua, Sze Hui and Wong, Siong Heng and Chiba, Shunsuke
Journal of organic chemistry, ISSN 0022-3263, 08/2011, Volume 76, Issue 15, pp. 6159 - 6168
Organic chemistry | Chemistry | Theory of reactions, general kinetics. Catalysis. Nomenclature, chemical documentation, computer chemistry | Heterocyclic compounds | Heterocyclic compounds with only one n hetero atom and condensed derivatives | Exact sciences and technology | General and physical chemistry | Catalysis | Heterocyclic compounds with n hetero atom and also o and/or s, se, te hetero atoms | Catalysts: preparations and properties | Preparations and properties | Carbolines - chemical synthesis | Pyrimidines - chemical synthesis | Heterocyclic Compounds - chemical synthesis | Alkynes - chemistry | Pyrimidines - chemistry | Oximes - chemistry | Isoquinolines - chemistry | Carbolines - chemistry | Copper - chemistry | Heterocyclic Compounds - chemistry | Isoquinolines - chemical synthesis | Ketones - chemistry | Organometallic Compounds - chemistry | Molecular Structure | Rhodium - chemistry | Ketones | Analysis | Chemical properties | Copper | Structure | Index Medicus
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8. Full Text Regioselective Synthesis of 7‑(Trimethylsilylethynyl)pyrazolo[1,5‑a]pyrimidines via Reaction of Pyrazolamines with Enynones
by Golubev, Pavel and Karpova, Ekaterina A and Pankova, Alena S and Sorokina, Mariia and Kuznetsov, Mikhail A
Journal of organic chemistry, ISSN 0022-3263, 11/2016, Volume 81, Issue 22, pp. 11268 - 11275
Pyrimidines | Amines | Research | Chemical properties | Chemical synthesis
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9. Full Text Design, Synthesis, and Evaluation of Thiophene[3,2‑d]pyrimidine Derivatives as HIV‑1 Non-nucleoside Reverse Transcriptase Inhibitors with Significantly Improved Drug Resistance Profiles
by Kang, Dongwei and Fang, Zengjun and Li, Zhenyu and Huang, Boshi and Zhang, Heng and Lu, Xueyi and Xu, Haoran and Zhou, Zhongxia and Ding, Xiao and Daelemans, Dirk and De Clercq, Erik and Pannecouque, Christophe and Zhan, Peng and Liu, Xinyong
Journal of medicinal chemistry, ISSN 0022-2623, 09/2016, Volume 59, Issue 17, pp. 7991 - 8007
Anti-HIV Agents - pharmacology | Pyrimidines - chemical synthesis | HIV Reverse Transcriptase - antagonists & inhibitors | Humans | Drug Resistance, Viral | Reverse Transcriptase Inhibitors - pharmacology | Male | Structure-Activity Relationship | Anti-HIV Agents - chemical synthesis | Pyrimidines - chemistry | Reverse Transcriptase Inhibitors - chemistry | Reverse Transcriptase Inhibitors - chemical synthesis | Reverse Transcriptase Inhibitors - pharmacokinetics | Sulfonamides - chemistry | Heterocyclic Compounds, 2-Ring - chemistry | Thiophenes - pharmacology | Heterocyclic Compounds, 2-Ring - pharmacokinetics | Pyrimidines - pharmacology | HIV-1 - genetics | Sulfonamides - pharmacology | Rats, Sprague-Dawley | Sulfonamides - pharmacokinetics | Heterocyclic Compounds, 2-Ring - pharmacology | Sulfonamides - chemical synthesis | Thiophenes - chemical synthesis | Thiophenes - pharmacokinetics | Anti-HIV Agents - chemistry | Animals | Anti-HIV Agents - pharmacokinetics | Cell Line, Tumor | Pyrimidines - pharmacokinetics | HIV-1 - enzymology | Mice | Molecular Docking Simulation | Mutation | Thiophenes - chemistry | Heterocyclic Compounds, 2-Ring - chemical synthesis | Index Medicus
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10. Full Text General and Efficient Copper‐Catalyzed Three‐Component Coupling Reaction towards Imidazoheterocycles: One‐Pot Synthesis of Alpidem and Zolpidem
by Chernyak, Natalia and Gevorgyan, Vladimir
Angewandte Chemie (International ed.), ISSN 1433-7851, 04/2010, Volume 49, Issue 15, pp. 2743 - 2746
multicomponent reactions | homogeneous catalysis | heterocycles | cyclization | imidazopyridines | Heterocycles | Multicomponent reactions | Cyclization | Imidazopyridines | Homogeneous catalysis | Pyridines - chemistry | Quinolines - chemistry | Imidazoles - chemistry | Pyridines - chemical synthesis | Heterocyclic Compounds - chemical synthesis | Pyrimidines - chemistry | Copper - chemistry | Anti-Anxiety Agents - chemical synthesis | Heterocyclic Compounds - chemistry | Anti-Anxiety Agents - chemistry | Catalysis | Imidazoles - chemical synthesis | Index Medicus
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11. Full Text A prebiotically plausible synthesis of pyrimidine β-ribonucleosides and their phosphate derivatives involving photoanomerization
by Xu, Jianfeng and Tsanakopoulou, Maria and Magnani, Christopher J and Szabla, Rafał and Šponer, Judit E and Šponer, Jiří and Góra, Robert W and Sutherland, John D
Nature chemistry, ISSN 1755-4330, 04/2017, Volume 9, Issue 4, pp. 303 - 309
Pyrimidines - chemical synthesis | Molecular Conformation | Ribonucleosides - chemistry | Phosphates - chemistry | Ribose - chemistry | Evolution, Chemical | Ribonucleosides - chemical synthesis | Oxazoles - chemistry | Phosphates - chemical synthesis | Pyrimidines - chemistry | Photochemical Processes | Index Medicus
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12. Full Text Synthesis and biological evaluation of thieno [2′,3′:4,5] pyrimido[1,2-b][1,2,4]triazines and thieno[2,3-d][1,2,4]triazolo[1,5-a] pyrimidines as anti-inflammatory and analgesic agents
by Ashour, Hayam M and Shaaban, Omaima G and Rizk, Ola H and El-Ashmawy, Ibrahim M
European journal of medicinal chemistry, ISSN 0223-5234, 04/2013, Volume 62, pp. 341 - 351
Ulcerogenic effect | Anti-inflammatory activity | Thienotriazolopyrimidines | Analgesic activity | Thienopyrimidotriazines | Analgesics - pharmacology | Rats, Wistar | Pyrimidines - chemical synthesis | Triazoles - chemistry | Male | Structure-Activity Relationship | Formaldehyde | Pyrimidines - chemistry | Anti-Inflammatory Agents, Non-Steroidal - pharmacology | Dose-Response Relationship, Drug | Analgesics - chemical synthesis | Triazines - chemistry | Triazoles - chemical synthesis | Molecular Structure | Anti-Inflammatory Agents, Non-Steroidal - chemical synthesis | Triazines - pharmacology | Analgesics - administration & dosage | Rats | Thiophenes - pharmacology | Edema - drug therapy | Pyrimidines - pharmacology | Triazoles - pharmacology | Thiophenes - chemical synthesis | Animals | Triazines - chemical synthesis | Anti-Inflammatory Agents, Non-Steroidal - administration & dosage | Edema - chemically induced | Thiophenes - chemistry | Pyrimidines | Analgesics | Anti-inflammatory drugs | Analysis | Pharmacy | Index Medicus
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13. Full Text Metal-Free Decarboxylative Hetero-Diels–Alder Synthesis of 3‑Hydroxypyridines: A Rapid Access to N‑Fused Bicyclic Hydroxypiperidine Scaffolds
by Jouanno, Laurie-Anne and Di Mascio, Vincent and Tognetti, Vincent and Joubert, Laurent and Sabot, Cyrille and Renard, Pierre-Yves
Journal of organic chemistry, ISSN 0022-3263, 02/2014, Volume 79, Issue 3, pp. 1303 - 1319
Indolizidines - chemical synthesis | Piperidines - chemistry | Pyridines - chemistry | Stereoisomerism | Quinolizidines - chemical synthesis | Indolizidines - chemistry | Pyridines - chemical synthesis | Piperidines - chemical synthesis | Cycloaddition Reaction | Pyrimidines - chemistry | Quinolizidines - chemistry | Metals - chemistry | Molecular Structure | Pyridine | Diels-Alder reaction | Research | Chemical properties | Chemical synthesis | Index Medicus | Organic chemistry | Chemical Sciences
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14. Full Text Substituted thiazoles V. Synthesis and antitumor activity of novel thiazolo[2,3- b]quinazoline and pyrido[4,3- d]thiazolo[3,2- a]pyrimidine analogues
by Al-Omary, Fatmah A.M and Hassan, Ghada S and El-Messery, Shahenda M and El-Subbagh, Hussein I
European journal of medicinal chemistry, ISSN 0223-5234, 2012, Volume 47, Issue 1, pp. 65 - 72
Antitumor activity | Thiazolo[2,3- b]quinazoline and pyrido[4,3- d]thiazolo[3,2- a]pyrimidine | Thiazolo[2,3-b]quinazoline and pyrido[4,3-d]thiazolo[3,2-a]pyrimidine | Biological and medical sciences | General aspects | Medical sciences | Antineoplastic agents | Pharmacology. Drug treatments | Quinazolines - chemical synthesis | Pyrimidines - chemical synthesis | Antineoplastic Agents - chemical synthesis | Humans | Pyrimidines - pharmacology | Antineoplastic Agents - chemistry | Pyrimidines - chemistry | Thiazoles - chemical synthesis | Cell Line, Tumor | Thiazoles - chemistry | Antineoplastic Agents - pharmacology | Thiazoles - pharmacology | Drug Evaluation, Preclinical | Quinazolines - pharmacology | Quinazolines - chemistry | Index Medicus
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15. Full Text Variolins and Related Alkaloids
by Walker, Scott R and Carter, Erin J and Huff, Belinda C and Morris, Jonathan C
Chemical reviews, ISSN 0009-2665, 07/2009, Volume 109, Issue 7, pp. 3080 - 3098
Physical Sciences | Chemistry | Chemistry, Multidisciplinary | Science & Technology | Aza Compounds - isolation & purification | Pyrimidines - chemical synthesis | Antineoplastic Agents - chemical synthesis | Aza Compounds - chemical synthesis | Aza Compounds - pharmacology | Pyrimidines - pharmacology | Pyrimidines - isolation & purification | Bridged Bicyclo Compounds, Heterocyclic - pharmacology | Indole Alkaloids - chemical synthesis | Indole Alkaloids - isolation & purification | Antineoplastic Agents - isolation & purification | Indole Alkaloids - pharmacology | Antineoplastic Agents - pharmacology | Bridged Bicyclo Compounds, Heterocyclic - isolation & purification | Cyclin-Dependent Kinases - antagonists & inhibitors | Bridged Bicyclo Compounds, Heterocyclic - chemical synthesis | Enzyme inhibitors | Chemical properties | Structure | Heterocyclic compounds | Clinical trials | Medical research | Biochemistry | Chemical synthesis | Chemical compounds | Index Medicus
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