X
Search Filters
Format Format
Format Format
X
Sort by Item Count (A-Z)
Filter by Count
Journal Article (29231) 29231
Publication (4162) 4162
Newsletter (417) 417
Book Chapter (138) 138
Book Review (118) 118
Conference Proceeding (85) 85
Book / eBook (22) 22
Dissertation (17) 17
Magazine Article (7) 7
Web Resource (7) 7
Newspaper Article (5) 5
Government Document (4) 4
Paper (2) 2
Data Set (1) 1
Reference (1) 1
Streaming Video (1) 1
Trade Publication Article (1) 1
more...
Subjects Subjects
Subjects Subjects
X
Sort by Item Count (A-Z)
Filter by Count
humans (15569) 15569
animals (13278) 13278
index medicus (12083) 12083
pyrimidines - pharmacology (10367) 10367
male (7130) 7130
pyrimidines (5980) 5980
mice (5369) 5369
biochemistry & molecular biology (4970) 4970
female (4947) 4947
rats (4525) 4525
oncology (3223) 3223
pyrimidines - therapeutic use (3162) 3162
pyrimidines - metabolism (3107) 3107
imatinib mesylate (2964) 2964
pharmacology & pharmacy (2896) 2896
cell line, tumor (2669) 2669
pyrimidines - chemistry (2526) 2526
benzamides (2356) 2356
research (2324) 2324
cell biology (2320) 2320
analysis (2288) 2288
cancer (2240) 2240
mutation (2181) 2181
dna (2141) 2141
kinetics (2111) 2111
middle aged (2111) 2111
adult (2097) 2097
cells, cultured (2037) 2037
dose-response relationship, drug (2017) 2017
expression (2004) 2004
cell line (1969) 1969
proteins (1947) 1947
dna repair (1937) 1937
antineoplastic agents - pharmacology (1924) 1924
protein kinase inhibitors - pharmacology (1886) 1886
article (1876) 1876
piperazines - pharmacology (1876) 1876
enzymes (1869) 1869
phosphorylation (1806) 1806
ultraviolet rays (1751) 1751
chemistry, medicinal (1727) 1727
physiological aspects (1686) 1686
dna damage (1662) 1662
structure-activity relationship (1654) 1654
metabolism (1599) 1599
pyrimidines - administration & dosage (1598) 1598
apoptosis (1595) 1595
time factors (1555) 1555
molecular sequence data (1518) 1518
apoptosis - drug effects (1475) 1475
aged (1472) 1472
cell proliferation - drug effects (1399) 1399
cells (1386) 1386
research article (1376) 1376
activation (1366) 1366
enzyme inhibitors - pharmacology (1361) 1361
signal transduction - drug effects (1353) 1353
base sequence (1348) 1348
signal transduction (1339) 1339
pyrazoles - pharmacology (1313) 1313
gene expression (1299) 1299
models, molecular (1293) 1293
nucleotides (1292) 1292
hematology (1270) 1270
in-vitro (1212) 1212
antineoplastic agents - therapeutic use (1188) 1188
piperazines - therapeutic use (1188) 1188
rats, sprague-dawley (1188) 1188
pyrimidines - pharmacokinetics (1180) 1180
nucleosides (1177) 1177
binding sites (1166) 1166
neurosciences (1160) 1160
multidisciplinary sciences (1158) 1158
pyrimidines - chemical synthesis (1157) 1157
protein binding (1139) 1139
dna - metabolism (1135) 1135
inhibition (1088) 1088
genetic aspects (1086) 1086
heterocyclic compounds (1085) 1085
in vitro techniques (1085) 1085
pyrimidine dimers - metabolism (1068) 1068
escherichia-coli (1054) 1054
organic compounds (1029) 1029
molecular structure (1023) 1023
organic nitrogen compounds (1001) 1001
genetics & heredity (998) 998
protein-tyrosine kinases - antagonists & inhibitors (994) 994
biochemistry (978) 978
genes (967) 967
leukemia, myelogenous, chronic, bcr-abl positive - drug therapy (965) 965
biophysics (963) 963
disease models, animal (960) 960
mice, inbred c57bl (960) 960
imatinib (941) 941
amino acid sequence (905) 905
azines (901) 901
cell survival - drug effects (900) 900
kinases (899) 899
chronic myeloid-leukemia (882) 882
rodents (877) 877
more...
Library Location Library Location
Library Location Library Location
X
Sort by Item Count (A-Z)
Filter by Count
Gerstein Science - Stacks (17) 17
Online Resources - Online (7) 7
Chemistry (A D Allen) - Stacks (3) 3
UofT at Scarborough - Stacks (3) 3
UofT at Mississauga - Stacks (2) 2
Collection Dvlpm't (Acquisitions) - Closed Orders (1) 1
St Josephs Health Centre - Stacks (1) 1
more...
Language Language
Language Language
X
Sort by Item Count (A-Z)
Filter by Count
English (28836) 28836
German (201) 201
Russian (186) 186
Japanese (171) 171
French (119) 119
Chinese (118) 118
Italian (43) 43
Polish (35) 35
Spanish (32) 32
Hungarian (15) 15
Czech (8) 8
Dutch (8) 8
Ukrainian (7) 7
Danish (4) 4
Hebrew (4) 4
Portuguese (4) 4
Finnish (3) 3
Romanian (3) 3
Norwegian (2) 2
Slovak (1) 1
Swedish (1) 1
Turkish (1) 1
more...
Publication Date Publication Date
Click on a bar to filter by decade
Slide to change publication date range


Journal of Eukaryotic Microbiology, ISSN 1066-5234, 09/2016, Volume 63, Issue 5, pp. 657 - 678
Comparison of the genomes of free‐living Bodo saltans and those of parasitic trypanosomatids reveals that the transition from a free‐living to a parasitic life... 
Trypanosoma | Leishmania | parasitism | adaptation | Leptomonas | Phytomonas | lateral gene transfer | Lateral gene transfer | Parasitism | Adaptation | LIFE-CYCLE | DEPENDENT PHOSPHOFRUCTOKINASE | FATTY-ACID SYNTHESIS | DIFFERENTIAL EXPRESSION | DIHYDROOROTATE DEHYDROGENASE | INSECT TRYPANOSOMATIDS | MICROBIOLOGY | BLOOD-STREAM FORM | SOLANESYL-DIPHOSPHATE SYNTHASE | COMPLEX-I | UBIQUINONE BIOSYNTHESIS | Mitochondria - enzymology | Dolichol - metabolism | Reactive Oxygen Species | Genes, Protozoan - genetics | Trypanosomatina - genetics | Microbodies - metabolism | Ubiquinone - metabolism | Vitamins - metabolism | Pyrimidines - biosynthesis | Eukaryota - metabolism | Protozoan Proteins - genetics | Protein Prenylation | Pyrimidines - metabolism | Amino Acids - metabolism | Coenzymes - metabolism | Trypanosomatina - metabolism | Urea - metabolism | Phospholipids - metabolism | Kinetoplastida - metabolism | Gluconeogenesis | Bacteria - metabolism | Oxidoreductases - metabolism | Purines - metabolism | Carbohydrate Metabolism | Ergosterol - biosynthesis | Lipid Metabolism | Mitochondria - metabolism | Kinetoplastida - enzymology | Mevalonic Acid - metabolism | Bacteria - genetics | Peroxisomes - metabolism | Polyamines - metabolism | Trypanosomatina - enzymology | Eukaryota - genetics | Kinetoplastida - genetics | Folic Acid - metabolism | Glycolysis | Purines - biosynthesis | Pentose Phosphate Pathway | Oxidases | Thiols | Isoenzymes | Genes | Genomics | Tryptophan | Carbohydrate metabolism | Phylogeny | Fatty acids | Fructose | Glucose metabolism | Pyrimidines | Anopheles | Lysine | Physiological aspects | Comparative analysis | Phosphotransferases
Journal Article
Drug Metabolism and Disposition, ISSN 0090-9556, 01/2010, Volume 38, Issue 1, pp. 168 - 176
This study investigated the role of a multispecific organic anion transporter, Oatp1a4/ Slco1a4 , in drug transport across the blood-brain barrier. In vitro... 
LOCALIZATION | INVOLVEMENT | POLYPEPTIDE-2 | PENETRATION | PHARMACOLOGY & PHARMACY | RAT-BRAIN | OATP2 | BCRP/ABCG2 | 17-BETA-ESTRADIOL-D-17-BETA-GLUCURONIDE | CANCER RESISTANCE PROTEIN | P-GLYCOPROTEIN | Fluorobenzenes - pharmacokinetics | Gene Expression - genetics | Pyrimidines - blood | Humans | Ion Pumps - genetics | Fluorobenzenes - administration & dosage | Quinolines - administration & dosage | Pyrimidines - metabolism | Brain - metabolism | Quinolines - pharmacokinetics | Choroid Plexus - blood supply | ATP-Binding Cassette Transporters - genetics | Ochratoxins - administration & dosage | Cell Membrane - metabolism | Cerebral Cortex - drug effects | Capillaries - metabolism | Fluorobenzenes - metabolism | Tetrahydroisoquinolines - pharmacology | Organic Cation Transport Proteins - metabolism | Pravastatin - metabolism | Liver - metabolism | Rosuvastatin Calcium | Sulfonamides - pharmacokinetics | Blood-Brain Barrier - metabolism | Mice, Knockout | Brain - drug effects | Taurocholic Acid - administration & dosage | Pravastatin - administration & dosage | Enkephalin, D-Penicillamine (2,5)- - administration & dosage | Pyrimidines - pharmacokinetics | Mice | Kinetics | Organic Cation Transport Proteins - genetics | Pravastatin - pharmacokinetics | Sulfonamides - administration & dosage | Quinolines - blood | Digoxin - metabolism | Taurocholic Acid - metabolism | Choroid Plexus - metabolism | Taurocholic Acid - blood | Ochratoxins - pharmacokinetics | ATP-Binding Cassette, Sub-Family B, Member 1 - antagonists & inhibitors | Ochratoxins - metabolism | Cerebral Cortex - metabolism | Organic Anion Transporters - metabolism | Brain - blood supply | Sulfonamides - blood | Organic Anion Transporters - genetics | Transfection | Fluorobenzenes - blood | Enkephalin, D-Penicillamine (2,5)- - pharmacokinetics | Recombinant Proteins - metabolism | Cell Line | Pyrimidines - administration & dosage | Mice, Inbred C57BL | Recombinant Proteins - genetics | Blood-Brain Barrier - drug effects | Digoxin - pharmacokinetics | Quinolines - metabolism | Taurocholic Acid - pharmacokinetics | Liver - blood supply | Pharmaceutical Preparations - metabolism | Animals | Digoxin - administration & dosage | Enkephalin, D-Penicillamine (2,5)- - metabolism | Acridines - pharmacology | Sulfonamides - metabolism
Journal Article
Drug Metabolism and Disposition, ISSN 0090-9556, 09/2012, Volume 40, Issue 9, pp. 1744 - 1756
Interindividual variability in activity of uptake transporters is evident in vivo, yet limited data exist in vitro, confounding in vitro-in vivo extrapolation.... 
DRUG TRANSPORTERS | IN-VITRO CLEARANCE | CRYOPRESERVED HUMAN HEPATOCYTES | HMG-COA REDUCTASE | PHARMACOLOGY & PHARMACY | ANION TRANSPORTING POLYPEPTIDES | HEPATIC-UPTAKE | HEALTHY-VOLUNTEERS | METABOLIC ENZYMES | RECEPTOR ANTAGONIST | PREDICTION | Antihypertensive Agents - pharmacology | Tetrazoles - pharmacology | Species Specificity | Valsartan | Hypoglycemic Agents - metabolism | Benzoates - metabolism | Humans | Antihypertensive Agents - metabolism | Hepatocytes - metabolism | Angiotensin II Type 1 Receptor Blockers - pharmacology | Angiotensin II Type 1 Receptor Blockers - metabolism | Organic Anion Transporters - metabolism | Pyrimidines - metabolism | Quinolines - pharmacology | Tetrazoles - metabolism | Carbamates - metabolism | Dose-Response Relationship, Drug | Fluorobenzenes - pharmacology | Drug Interactions | Hydroxymethylglutaryl-CoA Reductase Inhibitors - metabolism | Biological Transport | Piperidines - pharmacology | Hepatocytes - drug effects | Carbamates - pharmacology | Pravastatin - pharmacology | Fluorobenzenes - metabolism | Piperidines - metabolism | Pravastatin - metabolism | Valine - analogs & derivatives | Rats | Rosuvastatin Calcium | Pyrimidines - pharmacology | Sulfonamides - pharmacology | Hypoglycemic Agents - pharmacology | Quinolines - metabolism | Animals | Hydroxymethylglutaryl-CoA Reductase Inhibitors - pharmacology | Valine - metabolism | Models, Biological | Benzimidazoles - metabolism | Sulfonamides - metabolism | Benzoates - pharmacology | Benzimidazoles - pharmacology | Kinetics | Valine - pharmacology | Organic Anion Transporters - drug effects
Journal Article
Nature, ISSN 0028-0836, 06/2017, Volume 546, Issue 7656, pp. 168 - 172
Metabolic reprogramming by oncogenic signals promotes cancer initiation and progression. The oncogene KRAS and tumour suppressor STK11, which encodes the... 
REPLICATION | METABOLISM | PATHWAY | MULTIDISCIPLINARY SCIENCES | GROWTH | AMPK | LKB1 | Carbamyl Phosphate - metabolism | Metabolomics | AMP-Activated Protein Kinases - metabolism | Cell Proliferation | Proto-Oncogene Proteins p21(ras) - genetics | Humans | Lung Neoplasms - metabolism | Lung Neoplasms - pathology | Male | Pyrimidines - metabolism | S Phase | Cell Death | DNA - biosynthesis | Female | Transcription, Genetic | Protein-Serine-Threonine Kinases - metabolism | Carbamoyl-Phosphate Synthase (Ammonia) - genetics | Carcinoma, Non-Small-Cell Lung - pathology | DNA Damage - drug effects | Lung Neoplasms - genetics | Nitrogen - metabolism | Lung Neoplasms - enzymology | Ammonia - metabolism | Carcinoma, Non-Small-Cell Lung - genetics | Purines - metabolism | Carcinoma, Non-Small-Cell Lung - metabolism | Gene Silencing | Protein-Serine-Threonine Kinases - genetics | DNA Replication | Mitochondria - metabolism | Pyrimidines - pharmacology | Xenograft Model Antitumor Assays | Animals | Carbamoyl-Phosphate Synthase (Ammonia) - metabolism | Bicarbonates - metabolism | Mice | Carcinoma, Non-Small-Cell Lung - enzymology | DNA-Directed DNA Polymerase - metabolism | Carbamoyl-Phosphate Synthase (Ammonia) - deficiency | Pyrimidines | Gene mutations | Lung cancer | Cancer cells | Genetic aspects | Nucleotide sequencing | Health aspects | Methods | DNA sequencing | Correlation | Transcription | Toxicity | DNA damage | Oncology | K-Ras protein | LKB1 protein | Bicarbonate | Mitochondria | Phosphate | Carbonates | Signatures | Damage | Stalling | Deoxyribonucleic acid--DNA | Enzymes | Mortality | Non-small cell lung carcinoma | Nitrogen | Pools | Metabolism | Gene expression | Flow | Polymerase | DNA biosynthesis | Ammonia | Urea | Depletion | Lungs | Carbamoyl phosphate | Cell death | Human behavior | Tumors | Cancer | Index Medicus
Journal Article
Journal of Pharmacology and Experimental Therapeutics, ISSN 0022-3565, 02/2012, Volume 340, Issue 2, pp. 404 - 421
Parkinson's disease (PD) is a debilitating neurodegenerative disorder associated with severe motor impairments caused by the loss of dopaminergic innervation... 
LOCALIZATION | TRANSMISSION | MEDIATED MODULATION | RAT STRIATUM | GLUTAMATE-RECEPTOR-4 | MGLUR4 | BASAL GANGLIA | NEURONS | PHARMACOLOGY & PHARMACY | DYSFUNCTION | AGONISTS | Catalepsy - drug therapy | Receptors, G-Protein-Coupled - metabolism | Pyrimidines - blood | Humans | Male | Thallium - metabolism | Picolinic Acids - metabolism | Pyrimidines - metabolism | Brain - metabolism | Motor Neuron Disease - drug therapy | Corpus Striatum - pathology | Disease Models, Animal | Triazoles - therapeutic use | Glutamic Acid - pharmacology | Adenosine A2 Receptor Antagonists - therapeutic use | Brain - physiopathology | Rats | Psychomotor Performance - drug effects | Motor Neuron Disease - chemically induced | Rats, Sprague-Dawley | Motor Neuron Disease - pathology | Brain - drug effects | Drug Synergism | Triazoles - metabolism | Calcium Signaling - drug effects | Picolinic Acids - pharmacokinetics | Receptors, G-Protein-Coupled - antagonists & inhibitors | Brain - pathology | Corpus Striatum - drug effects | Tyrosine 3-Monooxygenase - metabolism | Triazoles - blood | Rats, Wistar | Substantia Nigra - pathology | Picolinic Acids - blood | Parkinson Disease - drug therapy | Receptors, Metabotropic Glutamate - metabolism | Receptors, G-Protein-Coupled - agonists | Substantia Nigra - metabolism | Corpus Striatum - metabolism | Dose-Response Relationship, Drug | Adenosine A2 Receptor Antagonists - metabolism | Motor Neuron Disease - metabolism | Oxidopamine - pharmacology | Transfection | Receptors, Metabotropic Glutamate - genetics | Reaction Time - drug effects | HEK293 Cells | Catalepsy - chemically induced | G Protein-Coupled Inwardly-Rectifying Potassium Channels - metabolism | Drug Therapy, Combination | Motor Neuron Disease - physiopathology | Haloperidol - pharmacology | Picolinic Acids - pharmacology | 3,4-Dihydroxyphenylacetic Acid - metabolism | Corpus Striatum - physiopathology | Levodopa - therapeutic use | Substantia Nigra - drug effects | Animals | Picolinic Acids - therapeutic use | Pyrimidines - therapeutic use | Adenosine A2 Receptor Antagonists - blood | Protein Binding | Receptors, Metabotropic Glutamate - agonists | Levodopa - metabolism | Monoamine Oxidase - metabolism
Journal Article
Nature, ISSN 0028-0836, 11/2015, Volume 527, Issue 7578, pp. 379 - 383
Journal Article
Nature, ISSN 0028-0836, 04/2015, Volume 520, Issue 7546, pp. 192 - 197
The metabolism of endothelial cells during vessel sprouting remains poorly studied. Here we report that endothelial loss of CFT1A, a rate-limiting enzyme of... 
OXIDATION | DISTRIBUTIONS | GLYCOLYSIS | REDUCTIVE GLUTAMINE-METABOLISM | ANGIOGENESIS | MULTIDISCIPLINARY SCIENCES | TUMOR | PROLIFERATION | GROWTH-FACTOR | CANCER | CULTURE | Carnitine O-Palmitoyltransferase - genetics | Human Umbilical Vein Endothelial Cells - metabolism | Blood Vessels - metabolism | Blood Vessels - pathology | Humans | Neovascularization, Pathologic - pathology | Nucleotides - chemistry | Carnitine O-Palmitoyltransferase - antagonists & inhibitors | Adenosine Triphosphate - metabolism | Carnitine O-Palmitoyltransferase - metabolism | Human Umbilical Vein Endothelial Cells - cytology | Nucleotides - biosynthesis | Nucleotides - pharmacology | Oxidation-Reduction - drug effects | DNA - biosynthesis | Carnitine O-Palmitoyltransferase - deficiency | Fatty Acids - metabolism | Disease Models, Animal | Carbon - metabolism | Fatty Acids - chemistry | Human Umbilical Vein Endothelial Cells - drug effects | Endothelial Cells - metabolism | Gene Silencing | Acetic Acid - pharmacology | Blood Vessels - cytology | Citric Acid Cycle | Animals | Retinopathy of Prematurity - drug therapy | Endothelial Cells - cytology | Neovascularization, Pathologic - drug therapy | Blood Vessels - drug effects | Cell Line, Tumor | Glucose - metabolism | Human Umbilical Vein Endothelial Cells - pathology | Cell Proliferation - drug effects | Mice | Neovascularization, Pathologic - metabolism | Retinopathy of Prematurity - metabolism | Endothelial Cells - enzymology | Endothelial Cells - drug effects | Retinopathy of Prematurity - pathology | Physiological aspects | Deoxyribonucleotides | Fatty acids | Carbon | Endothelium | Proteins | Angiogenesis | Protein synthesis | Glucose | Kinases | Deoxyribonucleic acid--DNA | Cells
Journal Article