X
Search Filters
Format Format
Subjects Subjects
Subjects Subjects
X
Sort by Item Count (A-Z)
Filter by Count
pyrimidinones - chemical synthesis (740) 740
pyrimidinones - chemistry (564) 564
pyrimidinones - pharmacology (559) 559
index medicus (484) 484
chemistry, medicinal (417) 417
humans (395) 395
animals (383) 383
structure-activity relationship (362) 362
chemistry, organic (299) 299
molecular structure (275) 275
derivatives (192) 192
rats (184) 184
chemistry, multidisciplinary (171) 171
mice (164) 164
biochemistry & molecular biology (156) 156
models, molecular (154) 154
chemistry (124) 124
male (114) 114
pharmacology & pharmacy (112) 112
catalysis (111) 111
drug design (108) 108
stereoisomerism (106) 106
magnetic resonance spectroscopy (101) 101
cell line, tumor (98) 98
inhibitors (95) 95
analysis (93) 93
antineoplastic agents - chemical synthesis (85) 85
dose-response relationship, drug (82) 82
crystallography, x-ray (80) 80
microbial sensitivity tests (79) 79
design (78) 78
antineoplastic agents - pharmacology (77) 77
potent (75) 75
pyrimidines - chemical synthesis (71) 71
pyrimidines (70) 70
female (68) 68
chemical phenomena (66) 66
cell line (65) 65
one-pot synthesis (65) 65
binding sites (64) 64
enzyme inhibitors - chemical synthesis (64) 64
enzyme inhibitors - pharmacology (64) 64
pyrimidinones (62) 62
article (61) 61
discovery (60) 60
drug screening assays, antitumor (59) 59
pyrimidinones - pharmacokinetics (57) 57
analogs (56) 56
organic chemistry (55) 55
pyrimidinones - metabolism (54) 54
antineoplastic agents - chemistry (53) 53
cancer (53) 53
kinetics (53) 53
pyrimidinones - therapeutic use (53) 53
cell proliferation - drug effects (52) 52
pyrimidines - pharmacology (52) 52
research (52) 52
enzyme inhibitors - chemistry (51) 51
synthesis (51) 51
anti-bacterial agents - chemical synthesis (50) 50
pyrimidines - chemistry (50) 50
anti-bacterial agents - pharmacology (49) 49
inhibitory concentration 50 (48) 48
agents (47) 47
cyclization (47) 47
in vitro techniques (47) 47
chemical properties (46) 46
chemical synthesis (46) 46
acid (45) 45
in-vitro (44) 44
molecular conformation (43) 43
drug discovery (41) 41
hiv-1 - drug effects (41) 41
pyrimidinone (41) 41
biginelli reaction (39) 39
chemistry, applied (38) 38
hydrogen bonding (38) 38
protein binding (38) 38
dogs (37) 37
ligands (36) 36
chemistry, physical (35) 35
molecular docking simulation (35) 35
pyridines - chemical synthesis (35) 35
pyrimidinones - toxicity (35) 35
thiophenes - chemical synthesis (35) 35
aldehydes (34) 34
spectrophotometry, infrared (34) 34
administration, oral (33) 33
indicators and reagents (33) 33
thiophenes - pharmacology (33) 33
antiviral agents (32) 32
models, chemical (32) 32
multidisciplinary sciences (32) 32
reverse transcriptase inhibitors - chemical synthesis (32) 32
reverse transcriptase inhibitors - pharmacology (32) 32
hiv (31) 31
biological evaluation (30) 30
rats, sprague-dawley (30) 30
uracil - analogs & derivatives (30) 30
anti-bacterial agents - chemistry (29) 29
more...
Language Language
Language Language
X
Sort by Item Count (A-Z)
Filter by Count
English (1114) 1114
German (18) 18
Japanese (9) 9
French (4) 4
Chinese (3) 3
Italian (3) 3
Polish (2) 2
Ukrainian (2) 2
Czech (1) 1
Hungarian (1) 1
Spanish (1) 1
more...
Publication Date Publication Date
Click on a bar to filter by decade
Slide to change publication date range


Journal Article
Nature chemical biology, ISSN 1552-4450, 12/2014, Volume 10, Issue 12, pp. 1013 - 1019
Vps34 is a phosphoinositide 3-kinase (PI3K) class III isoform that has attracted major attention over the recent years because of its role in autophagy. Herein... 
KINASE VPS34 | LIPID KINASE | PHOSPHATIDYLINOSITOL 3-PHOSPHATE | T-CELL HOMEOSTASIS | BIOCHEMISTRY & MOLECULAR BIOLOGY | DISEASE | MECHANISMS | OPTIMIZATION | MAMMALIAN-CELLS | MTOR | REVEALS | Kidney - pathology | Antineoplastic Agents - chemical synthesis | Humans | Kidney - enzymology | Sirolimus - chemical synthesis | Autophagy - drug effects | Endosomes - metabolism | TOR Serine-Threonine Kinases - antagonists & inhibitors | Lysosomes - metabolism | TOR Serine-Threonine Kinases - genetics | Adenosine Triphosphate - metabolism | Endosomes - drug effects | Class III Phosphatidylinositol 3-Kinases - chemistry | Pyrimidinones - pharmacology | Antineoplastic Agents - pharmacology | Autophagy - genetics | Pyrimidinones - chemical synthesis | Everolimus | Lysosomes - drug effects | Protein Kinase Inhibitors - chemical synthesis | Catalytic Domain | Gene Expression | Sirolimus - analogs & derivatives | Signal Transduction | Pyridines - chemical synthesis | Recombinant Proteins - chemistry | Recombinant Proteins - genetics | Sirolimus - pharmacology | Drug Synergism | TOR Serine-Threonine Kinases - chemistry | Class III Phosphatidylinositol 3-Kinases - genetics | Cell Line, Tumor | Cell Proliferation - drug effects | Class III Phosphatidylinositol 3-Kinases - antagonists & inhibitors | Molecular Docking Simulation | Protein Kinase Inhibitors - pharmacology | Pyridines - pharmacology | Kinetics | Adenosine Triphosphate - chemistry | Proteins | Lipids | Kinases | Autophagy | Binding sites | Adenosine triphosphatase
Journal Article
Organic and Biomolecular Chemistry, ISSN 1477-0520, 6/2012, Volume 1, Issue 22, pp. 4311 - 4326
Journal Article
Journal Article
European Journal of Medicinal Chemistry, ISSN 0223-5234, 01/2018, Volume 143, pp. 1779 - 1789
Journal Article
Journal Article
Journal of Medicinal Chemistry, ISSN 0022-2623, 05/2007, Volume 50, Issue 10, pp. 2297 - 2300
Journal Article
Organic Letters, ISSN 1523-7060, 09/2015, Volume 17, Issue 18, pp. 4502 - 4505
A divergent cascade annulation has been developed using readily available vinyl azides and carbazates with a wide range of substituents. Vinyl azides were... 
ISOQUINOLINES | CHEMISTRY, ORGANIC | DIVERSITY-ORIENTED SYNTHESIS | Hydrazines - chemistry | Imidazoles - chemistry | Molecular Structure | Catalysis | Imidazoles - chemical synthesis | Pyrimidinones - chemical synthesis | Azides - chemistry | Pyrimidinones - chemistry
Journal Article
Organic Letters, ISSN 1523-7060, 02/2012, Volume 14, Issue 4, pp. 1122 - 1125
The total synthesis of (+/-)-janoxepin, a novel antiplasmodial D-leucine derived oxepine-pyrimidinone-ketopiperazine isolated from the fungus Aspergillus... 
CHEMISTRY, ORGANIC | METABOLITES | FUNGUS | COMBINATION | ALKALOIDS | Biological Products - chemical synthesis | Aspergillus - chemistry | Models, Molecular | Molecular Structure | Piperazines - chemistry | Pyrimidinones - chemical synthesis | Pyrimidinones - chemistry
Journal Article