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The New England journal of medicine, ISSN 1533-4406, 11/2017, Volume 377, Issue 19, pp. 1813 - 1823
In patients with surgically resected melanoma, those with BRAF mutations who received 1 year of oral adjuvant therapy with dabrafenib and trametinib had a 53%... 
Medicine, General & Internal | Life Sciences & Biomedicine | General & Internal Medicine | Science & Technology | Skin Neoplasms - drug therapy | Oximes - adverse effects | Humans | Middle Aged | Antineoplastic Combined Chemotherapy Protocols - adverse effects | Oximes - therapeutic use | Male | Adjuvants, Immunologic - adverse effects | Young Adult | Melanoma - genetics | Skin Neoplasms - mortality | Aged, 80 and over | Adult | Female | Imidazoles - therapeutic use | Adjuvants, Immunologic - therapeutic use | Skin Neoplasms - surgery | Double-Blind Method | Imidazoles - adverse effects | Pyrimidinones - adverse effects | Pyrimidinones - therapeutic use | Neoplasm Recurrence, Local | Antineoplastic Combined Chemotherapy Protocols - therapeutic use | Proto-Oncogene Proteins B-raf - genetics | Melanoma - drug therapy | Skin Neoplasms - genetics | Adolescent | Survival Analysis | Aged | Pyridones - therapeutic use | Melanoma - surgery | Mutation | Neoplasm Staging | Pyridones - adverse effects | Melanoma - mortality | Usage | Relapse | Patient outcomes | Analysis | Melanoma | Adjuvant treatment | Outcome and process assessment (Health Care) | Reports | Drug therapy | Cancer | Diseases | Medical imaging | Oncology | Metastasis | FDA approval | Kinases | Cancer therapies | Survival | Skin cancer | Metastases | Medical prognosis | Immunotherapy | Drug dosages | Index Medicus | Abridged Index Medicus
Journal Article
Cancer discovery, ISSN 2159-8290, 06/2012, Volume 2, Issue 6, pp. 524 - 539
Inhibition of the protein kinase WEE1 synergizes with chemotherapy in preclinical models and WEE1 inhibitors are being explored as potential cancer therapies.... 
Life Sciences & Biomedicine | Oncology | Science & Technology | Protein Kinases - metabolism | Thiophenes - therapeutic use | Pyrazoles - therapeutic use | Apoptosis - drug effects | Humans | Deoxycytidine - pharmacology | Antineoplastic Agents - therapeutic use | Thiazoles - therapeutic use | Quinolines - pharmacology | Tumor Suppressor Protein p53 - genetics | Breast Neoplasms - metabolism | Cell Cycle Proteins - antagonists & inhibitors | DNA-Binding Proteins - metabolism | Deoxycytidine - therapeutic use | Cyclins - metabolism | Urea - analogs & derivatives | Female | Antineoplastic Agents - pharmacology | Gene Expression Regulation, Neoplastic - drug effects | Pyrazoles - pharmacology | Cell Line | Pyrimidinones | Thiophenes - pharmacology | Pyrimidines - pharmacology | Mice, SCID | Breast Neoplasms - drug therapy | Enhancer of Zeste Homolog 2 Protein | Transcription Factors - metabolism | Xenograft Model Antitumor Assays | Polycomb Repressive Complex 2 | Urea - therapeutic use | Animals | Mitosis - drug effects | Tumor Burden - drug effects | Breast Neoplasms - pathology | Protein Kinase Inhibitors - therapeutic use | Pyrimidines - therapeutic use | Nuclear Proteins - antagonists & inhibitors | Cell Line, Tumor | Checkpoint Kinase 1 | Mice | Protein Kinase Inhibitors - pharmacology | Quinolines - therapeutic use | S Phase - drug effects | Thiazoles - pharmacology | Deoxycytidine - analogs & derivatives | Urea - pharmacology | Protein-Tyrosine Kinases - antagonists & inhibitors | Index Medicus
Journal Article
Mayo Clinic proceedings, ISSN 0025-6196, 2011, Volume 86, Issue 10, pp. 1009 - 1026
.... This review article is structured to discuss antiviral therapeutics on the basis of these 3 major antiviral categories, with the caveat that some drugs discussed... 
Internal Medicine | Medicine, General & Internal | Life Sciences & Biomedicine | General & Internal Medicine | Science & Technology | Acyclovir - therapeutic use | Foscarnet - pharmacology | Hepatitis C - drug therapy | HIV Infections - epidemiology | Humans | Ganciclovir - analogs & derivatives | Interferons - therapeutic use | Oligopeptides - therapeutic use | Hepatitis - drug therapy | Valacyclovir | Adenine - therapeutic use | Lamivudine - therapeutic use | Ganciclovir - therapeutic use | Proline - pharmacology | Protease Inhibitors - therapeutic use | Guanine - therapeutic use | Oseltamivir - pharmacology | Virus Replication - drug effects | Antiviral Agents - pharmacology | Adenine - analogs & derivatives | Valganciclovir | Organophosphonates - therapeutic use | Proline - analogs & derivatives | Antiviral Agents - therapeutic use | Comorbidity | Interferons - pharmacology | Pyrimidinones - therapeutic use | Acyclovir - pharmacology | Zanamivir - therapeutic use | Herpesviridae Infections - drug therapy | Thymidine - analogs & derivatives | Valine - therapeutic use | Oligopeptides - pharmacology | Telbivudine | Ribavirin - pharmacology | Guanine - analogs & derivatives | Oseltamivir - therapeutic use | Guanine - pharmacology | Hepatitis C - epidemiology | Nucleosides - pharmacology | Ganciclovir - pharmacology | Pyrimidinones - pharmacology | Influenza, Human - drug therapy | Drug Therapy, Combination | Nucleosides - therapeutic use | Acyclovir - analogs & derivatives | Ribavirin - therapeutic use | Valine - analogs & derivatives | Zanamivir - pharmacology | Adenine - pharmacology | Proline - therapeutic use | Organophosphonates - pharmacology | Hepatitis B, Chronic - drug therapy | HIV Infections - drug therapy | Lamivudine - pharmacology | Foscarnet - therapeutic use | Valine - pharmacology | Amantadine - pharmacology | Antiviral agents | Diagnosis | Research | Drug therapy | HIV infection | Health aspects | Index Medicus | Abridged Index Medicus | Symposium on Antimicrobial Therapy
Journal Article
Clinical cancer research, ISSN 1557-3265, 03/2014, Volume 20, Issue 10, pp. 2516 - 2522
Journal Article
Journal Article
Cancer chemotherapy and pharmacology, ISSN 1432-0843, 11/2014, Volume 75, Issue 1, pp. 183 - 189
To identify the maximum tolerated dose (MTD) and recommended Phase II dose of MEK/AKT inhibitor combination of trametinib and afuresertib.Eligibility criteria... 
Medicine & Public Health | MEK Inhibitor | Afuresertib | Oncology | Cancer Research | Pharmacology/Toxicology | Combination therapy | AKT Inhibitor | Trametinib | MEK inhibitor | AKT inhibitor | Pharmacology & Pharmacy | Life Sciences & Biomedicine | Science & Technology | Thiophenes - therapeutic use | Pyrazoles - therapeutic use | Antineoplastic Combined Chemotherapy Protocols - administration & dosage | Thiophenes - adverse effects | Humans | Middle Aged | Antineoplastic Combined Chemotherapy Protocols - pharmacokinetics | Antineoplastic Combined Chemotherapy Protocols - adverse effects | Male | Antineoplastic Agents - therapeutic use | Thiophenes - administration & dosage | Antineoplastic Agents - administration & dosage | Protein Kinase Inhibitors - adverse effects | Dose-Response Relationship, Drug | Early Termination of Clinical Trials | Pyridones - administration & dosage | Multiple Myeloma - drug therapy | Neoplasms - blood | Antineoplastic Agents - adverse effects | Adult | Female | Antineoplastic Agents - pharmacokinetics | Multiple Myeloma - enzymology | Pyrazoles - pharmacokinetics | Multiple Myeloma - blood | Pyrazoles - adverse effects | Protein Kinase Inhibitors - pharmacokinetics | MAP Kinase Kinase 1 - antagonists & inhibitors | Pyridones - pharmacokinetics | Pyrimidinones - adverse effects | Pyrimidinones - therapeutic use | Neoplasms - enzymology | Neoplasms - drug therapy | Protein Kinase Inhibitors - administration & dosage | Thiophenes - pharmacokinetics | Pyrazoles - administration & dosage | Pyrimidinones - pharmacokinetics | Tumor Burden - drug effects | Antineoplastic Combined Chemotherapy Protocols - therapeutic use | MAP Kinase Kinase 2 - antagonists & inhibitors | Protein Kinase Inhibitors - therapeutic use | Aged | Pyridones - therapeutic use | Pyrimidinones - administration & dosage | Proto-Oncogene Proteins c-akt - antagonists & inhibitors | Pyridones - adverse effects | Cohort Studies | Complications and side effects | Medical research | Care and treatment | Type 1 diabetes | Analysis | Gastrointestinal diseases | Multiple myeloma | Melanoma | Medicine, Experimental | Aspartate | Nausea | Tumors | Index Medicus
Journal Article
Journal Article
Journal of the American Academy of Dermatology, ISSN 0190-9622, 08/2017, Volume 77, Issue 2, pp. 356 - 368
Journal Article
Current topics in medicinal chemistry, ISSN 1568-0266, 2004, Volume 4, Issue 10, pp. 1079 - 1095
... reconstitution of the immune system. Therapeutic regimens containing one or more HIV protease inhibitors thus provide a highly effective method for disease management... 
Pharmacology & Pharmacy | Life Sciences & Biomedicine | Chemistry, Medicinal | Science & Technology | Anti-HIV Agents - pharmacology | Pyridines - chemistry | Humans | Saquinavir - therapeutic use | Urethane - chemistry | Pyrimidinones - chemistry | Oligopeptides - therapeutic use | HIV Protease Inhibitors - pharmacology | Saquinavir - pharmacology | Urethane - therapeutic use | Atazanavir Sulfate | Phenylbutyrates - pharmacology | Ritonavir - therapeutic use | Oligopeptides - chemistry | Saquinavir - chemistry | Lopinavir | Pyrimidinones - therapeutic use | Models, Molecular | Sulfonamides - pharmacology | HIV Protease Inhibitors - therapeutic use | Nelfinavir - pharmacology | Anti-HIV Agents - chemistry | Carbamates | Urethane - pharmacology | Oligopeptides - pharmacology | Organophosphates - therapeutic use | Indinavir - pharmacology | Urethane - analogs & derivatives | HIV - drug effects | Molecular Mimicry | Phenylbutyrates - chemistry | Anti-HIV Agents - therapeutic use | Pyrimidinones - pharmacology | Ritonavir - pharmacology | Molecular Structure | Pyridines - therapeutic use | Nelfinavir - therapeutic use | Peptides - chemistry | Sulfonamides - chemistry | Dipeptides - pharmacology | HIV Protease Inhibitors - chemistry | Clinical Trials as Topic | Dipeptides - chemistry | Ritonavir - chemistry | Peptides - pharmacology | Organophosphates - pharmacology | Sulfonamides - therapeutic use | HIV Infections - drug therapy | Organophosphates - chemistry | Pyridines - pharmacology | Peptides - therapeutic use | Indinavir - therapeutic use | Index Medicus
Journal Article