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JOURNAL OF BIOLOGICAL CHEMISTRY, ISSN 0021-9258, 11/2017, Volume 292, Issue 44, pp. 18024 - 18043
Non-structural protein 5B (NS5B) is the RNA-dependent RNA polymerase that catalyzes replication of the hepatitis C virus (HCV) RNA genome and therefore is... 
NONNUCLEOSIDE INHIBITORS | CRYSTAL-STRUCTURE | BIOCHEMISTRY & MOLECULAR BIOLOGY | allosteric regulation | RNA-protein interaction | MOLECULAR-WEIGHT PROTEINS | VIRAL REPLICATION | RELAXATION DISPERSION EXPERIMENTS | REPLICATION COMPARTMENT | METHYL-TROSY | STRUCTURAL BASIS | nuclear magnetic resonance (NMR) | NONSTRUCTURAL PROTEIN | FUZZY COMPLEXES | protein-protein interaction | protein dynamic | Triazoles - chemistry | RNA Replicase - metabolism | RNA Replicase - antagonists & inhibitors | Antiviral Agents - metabolism | Pyrones - pharmacology | Pyrones - chemistry | Viral Nonstructural Proteins - chemistry | Isoleucine - chemistry | Oligoribonucleotides - metabolism | Antiviral Agents - chemistry | Enzyme Inhibitors - chemistry | Gene Deletion | Nuclear Magnetic Resonance, Biomolecular | Protein Interaction Domains and Motifs | Oligoribonucleotides - chemistry | Peptide Fragments - genetics | Allosteric Regulation - drug effects | Recombinant Proteins - metabolism | Antiviral Agents - pharmacology | Peptide Fragments - metabolism | Mutagenesis, Site-Directed | Enzyme Inhibitors - metabolism | RNA Replicase - genetics | Allosteric Site - drug effects | Enzyme Inhibitors - pharmacology | Solubility | Models, Molecular | Protein Refolding - drug effects | Recombinant Proteins - chemistry | Viral Nonstructural Proteins - genetics | Intrinsically Disordered Proteins - genetics | Triazoles - pharmacology | Point Mutation | Triazoles - metabolism | Hepacivirus - enzymology | Peptide Fragments - chemistry | Intrinsically Disordered Proteins - chemistry | Peptide Fragments - antagonists & inhibitors | RNA Replicase - chemistry | Protein Conformation | Viral Nonstructural Proteins - metabolism | Pyrones - metabolism | Viral Nonstructural Proteins - antagonists & inhibitors | Intrinsically Disordered Proteins - metabolism | Life Sciences | Biomolecules | Biochemistry, Molecular Biology | Molecular Bases of Disease
Journal Article
Proceedings of the National Academy of Sciences of the United States of America, ISSN 0027-8424, 9/2014, Volume 111, Issue 38, pp. 13817 - 13821
The recent success of antibody-drug conjugates (ADCs) in the treatment of cancer has led to a revived interest in microtubuledestabilizing agents. Here, we... 
Microtubules | Drug interactions | Antineoplastics | Ligands | Dimers | Breast cancer | Molecular mechanisms of action | Crystallography | Binding sites | Crystal structure | X-ray crystallography | Microtubule-targeting agents | Drug mechanism | microtubule-targeting agents | BETA-TUBULIN | VINCA-DOMAIN | MAYTANSINE | MULTIDISCIPLINARY SCIENCES | RESOLUTION | ANTIMITOTIC AGENTS | MACROCYCLIC LACTONE ANTIBIOTICS | POTENT ANTITUMOR-ACTIVITY | BREAST-CANCER | STRUCTURAL BASIS | RHIZOXIN | drug mechanism | Tubulin Modulators - chemistry | Humans | Polyketides - chemistry | Antineoplastic Agents, Phytogenic - chemistry | Crystallography, X-Ray | Maytansine - therapeutic use | Breast Neoplasms - drug therapy | Tubulin Modulators - therapeutic use | Pyrones - chemistry | Animals | Antibiotics, Antineoplastic - chemistry | Antibiotics, Antineoplastic - therapeutic use | Macrolides - chemistry | Cattle | Maytansine - chemistry | Pyrones - therapeutic use | Female | Microtubules - chemistry | Tubulin - chemistry | Antineoplastic Agents, Phytogenic - therapeutic use | Macrolides - therapeutic use | Polyketides - therapeutic use | Binding Sites | Clinical Trials, Phase I as Topic | Antimitotic agents | Pharmaceutical research | Physiological aspects | Dosage and administration | Research | Tubulins | Antineoplastic agents | Binding sites (Biochemistry) | Biological Sciences
Journal Article
by Mao, ZL and Sun, WB and Fu, LY and Luo, HY and Lai, DW and Zhou, LG
MOLECULES, ISSN 1420-3049, 04/2014, Volume 19, Issue 4, pp. 5088 - 5108
Natural dibenzo-alpha-pyrones are an important group of metabolites derived from fungi, mycobionts, plants and animal feces. They exhibit a variety of... 
dibenzo-alpha-pyrones | DNA-POLYMERASE-ALPHA | 6H-dibenzo[b,d]pyran-6-ones | CHEMISTRY, ORGANIC | CELL-PROLIFERATION | ALTERNARIOL MONOMETHYL ETHER | CYTOTOXIC METABOLITES | biological activities | PHOMA SP TC-1674 | ENDOPHYTIC FUNGUS | CHEMICAL-CONSTITUENTS | 6H-benzo[c]chromen-6-ones | dibenzo-alpha-pyranones | TENUAZONIC ACID | ELLAGIC ACID | HYALODENDRIELLA SP PONIPODEF12 | Anti-Infective Agents - isolation & purification | Bacteria - chemistry | Antioxidants - chemistry | Anti-Infective Agents - metabolism | Anti-Infective Agents - pharmacology | Antioxidants - metabolism | Humans | Benzopyrans - metabolism | Biological Products - pharmacology | Structure-Activity Relationship | Anti-Allergic Agents - pharmacology | Fungi - metabolism | Pyrones - pharmacology | Benzopyrans - chemistry | Pyrones - chemistry | Anti-Allergic Agents - isolation & purification | Anti-Infective Agents - chemistry | Biotransformation | Anti-Allergic Agents - chemistry | Plants - chemistry | Benzopyrans - pharmacology | Bacteria - metabolism | Antioxidants - pharmacology | Fungi - chemistry | Benzopyrans - isolation & purification | Biological Products - isolation & purification | Biological Products - chemistry | Plants - metabolism | Animals | Feces - chemistry | Anti-Allergic Agents - metabolism | Antioxidants - isolation & purification | Pyrones - isolation & purification | Biological Products - metabolism | Pyrones - metabolism | dibenzo-α-pyranones | dibenzo-α-pyrones
Journal Article
Journal Article
Antimicrobial Agents and Chemotherapy, ISSN 0066-4804, 12/2014, Volume 58, Issue 12, pp. 7215 - 7224
Direct-acting antivirals (DAAs) targeting proteins encoded by the hepatitis C virus (HCV) genome have great potential for the treatment of HCV infections.... 
PROTEIN 5B POLYMERASE | NS5B POLYMERASE | NONNUCLEOSIDE INHIBITORS | PRECLINICAL CHARACTERIZATION | IN-VITRO | DEPENDENT RNA-POLYMERASE | CRYSTAL-STRUCTURE | DE-NOVO INITIATION | MICROBIOLOGY | PHARMACOLOGY & PHARMACY | CHIMERIC REPLICONS | TREATMENT-NAIVE PATIENTS | Replicon - drug effects | Triazoles - chemistry | Humans | Hepacivirus - genetics | Benzofurans - pharmacology | RNA Replicase - antagonists & inhibitors | Structure-Activity Relationship | Pyridazines - pharmacology | Benzimidazoles - chemistry | Pyrones - pharmacology | Benzofurans - chemistry | Pyrones - chemistry | Antiviral Agents - chemistry | Cyclohexanols - chemistry | Enzyme Inhibitors - chemistry | Cyclohexanols - pharmacology | Hepacivirus - drug effects | Antiviral Agents - pharmacology | Sulfonamides - chemistry | Purines - pharmacology | RNA Replicase - genetics | Viral Proteins - chemistry | Enzyme Inhibitors - pharmacology | Recombinant Proteins - chemistry | Thiophenes - pharmacology | Viral Proteins - genetics | Genotype | Viral Proteins - antagonists & inhibitors | Recombinant Proteins - genetics | Sulfonamides - pharmacology | Pyridazines - chemistry | Triazoles - pharmacology | Drug Resistance, Viral - genetics | Hepacivirus - enzymology | Purines - chemistry | RNA Replicase - chemistry | Benzimidazoles - pharmacology | Thiophenes - chemistry | Antiviral Agents
Journal Article
Journal of Inorganic Biochemistry, ISSN 0162-0134, 08/2012, Volume 113, pp. 25 - 30
Journal Article