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British Journal of Pharmacology, ISSN 0007-1188, 09/2007, Volume 152, Issue 1, pp. 141 - 150
Background and purpose: ARL 67156, 6- N, N-Diethyl-D-beta-gamma-dibromomethylene adenosine triphosphate, originally named FPL 67156, is the only commercially... 
extracellular nucleotide | CD39 | FPL 67156 | ARL 67156 | NTPDase | Ecto‐5′‐nucleotidase | ecto‐ATPase | NPP | Ecto-ATPase | Extracellular nucleotide | Ecto-5′-nucleotidase | ecto-ATPase | PHOSPHODIESTERASE-I | GUINEA-PIG | ecto-5'-nucleotidase | NUCLEOTIDE PYROPHOSPHATASES/PHOSPHODIESTERASES | CLONING | NERVE-STIMULATION | SUPERIOR CERVICAL-GANGLIA | PHARMACOLOGY & PHARMACY | ISOLATED VAS-DEFERENS | AUTOTAXIN NPP2 | DIADENOSINE POLYPHOSPHATES | 5'-Nucleotidase - antagonists & inhibitors | Nucleotidases - genetics | Uridine Triphosphate - metabolism | Humans | Substrate Specificity | Nucleotidases - antagonists & inhibitors | Antigens, CD - metabolism | Adenosine Triphosphate - pharmacology | Pyrophosphatases - antagonists & inhibitors | Adenosine Triphosphate - metabolism | Recombinant Proteins - metabolism | Recombinant Proteins - antagonists & inhibitors | Phosphoric Diester Hydrolases - metabolism | Thymidine Monophosphate - metabolism | Apyrase - antagonists & inhibitors | Adenosine Monophosphate - metabolism | Apyrase - metabolism | Enzyme Inhibitors - pharmacology | Adenosine Triphosphatases - metabolism | Dinucleoside Phosphates - metabolism | Thymidine Monophosphate - analogs & derivatives | Adenosine Triphosphate - analogs & derivatives | Hydrolysis | Pyrophosphatases - metabolism | Adenosine Triphosphatases - antagonists & inhibitors | Nucleotidases - metabolism | Animals | Adenosine Triphosphatases - genetics | Mice | Adenosine Diphosphate - metabolism | Kinetics | 5'-Nucleotidase - metabolism | Index Medicus | Research Papers
Journal Article
Journal of Pharmacology and Experimental Therapeutics, ISSN 0022-3565, 07/2010, Volume 334, Issue 1, pp. 310 - 317
Journal Article
by Gad, Helge and Gad, Helge and Koolmeister, Tobias and Koolmeister, Tobias and Jemth, Ann-Sofie and Jemth, Ann-Sofie and Eshtad, Saeed and Eshtad, Saeed and Jacques, Sylvain A and Jacques, Sylvain A and Ström, Cecilia E and Ström, Cecilia E and Svensson, Linda M and Svensson, Linda M and Schultz, Niklas and Schultz, Niklas and Lundbäck, Thomas and Lundbäck, Thomas and Einarsdottir, Berglind Osk and Einarsdottir, Berglind Osk and Saleh, Aljona and Saleh, Aljona and Göktürk, Camilla and Göktürk, Camilla and Baranczewski, Pawel and Baranczewski, Pawel and Svensson, Richard and Svensson, Richard and Berntsson, Ronnie P-A and Berntsson, Ronnie P.-A and Gustafsson, Robert and Gustafsson, Robert and Strömberg, Kia and Strömberg, Kia and Sanjiv, Kumar and Sanjiv, Kumar and Jacques-Cordonnier, Marie-Caroline and Jacques-Cordonnier, Marie-Caroline and Desroses, Matthieu and Desroses, Matthieu and Gustavsson, Anna-Lena and Gustavsson, Anna-Lena and Olofsson, Roger and Olofsson, Roger and Johansson, Fredrik and Johansson, Fredrik and Homan, Evert J and Homan, Evert J and Loseva, Olga and Loseva, Olga and Bräutigam, Lars and Bräutigam, Lars and Johansson, Lars and Johansson, Lars and Höglund, Andreas and Höglund, Andreas and Hagenkort, Anna and Hagenkort, Anna and Pham, Therese and Pham, Therese and Altun, Mikael and Altun, Mikael and Gaugaz, Fabienne Z and Gaugaz, Fabienne Z and Vikingsson, Svante and Vikingsson, Svante and Evers, Bastiaan and Evers, Bastiaan and Henriksson, Martin and Henriksson, Martin and Vallin, Karl S A and Vallin, Karl S.A and Wallner, Olov A and Wallner, Olov A and Hammarström, Lars G.J and Hammarström, Lars G J and Wiita, Elisee and Wiita, Elisee and Almlöf, Ingrid and Almlöf, Ingrid and Kalderén, Christina and Kalderén, Christina and Axelsson, Hanna and Axelsson, Hanna and Djureinovic, Tatjana and Djureinovic, Tatjana and Puigvert, Jordi Carreras and Puigvert, Jordi Carreras and Häggblad, Maria and Häggblad, Maria and Jeppsson, Fredrik and Jeppsson, Fredrik and Martens, Ulf and Martens, Ulf and Lundin, Cecilia and Lundin, Cecilia and Lundgren, B and Lundgren, Bo and Granelli, Ingrid and Granelli, Ingrid and ... and Institutionen för medicin och hälsa and Avdelningen för läkemedelsforskning and Linköpings universitet and Hälsouniversitetet
Nature, ISSN 0028-0836, 2014, Volume 508, Issue 7495, pp. 215 - 221
Cancers have dysfunctional redox regulation resulting in reactive oxygen species production, damaging both DNA and free dNTPs. The MTH1 protein sanitizes... 
TARGET | CELLS | OXIDATIVE STRESS | REPAIR | HMTH1 | PROTEIN | MULTIDISCIPLINARY SCIENCES | DNA-SYNTHESIS | MUTAGENIC SUBSTRATE | CELLULAR SENESCENCE | 8-OXOGUANINE | Neoplasms - metabolism | Humans | Molecular Conformation | Male | Molecular Targeted Therapy | Pyrimidines - chemistry | Pyrophosphatases - antagonists & inhibitors | Enzyme Inhibitors - pharmacokinetics | Enzyme Inhibitors - chemistry | DNA Repair Enzymes - metabolism | Oxidation-Reduction - drug effects | Female | Deoxyguanine Nucleotides - metabolism | Cell Death - drug effects | DNA Repair Enzymes - antagonists & inhibitors | DNA Repair Enzymes - chemistry | Phosphoric Monoester Hydrolases - antagonists & inhibitors | Cell Survival - drug effects | Catalytic Domain | Reproducibility of Results | Crystallization | Enzyme Inhibitors - pharmacology | Models, Molecular | Pyrimidines - pharmacology | Nucleotides - metabolism | Enzyme Inhibitors - therapeutic use | Neoplasms - drug therapy | Xenograft Model Antitumor Assays | Animals | Pyrimidines - therapeutic use | Pyrimidines - pharmacokinetics | Mice | DNA Damage | Neoplasms - pathology | Phosphoric Monoester Hydrolases - metabolism | Phosphoric Monoester Hydrolases - chemistry | Prevention | Deoxyribonucleotides | DNA damage | Cancer cells | Physiological aspects | Research | Binding proteins | Cancer | Cytotoxicity | Kinases | Cancer therapies | Defects | Proteins | Genotype & phenotype | Mutagenesis | Rodents | Cell cycle | Mutation | Deoxyribonucleic acid--DNA | Tumors | Apoptosis | Index Medicus | Medical and Health Sciences | MEDICINE | Medicin och hälsovetenskap | MEDICIN
Journal Article
Nucleic acids research, ISSN 0305-1048, 10/2014, Volume 42, Issue 19, pp. 11912 - 11920
Journal Article
Cell Biochemistry and Biophysics, ISSN 1085-9195, 12/2011, Volume 61, Issue 3, pp. 493 - 505
We identified significantly higher expression of the genes glycogen debranching enzyme 6 (AGL), enolase 1 (ENOSF1), ectonucleotide pyrophosphatase 2 (ENPP2_1),... 
Life Sciences | Biochemistry, general | Biotechnology | Human left cerebrum | AGL , ENOSF1 , ENPP2_1 , GSTM3_3 and MAN2B2 computational network | Biophysics and Biological Physics | Pharmacology/Toxicology | Metabolism | Chimpanzee left cerebrum | Cell Biology | AGL, ENOSF1, ENPP2_1, GSTM3_3 and MAN2B2 computational network | DIFFERENTIAL EXPRESSION | NITRIC-OXIDE SYNTHASE | ALPHA-MANNOSIDASE | K562 CELLS | BIOCHEMISTRY & MOLECULAR BIOLOGY | CELL BIOLOGY | BIOPHYSICS | TRAUMATIC BRAIN-INJURY | MESSENGER-RNA | NEURON-SPECIFIC ENOLASE | IN-VIVO | GENE-EXPRESSION | MU CLASS | Species Specificity | Tumor Suppressor Proteins - antagonists & inhibitors | Humans | Phosphopyruvate Hydratase - metabolism | Mannosidases - metabolism | Gene Regulatory Networks | DNA-Binding Proteins - metabolism | Glutathione Transferase - antagonists & inhibitors | Glutathione Transferase - genetics | Phosphopyruvate Hydratase - genetics | Glycogen Debranching Enzyme System - genetics | Tumor Suppressor Proteins - genetics | Biomarkers, Tumor - metabolism | Cerebrum - metabolism | Mannosidases - genetics | Biomarkers, Tumor - antagonists & inhibitors | Glycogen Debranching Enzyme System - antagonists & inhibitors | Computational Biology - methods | Tumor Suppressor Proteins - metabolism | DNA-Binding Proteins - antagonists & inhibitors | Glycogen Debranching Enzyme System - metabolism | Phosphoric Diester Hydrolases - metabolism | Enzyme Inhibitors - pharmacology | Pan troglodytes - genetics | Glutathione Transferase - metabolism | Pan troglodytes - metabolism | Phosphopyruvate Hydratase - antagonists & inhibitors | Mannosidases - antagonists & inhibitors | Phosphoric Diester Hydrolases - genetics | DNA-Binding Proteins - genetics | Gene Expression Regulation, Enzymologic | Cerebrum - enzymology | Metabolic Networks and Pathways - genetics | Animals | Biomarkers, Tumor - genetics | Enzyme Activation | Cell proliferation | Enzymes | Proteoglycans | Glycogen | Adenosinetriphosphatase | Amino acids | Carbohydrate metabolism | Arachidonic acid | DNA repair | Mannosidase | pyrophosphatase | Computer programs | Glutathione transferase | Cerebrum | Computer applications | Drug metabolism | Lipid metabolism | Differentiation | Phosphopyruvate hydratase | Index Medicus
Journal Article
Plant Cell, ISSN 1040-4651, 12/2015, Volume 27, Issue 12, pp. 3383 - 3396
The presence of a large central vacuole is one of the hallmarks of a prototypical plant cell, and the multiple functions of this compartment require massive... 
Proton pumps | Protons | Tonoplast | RESEARCH ARTICLES | Plant roots | Acidification | Auxins | Plants | Vacuoles | Plant cells | Seedlings | MEMBRANE H+-ATPASE | BIOCHEMISTRY & MOLECULAR BIOLOGY | DROUGHT | PLASMA-MEMBRANE | SALT TOLERANCE | PLANT SCIENCES | CELL BIOLOGY | PYROPHOSPHATASE GENE AVP1 | TRANSPORT ACTIVITY | ARABIDOPSIS | TONOPLAST | FLUORESCENT PROTEIN | PLANT-GROWTH | Meristem - enzymology | Meristem - cytology | Vacuolar Proton-Translocating ATPases - genetics | Vacuoles - enzymology | Arabidopsis - physiology | Arabidopsis - enzymology | Meristem - physiology | Plant Roots - genetics | Seedlings - genetics | Inorganic Pyrophosphatase - metabolism | Seedlings - enzymology | Vacuolar Proton-Translocating ATPases - metabolism | Arabidopsis Proteins - metabolism | Plant Roots - physiology | Meristem - genetics | Arabidopsis Proteins - genetics | Cold Temperature | Genome, Plant - genetics | Flowers - enzymology | Seedlings - cytology | Arabidopsis - cytology | Flowers - cytology | Inorganic Pyrophosphatase - antagonists & inhibitors | Acclimatization | Plant Roots - cytology | Sequence Analysis, DNA | Arabidopsis - genetics | Phenotype | Vacuolar Proton-Translocating ATPases - antagonists & inhibitors | Inorganic Pyrophosphatase - genetics | Seedlings - physiology | Plant Roots - enzymology | Endosomes - enzymology | Flowers - physiology | Mutagenesis, Insertional | Flowers - genetics | Arabidopsis Proteins - antagonists & inhibitors | trans-Golgi Network - enzymology | Hydrogen-Ion Concentration | Physiological aspects | Adenosine triphosphatase | Membrane proteins | Index Medicus
Journal Article
Journal of Biological Chemistry, ISSN 0021-9258, 03/2008, Volume 283, Issue 12, pp. 7776 - 7789
Autotaxin is a type II ectonucleotide pyrophosphate phosphodiesterase enzyme. It has been recently discovered that it also has a lysophospholipase D activity.... 
BREAST-CANCER | NUCLEOTIDE PYROPHOSPHATASES/PHOSPHODIESTERASES | DIVALENT-CATIONS | PHOSPHODIESTERASE-I | LYSOPHOSPHOLIPASE-D ACTIVITY | BIOCHEMISTRY & MOLECULAR BIOLOGY | LYSOPHOSPHATIDIC ACID SYNTHESIS | MOTILITY-STIMULATING PROTEIN | PREADIPOCYTE PROLIFERATION | ADIPOCYTE DIFFERENTIATION | MOLECULAR-CLONING | Organ Specificity - drug effects | Gene Expression Regulation, Enzymologic - drug effects | Lysophospholipids - metabolism | Phosphoric Diester Hydrolases - biosynthesis | Pyrophosphatases - biosynthesis | Cricetulus | Humans | Lysophosphatidylcholines - genetics | Pyrophosphatases - genetics | Cercopithecus aethiops | Molecular Sequence Data | Substrate Specificity - physiology | Gene Expression Regulation, Enzymologic - physiology | Pyrophosphatases - antagonists & inhibitors | Base Sequence | Phosphodiesterase I - genetics | CHO Cells | Organ Specificity - physiology | Perylene - analogs & derivatives | Cricetinae | Isoenzymes - genetics | Enzyme Inhibitors - pharmacology | Lysophosphatidylcholines - metabolism | Phosphodiesterase I - biosynthesis | Multienzyme Complexes - genetics | Phosphoric Diester Hydrolases - genetics | Multienzyme Complexes - antagonists & inhibitors | Perylene - pharmacology | Lysophospholipids - genetics | Animals | Substrate Specificity - drug effects | Multienzyme Complexes - biosynthesis | Mice | Isoenzymes - biosynthesis | COS Cells | Isoenzymes - antagonists & inhibitors | Phosphodiesterase I - antagonists & inhibitors | Index Medicus | Enzyme Inhibitors | Lysophosphatidylcholines | Multienzyme Complexes | Isoenzymes | Substrate Specificity | Organ Specificity | Gene Expression Regulation, Enzymologic | Life Sciences | Lysophospholipids | Phosphoric Diester Hydrolases | Ethics | Pyrophosphatases | Perylene | Phosphodiesterase I
Journal Article
Molecular Carcinogenesis, ISSN 0899-1987, 09/2009, Volume 48, Issue 9, pp. 801 - 809
Increased expression of autotaxin in tumors including glioblastoma, breast, renal, ovarian, lung, and thyroid cancers is associated with increased tumor... 
Chemotherapy | Metastasis | Lysophosphatidylcholine | Lysophosphatidate | lysophosphatidylcholine | PROTEIN | BIOCHEMISTRY & MOLECULAR BIOLOGY | TUMOR | RECEPTOR | lysophosphatidate | IDENTIFICATION | chemotherapy | LYSOPHOSPHOLIPASE-D | ONCOLOGY | metastasis | ACID LPA | G2A | CARCINOMA | MOTILITY | Lysophospholipids - metabolism | RNA, Small Interfering - genetics | Humans | Pyrophosphatases - genetics | Multienzyme Complexes - metabolism | Cell Movement - genetics | Cell Movement - physiology | Breast Neoplasms - metabolism | Pyrophosphatases - antagonists & inhibitors | Transfection | RNA Interference | Melanoma - genetics | Receptors, Lysophosphatidic Acid - antagonists & inhibitors | Phosphodiesterase I - genetics | Melanoma - metabolism | Cell Line | Lysophosphatidylcholines - pharmacology | Enzyme Inhibitors - pharmacology | Lysophosphatidylcholines - metabolism | Multienzyme Complexes - genetics | Melanoma - pathology | Multienzyme Complexes - antagonists & inhibitors | Reverse Transcriptase Polymerase Chain Reaction | Blotting, Western | Organophosphates - pharmacology | Pyrophosphatases - metabolism | Catalysis - drug effects | Cell Movement - drug effects | Phosphoric Diester Hydrolases | Organophosphonates - pharmacology | Breast Neoplasms - genetics | Breast Neoplasms - pathology | Phosphodiesterase I - metabolism | Anilides - pharmacology | Cell Line, Tumor | Pyridines - pharmacology | Kinetics | Phosphodiesterase I - antagonists & inhibitors | Index Medicus
Journal Article
American Journal of Physiology - Cell Physiology, ISSN 0363-6143, 09/2005, Volume 289, Issue 3, pp. 617 - 624
Stimulation of ATP or adenosine receptors causes important physiological changes in retinal pigment epithelial (RPE) cells that may influence their... 
Retinal detachment | PC-1 | CD39L1 | P2Y | ATP release | CD39 | Photoreceptors | Ectoapyrase | ADP | P2Y RECEPTOR AGONIST | PHYSIOLOGY | RAT | ALKALINE-PHOSPHATASE | ADENOSINE | RELEASE | ectoapyrase | CELL BIOLOGY | photoreceptors | ECTO-NUCLEOTIDE PYROPHOSPHATASE | METABOLISM | FLUID TRANSPORT | retinal detachment | EXPRESSION | CELL-LINE | Calcium - metabolism | Calcium Signaling - physiology | Humans | Glycoproteins - metabolism | Pyrophosphatases - genetics | Multienzyme Complexes - metabolism | Receptors, Purinergic P2Y1 | Antigens, CD - genetics | Antigens, CD - metabolism | Glucose-6-Phosphate Isomerase - genetics | Pyrophosphatases - antagonists & inhibitors | Extracellular Space - metabolism | Adenosine Triphosphate - pharmacokinetics | Cattle | Receptors, Purinergic P2Y12 | Membrane Proteins - metabolism | Glycoproteins - genetics | Cell Line | Phosphoric Diester Hydrolases - metabolism | Apyrase - antagonists & inhibitors | Purines - metabolism | Apyrase - metabolism | Enzyme Inhibitors - pharmacology | Glycoproteins - antagonists & inhibitors | Adenosine Triphosphatases - metabolism | Multienzyme Complexes - genetics | Phosphoric Diester Hydrolases - genetics | Multienzyme Complexes - antagonists & inhibitors | Reverse Transcriptase Polymerase Chain Reaction | Adenosine Diphosphate - pharmacology | Gene Expression Regulation, Enzymologic | Glucose-6-Phosphate Isomerase - metabolism | Pyrophosphatases - metabolism | Adenosine Triphosphatases - antagonists & inhibitors | Animals | Apyrase - genetics | Receptors, Purinergic P2 - metabolism | Glucose-6-Phosphate Isomerase - antagonists & inhibitors | Pigment Epithelium of Eye - enzymology | Adenosine Triphosphatases - genetics | Pigment Epithelium of Eye - cytology | Phosphodiesterase I | Index Medicus
Journal Article