Articles

Search Articles

Advanced search
Help

Catalogue

Articles

Databases

X
Search Filters
Format Format
Format Format
X
Sort by Item Count (A-Z)
Filter by Count
Journal Article (8222) 8222
Publication (1016) 1016
Book Review (38) 38
Book Chapter (14) 14
Magazine Article (13) 13
Conference Proceeding (9) 9
Dissertation (5) 5
Book / eBook (4) 4
Reference (4) 4
Data Set (1) 1
Paper (1) 1
more...
Subjects Subjects
Subjects Subjects
X
Sort by Item Count (A-Z)
Filter by Count
humans (5928) 5928
male (4430) 4430
index medicus (4085) 4085
female (3624) 3624
animals (3223) 3223
pyrroles - therapeutic use (2825) 2825
pyrroles - pharmacology (2642) 2642
middle aged (2614) 2614
atorvastatin calcium (2604) 2604
heptanoic acids - therapeutic use (1869) 1869
aged (1846) 1846
adult (1687) 1687
atorvastatin (1581) 1581
pyrroles - administration & dosage (1473) 1473
mice (1298) 1298
pharmacology & pharmacy (1175) 1175
rats (1131) 1131
treatment outcome (1124) 1124
hydroxymethylglutaryl-coa reductase inhibitors - therapeutic use (1077) 1077
statins (1059) 1059
oncology (993) 993
heptanoic acids - pharmacology (974) 974
heptanoic acids - administration & dosage (956) 956
pyrroles - adverse effects (883) 883
cholesterol, ldl - blood (862) 862
cholesterol (860) 860
cardiac & cardiovascular systems (836) 836
anticholesteremic agents - therapeutic use (810) 810
dose-response relationship, drug (781) 781
cancer (733) 733
expression (705) 705
indoles - therapeutic use (703) 703
research (649) 649
indoleamine-pyrrole 2,3,-dioxygenase - metabolism (622) 622
inflammation (603) 603
simvastatin (597) 597
time factors (591) 591
risk factors (578) 578
drug therapy (566) 566
indoles - pharmacology (566) 566
sunitinib (566) 566
immunology (548) 548
hydroxymethylglutaryl-coa reductase inhibitors - pharmacology (547) 547
peripheral vascular disease (540) 540
analysis (538) 538
hypercholesterolemia - drug therapy (536) 536
atherosclerosis (535) 535
hydroxymethylglutaryl-coa reductase inhibitors - administration & dosage (533) 533
care and treatment (530) 530
cholesterol - blood (528) 528
article (508) 508
double-blind method (500) 500
cells, cultured (484) 484
therapy (474) 474
biochemistry & molecular biology (448) 448
cell line, tumor (440) 440
disease models, animal (432) 432
triglycerides - blood (429) 429
hematology (426) 426
aged, 80 and over (420) 420
dendritic cells (419) 419
drug therapy, combination (417) 417
lipids (417) 417
research article (417) 417
angiogenesis (416) 416
prospective studies (416) 416
heptanoic acids - adverse effects (411) 411
pyrroles - pharmacokinetics (411) 411
indoleamine 2,3-dioxygenase (405) 405
disease (402) 402
pyrroles (400) 400
pyrroles - chemistry (398) 398
abridged index medicus (397) 397
antineoplastic agents - therapeutic use (397) 397
hypercholesterolemia (395) 395
pravastatin (392) 392
proteins (392) 392
lipids - blood (389) 389
mice, inbred c57bl (383) 383
medicine, research & experimental (380) 380
inhibition (379) 379
health aspects (375) 375
rats, sprague-dawley (375) 375
apoptosis (372) 372
cholesterol, hdl - blood (372) 372
medicine (372) 372
carcinoma, renal cell - drug therapy (371) 371
cell biology (366) 366
anticholesteremic agents - administration & dosage (361) 361
blood pressure - drug effects (358) 358
indoles - adverse effects (356) 356
prevention (356) 356
cells (347) 347
medicine, general & internal (347) 347
in-vivo (346) 346
kidney neoplasms - drug therapy (346) 346
physiological aspects (344) 344
enzymes (341) 341
rodents (338) 338
biomarkers - blood (336) 336
more...
Library Location Library Location
Language Language
Language Language
X
Sort by Item Count (A-Z)
Filter by Count
English (7939) 7939
German (62) 62
Chinese (61) 61
Russian (48) 48
Japanese (35) 35
French (34) 34
Spanish (21) 21
Hungarian (14) 14
Italian (12) 12
Polish (8) 8
Portuguese (4) 4
Ukrainian (4) 4
Danish (3) 3
Czech (2) 2
Lithuanian (2) 2
Norwegian (2) 2
Swedish (2) 2
Turkish (2) 2
Dutch (1) 1
more...
Publication Date Publication Date
Click on a bar to filter by decade
Slide to change publication date range


1. Full Text What is the optimal blood pressure in patients after acute coronary syndromes?: Relationship of blood pressure and cardiovascular events in the pravastatin or atorvastatin evaluation and infection therapy-thrombolysis in myocardial infarction (PROVE IT-TIMI) 22 trial
by Bangalore, Sripal and Qin, Jie and Sloan, Sarah and Murphy, Sabina A and Cannon, Christopher P and PROVE IT-TIMI 22 Trial Investigato and PROVE IT-TIMI 22 Trial Investigators and for the PROVE IT-TIMI 22 Trial Investigators
Circulation, ISSN 0009-7322, 11/2010, Volume 122, Issue 21, pp. 2142 - 2151
Background-Aggressive blood pressure (BP) control has been advocated in patients with acute coronary syndrome, but few data exist in this population relative... 
blood pressure | acute coronary syndrome | hypertension | prognosis | MORTALITY | CARDIAC & CARDIOVASCULAR SYSTEMS | J-CURVE | MANAGEMENT | PREVENTION | RISK | DEATH | HYPERTENSIVE PATIENTS | HEART-DISEASE | REDUCTION | PERIPHERAL VASCULAR DISEASE | POINT | Myocardial Infarction - mortality | Prognosis | Follow-Up Studies | Humans | Middle Aged | Acute Coronary Syndrome - mortality | Acute Coronary Syndrome - physiopathology | Male | Heptanoic Acids - adverse effects | Incidence | Pyrroles - administration & dosage | Heptanoic Acids - administration & dosage | Hypertension - prevention & control | Pravastatin - adverse effects | Pyrroles - adverse effects | Adult | Female | Myocardial Infarction - physiopathology | Blood Pressure - drug effects | Blood Pressure - physiology | Hypertension - mortality | Risk Factors | Proportional Hazards Models | Treatment Outcome | Anticholesteremic Agents - adverse effects | Acute Coronary Syndrome - drug therapy | Atorvastatin Calcium | Myocardial Infarction - drug therapy | Pravastatin - administration & dosage | Anticholesteremic Agents - administration & dosage | Thrombolytic Therapy | Aged | Control | Usage | Patient outcomes | Physiological aspects | Blood pressure | Research | Drug therapy | Pravastatin | Health aspects | Heart attack | Risk factors
Journal Article
Details down arrow
Digital rights down arrow
loading Loading Rights
2. Full Text Evidence for Therapeutic Drug Monitoring of Targeted Anticancer Therapies
by Bo Gao and Shang Yeap and Arthur Clements and Bavanthi Balakrishnar and Mark Wong and Howard Gurney
Journal of Clinical Oncology, ISSN 0732-183X, 11/2012, Volume 30, Issue 32, pp. 4017 - 4025
Therapeutic drug monitoring (TDM) provides valuable guidance for dose adjustment of antibiotics, immunosuppressives, antiepileptics, and other drugs, but its... 
ANTI-CD20 MONOCLONAL-ANTIBODY | ONCOLOGY | FC-GAMMA-RIIIA | PROGRESSION-FREE SURVIVAL | MULTICENTER PHASE-II | SQUAMOUS-CELL CARCINOMA | TYROSINE KINASE INHIBITOR | ENDOTHELIAL GROWTH-FACTOR | SUNITINIB MALATE SU11248 | CHRONIC MYELOID-LEUKEMIA | IMATINIB PLASMA-LEVELS | Neoplasms - metabolism | Niacinamide - analogs & derivatives | Piperazines - administration & dosage | Thiazoles - blood | Injections, Intravenous | Area Under Curve | Pyrimidines - blood | Humans | Antibodies, Monoclonal, Murine-Derived - administration & dosage | Half-Life | Thiazoles - administration & dosage | Phenylurea Compounds | Antineoplastic Agents - administration & dosage | Benzenesulfonates - administration & dosage | Drug Monitoring - methods | Indoles - administration & dosage | Antibodies, Monoclonal - blood | Antibodies, Monoclonal, Humanized | Neoplasms - blood | Antineoplastic Agents - adverse effects | Pyrroles - administration & dosage | Benzenesulfonates - blood | Antineoplastic Agents - pharmacokinetics | Cetuximab | Piperazines - blood | Everolimus | Molecular Targeted Therapy - methods | Dasatinib | Sirolimus - analogs & derivatives | Pyridines - administration & dosage | Pyrimidines - administration & dosage | Indoles - blood | Rituximab | Pyrroles - blood | Sirolimus - blood | Evidence-Based Medicine | Imatinib Mesylate | Neoplasms - drug therapy | Sirolimus - administration & dosage | Antibodies, Monoclonal, Murine-Derived - blood | Pyridines - blood | Animals | Antibodies, Monoclonal - administration & dosage | Antineoplastic Agents - blood | Benzamides
Journal Article
Details down arrow
Digital rights down arrow
loading Loading Rights
3. Full Text Increased indoleamine 2,3-dioxygenase (IDO) activity and elevated serum levels of tryptophan catabolites in patients with chronic kidney disease: a possible link between chronic inflammation and uraemic symptoms
by Schefold, Jörg C and Zeden, Jan-Philip and Fotopoulou, Christina and von Haehling, Stephan and Pschowski, Rene and Hasper, Dietrich and Volk, Hans-Dieter and Schuett, Christine and Reinke, Petra
Nephrology Dialysis Transplantation, ISSN 0931-0509, 6/2009, Volume 24, Issue 6, pp. 1901 - 1908
Background. Tryptophan (Trp) is catabolized by indoleamine 2,3-dioxygenase (IDO). Changes in Trp metabolism and IDO activity in chronic kidney disease (CKD)... 
Infection | Kynurenine | IDO | Renal failure | Immune system | C-REACTIVE PROTEIN | MORTALITY | CELLS | infection | kynurenine | INDUCTION | TRANSPLANTATION | immune system | renal failure | HEMODIALYSIS-PATIENTS | IMMUNE ACTIVATION | UROLOGY & NEPHROLOGY | DEGRADATION | CARDIOVASCULAR RISK | CHRONIC-RENAL-FAILURE | Kynurenic Acid - blood | Prognosis | Prospective Studies | Humans | Middle Aged | Quinolinic Acid - blood | Male | 5-Hydroxytryptophan - blood | Case-Control Studies | Inflammation - blood | Serotonin - blood | Kynurenine - blood | C-Reactive Protein - metabolism | Tryptophan - blood | Adult | Female | Kidney Failure, Chronic - enzymology | Indoleamine-Pyrrole 2,3,-Dioxygenase - blood | Uremia - enzymology | Receptors, Tumor Necrosis Factor, Type I - blood | Inflammation Mediators - blood | Renal Insufficiency, Chronic - enzymology | Kidney Failure, Chronic - therapy | Renal Insufficiency, Chronic - blood | Kidney Failure, Chronic - blood | Uremia - blood | Creatinine - blood | Aged | Inflammation - enzymology | Renal Dialysis
Journal Article
Details down arrow
Digital rights down arrow
loading Loading Rights
4. Full Text Simultaneous analysis of anticancer agents bortezomib, imatinib, nilotinib, dasatinib, erlotinib, lapatinib, sorafenib, sunitinib and vandetanib in human plasma using LC/MS/MS
by Andriamanana, Irina and Gana, Ines and Duretz, Bénédicte and Hulin, Anne
Journal of Chromatography B, ISSN 1570-0232, 05/2013, Volume 926, pp. 83 - 91
► The quantification of nine inhibitors of tyrosine kinase in a single run. ► The improvement of the specificity using LCMSMS and confirmation/quantification... 
Tyrosine kinase inhibitor | LC–MS/MS | Anticancer targeted therapy | LC-MS/MS | ACCELERATED PHASE | CHEMISTRY, ANALYTICAL | TARGETED-THERAPY | BIOCHEMICAL RESEARCH METHODS | ANTITUMOR-ACTIVITY | MASS-SPECTROMETRY | EGFR | CHRONIC MYELOID-LEUKEMIA | LUNG-CANCER | GROWTH | CLINICAL-RESPONSE | Erlotinib Hydrochloride | Niacinamide - analogs & derivatives | Dasatinib | Reproducibility of Results | Thiazoles - blood | Bortezomib | Niacinamide - blood | Pyrimidines - blood | Benzamides - blood | Humans | Indoles - blood | Phenylurea Compounds - blood | Pyrroles - blood | Imatinib Mesylate | Piperidines - blood | Quinazolines - blood | Antineoplastic Agents - blood | Chromatography, Liquid - methods | Piperazines - blood | Pyrazines - blood | Tandem Mass Spectrometry - methods | Boronic Acids - blood | Antimitotic agents | Care and treatment | Antineoplastic agents | Analysis | Cancer | Human | Analytical chemistry | Ionization | Formic acid | Formates | Mass spectrometry | Chromatography | Standards
Journal Article
Details down arrow
Digital rights down arrow
loading Loading Rights
5. Full Text Lipid-lowering efficacy of atorvastatin
by Adams, Stephen P and Adams, Stephen P and Tsang, Michael and Tsang, Michael and Wright, James M and Wright, James M
The Cochrane database of systematic reviews, ISSN 1469-493X, 2015, Volume 2015, Issue 3, p. CD008226
Background This represents the first update of this review, which was published in 2012. Atorvastatin is one of themost widely prescribed drugs and the most... 
C-REACTIVE PROTEIN | RANDOMIZED-CONTROLLED-TRIAL | COA REDUCTASE INHIBITOR | Hyperlipidemias [blood; drug therapy] | Triglycerides [blood] | Lipids [blood] | Pyrroles [administration & dosage] | Humans | LOW-DENSITY-LIPOPROTEIN | MONOCYTE CHEMOATTRACTANT PROTEIN-1 | Cholesterol [blood] | Heptanoic Acids [administration & dosage] Hydroxymethylglutaryl-CoA Reductase Inhibitors [administration & dosage] | LOW-DOSE ATORVASTATIN | Randomized Controlled Trials as Topic | Dose-Response Relationship, Drug | MEDICINE, GENERAL & INTERNAL | HIGH-RISK PATIENTS | Cholesterol, HDL [blood] | HETEROZYGOUS FAMILIAL HYPERCHOLESTEROLEMIA | CORONARY-HEART-DISEASE | Cholesterol, LDL [blood] | TYPE-2 DIABETES-MELLITUS | Hydroxymethylglutaryl-CoA Reductase Inhibitors - administration & dosage | Hyperlipidemias - blood | Cholesterol - blood | Hyperlipidemias - drug therapy | Male | Pyrroles - administration & dosage | Lipids - blood | Sex Factors | Triglycerides - blood | Atorvastatin | Cholesterol, HDL - blood | Heptanoic Acids - administration & dosage | Cholesterol, LDL - blood | Female | Controlled Before-After Studies
Journal Article
Details down arrow
Digital rights down arrow
loading Loading Rights
6. Full Text Salt Sensitivity of Angiogenesis Inhibition–Induced Blood Pressure Rise: Role of Interstitial Sodium Accumulation?
by Lankhorst, Stephanie and Severs, David and Markó, Lajos and Rakova, Natalia and Titze, Jens and Müller, Dominik N and Danser, A.H Jan and van den Meiracker, Anton H
Hypertension, ISSN 0194-911X, 05/2017, Volume 69, Issue 5, pp. 919 - 926
In response to salt loading, Na and Cl accumulate in the skin in excess of water, stimulating skin lymphangiogenesis via activation of the mononuclear... 
sunitinib | angiogenesis inhibition | vascular endothelial growth factor | salt sensitivity | lymphangiogenesis | storage | hypertension | HOMEOSTASIS | METASTASIS | Na+ storage | RATS | PROTEINURIA | KINASE INHIBITORS | PERIPHERAL VASCULAR DISEASE | ENDOTHELIAL GROWTH-FACTOR | RECEPTOR-3 | Pyrroles | Rats | Rats, Inbred WKY | Male | Hypertension - physiopathology | Lymphangiogenesis - drug effects | Animals | Hypertension - chemically induced | Sodium, Dietary - administration & dosage | Blood Pressure - drug effects | Indoles | Skin - physiopathology | Skin - drug effects | Index Medicus
Journal Article
Details down arrow
Digital rights down arrow
loading Loading Rights
7. Full Text Chronic Low-Grade Inflammation in Elderly Persons Is Associated with Altered Tryptophan and Tyrosine Metabolism: Role in Neuropsychiatric Symptoms
by Capuron, Lucile and Schroecksnadel, Sebastian and Féart, Catherine and Aubert, Agnès and Higueret, Denise and Barberger-Gateau, Pascale and Layé, Sophie and Fuchs, Dietmar
Biological Psychiatry, ISSN 0006-3223, 2011, Volume 70, Issue 2, pp. 175 - 182
Background Neuropsychiatric symptoms are common complaints of elderly persons. Recent data suggest that chronic low-grade inflammation, a fundamental... 
Psychiatry | Aging | enzymatic pathways | tyrosine | neuropsychiatric symptoms | inflammation | tryptophan | DEPRESSION | SERUM PHENYLALANINE | IMMUNE STIMULATION | CELLS IN-VITRO | PSYCHIATRY | MONONUCLEAR-CELLS | DISORDERS | AGED MICE | NEUROSCIENCES | INTERFERON-ALPHA | CANCER-PATIENTS | NITRIC-OXIDE | Enzyme-Linked Immunosorbent Assay - methods | Humans | Fatigue - etiology | Male | Tyrosine - blood | Inflammation - blood | Inflammation - complications | Psychiatric Status Rating Scales | C-Reactive Protein - metabolism | Tryptophan - blood | Interleukin-6 - blood | Nitrites - blood | Aged, 80 and over | Female | Mental Disorders - etiology | Sleep Wake Disorders - etiology | Indoleamine-Pyrrole 2,3,-Dioxygenase - blood | Fasting | Mental Disorders - blood | Fatigue - blood | Neopterin - blood | Movement Disorders | Sleep Wake Disorders - blood | Aged | Chronic Disease | Tyrosine | Enzymes | Gerontology | Tryptophan | Physiological aspects | Phenols | Inflammation | Food and nutrition
Journal Article
Details down arrow
Digital rights down arrow
loading Loading Rights
8. Full Text Clinical evaluation of continuous daily dosing of sunitinib malate in patients with advanced gastrointestinal stromal tumour after imatinib failure
by George, S and Blay, J.Y and Casali, P.G and Le Cesne, A and Stephenson, P and DePrimo, S.E and Harmon, C.S and Law, C.N.J and Morgan, J.A and Ray-Coquard, I and Tassell, V and Cohen, D.P and Demetri, G.D
European Journal of Cancer, ISSN 0959-8049, 2009, Volume 45, Issue 11, pp. 1959 - 1968
Abstract Aims To assess the antitumour activity, safety, pharmacokinetics and pharmacodynamics of continuous daily sunitinib dosing in patients with... 
Hematology, Oncology and Palliative Medicine | Sunitinib | GIST | Continuous daily dosing | Targeted therapy | Receptor tyrosine kinases | VIVO | CANCER | RENAL-CELL CARCINOMA | SU11248 | HYPOTHYROIDISM | BIOMARKERS | IN-VITRO | ONCOLOGY | TYROSINE KINASE INHIBITOR | GROWTH-FACTOR | MUTATIONS | Pyrroles - pharmacokinetics | Humans | Middle Aged | Drug Resistance, Neoplasm | Male | Angiogenesis Inhibitors - blood | Aged, 80 and over | Angiogenesis Inhibitors - therapeutic use | Adult | Female | Gastrointestinal Stromal Tumors - mortality | Pyrroles - therapeutic use | Proto-Oncogene Proteins c-kit - blood | Drug Administration Schedule | Indoles - blood | Vascular Endothelial Growth Factor A - blood | Vascular Endothelial Growth Factor Receptor-2 - blood | Survival Rate | Treatment Outcome | Angiogenesis Inhibitors - pharmacokinetics | Piperazines - therapeutic use | Pyrroles - blood | Imatinib Mesylate | Vascular Endothelial Growth Factor Receptor-3 - blood | Biomarkers, Tumor - blood | Disease-Free Survival | Gastrointestinal Stromal Tumors - drug therapy | Pyrimidines - therapeutic use | Gastrointestinal Stromal Tumors - blood | Indoles - pharmacokinetics | Indoles - therapeutic use | Aged | Benzamides | Tyrosine | Care and treatment | Angiogenesis inhibitors | Sarcoma | Phosphotransferases
Journal Article
Details down arrow
Digital rights down arrow
loading Loading Rights
9. Full Text Differential Regulation of Lipoprotein Kinetics by Atorvastatin and Fenofibrate in Subjects With the Metabolic Syndrome
by Gerald F. Watts and P. Hugh R. Barrett and Juying Ji and Adrian P. Serone and Dick C. Chan and Kevin D. Croft and Franziska Loehrer and Anthony G. Johnson
Diabetes, ISSN 0012-1797, 03/2003, Volume 52, Issue 3, pp. 803 - 811
Differential Regulation of Lipoprotein Kinetics by Atorvastatin and Fenofibrate in Subjects With the Metabolic Syndrome Gerald F. Watts 1 , P. Hugh R. Barrett... 
Ester transfer protein | CETP, cholesteryl | HMG, hydroxymethylglutaryl | HOMA, homeostasis model assessment | IDL, intermediate-density lipoprotein | ApoB, apolipoprotein B-100 | GCMS, gas chromatography | ApoAI, apolipoprotein AI | FCR, fractional catabolic rate | DIABETES-MELLITUS | PPAR-ALPHA | FAMILIAL HYPERCHOLESTEROLEMIA | IN-VIVO EVIDENCE | ENDOCRINOLOGY & METABOLISM | LOW-DENSITY-LIPOPROTEIN | CHOLESTERYL ESTER TRANSFER | CARDIOVASCULAR-DISEASE | PROLIFERATOR-ACTIVATED RECEPTOR | APOLIPOPROTEIN-B METABOLISM | A-I | Lipoproteins, HDL - blood | Cholesterol - blood | Heptanoic Acids - therapeutic use | Humans | Middle Aged | Apolipoprotein B-100 | Male | Apolipoproteins B - blood | Insulin - blood | Fenofibrate - therapeutic use | Metabolic Syndrome - drug therapy | Obesity - blood | Metabolic Syndrome - blood | Placebos | Adult | Cholesterol, LDL - blood | Pyrroles - therapeutic use | Blood Glucose - analysis | Double-Blind Method | Lipoproteins - blood | Cross-Over Studies | Diet | Lipoproteins, VLDL - blood | Triglycerides - blood | Atorvastatin | Cholesterol, HDL - blood | Hypolipidemic Agents - therapeutic use | Lipoproteins, IDL | Kinetics | Lipoproteins, LDL - blood | Apolipoprotein A-I - blood | Physiological aspects | Insulin resistance | Metabolic syndrome X
Journal Article
Details down arrow
Digital rights down arrow
loading Loading Rights
10. Effects of 90-day hypolipidemic treatment on insulin resistance, adipokines and proinflammatory cytokines in patients with mixed hyperlipidemia and impaired fasting glucose
by Buldak, L and Dulawa-Buldak, A and Labuzek, K and Okopien, B
INTERNATIONAL JOURNAL OF CLINICAL PHARMACOLOGY AND THERAPEUTICS, ISSN 0946-1965, 11/2012, Volume 50, Issue 11, pp. 805 - 813
Objective: Concerns regarding worsening insulin sensitivity associated with statin treatment have recently emerged. Therefore the aim of this study was to... 
PPAR-ALPHA | proinflammatory cytokines | LEPTIN LEVELS | atorvastatin | LDL CHOLESTEROL | ADIPONECTIN RECEPTORS | INFLAMMATION | CARDIOVASCULAR-DISEASE | PHARMACOLOGY & PHARMACY | fenofibrate | adipokines | CORONARY-HEART-DISEASE | insulin resistance | ADIPOSE-TISSUE | Glucose Metabolism Disorders - immunology | Heptanoic Acids - therapeutic use | Humans | Middle Aged | Tumor Necrosis Factor-alpha - blood | Glucose Metabolism Disorders - drug therapy | Male | Insulin - blood | Fenofibrate - therapeutic use | Adipokines - blood | Hyperlipoproteinemia Type V - drug therapy | Leptin - blood | Time Factors | Interleukin-6 - blood | Lipids - blood | Hyperlipoproteinemia Type V - diagnosis | Poland | Adult | Female | Drug Therapy, Combination | Pyrroles - therapeutic use | Hyperlipoproteinemia Type V - immunology | Cytokines - blood | Hyperlipoproteinemia Type V - blood | Risk Reduction Behavior | Inflammation Mediators - blood | Insulin Resistance | Treatment Outcome | Biomarkers - blood | Glucose Metabolism Disorders - diagnosis | Adiponectin - blood | Blood Glucose - drug effects | Atorvastatin Calcium | Analysis of Variance | Hydroxymethylglutaryl-CoA Reductase Inhibitors - therapeutic use | Glucose Metabolism Disorders - blood | Resistin - blood | Aged | Hypolipidemic Agents - therapeutic use | Blood Glucose - metabolism | Fenofibrate | Atorvastatin | Insulin resistance | Proinflammatory cytokines | Adipokines
Journal Article
Details down arrow
11. Full Text Home Blood-Pressure Monitoring in Patients Receiving Sunitinib
by Azizi, Michel and Chedid, Antoine and Oudard, Stéphane
The New England Journal of Medicine, ISSN 0028-4793, 01/2008, Volume 358, Issue 1, pp. 95 - 97
To the Editor: The use of sunitinib, an inhibitor of the split-kinase-domain family of receptor tyrosine kinases (including vascular endothelial growth factor... 
HYPERTENSION | MEDICINE, GENERAL & INTERNAL | Humans | Home Nursing | Receptor Protein-Tyrosine Kinases | Heart Rate - drug effects | Indoles - adverse effects | Telemedicine | Antineoplastic Agents - adverse effects | Hypertension - chemically induced | Pyrroles - adverse effects | Blood Pressure - drug effects | Blood Pressure Monitoring, Ambulatory | Carcinoma, Renal Cell - drug therapy | Hypertension - diagnosis | Kidney Neoplasms - drug therapy | Angiogenesis Inhibitors - adverse effects | Index Medicus | Abridged Index Medicus
Journal Article
Details down arrow
Digital rights down arrow
loading Loading Rights
12. Full Text J-curve revisited: An analysis of blood pressure and cardiovascular events in the Treating to New Targets (TNT) Trial
by Bangalore, Sripal and Messerli, Franz H and Wun, Chuan-Chuan and Zuckerman, Andrea L and Demicco, David and Kostis, John B and Larosa, John C and Treating New Targets Steering Comm and Treating to New Targets Steering Committee and Investigators and for the Treating to New Targets Steering Committee and Investigators
European Heart Journal, ISSN 0195-668X, 12/2010, Volume 31, Issue 23, pp. 2897 - 2908
In patients with coronary artery disease (CAD), a J-curve relationship has been reported between blood pressure (BP) and future cardiovascular events. However,... 
J-Curve | Blood pressure | TNT trial | MORTALITY | CARDIAC & CARDIOVASCULAR SYSTEMS | METAANALYSIS | MYOCARDIAL-INFARCTION | REGRESSION-MODELS | RANDOMIZED-TRIAL | RISK | DEATH | CORONARY HEART-DISEASE | HYPERTENSIVE PATIENTS | REDUCTION | Myocardial Infarction - mortality | Humans | Middle Aged | Antihypertensive Agents - administration & dosage | Coronary Disease - physiopathology | Hypertension - drug therapy | Male | Stroke - physiopathology | Coronary Disease - mortality | Dose-Response Relationship, Drug | Pyrroles - administration & dosage | Heptanoic Acids - administration & dosage | Adult | Female | Myocardial Infarction - physiopathology | Blood Pressure - physiology | Hypertension - mortality | Stroke - mortality | Myocardial Infarction - etiology | Double-Blind Method | Risk Factors | Coronary Disease - etiology | Treatment Outcome | Heart Arrest - physiopathology | Hypertension - physiopathology | Atorvastatin Calcium | Stroke - etiology | Heart Arrest - mortality | Heart Arrest - etiology | Aged
Journal Article
Details down arrow
Digital rights down arrow
loading Loading Rights
13. Full Text Permeability Analysis of Neuroactive Drugs Through a Dynamic Microfluidic In Vitro Blood–Brain Barrier Model
by Booth, R and Kim, H
Annals of Biomedical Engineering, ISSN 0090-6964, 12/2014, Volume 42, Issue 12, pp. 2379 - 2391
This paper presents the permeability analysis of neuroactive drugs and correlation with in vivo brain/plasma ratios in a dynamic microfluidic blood–brain... 
Biomedical Engineering | Biochemistry, general | Microsystems | μ BBB | Biomedicine | BBB | Central nervous system | Mechanics | Biophysics and Biological Physics | Drug discovery | Biomedicine general | Endothelial cells | μBBB | VIVO | ENGINEERING, BIOMEDICAL | NEUROVASCULAR UNIT | PENETRATION | mu BBB | MASS-SPECTROMETRY | LC-MS/MS | PLASMA | SHEAR-STRESS | ENDOTHELIAL-CELLS | VARENICLINE | L-Lactate Dehydrogenase - metabolism | Coculture Techniques | Varenicline | Quinoxalines - pharmacology | Biological Transport | Piperidines - pharmacology | Indoles - pharmacology | Microfluidic Analytical Techniques | Cell Survival - drug effects | Sertraline - pharmacology | Endothelial Cells - metabolism | Valine - analogs & derivatives | Cells, Cultured | Rats | gamma-Aminobutyric Acid - pharmacology | Benzazepines - pharmacology | Permeability | Rats, Sprague-Dawley | Blood-Brain Barrier - metabolism | Pyrroles - pharmacology | Animals | Cyclohexanecarboxylic Acids - pharmacology | Tetrahydronaphthalenes - pharmacology | Neuroglia - metabolism | Mice | Valine - pharmacology | Amines - pharmacology | Ethosuximide - pharmacology | Drugs | Analysis | Microfluidics | Surgical implants | Biomedical materials | Dynamics | In vivo tests | Mathematical models
Journal Article
Details down arrow
Digital rights down arrow
loading Loading Rights
14. Full Text Therapeutic Drug Monitoring of the new targeted anticancer agents imatinib, nilotinib, dasatinib, sunitinib, sorafenib and lapatinib by LC tandem mass spectrometry
by Haouala, A and Zanolari, B and Rochat, B and Montemurro, M and Zaman, K and Duchosal, M.A and Ris, H.B and Leyvraz, S and Widmer, N and Decosterd, L.A
Journal of Chromatography B, ISSN 1570-0232, 07/2009, Volume 877, Issue 22, pp. 1982 - 1996
The treatment of some cancer patients has shifted from traditional, non-specific cytotoxic chemotherapy to chronic treatment with molecular targeted therapies.... 
Nilotinib | Dasatinib | Plasma | Imatinib | Sunitinib | Sorafenib | Lapatinib | LC–MS/MS | Anticancer targeted therapy | Tyrosine kinase inhibitors | LC-MS/MS | CHRONIC MYELOGENOUS LEUKEMIA | CHEMISTRY, ANALYTICAL | HUMAN PLASMA | BIOCHEMICAL RESEARCH METHODS | KINASE INHIBITOR | CLINICAL PHARMACOKINETICS | CHRONIC MYELOID-LEUKEMIA | PERFORMANCE LIQUID-CHROMATOGRAPHY | FACTOR RECEPTOR INHIBITOR | IN-VITRO | REFRACTORY SOLID TUMORS | GASTROINTESTINAL STROMAL TUMORS | Niacinamide - analogs & derivatives | Thiazoles - blood | Pyrimidines - blood | Humans | Antineoplastic Agents - therapeutic use | Benzenesulfonates - therapeutic use | Phenylurea Compounds | Drug Monitoring - methods | Thiazoles - therapeutic use | Benzenesulfonates - blood | Piperazines - blood | Pyrroles - therapeutic use | Tandem Mass Spectrometry - methods | Pyridines - therapeutic use | Indoles - blood | Piperazines - therapeutic use | Pyrroles - blood | Imatinib Mesylate | Quinazolines - blood | Neoplasms - drug therapy | Pyridines - blood | Pyrimidines - therapeutic use | Quinazolines - therapeutic use | Antineoplastic Agents - blood | Indoles - therapeutic use | Benzamides | Chromatography, Liquid - methods | Tyrosine | Chemotherapy | Plasma physics | Formic acid | Nitriles | Rain and rainfall | Health aspects | Phosphotransferases | Mass spectrometry | Cancer | Index Medicus
Journal Article
Details down arrow
Digital rights down arrow
loading Loading Rights