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1. Full Text Evidence for Therapeutic Drug Monitoring of Targeted Anticancer Therapies
by Bo Gao and Shang Yeap and Arthur Clements and Bavanthi Balakrishnar and Mark Wong and Howard Gurney
Journal of clinical oncology, ISSN 0732-183X, 11/2012, Volume 30, Issue 32, pp. 4017 - 4025
Life Sciences & Biomedicine | Oncology | Science & Technology | Biological and medical sciences | Medical sciences | Tumors | Neoplasms - metabolism | Niacinamide - analogs & derivatives | Piperazines - administration & dosage | Thiazoles - blood | Injections, Intravenous | Area Under Curve | Pyrimidines - blood | Humans | Antibodies, Monoclonal, Murine-Derived - administration & dosage | Half-Life | Thiazoles - administration & dosage | Phenylurea Compounds | Antineoplastic Agents - administration & dosage | Benzenesulfonates - administration & dosage | Drug Monitoring - methods | Indoles - administration & dosage | Antibodies, Monoclonal - blood | Antibodies, Monoclonal, Humanized | Neoplasms - blood | Antineoplastic Agents - adverse effects | Pyrroles - administration & dosage | Benzenesulfonates - blood | Antineoplastic Agents - pharmacokinetics | Cetuximab | Piperazines - blood | Everolimus | Molecular Targeted Therapy - methods | Dasatinib | Sirolimus - analogs & derivatives | Pyridines - administration & dosage | Pyrimidines - administration & dosage | Indoles - blood | Rituximab | Pyrroles - blood | Sirolimus - blood | Evidence-Based Medicine | Imatinib Mesylate | Neoplasms - drug therapy | Sirolimus - administration & dosage | Antibodies, Monoclonal, Murine-Derived - blood | Pyridines - blood | Animals | Antibodies, Monoclonal - administration & dosage | Antineoplastic Agents - blood | Benzamides | Index Medicus
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2. Full Text Simultaneous analysis of anticancer agents bortezomib, imatinib, nilotinib, dasatinib, erlotinib, lapatinib, sorafenib, sunitinib and vandetanib in human plasma using LC/MS/MS
by Andriamanana, Irina and Gana, Ines and Duretz, Bénédicte and Hulin, Anne
Journal of chromatography. B, Analytical technologies in the biomedical and life sciences, ISSN 1570-0232, 05/2013, Volume 926, pp. 83 - 91
Tyrosine kinase inhibitor | LC–MS/MS | Anticancer targeted therapy | LC-MS/MS | Biochemistry & Molecular Biology | Physical Sciences | Chemistry | Life Sciences & Biomedicine | Biochemical Research Methods | Chemistry, Analytical | Science & Technology | Erlotinib Hydrochloride | Niacinamide - analogs & derivatives | Dasatinib | Reproducibility of Results | Thiazoles - blood | Bortezomib | Niacinamide - blood | Pyrimidines - blood | Benzamides - blood | Humans | Indoles - blood | Phenylurea Compounds - blood | Pyrroles - blood | Imatinib Mesylate | Piperidines - blood | Quinazolines - blood | Antineoplastic Agents - blood | Chromatography, Liquid - methods | Piperazines - blood | Pyrazines - blood | Tandem Mass Spectrometry - methods | Boronic Acids - blood | Antimitotic agents | Care and treatment | Antineoplastic agents | Analysis | Cancer | Index Medicus | Human | Analytical chemistry | Ionization | Formic acid | Formates | Mass spectrometry | Chromatography | Standards
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3. Full Text Increased indoleamine 2,3-dioxygenase (IDO) activity and elevated serum levels of tryptophan catabolites in patients with chronic kidney disease: a possible link between chronic inflammation and uraemic symptoms
by Schefold, Jörg C and Zeden, Jan-Philip and Fotopoulou, Christina and von Haehling, Stephan and Pschowski, Rene and Hasper, Dietrich and Volk, Hans-Dieter and Schuett, Christine and Reinke, Petra
Nephrology, dialysis, transplantation, ISSN 0931-0509, 6/2009, Volume 24, Issue 6, pp. 1901 - 1908
Infection | Kynurenine | IDO | Renal failure | Immune system | Transplantation | Life Sciences & Biomedicine | Urology & Nephrology | Science & Technology | Emergency and intensive care: renal failure. Dialysis management | Anesthesia. Intensive care medicine. Transfusions. Cell therapy and gene therapy | Nephropathies. Renovascular diseases. Renal failure | Nephrology. Urinary tract diseases | Biological and medical sciences | Intensive care medicine | Medical sciences | Kynurenic Acid - blood | Prognosis | Prospective Studies | Humans | Middle Aged | Quinolinic Acid - blood | Male | 5-Hydroxytryptophan - blood | Case-Control Studies | Inflammation - blood | Serotonin - blood | Kynurenine - blood | C-Reactive Protein - metabolism | Tryptophan - blood | Adult | Female | Kidney Failure, Chronic - enzymology | Indoleamine-Pyrrole 2,3,-Dioxygenase - blood | Uremia - enzymology | Receptors, Tumor Necrosis Factor, Type I - blood | Inflammation Mediators - blood | Renal Insufficiency, Chronic - enzymology | Kidney Failure, Chronic - therapy | Renal Insufficiency, Chronic - blood | Kidney Failure, Chronic - blood | Uremia - blood | Creatinine - blood | Aged | Inflammation - enzymology | Renal Dialysis | Index Medicus
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4. Full Text Salt Sensitivity of Angiogenesis Inhibition–Induced Blood Pressure Rise: Role of Interstitial Sodium Accumulation?
by Lankhorst, Stephanie and Severs, David and Markó, Lajos and Rakova, Natalia and Titze, Jens and Müller, Dominik N and Danser, A.H Jan and van den Meiracker, Anton H
Hypertension (Dallas, Tex. 1979), ISSN 0194-911X, 05/2017, Volume 69, Issue 5, pp. 919 - 926
sunitinib | angiogenesis inhibition | vascular endothelial growth factor | salt sensitivity | lymphangiogenesis | storage | hypertension | Peripheral Vascular Disease | Life Sciences & Biomedicine | Cardiovascular System & Cardiology | Science & Technology | Pyrroles | Rats | Rats, Inbred WKY | Male | Hypertension - physiopathology | Lymphangiogenesis - drug effects | Animals | Hypertension - chemically induced | Sodium, Dietary - administration & dosage | Blood Pressure - drug effects | Indoles | Skin - physiopathology | Skin - drug effects | Index Medicus
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5. Full Text Chronic Low-Grade Inflammation in Elderly Persons Is Associated with Altered Tryptophan and Tyrosine Metabolism: Role in Neuropsychiatric Symptoms
by Capuron, Lucile and Schroecksnadel, Sebastian and Féart, Catherine and Aubert, Agnès and Higueret, Denise and Barberger-Gateau, Pascale and Layé, Sophie and Fuchs, Dietmar
Biological psychiatry (1969), ISSN 0006-3223, 2011, Volume 70, Issue 2, pp. 175 - 182
Psychiatry | Aging | enzymatic pathways | tyrosine | neuropsychiatric symptoms | inflammation | tryptophan | Neurosciences | Neurosciences & Neurology | Life Sciences & Biomedicine | Science & Technology | Biological and medical sciences | Psychology. Psychoanalysis. Psychiatry | Medical sciences | Psychopathology. Psychiatry | Geriatrics | Enzyme-Linked Immunosorbent Assay - methods | Humans | Fatigue - etiology | Male | Tyrosine - blood | Inflammation - blood | Inflammation - complications | Psychiatric Status Rating Scales | C-Reactive Protein - metabolism | Tryptophan - blood | Interleukin-6 - blood | Nitrites - blood | Aged, 80 and over | Female | Mental Disorders - etiology | Sleep Wake Disorders - etiology | Indoleamine-Pyrrole 2,3,-Dioxygenase - blood | Fasting | Mental Disorders - blood | Fatigue - blood | Neopterin - blood | Movement Disorders | Sleep Wake Disorders - blood | Aged | Chronic Disease | Tyrosine | Enzymes | Gerontology | Tryptophan | Physiological aspects | Phenols | Inflammation | Food and nutrition | Index Medicus | Life Sciences
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6. Full Text Clinical evaluation of continuous daily dosing of sunitinib malate in patients with advanced gastrointestinal stromal tumour after imatinib failure
by George, S and Blay, J.Y and Casali, P.G and Le Cesne, A and Stephenson, P and DePrimo, S.E and Harmon, C.S and Law, C.N.J and Morgan, J.A and Ray-Coquard, I and Tassell, V and Cohen, D.P and Demetri, G.D
European journal of cancer (1990), ISSN 0959-8049, 2009, Volume 45, Issue 11, pp. 1959 - 1968
Hematology, Oncology and Palliative Medicine | Sunitinib | GIST | Continuous daily dosing | Targeted therapy | Receptor tyrosine kinases | Life Sciences & Biomedicine | Oncology | Science & Technology | Biological and medical sciences | Medical sciences | Pharmacology. Drug treatments | Tumors | Pyrroles - pharmacokinetics | Humans | Middle Aged | Drug Resistance, Neoplasm | Male | Angiogenesis Inhibitors - blood | Aged, 80 and over | Angiogenesis Inhibitors - therapeutic use | Adult | Female | Gastrointestinal Stromal Tumors - mortality | Pyrroles - therapeutic use | Proto-Oncogene Proteins c-kit - blood | Drug Administration Schedule | Indoles - blood | Vascular Endothelial Growth Factor A - blood | Vascular Endothelial Growth Factor Receptor-2 - blood | Survival Rate | Treatment Outcome | Angiogenesis Inhibitors - pharmacokinetics | Piperazines - therapeutic use | Pyrroles - blood | Imatinib Mesylate | Vascular Endothelial Growth Factor Receptor-3 - blood | Biomarkers, Tumor - blood | Disease-Free Survival | Gastrointestinal Stromal Tumors - drug therapy | Pyrimidines - therapeutic use | Gastrointestinal Stromal Tumors - blood | Indoles - pharmacokinetics | Indoles - therapeutic use | Aged | Benzamides | Tyrosine | Care and treatment | Angiogenesis inhibitors | Sarcoma | Phosphotransferases | Index Medicus
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7. Full Text Differential Regulation of Lipoprotein Kinetics by Atorvastatin and Fenofibrate in Subjects With the Metabolic Syndrome
by Gerald F. Watts and P. Hugh R. Barrett and Juying Ji and Adrian P. Serone and Dick C. Chan and Kevin D. Croft and Franziska Loehrer and Anthony G. Johnson
Diabetes (New York, N.Y.), ISSN 0012-1797, 03/2003, Volume 52, Issue 3, pp. 803 - 811
Ester transfer protein | CETP, cholesteryl | HMG, hydroxymethylglutaryl | HOMA, homeostasis model assessment | IDL, intermediate-density lipoprotein | ApoB, apolipoprotein B-100 | GCMS, gas chromatography | ApoAI, apolipoprotein AI | FCR, fractional catabolic rate | Life Sciences & Biomedicine | Endocrinology & Metabolism | Science & Technology | Fundamental and applied biological sciences. Psychology | Biological and medical sciences | Lipoproteins, HDL - blood | Cholesterol - blood | Heptanoic Acids - therapeutic use | Humans | Middle Aged | Apolipoprotein B-100 | Male | Apolipoproteins B - blood | Insulin - blood | Fenofibrate - therapeutic use | Metabolic Syndrome - drug therapy | Obesity - blood | Metabolic Syndrome - blood | Placebos | Adult | Cholesterol, LDL - blood | Pyrroles - therapeutic use | Blood Glucose - analysis | Double-Blind Method | Lipoproteins - blood | Cross-Over Studies | Diet | Lipoproteins, VLDL - blood | Triglycerides - blood | Atorvastatin | Cholesterol, HDL - blood | Hypolipidemic Agents - therapeutic use | Lipoproteins, IDL | Kinetics | Lipoproteins, LDL - blood | Apolipoprotein A-I - blood | Physiological aspects | Insulin resistance | Metabolic syndrome X | Index Medicus | Abridged Index Medicus
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8. Full Text J-curve revisited: An analysis of blood pressure and cardiovascular events in the Treating to New Targets (TNT) Trial
by Bangalore, Sripal and Messerli, Franz H and Wun, Chuan-Chuan and Zuckerman, Andrea L and Demicco, David and Kostis, John B and Larosa, John C and Treating New Targets Steering Comm and Treating to New Targets Steering Committee and Investigators and for the Treating to New Targets Steering Committee and Investigators
European heart journal, ISSN 0195-668X, 12/2010, Volume 31, Issue 23, pp. 2897 - 2908
J-Curve | Blood pressure | TNT trial | Cardiac & Cardiovascular Systems | Life Sciences & Biomedicine | Cardiovascular System & Cardiology | Science & Technology | Cardiology. Vascular system | Biological and medical sciences | Medical sciences | Myocardial Infarction - mortality | Humans | Middle Aged | Antihypertensive Agents - administration & dosage | Coronary Disease - physiopathology | Hypertension - drug therapy | Male | Stroke - physiopathology | Coronary Disease - mortality | Dose-Response Relationship, Drug | Pyrroles - administration & dosage | Heptanoic Acids - administration & dosage | Adult | Female | Myocardial Infarction - physiopathology | Blood Pressure - physiology | Hypertension - mortality | Stroke - mortality | Myocardial Infarction - etiology | Double-Blind Method | Risk Factors | Coronary Disease - etiology | Treatment Outcome | Heart Arrest - physiopathology | Hypertension - physiopathology | Atorvastatin Calcium | Stroke - etiology | Heart Arrest - mortality | Heart Arrest - etiology | Aged | Index Medicus
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9. Full Text Permeability Analysis of Neuroactive Drugs Through a Dynamic Microfluidic In Vitro Blood–Brain Barrier Model
by Booth, R and Kim, H
Annals of biomedical engineering, ISSN 0090-6964, 12/2014, Volume 42, Issue 12, pp. 2379 - 2391
Biomedical Engineering | Biochemistry, general | Microsystems | μ BBB | Biomedicine | BBB | Central nervous system | Mechanics | Biophysics and Biological Physics | Drug discovery | Biomedicine general | Endothelial cells | μBBB | Engineering | Technology | Engineering, Biomedical | Science & Technology | L-Lactate Dehydrogenase - metabolism | Coculture Techniques | Varenicline | Quinoxalines - pharmacology | Biological Transport | Piperidines - pharmacology | Indoles - pharmacology | Microfluidic Analytical Techniques | Cell Survival - drug effects | Sertraline - pharmacology | Endothelial Cells - metabolism | Valine - analogs & derivatives | Cells, Cultured | Rats | gamma-Aminobutyric Acid - pharmacology | Benzazepines - pharmacology | Permeability | Rats, Sprague-Dawley | Blood-Brain Barrier - metabolism | Pyrroles - pharmacology | Animals | Cyclohexanecarboxylic Acids - pharmacology | Tetrahydronaphthalenes - pharmacology | Neuroglia - metabolism | Mice | Valine - pharmacology | Amines - pharmacology | Ethosuximide - pharmacology | Drugs | Analysis | Microfluidics | Index Medicus | Surgical implants | Biomedical materials | Dynamics | In vivo tests | Mathematical models
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