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Mucosal Immunology, ISSN 1933-0219, 03/2016, Volume 9, Issue 2, pp. 336 - 351
A crosstalk between commensals, gut immune cells, and colonic epithelia is required for a proper function of intestinal mucosal barrier. Here we investigated... 
INFLAMMATORY-BOWEL-DISEASE | INTERFERON-GAMMA | MURINE COLITIS | INDOLEAMINE 2,3-DIOXYGENASE | IN-VIVO | BARRIER FUNCTION | LY6C(HI) MONOCYTES | T-CELL | IMMUNOLOGY | IL-18 BINDING-PROTEIN | IMMUNE DEFENSE | Heparin-binding EGF-like Growth Factor - genetics | Indoleamine-Pyrrole 2,3,-Dioxygenase - genetics | Antigens, CD - immunology | Dextran Sulfate | Interleukin-12 - genetics | Colitis - genetics | Dendritic Cells - immunology | Lectins, C-Type - immunology | Dendritic Cells - pathology | Colitis - pathology | Colon - immunology | Disease Resistance - immunology | Indoleamine-Pyrrole 2,3,-Dioxygenase - immunology | Lectins, C-Type - genetics | Antigens, CD - genetics | Interleukin-15 - immunology | CD11b Antigen - genetics | Intestinal Mucosa - immunology | Colitis - chemically induced | Integrin alpha Chains - immunology | Female | Interferon-gamma - genetics | Receptors, Immunologic - immunology | Colitis - immunology | Heparin-binding EGF-like Growth Factor - immunology | CD11b Antigen - immunology | Signal Transduction | Colon - pathology | Gene Expression Regulation | Intercellular Signaling Peptides and Proteins - genetics | Epithelial Cells - pathology | Mice, Transgenic | Animals | Interleukin-15 - genetics | Epithelial Cells - immunology | Interferon-gamma - immunology | Interleukin-12 - immunology | Mice | Mice, Inbred BALB C | Receptors, Immunologic - genetics | Integrin alpha Chains - genetics | Intercellular Signaling Peptides and Proteins - immunology | Intestinal Mucosa - pathology | Index Medicus
Journal Article
British Journal of Cancer, ISSN 0007-0920, 03/2015, Volume 112, Issue 6, pp. 1067 - 1075
Journal Article
Journal of Virology, ISSN 0022-538X, 09/2007, Volume 81, Issue 18, pp. 9838 - 9850
Article Usage Stats Services JVI Citing Articles Google Scholar PubMed Related Content Social Bookmarking CiteULike Delicious Digg Facebook Google+ Mendeley... 
TOLL-LIKE RECEPTOR-3 | DOUBLE-STRANDED-RNA | INNATE IMMUNE RECOGNITION | VIROLOGY | NITRIC-OXIDE SYNTHASE | GAMMA-INTERFERON | INTERFERON REGULATORY FACTOR-3 | HUMAN FETAL ASTROCYTES | CENTRAL-NERVOUS-SYSTEM | HUMAN-IMMUNODEFICIENCY-VIRUS | HUMAN-CYTOMEGALOVIRUS | Indoleamine-Pyrrole 2,3,-Dioxygenase - genetics | Encephalitis, Viral - genetics | Membrane Glycoproteins - metabolism | Virus Replication - genetics | Humans | NF-kappa B - metabolism | Cytomegalovirus Infections - immunology | Astrocytes - enzymology | Cytomegalovirus Infections - genetics | Indoleamine-Pyrrole 2,3,-Dioxygenase - immunology | Tryptophan - metabolism | HIV Infections - immunology | Cytomegalovirus - genetics | Virus Replication - drug effects | Poly I-C - pharmacology | Viral Envelope Proteins - genetics | Microglia - enzymology | Toll-Like Receptor 3 - immunology | Toll-Like Receptor 3 - agonists | Toll-Like Receptor 3 - metabolism | Macrophages - enzymology | Gene Expression Regulation, Enzymologic - genetics | Tryptophan - immunology | Ligands | Encephalitis, Viral - immunology | Gene Expression Regulation, Enzymologic - drug effects | NF-kappa B - immunology | Kynurenine - genetics | HIV Infections - enzymology | Encephalitis, Viral - enzymology | Macrophages - virology | Microglia - immunology | Astrocytes - immunology | Viral Envelope Proteins - metabolism | Kynurenine - metabolism | Membrane Glycoproteins - immunology | Astrocytes - virology | Macrophages - immunology | Cytokines - immunology | Interferon Regulatory Factor-3 - immunology | Indoleamine-Pyrrole 2,3,-Dioxygenase - biosynthesis | Nitric Oxide - immunology | HIV Infections - genetics | Cells, Cultured | Virus Replication - immunology | HIV-1 - genetics | Proteins - immunology | Membrane Glycoproteins - genetics | Cytomegalovirus - immunology | Cytomegalovirus Infections - enzymology | HIV-1 - immunology | Proteins - metabolism | Microglia - virology | Interferon Regulatory Factor-3 - metabolism | Viral Envelope Proteins - immunology | Gene Expression Regulation, Enzymologic - immunology | Nitric Oxide - metabolism | Kynurenine - immunology | Cytokines - pharmacology | Interferon Inducers - pharmacology | Index Medicus | Cellular Response to Infection
Journal Article
Scientific Reports, ISSN 2045-2322, 03/2017, Volume 7, Issue 1, pp. 43337 - 43337
A controlled inflammatory response is required for protection against infection, but persistent inflammation causes tissue damage. Dendritic cells (DCs) have a... 
HUMAN DENDRITIC CELLS | IDO | MULTIDISCIPLINARY SCIENCES | ENDOTOXIN TOLERANCE | REGULATORY T-CELLS | INNATE IMMUNE-RESPONSE | MONONUCLEAR-CELLS | INFLAMMATORY RESPONSE | NF-KAPPA-B | LIPOPOLYSACCHARIDE TOLERANCE | POLARIZATION | Indoleamine-Pyrrole 2,3,-Dioxygenase - genetics | Cell Adhesion Molecules - genetics | Monocytes - cytology | Dendritic Cells - immunology | Humans | Transcription Factor RelB - immunology | Lectins, C-Type - immunology | NF-kappa B - immunology | Monocytes - immunology | Cell Adhesion Molecules - immunology | Indoleamine-Pyrrole 2,3,-Dioxygenase - immunology | Lectins, C-Type - genetics | Interleukin-4 - pharmacology | TNF Receptor-Associated Factor 3 - genetics | Dendritic Cells - drug effects | Transcription Factor RelB - genetics | Basic Helix-Loop-Helix Transcription Factors - genetics | Signal Transduction | Programmed Cell Death 1 Ligand 2 Protein - genetics | Gene Expression Regulation | Protein-Serine-Threonine Kinases - genetics | Receptors, Aryl Hydrocarbon - genetics | Granulocyte-Macrophage Colony-Stimulating Factor - pharmacology | Immune Tolerance | Toll-Like Receptor 4 - genetics | Toll-Like Receptor 4 - immunology | B7-H1 Antigen - genetics | B7-H1 Antigen - immunology | Receptors, Cell Surface - immunology | Programmed Cell Death 1 Ligand 2 Protein - immunology | Monocytes - drug effects | NF-kappa B - genetics | Cell Differentiation - drug effects | Interleukin-10 - genetics | TNF Receptor-Associated Factor 3 - immunology | Lipopolysaccharides - pharmacology | Basic Helix-Loop-Helix Transcription Factors - immunology | Protein-Serine-Threonine Kinases - immunology | Dendritic Cells - cytology | Primary Cell Culture | Interleukin-10 - immunology | Receptors, Aryl Hydrocarbon - immunology | Receptors, Cell Surface - genetics | Index Medicus
Journal Article
by Yu, JP and Wang, Y and Yan, F and Zhang, P and Li, H and Zhao, H and Yan, CH and Ren, XB
JOURNAL OF IMMUNOLOGY, ISSN 0022-1767, 09/2014, Volume 193, Issue 5, pp. 2574 - 2586
Immunotherapy for cancer treatment is achieved through the activation of competent immune effector cells and the inhibition of immunosuppressive cells, such as... 
LUNG-CANCER | STAT3 ACTIVATION | SIGNALING PATHWAYS | DENDRITIC CELLS | SYNERGISTIC INDUCTION | IFN-GAMMA | INDOLEAMINE 2,3-DIOXYGENASE | IKK-ALPHA | TNF-ALPHA | IMMUNOLOGY | BLOOD MONONUCLEAR-CELLS | Cell Nucleus - immunology | Indoleamine-Pyrrole 2,3,-Dioxygenase - genetics | Triterpenes - pharmacology | Breast Neoplasms - immunology | Humans | Transcription Factor RelB - immunology | Neoplasm Proteins - immunology | Indoleamine-Pyrrole 2,3,-Dioxygenase - immunology | Cell Nucleus - pathology | Myeloid Cells - immunology | Female | Gene Expression Regulation, Neoplastic - drug effects | Neoplasm Proteins - genetics | Active Transport, Cell Nucleus - genetics | STAT3 Transcription Factor - genetics | Transcription Factor RelB - genetics | Interleukin-6 - genetics | Protein-Serine-Threonine Kinases - genetics | Gene Expression Regulation, Neoplastic - immunology | Up-Regulation - drug effects | Breast Neoplasms - genetics | Cell Nucleus - genetics | Up-Regulation - immunology | Breast Neoplasms - pathology | Active Transport, Cell Nucleus - drug effects | Interleukin-6 - immunology | Protein-Serine-Threonine Kinases - immunology | Active Transport, Cell Nucleus - immunology | Myeloid Cells - pathology | STAT3 Transcription Factor - immunology | Index Medicus | Abridged Index Medicus | MDSCs | Breast cancer | IDO | STAT3 | Noncanonical NF-κB
Journal Article
Proceedings of the National Academy of Sciences of the United States of America, ISSN 0027-8424, 11/2017, Volume 114, Issue 46, pp. E9942 - E9951
Immunotherapies, particularly checkpoint inhibitors, have set off a revolution in cancer therapy by releasing the power of the immune system. However, only... 
Mesothelin | Mucin 16 | Immunotherapy | Immunopeptidome | Ovarian cancer | SURVIVAL | ovarian cancer | mucin 16 | MULTIDISCIPLINARY SCIENCES | IMMUNE PRIVILEGE | immunopeptidome | TUMOR | ANTIGENS | CANCER-IMMUNOTHERAPY | IDENTIFICATION | mesothelin | ADVANCED MELANOMA | immunotherapy | EXPRESSION | T-CELLS | Membrane Glycoproteins - analysis | Kallikreins - immunology | CA-125 Antigen - immunology | Galectin 1 - immunology | Membrane Glycoproteins - metabolism | Humans | Vaccination | Gene Expression Regulation, Neoplastic | Ovarian Neoplasms - pathology | Neoplasms, Glandular and Epithelial - metabolism | Indoleamine-Pyrrole 2,3,-Dioxygenase - immunology | Neoplasms, Glandular and Epithelial - immunology | Histocompatibility Antigens Class I - metabolism | Female | Histocompatibility Antigens Class II - metabolism | Ovarian Neoplasms - metabolism | Membrane Glycoproteins - immunology | HLA-DR Antigens - metabolism | Neoplasms, Glandular and Epithelial - pathology | GPI-Linked Proteins - immunology | Histocompatibility Antigens Class I - immunology | Membrane Proteins - immunology | Antigen Presentation - immunology | Membrane Glycoproteins - genetics | Histocompatibility Antigens Class II - immunology | Carcinoma, Ovarian Epithelial | Ligands | HLA-DR Antigens - immunology | Ovarian Neoplasms - immunology | Physiological aspects | Antigens | Peptides | Health aspects | Transcription factors | Ovarian carcinoma | Transcription | Gene expression | Immune systems | Molecules | Mucin | Immune checkpoint | Histocompatibility antigen HLA | Immune system | Cancer | Index Medicus | Biological Sciences | PNAS Plus
Journal Article
Blood, ISSN 0006-4971, 04/2007, Volume 109, Issue 8, pp. 3139 - 3146
Although typically considered a neurotransmitter, there is substantial evidence that serotonin (5-HT) plays an important role in the pathogenesis of... 
IMMUNE-RESPONSE | IN-VITRO | DENDRITIC CELLS | MESSENGER-RNA | LYMPHOCYTE | TRYPTOPHAN-HYDROXYLASE | CONTACT SENSITIVITY | RELEASE | HEMATOLOGY | EXPRESSION | DELAYED-TYPE HYPERSENSITIVITY | Indoleamine-Pyrrole 2,3,-Dioxygenase - metabolism | I-kappa B Proteins - immunology | Male | Autocrine Communication - drug effects | Receptors, Serotonin - immunology | I-kappa B Proteins - metabolism | Indoleamine-Pyrrole 2,3,-Dioxygenase - immunology | Enzyme Activation - immunology | Signal Transduction - immunology | Inflammation - metabolism | Lymphocyte Activation - immunology | Autocrine Communication - immunology | Protein Processing, Post-Translational - drug effects | T-Lymphocytes - metabolism | Phosphorylation - drug effects | Receptor, Serotonin, 5-HT1B - biosynthesis | Protein Processing, Post-Translational - immunology | Serotonin - immunology | Fenclonine - pharmacology | Mitogen-Activated Protein Kinase 3 - immunology | Mitogen-Activated Protein Kinase 1 - immunology | NF-KappaB Inhibitor alpha | Gene Expression Regulation - immunology | Cells, Cultured | Inflammation - immunology | Enzyme Activation - drug effects | Receptors, Serotonin - metabolism | Gene Expression Regulation - drug effects | Animals | Mitogen-Activated Protein Kinase 3 - metabolism | Signal Transduction - drug effects | Lymphocyte Activation - drug effects | Serotonin - metabolism | T-Lymphocytes - immunology | Mice | Mice, Inbred BALB C | Receptor, Serotonin, 5-HT1B - immunology | Mitogen-Activated Protein Kinase 1 - metabolism | Index Medicus | Abridged Index Medicus | Plenary Paper
Journal Article
Science Translational Medicine, ISSN 1946-6234, 05/2010, Volume 2, Issue 32, pp. 32ra36 - ra36
Journal Article
The Journal of Immunology, ISSN 0022-1767, 10/2008, Volume 181, Issue 8, pp. 5396 - 5404
Human plasmacytoid dendritic cells (PDCs) can drive naive, allogeneic CD4(+)CD25(-) T cells to differentiate into CD4(+)CD25(+) Foxp3(+) regulatory T cells... 
IMMUNOSUPPRESSIVE PATHWAY | TGF-BETA | IN-VIVO | CD4(+) | INDUCTION | IMMUNOLOGY | EX-VIVO | VERSUS-HOST-DISEASE | DRAINING LYMPH-NODES | TRYPTOPHAN CATABOLISM | CUTTING EDGE | Forkhead Transcription Factors - immunology | Gene Expression Regulation, Enzymologic - drug effects | Adjuvants, Immunologic - pharmacology | Coculture Techniques | Dendritic Cells - immunology | Humans | Indoleamine-Pyrrole 2,3,-Dioxygenase - immunology | T-Lymphocytes, Regulatory - immunology | Plasma Cells - enzymology | Toll-Like Receptor 9 - immunology | Forkhead Transcription Factors - metabolism | Tryptophan - analogs & derivatives | B7-1 Antigen - biosynthesis | Tryptophan - antagonists & inhibitors | Indoleamine-Pyrrole 2,3,-Dioxygenase - biosynthesis | B7-1 Antigen - immunology | Kynurenine - pharmacology | Cells, Cultured | Enzyme Inhibitors - pharmacology | Up-Regulation - drug effects | Cell Differentiation - immunology | Up-Regulation - immunology | Cell Differentiation - drug effects | Dendritic Cells - enzymology | Kynurenine - antagonists & inhibitors | HLA-DR Antigens - immunology | Tryptophan - pharmacology | Gene Expression Regulation, Enzymologic - immunology | HLA-DR Antigens - biosynthesis | Oligodeoxyribonucleotides - pharmacology | Toll-Like Receptor 9 - metabolism | T-Lymphocytes, Regulatory - enzymology | Plasma Cells - immunology | Index Medicus | Abridged Index Medicus
Journal Article
Immunity, ISSN 1074-7613, 2009, Volume 31, Issue 6, pp. 974 - 985
Immunity to in humans and in mice requires interferon gamma (IFN-γ). Whereas IFN-γ has been studied extensively for its effects on macrophages in tuberculosis,... 
MOLIMMUNO | CELLIMMUNO | MACROPHAGE RESPONSES | HUMAN-FIBROBLASTS | DENDRITIC CELLS | TRYPTOPHAN-METABOLITES | NITRIC-OXIDE SYNTHASE | LUNG EPITHELIAL-CELLS | IFN-GAMMA | INDOLEAMINE 2,3-DIOXYGENASE | ENDOTHELIAL-CELLS | TOXOPLASMA-GONDII | IMMUNOLOGY | Indoleamine-Pyrrole 2,3,-Dioxygenase - metabolism | T-Lymphocytes, Helper-Inducer - microbiology | Bacteremia - immunology | Lung - microbiology | Oligonucleotide Array Sequence Analysis | Mycobacterium tuberculosis - immunology | Gene Expression Profiling | Interferon-gamma - metabolism | Indoleamine-Pyrrole 2,3,-Dioxygenase - immunology | Bacteremia - microbiology | Endothelial Cells - microbiology | Respiratory Mucosa - pathology | Respiratory Mucosa - microbiology | Interleukin-23 - metabolism | T-Lymphocytes, Helper-Inducer - immunology | Respiratory Mucosa - immunology | Female | Tuberculosis, Pulmonary - enzymology | Kynurenine - metabolism | Receptors, Interferon - genetics | Neutrophil Infiltration - immunology | Lung - pathology | Mice, Inbred C57BL | Pneumonia, Bacterial - enzymology | Cells, Cultured | Interleukin-23 - immunology | Mice, Knockout | Endothelial Cells - immunology | Interleukin-17 - metabolism | Tuberculosis, Pulmonary - immunology | Animals | Pneumonia, Bacterial - immunology | Mice | Endothelial Cells - pathology | Kynurenine - immunology | Lung - immunology | Index Medicus
Journal Article
International Immunology, ISSN 0953-8178, 11/2011, Volume 23, Issue 11, pp. 701 - 712
Rheumatoid arthritis (RA) is a chronic inflammatory disease that causes irreversible joint damage and significant disability. However, the fundamental... 
Joint destruction | Chronic inflammation | Collagen-induced arthritis | Rheumatoid arthritis | IL-6 | RHEUMATOID-ARTHRITIS | INTERLEUKIN-1 RECEPTOR ANTAGONIST | STAT3 | MONOCLONAL-ANTIBODY | IMMUNOLOGY | rheumatoid arthritis | OSTEOCLASTOGENESIS | RODENT MODELS | TUMOR-NECROSIS-FACTOR | collagen-induced arthritis | REGULATORY T-CELLS | DOUBLE-BLIND | joint destruction | NF-KAPPA-B | chronic inflammation | Tumor Necrosis Factor-alpha - metabolism | Inflammation - pathology | Arthritis, Experimental - drug therapy | RANK Ligand - metabolism | Humans | Arthritis, Rheumatoid - complications | Interleukin-1beta - adverse effects | Arthritis, Experimental - pathology | RANK Ligand - immunology | Inflammation - complications | Signal Transduction - immunology | Osteoclasts - immunology | Arthritis, Rheumatoid - drug therapy | Inflammation - drug therapy | Interleukin-1beta - metabolism | Piperidines | Gene Expression - immunology | STAT3 Transcription Factor - deficiency | Tumor Necrosis Factor-alpha - immunology | Mice, Inbred DBA | Pyrroles - therapeutic use | Interleukin-6 - metabolism | Joints - metabolism | STAT3 Transcription Factor - genetics | Joints - drug effects | Mice, Inbred C57BL | Enzyme Inhibitors - pharmacology | Interleukin-1beta - immunology | Joints - pathology | Arthritis, Experimental - immunology | Inflammation - immunology | Pyrimidines - pharmacology | Arthritis, Rheumatoid - pathology | Pyrroles - pharmacology | Animals | Tumor Necrosis Factor-alpha - adverse effects | Interleukin-6 - pharmacology | RANK Ligand - antagonists & inhibitors | Pyrimidines - therapeutic use | Fibroblasts - drug effects | Interleukin-6 - immunology | Fibroblasts - immunology | Mice | STAT3 Transcription Factor - immunology | Arthritis, Rheumatoid - immunology | STAT3 Transcription Factor - antagonists & inhibitors | Chronic Disease | Osteoclasts - drug effects | Index Medicus | Animal models | Transcription | Leukemia inhibitory factor | Stat3 protein | Data processing | Inflammation | Joint diseases | Osteoblasts | Inflammatory diseases | Interleukin 6 | Osteoclastogenesis | Collagen | Interleukin 1 | TRANCE protein | Tumor necrosis factor- alpha
Journal Article
The Journal of Immunology, ISSN 0022-1767, 10/2009, Volume 183, Issue 8, pp. 5113 - 5120
Chronic inflammatory airway diseases including asthma are characterized by immune dysfunction to inhaled allergens. Our previous studies demonstrated that T... 
FACTOR VEGF | LUNG | INTERFERON-GAMMA | INTERLEUKIN-17 | SENSITIZATION | INFLAMMATION | EXPERIMENTAL ASTHMA | ENDOTOXIN | IMMUNOLOGY | IL-23 | EXPOSURE | Vascular Endothelial Growth Factor Receptor-1 - antagonists & inhibitors | Asthma - metabolism | Ovalbumin - immunology | Apoptosis - drug effects | Interleukin-17 - immunology | Immunity, Active - immunology | Vascular Endothelial Growth Factor A - metabolism | Th1 Cells - immunology | Lipopolysaccharides - immunology | T-Lymphocytes, Helper-Inducer - drug effects | Th1 Cells - metabolism | Vascular Endothelial Growth Factor Receptor-2 - antagonists & inhibitors | Inflammation - metabolism | Allergens - immunology | T-Lymphocytes, Helper-Inducer - immunology | Interleukin-12 - antagonists & inhibitors | Asthma - immunology | Indoles - pharmacology | Lung - metabolism | Interleukin-6 - metabolism | Vascular Endothelial Growth Factor A - pharmacology | Th1 Cells - drug effects | Immunity, Active - drug effects | T-Lymphocytes, Helper-Inducer - metabolism | Immunity, Innate - drug effects | Interleukin-6 - genetics | Interleukin-17 - genetics | Vascular Endothelial Growth Factor Receptor-2 - metabolism | Vascular Endothelial Growth Factor A - immunology | Vascular Endothelial Growth Factor Receptor-1 - metabolism | Inflammation - immunology | Interleukin-12 - metabolism | Asthma - drug therapy | Mice, Knockout | Immunity, Innate - immunology | Interleukin-17 - metabolism | Pyrroles - pharmacology | Animals | Apoptosis - immunology | Lung - drug effects | Interleukin-12 - immunology | Interleukin-6 - immunology | Mice | Mice, Inbred BALB C | Protein Kinase Inhibitors - pharmacology | Lung - immunology | Index Medicus | Abridged Index Medicus
Journal Article
Journal of Immunology, ISSN 0022-1767, 11/2010, Volume 185, Issue 10, pp. 5953 - 5961
Journal Article