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1. Full Text Microcosm evaluation of the effects of an eight pharmaceutical mixture to the aquatic macrophytes Lemna gibba and Myriophyllum sibiricum
by Brain, Richard A and Johnson, David J and Richards, Sean M and Hanson, Mark L and Sanderson, Hans and Lam, Monica W and Young, Cora and Mabury, Scott A and Sibley, Paul K and Solomon, Keith R
Aquatic Toxicology, ISSN 0166-445X, 2004, Volume 70, Issue 1, pp. 23 - 40
Pharmaceuticals have been detected in surface waters of the US and Europe, originating largely from two sources, sewage effluent and agricultural runoff. These... 
Endpoint sensitivity | Pharmaceutical mixture | Lemna gibba | Toxicity | Myriophyllum sibiricum | pharmaceutical mixture | toxicity | ENVIRONMENT | ECOTOXICOLOGY | FRESH-WATER MICROCOSMS | endpoint sensitivity | RESPONSES | CHLORPYRIFOS | ALGAL TOXICITY | ISOPENTENYL DIPHOSPHATE | BIOSYNTHESIS | MARINE & FRESHWATER BIOLOGY | DEGRADATION | AGENTS | TOXICOLOGY | Levofloxacin | Magnoliopsida - drug effects | Ofloxacin - toxicity | Heterocyclic Compounds - toxicity | Acetaminophen - toxicity | Caffeine - toxicity | Sulfamethoxazole - toxicity | Biomass | Dose-Response Relationship, Drug | Atorvastatin Calcium | Heptanoic Acids - toxicity | Water Pollutants, Chemical - toxicity | Analysis of Variance | Pyrroles - toxicity | Sertraline - toxicity | Biological Assay | Carbamazepine - toxicity | Trimethoprim - toxicity | Complex Mixtures - toxicity | Pharmaceutical Solutions - toxicity | Toxicity Tests | Magnoliopsida - growth & development
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2. Full Text Anticancer Properties of Halogenated Pyrrolo[3,2‐d]pyrimidines with Decreased Toxicity via N5 Substitution
by Cawrse, Brian M and Lapidus, Rena S and Cooper, Brandon and Choi, Eun Yong and Seley‐Radtke, Katherine L
ChemMedChem, ISSN 1860-7179, 01/2018, Volume 13, Issue 2, pp. 178 - 185
Halogenated pyrrolo[3,2‐d]pyrimidine analogues have shown antiproliferative activity in recent studies, with cell accumulation occurring in the G2/M stage... 
triple-negative breast cancer | antiproliferative | prodrugs | pyrrolopyrimidines | anticancer | GYRASE B GYRB | BROAD-SPECTRUM | DESIGN | CHEMISTRY, MEDICINAL | KINASE INHIBITOR | ANTITUMOR AGENTS | PYRROLOPYRIMIDINE INHIBITORS | POTENT | PHARMACOLOGY & PHARMACY | OPTIMIZATION | ANTIPROLIFERATIVE ACTIVITIES | DERIVATIVES | Cell Survival - drug effects | Pyrroles - pharmacokinetics | Humans | Structure-Activity Relationship | Antineoplastic Agents - chemistry | Pyrimidines - chemistry | Antineoplastic Agents - toxicity | Dose-Response Relationship, Drug | Maximum Tolerated Dose | Animals | Pyrimidines - toxicity | Pyrroles - toxicity | Halogenation | Cell Line, Tumor | Pyrimidines - pharmacokinetics | Pyrroles - chemistry | Antineoplastic Agents - pharmacokinetics | Mice | DNA Damage | Drug Screening Assays, Antitumor | Toxicity | Radioactive half-life | Pharmacology | Tumor cell lines | Metabolism | Anticancer properties | Substitutes | Pyrimidines | Synthesis | Cell lines | Halogenated | Apoptosis | Cancer | prodrug | Pyrrolopyrimidine | triple negative breast cancer
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3. Full Text Thiamethoxam Toxicity and Effects on Consumption Behavior in Orius insidiosus (Hemiptera: Anthocoridae) on Soybean
by Camargo, Carolina and Hunt, Thomas E and Giesler, Loren J and Siegfried, Blair D
Environmental Entomology, ISSN 0046-225X, 06/2017, Volume 46, Issue 3, pp. 693 - 699
Abstract Neonicotinoid residues can be present in soybean vegetative tissue, prey insects, and flower tissues, possibly making them toxic to pollinators and... 
Consumption | Thiamethoxam | Orius Insidiosus | Aphis Glycines | Toxicity | toxicity | NEONICOTINOID SEED TREATMENTS | thiamethoxam | PREDATORS | consumption | SELECTIVE INSECTICIDES | SAY | PEST-MANAGEMENT | Orius insidiosus | ENTOMOLOGY | LIFE-HISTORY CHARACTERISTICS | FUNCTIONAL-RESPONSE | IMPACT | NATURAL ENEMIES | APHIS-GLYCINES MATSUMURA | Aphis glycines | Alanine - toxicity | Aphids - chemistry | Nitro Compounds - toxicity | Dioxoles - toxicity | Fungicides, Industrial - toxicity | Neonicotinoids | Oxazines - toxicity | Alanine - analogs & derivatives | Predatory Behavior - drug effects | Soybeans - chemistry | Thiazoles - toxicity | Animals | Heteroptera - drug effects | Pyrroles - toxicity | Pyrazoles - toxicity | Anilides - toxicity | Insecticides - toxicity | Index Medicus
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4. Full Text Cholesteryl Ester Transfer Protein Inhibitor Torcetrapib and Off-Target Toxicity A Pooled Analysis of the Rating Atherosclerotic Disease Change by Imaging With a New CETP Inhibitor (RADIANCE) Trials
by Vergeer, Menno and Bots, Michiel L and van Leuven, Sander I and Basart, Dick C and Sijbrands, Eric J and Evans, Gregory W and Grobbee, Diederick E and Visseren, Frank L and Stalenhoef, Anton F and Stroes, Erik S and Kastelein, John J. P
Circulation, ISSN 0009-7322, 2008, Volume 118, Issue 24, pp. 2515 - 2522
Background-Torcetrapib, an inhibitor of cholesteryl ester transfer protein, has been shown to increase the cardiovascular event rate despite conferring a... 
Drugs | Imaging | Cholesterol | INTIMA-MEDIA THICKNESS | REDUCING CHOLESTEROL | CARDIAC & CARDIOVASCULAR SYSTEMS | drugs | SAFETY | imaging | ARTERIAL BIOLOGY | PRIMARY ALDOSTERONISM | BLOOD-PRESSURE | HIGH-DENSITY-LIPOPROTEIN | DOUBLE-BLIND | cholesterol | PERIPHERAL VASCULAR DISEASE | EXTENDED-RELEASE NIACIN | PROGRESSION | Cholesterol Ester Transfer Proteins - antagonists & inhibitors | Atherosclerosis - drug therapy | Humans | Middle Aged | Male | Quinolines - administration & dosage | Anticholesteremic Agents - adverse effects | Atorvastatin Calcium | Anticholesteremic Agents - therapeutic use | Pyrroles - administration & dosage | Heptanoic Acids - administration & dosage | Adult | Female | Mineralocorticoids | Blood Pressure - drug effects | Quinolines - toxicity | Index Medicus | Abridged Index Medicus
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5. Full Text Multi-parameter in vitro toxicity testing of crizotinib, sunitinib, erlotinib, and nilotinib in human cardiomyocytes
by Doherty, Kimberly R and Wappel, Robert L and Talbert, Dominique R and Trusk, Patricia B and Moran, Diarmuid M and Kramer, James W and Brown, Arthur M and Shell, Scott A and Bacus, Sarah
Toxicology and Applied Pharmacology, ISSN 0041-008X, 10/2013, Volume 272, Issue 1, pp. 245 - 255
Tyrosine kinase inhibitors (TKi) have greatly improved the treatment and prognosis of multiple cancer types. However, unexpected cardiotoxicity has arisen in a... 
Cardiomyocytes | Preclinical | Cardiotoxicity | Drug evaluation | In vitro | Tyrosine kinase inhibitors | EFFICACY | SAFETY | CELL-DERIVED CARDIOMYOCYTES | HEART | LUNG-CANCER | IMATINIB | TYROSINE KINASE INHIBITOR | PHARMACOLOGY & PHARMACY | TOXICOLOGY | Caspase 7 - metabolism | Erlotinib Hydrochloride | Reactive Oxygen Species - metabolism | Humans | Caspase 3 - metabolism | Ion Channels - drug effects | Lipids - biosynthesis | ERG1 Potassium Channel | RNA - isolation & purification | Pyrimidines - toxicity | Real-Time Polymerase Chain Reaction | Cell Survival - drug effects | Cells, Cultured | Indoles - toxicity | Cholesterol - metabolism | Enzyme Activation - drug effects | Ether-A-Go-Go Potassium Channels - genetics | RNA - biosynthesis | Patch-Clamp Techniques | Myocytes, Cardiac - drug effects | Quinazolines - toxicity | Pyridines - toxicity | Pyrroles - toxicity | Pluripotent Stem Cells - drug effects | Pyrazoles - toxicity | Protein Kinase Inhibitors - toxicity | Ether-A-Go-Go Potassium Channels - biosynthesis | Myocytes, Cardiac - ultrastructure | Protein-Tyrosine Kinases - antagonists & inhibitors | Erlotinib | Heart cells | Index Medicus | OXYGEN | APOPTOSIS | ETHERS | CHOLESTEROL | NEOPLASMS | TYROSINE | IN VITRO | DRUGS | GENES | TOXICITY | 60 APPLIED LIFE SCIENCES | LIPIDS
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6. Full Text Pharmacogenetic Pathway Analysis for Determination of Sunitinib-Induced Toxicity
by Nielka P. van Erp and Karel Eechoute and Astrid A. van der Veldt and John B. Haanen and An K.L. Reyners and Ron H.J. Mathijssen and Epie Boven and Tahar van der Straaten and Renée F. Baak-Pablo and Judith A.M. Wessels and Henk-Jan Guchelaar and Hans Gelderblom
Journal of Clinical Oncology, ISSN 0732-183X, 09/2009, Volume 27, Issue 26, pp. 4406 - 4412
Purpose To identify genetic markers in the pharmacokinetic and pharmacodynamic pathways of sunitinib that predispose for development of toxicities:... 
UNPHASED GENOTYPE DATA | PHARMACOKINETICS | ONCOLOGY | IN-VIVO | TYROSINE KINASE INHIBITOR | GENETIC-VARIANTS | ANTITUMOR-ACTIVITY | GASTROINTESTINAL STROMAL TUMORS | FACTOR RECEPTOR | RENAL-CELL CARCINOMA | ENDOTHELIAL GROWTH-FACTOR | Haplotypes | Cytochrome P-450 CYP1A1 - genetics | Pharmacogenetics - methods | Genetic Predisposition to Disease - genetics | Pyrroles - pharmacokinetics | Drug-Related Side Effects and Adverse Reactions - chemically induced | Humans | Middle Aged | Risk Factors | Male | Mucositis - chemically induced | Young Adult | Indoles - adverse effects | Antineoplastic Agents - adverse effects | Drug-Related Side Effects and Adverse Reactions - genetics | Leukopenia - chemically induced | Aged, 80 and over | Pyrroles - adverse effects | Adult | Female | Indoles - pharmacokinetics | Aged | Polymorphism, Single Nucleotide | Index Medicus
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7. Full Text Quality‐adjusted time without symptoms or toxicity analysis of pazopanib versus sunitinib in patients with renal cell carcinoma
by Beaumont, Jennifer L and Salsman, John M and Diaz, Jose and Deen, Keith C and McCann, Lauren and Powles, Thomas and Hackshaw, Michelle D and Motzer, Robert J and Cella, David
Cancer, ISSN 0008-543X, 04/2016, Volume 122, Issue 7, pp. 1108 - 1115
BACKGROUND In a phase 3, randomized, open‐label trial (Pazopanib versus Sunitinib in the Treatment of Locally Advanced and/or Metastatic Renal Cell Carcinoma,... 
sunitinib | angiogenesis inhibitors | pazopanib | drug toxicity | renal cell carcinomas | SURVIVAL | ONCOLOGY | Humans | Middle Aged | Male | Kidney Neoplasms - mortality | Young Adult | Carcinoma, Renal Cell - mortality | Disease-Free Survival | Indoles - adverse effects | Antineoplastic Agents - adverse effects | Adolescent | Pyrimidines - adverse effects | Aged, 80 and over | Pyrroles - adverse effects | Quality of Life | Sulfonamides - adverse effects | Adult | Female | Aged | Carcinoma, Renal Cell - drug therapy | Kidney Neoplasms - drug therapy | Angiogenesis Inhibitors - adverse effects | Care and treatment | Usage | Clinical trials | Dosage and administration | Carcinoma, Renal cell | Diagnosis | Pazopanib | Index Medicus | Abridged Index Medicus
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8. Full Text Toxicity of human pharmaceuticals and personal care products to benthic invertebrates
by Dussault, Ève B and Balakrishnan, Vimal K and Sverko, Ed and Solomon, Keith R and Sibley, Paul K
Environmental Toxicology and Chemistry, ISSN 0730-7268, 02/2008, Volume 27, Issue 2, pp. 425 - 432
Despite concerns about potential risks associated with the presence of pharmaceuticals and personal care products (PPCPs) in the environment, few toxicological... 
Personal care products | Toxicity | Benthic invertebrates | Pharmaceuticals | toxicity | ESTROGENS | SEWAGE-TREATMENT PLANTS | BEHAVIOR | benthic invertebrates | WASTE-WATER CONTAMINANTS | US STREAMS | CARBAMAZEPINE | pharmaceuticals | TANDEM MASS-SPECTROMETRY | ENVIRONMENTAL SCIENCES | LEMNA-GIBBA | DRUGS | personal care products | TOXICOLOGY | NATIONAL RECONNAISSANCE | Anticholesteremic Agents - toxicity | Environmental Monitoring | Humans | Biological Assay - methods | Estrogens - toxicity | Triclosan - toxicity | Anticonvulsants - toxicity | Dose-Response Relationship, Drug | Atorvastatin Calcium | Heptanoic Acids - toxicity | Animals | Estradiol - toxicity | Pyrroles - toxicity | Ecosystem | Invertebrates - drug effects | Carbamazepine - toxicity | Anti-Infective Agents, Local - toxicity | Analytical chemistry | Drinking water | Aquatic plants | Risk | Organisms | Environmental impact | Experiments | Chemicals | Studies | Birth control | Surface water | Health & beauty aids | Hormone replacement therapy | Invertebrates | Index Medicus
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9. Full Text Toxicity of statins on rat skeletal muscle mitochondria
by Kaufmann, P and Török, M and Zahno, A and Waldhauser, K M and Brecht, K and Krähenbühl, S
Cellular and Molecular Life Sciences, ISSN 1420-682X, 10/2006, Volume 63, Issue 19, pp. 2415 - 2425
We investigated mitochondrial toxicity of four lipophilic stains (cerivastatin, fluvastatin, atorvastatin, simvastatin) and one hydrophilic statin... 
Life Sciences | Biochemistry, general | Life Sciences, general | statins | mitochondria | β-oxidation | apoptosis | Rhabdomyolysis | Biomedicine general | respiratory chain | Cell Biology | Mitochondria | Respiratory chain | Statins | Apoptosis | COA REDUCTASE INHIBITORS | DRUG-INTERACTIONS | BIOCHEMISTRY & MOLECULAR BIOLOGY | MYOPATHY | CELL BIOLOGY | rhabdomyolysis | LIVER-MITOCHONDRIA | beta-oxidation | PRAVASTATIN | CARNITINE PALMITOYLTRANSFERASE | SIMVASTATIN | MEMBRANE PERMEABILIZATION | Membrane Potentials - drug effects | Hydroxymethylglutaryl-CoA Reductase Inhibitors - toxicity | Apoptosis - drug effects | Mitochondrial Membranes - physiology | Cytochromes c - metabolism | Muscle, Skeletal - ultrastructure | Rats | Indoles - toxicity | Pravastatin - toxicity | Oxygen - metabolism | Mitochondrial Membranes - drug effects | Atorvastatin Calcium | Heptanoic Acids - toxicity | Animals | Pyridines - toxicity | Pyrroles - toxicity | Muscle, Skeletal - drug effects | Mitochondria, Muscle - ultrastructure | Mitochondria, Muscle - drug effects | Apoptosis - physiology | DNA Fragmentation - drug effects | Fatty Acids, Monounsaturated - toxicity | Fatty Acids - metabolism | Simvastatin - toxicity | Cardiovascular agents | Skeletal system | Toxicity | Rodents
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10. Full Text Modulating therapeutic activity and toxicity of pyrrolobenzodiazepine antibody-drug conjugates with self-immolative disulfide linkers
by Pillow, Thomas H and Schutten, Melissa and Yu, Shang-Fan and Ohri, Rachana and Sadowsky, Jack and Poon, Kirsten Achilles and Solis, Willy and Zhong, Fiona and Del Rosario, Geoffrey and Go, Mary Ann T and Lau, Jeffrey and Yee, Sharon and He, Jintang and Liu, Luna and Ng, Carl and Xu, Keyang and Leipold, Douglas D and Kamath, Amrita V and Zhang, Donglu and Masterson, Luke and Gregson, Stephen J and Howard, Philip W and Fang, Fan and Chen, Jinhua and Gunzner-Toste, Janet and Kozak, Katherine K and Spencer, Susan and Polakis, Paul and Polson, Andrew G and Flygare, John A and Junutula, Jagath R
Molecular Cancer Therapeutics, ISSN 1535-7163, 05/2017, Volume 16, Issue 5, pp. 871 - 878
A novel disulfide linker was designed to enable a direct connection between cytotoxic pyrrolobenzodiazepine (PBD) drugs and the cysteine on a targeting... 
TARGETED TREATMENT | DESIGN | ONCOLOGY | STABILITY | IN-VIVO | BIOLOGICAL EVALUATION | CHEMISTRY | LYMPHOMA | SELECTION | CANCER-THERAPY | DELIVERY | Antibodies - chemistry | Humans | Antineoplastic Agents - administration & dosage | Immunoconjugates - administration & dosage | Pyrroles - immunology | Disulfides - chemistry | Pyrroles - administration & dosage | Antibodies - immunology | Cell Survival - drug effects | Antineoplastic Agents - immunology | Antineoplastic Agents - chemistry | Immunoconjugates - chemistry | Neoplasms - drug therapy | Benzodiazepines - immunology | Xenograft Model Antitumor Assays | Antibodies - administration & dosage | Animals | Disulfides - immunology | Neoplasms - immunology | Benzodiazepines - chemistry | Cell Line, Tumor | Pyrroles - chemistry | Benzodiazepines - administration & dosage | Cell Proliferation - drug effects | Mice | Neoplasms - pathology | Drugs | Conjugates | Cysteine | Effectiveness | Toxicity | Xenografts | Rats | Cytotoxicity | Safety | Cancer
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11. Full Text Cardiac Toxicity of Sunitinib and Sorafenib in Patients With Metastatic Renal Cell Carcinoma
by Manuela Schmidinger and Christoph C. Zielinski and Ursula M. Vogl and Andja Bojic and Marija Bojic and Christoph Schukro and Marquerite Ruhsam and Michael Hejna and Herwig Schmidinger
Journal of Clinical Oncology, ISSN 0732-183X, 11/2008, Volume 26, Issue 32, pp. 5204 - 5212
Purpose Sunitinib and sorafenib are tyrosine kinase inhibitors (TKIs) that have considerable efficacy in metastatic renal cell carcinoma. TKI-associated... 
INTERFERON-ALPHA | MYOCARDIAL-INFARCTION | ONCOLOGY | HEART-FAILURE | CARDIOTOXICITY | DYSFUNCTION | ANTITUMOR-ACTIVITY | INHIBITOR | CANCER | IMATINIB MESYLATE | ENDOTHELIAL GROWTH-FACTOR | Niacinamide - analogs & derivatives | Prospective Studies | Humans | Middle Aged | Cardiovascular Diseases - therapy | Male | Phenylurea Compounds | Protein Kinase Inhibitors - adverse effects | Benzenesulfonates - adverse effects | Neoplasm Metastasis | Pyridines - adverse effects | Time Factors | Aged, 80 and over | Cardiovascular Diseases - mortality | Electrocardiography | Pyrroles - adverse effects | Carcinoma, Renal Cell - enzymology | Female | Carcinoma, Renal Cell - drug therapy | Cardiovascular Diseases - diagnosis | Echocardiography | Carcinoma, Renal Cell - pathology | Risk Factors | Kaplan-Meier Estimate | Treatment Outcome | Biomarkers - blood | Kidney Neoplasms - mortality | Carcinoma, Renal Cell - mortality | Indoles - adverse effects | Kidney Neoplasms - enzymology | Kidney Neoplasms - pathology | Aged | Cardiovascular Diseases - chemically induced | Kidney Neoplasms - drug therapy | Index Medicus
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12. Full Text Retrospective evaluation of toceranib phosphate (Palladia®) toxicity in cats
by Merrick, C. H and Pierro, J and Schleis, S. E and Sones, E. A and Wright, Z. M and Regan, R. C and Siedlecki, C. T and Bergman, P. J
Veterinary and Comparative Oncology, ISSN 1476-5810, 09/2017, Volume 15, Issue 3, pp. 710 - 717
The purpose of this study was to describe the toxicity profile of toceranib phosphate in tumour bearing cats. Medical records were reviewed from seven... 
toceranib | toxicity | Palladia | cancer | feline | DOGS | TYROSINE KINASE INHIBITOR | SU11654 | VETERINARY SCIENCES | TUMORS | IMATINIB MESYLATE | Cats | Azotemia - veterinary | Neutropenia - veterinary | Azotemia - chemically induced | Cat Diseases - drug therapy | Gastrointestinal Tract - drug effects | Indoles - toxicity | Male | Alanine Transaminase - blood | Antineoplastic Agents - therapeutic use | Thrombocytopenia - chemically induced | Antineoplastic Agents - toxicity | Neoplasms - drug therapy | Neoplasms - veterinary | Animals | Pyrroles - toxicity | Female | Indoles - therapeutic use | Retrospective Studies | Neutropenia - chemically induced | Pyrroles - therapeutic use | Thrombocytopenia - veterinary | Phosphates | Palladium | Analysis | Index Medicus
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13. Full Text Human brain imaging of nicotinic acetylcholine α4β2 receptors using [18F]Nifene: Selectivity, functional activity, toxicity, aging effects, gender effects, and extrathalamic pathways
by Mukherjee, Jogeshwar and Lao, Patrick J and Betthauser, Tobey J and Samra, Gurleen K and Pan, Min‐Liang and Patel, Ishani H and Liang, Christopher and Metherate, Raju and Christian, Bradley T
Journal of Comparative Neurology, ISSN 0021-9967, 01/2018, Volume 526, Issue 1, pp. 80 - 95
Nicotinic acetylcholinergic receptors (nAChR's) have been implicated in several brain disorders, including addiction, Parkinson's disease, Alzheimer's disease... 
RRID:SCR_007416 | receptor selectivity | RRID:SCR_014214 | cortical pathway | RRID:SCR_005279 | translational research | white matter tracts | thalamus | Brain - diagnostic imaging | Pyrroles - pharmacokinetics | Humans | Middle Aged | Pyridines - pharmacokinetics | Male | Macaca mulatta | Positron-Emission Tomography | Nicotine - pharmacology | Brain - metabolism | Dose-Response Relationship, Drug | Young Adult | Protein Binding - drug effects | Adult | Female | Nicotinic Agonists - pharmacology | Receptors, Nicotinic - metabolism | Rats | Sex Characteristics | Rats, Sprague-Dawley | Brain - drug effects | Animals | Aging - physiology | Aged | Mice | Index Medicus
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