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1. Full Text Multi-parameter in vitro toxicity testing of crizotinib, sunitinib, erlotinib, and nilotinib in human cardiomyocytes
by Doherty, Kimberly R and Wappel, Robert L and Talbert, Dominique R and Trusk, Patricia B and Moran, Diarmuid M and Kramer, James W and Brown, Arthur M and Shell, Scott A and Bacus, Sarah
Toxicology and applied pharmacology, ISSN 0041-008X, 10/2013, Volume 272, Issue 1, pp. 245 - 255
Cardiomyocytes | Preclinical | Cardiotoxicity | Drug evaluation | In vitro | Tyrosine kinase inhibitors | Pharmacology & Pharmacy | Toxicology | Life Sciences & Biomedicine | Science & Technology | Biological and medical sciences | Medical sciences | Drug toxicity and drugs side effects treatment | Miscellaneous (drug allergy, mutagens, teratogens...) | Pharmacology. Drug treatments | Caspase 7 - metabolism | Erlotinib Hydrochloride | Reactive Oxygen Species - metabolism | Humans | Caspase 3 - metabolism | Ion Channels - drug effects | Lipids - biosynthesis | ERG1 Potassium Channel | RNA - isolation & purification | Pyrimidines - toxicity | Real-Time Polymerase Chain Reaction | Cell Survival - drug effects | Cells, Cultured | Indoles - toxicity | Cholesterol - metabolism | Enzyme Activation - drug effects | Ether-A-Go-Go Potassium Channels - genetics | RNA - biosynthesis | Patch-Clamp Techniques | Myocytes, Cardiac - drug effects | Quinazolines - toxicity | Pyridines - toxicity | Pyrroles - toxicity | Pluripotent Stem Cells - drug effects | Pyrazoles - toxicity | Protein Kinase Inhibitors - toxicity | Ether-A-Go-Go Potassium Channels - biosynthesis | Myocytes, Cardiac - ultrastructure | Protein-Tyrosine Kinases - antagonists & inhibitors | Erlotinib | Heart cells | Index Medicus | OXYGEN | APOPTOSIS | ETHERS | CHOLESTEROL | NEOPLASMS | TYROSINE | IN VITRO | DRUGS | GENES | TOXICITY | 60 APPLIED LIFE SCIENCES | LIPIDS
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2. Full Text Thiamethoxam Toxicity and Effects on Consumption Behavior in Orius insidiosus (Hemiptera: Anthocoridae) on Soybean
by Camargo, Carolina and Hunt, Thomas E and Giesler, Loren J and Siegfried, Blair D
Environmental entomology, ISSN 0046-225X, 06/2017, Volume 46, Issue 3, pp. 693 - 699
Consumption | Thiamethoxam | Orius Insidiosus | Aphis Glycines | Toxicity | Life Sciences & Biomedicine | Entomology | Science & Technology | Alanine - toxicity | Aphids - chemistry | Nitro Compounds - toxicity | Dioxoles - toxicity | Fungicides, Industrial - toxicity | Neonicotinoids | Oxazines - toxicity | Alanine - analogs & derivatives | Predatory Behavior - drug effects | Soybeans - chemistry | Thiazoles - toxicity | Animals | Heteroptera - drug effects | Pyrroles - toxicity | Pyrazoles - toxicity | Anilides - toxicity | Insecticides - toxicity | Index Medicus
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3. Full Text Microcosm evaluation of the effects of an eight pharmaceutical mixture to the aquatic macrophytes Lemna gibba and Myriophyllum sibiricum
by Brain, Richard A and Johnson, David J and Richards, Sean M and Hanson, Mark L and Sanderson, Hans and Lam, Monica W and Young, Cora and Mabury, Scott A and Sibley, Paul K and Solomon, Keith R
Aquatic toxicology, ISSN 0166-445X, 2004, Volume 70, Issue 1, pp. 23 - 40
Endpoint sensitivity | Pharmaceutical mixture | Lemna gibba | Toxicity | Myriophyllum sibiricum | Toxicology | Life Sciences & Biomedicine | Marine & Freshwater Biology | Science & Technology | Fundamental and applied biological sciences. Psychology | Biological and medical sciences | Applied ecology | Ecotoxicology, biological effects of pollution | Animal, plant and microbial ecology | Effects of pollution and side effects of pesticides on plants and fungi | Levofloxacin | Magnoliopsida - drug effects | Ofloxacin - toxicity | Heterocyclic Compounds - toxicity | Acetaminophen - toxicity | Caffeine - toxicity | Sulfamethoxazole - toxicity | Biomass | Dose-Response Relationship, Drug | Atorvastatin Calcium | Heptanoic Acids - toxicity | Water Pollutants, Chemical - toxicity | Analysis of Variance | Pyrroles - toxicity | Sertraline - toxicity | Biological Assay | Carbamazepine - toxicity | Trimethoprim - toxicity | Complex Mixtures - toxicity | Pharmaceutical Solutions - toxicity | Toxicity Tests | Magnoliopsida - growth & development | Index Medicus
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4. Full Text In vitro and in vivo toxicity of rinsed and aged nanocellulose–polypyrrole composites
by Ferraz, Natalia and Strømme, Maria and Fellström, Bengt and Pradhan, Sulena and Nyholm, Leif and Mihranyan, Albert
Journal of biomedical materials research. Part A, ISSN 1549-3296, 08/2012, Volume 100A, Issue 8, pp. 2128 - 2138
polypyrrole | hemodialysis | nanocellulose | aging | cytotoxicity | Engineering | Materials Science | Technology | Engineering, Biomedical | Materials Science, Biomaterials | Science & Technology | Technology. Biomaterials. Equipments | Emergency and intensive care: renal failure. Dialysis management | Anesthesia. Intensive care medicine. Transfusions. Cell therapy and gene therapy | Biological and medical sciences | Intensive care medicine | Medical sciences | Surgery (general aspects). Transplantations, organ and tissue grafts. Graft diseases | L-Lactate Dehydrogenase - metabolism | Monocytes - cytology | Humans | Cellulose - toxicity | Body Weight - drug effects | Toxicity Tests, Acute | Cellulose - ultrastructure | Electricity | Time Factors | Dermis - cytology | Fibroblasts - metabolism | Cell Survival - drug effects | Electrochemical Techniques | Cells, Cultured | Nanoparticles - toxicity | Monocytes - drug effects | Monocytes - enzymology | Animals | Pyrroles - toxicity | Fibroblasts - drug effects | Polymers - toxicity | Cell Proliferation - drug effects | Fibroblasts - cytology | Mice | Toxicity Tests | Index Medicus
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5. Full Text Retrospective evaluation of toceranib phosphate (Palladia®) toxicity in cats
by Merrick, C. H and Pierro, J and Schleis, S. E and Sones, E. A and Wright, Z. M and Regan, R. C and Siedlecki, C. T and Bergman, P. J
Veterinary & comparative oncology, ISSN 1476-5810, 09/2017, Volume 15, Issue 3, pp. 710 - 717
toceranib | toxicity | Palladia | cancer | feline | Life Sciences & Biomedicine | Veterinary Sciences | Science & Technology | Cats | Azotemia - veterinary | Neutropenia - veterinary | Azotemia - chemically induced | Cat Diseases - drug therapy | Gastrointestinal Tract - drug effects | Indoles - toxicity | Male | Alanine Transaminase - blood | Antineoplastic Agents - therapeutic use | Thrombocytopenia - chemically induced | Antineoplastic Agents - toxicity | Neoplasms - drug therapy | Neoplasms - veterinary | Animals | Pyrroles - toxicity | Female | Indoles - therapeutic use | Retrospective Studies | Neutropenia - chemically induced | Pyrroles - therapeutic use | Thrombocytopenia - veterinary | Phosphates | Palladium | Analysis | Index Medicus
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6. Full Text Quality‐adjusted time without symptoms or toxicity analysis of pazopanib versus sunitinib in patients with renal cell carcinoma
by Beaumont, Jennifer L and Salsman, John M and Diaz, Jose and Deen, Keith C and McCann, Lauren and Powles, Thomas and Hackshaw, Michelle D and Motzer, Robert J and Cella, David
Cancer, ISSN 0008-543X, 04/2016, Volume 122, Issue 7, pp. 1108 - 1115
sunitinib | angiogenesis inhibitors | pazopanib | drug toxicity | renal cell carcinomas | Life Sciences & Biomedicine | Oncology | Science & Technology | Humans | Middle Aged | Male | Kidney Neoplasms - mortality | Young Adult | Carcinoma, Renal Cell - mortality | Disease-Free Survival | Indoles - adverse effects | Antineoplastic Agents - adverse effects | Adolescent | Pyrimidines - adverse effects | Aged, 80 and over | Pyrroles - adverse effects | Quality of Life | Sulfonamides - adverse effects | Adult | Female | Aged | Carcinoma, Renal Cell - drug therapy | Kidney Neoplasms - drug therapy | Angiogenesis Inhibitors - adverse effects | Care and treatment | Usage | Clinical trials | Dosage and administration | Carcinoma, Renal cell | Diagnosis | Pazopanib | Index Medicus | Abridged Index Medicus
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7. Full Text Pharmacogenetic Pathway Analysis for Determination of Sunitinib-Induced Toxicity
by Nielka P. van Erp and Karel Eechoute and Astrid A. van der Veldt and John B. Haanen and An K.L. Reyners and Ron H.J. Mathijssen and Epie Boven and Tahar van der Straaten and Renée F. Baak-Pablo and Judith A.M. Wessels and Henk-Jan Guchelaar and Hans Gelderblom
Journal of clinical oncology, ISSN 0732-183X, 09/2009, Volume 27, Issue 26, pp. 4406 - 4412
UNPHASED GENOTYPE DATA | PHARMACOKINETICS | IN-VIVO | TYROSINE KINASE INHIBITOR | GENETIC-VARIANTS | ANTITUMOR-ACTIVITY | GASTROINTESTINAL STROMAL TUMORS | FACTOR RECEPTOR | UMCG Approved | RENAL-CELL CARCINOMA | ENDOTHELIAL GROWTH-FACTOR | Life Sciences & Biomedicine | Oncology | Science & Technology | Biological and medical sciences | Medical sciences | Tumors | Haplotypes | Cytochrome P-450 CYP1A1 - genetics | Pharmacogenetics - methods | Genetic Predisposition to Disease - genetics | Pyrroles - pharmacokinetics | Drug-Related Side Effects and Adverse Reactions - chemically induced | Humans | Middle Aged | Risk Factors | Male | Mucositis - chemically induced | Young Adult | Indoles - adverse effects | Antineoplastic Agents - adverse effects | Drug-Related Side Effects and Adverse Reactions - genetics | Leukopenia - chemically induced | Aged, 80 and over | Pyrroles - adverse effects | Adult | Female | Indoles - pharmacokinetics | Aged | Polymorphism, Single Nucleotide | Index Medicus
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8. Full Text Protein cross-linking in primary cultured mouse hepatocytes by dehydropyrrolizidine alkaloids: Structure–toxicity relationship
by Xiong, Fen and Jiang, Kaiyuan and Chen, Yan and Ju, Zhengcai and Yang, Li and Xiong, Aizhen and Wang, Zhengtao
Toxicon (Oxford), ISSN 0041-0101, 10/2020, Volume 186, pp. 4 - 11
Structure-toxicity relationship | Metabolic activation | Cell viability | Primary cultured mouse hepatocytes | Pyrrole-protein adducts | Pyrrolizidine alkaloids | Pharmacology & Pharmacy | Toxicology | Life Sciences & Biomedicine | Science & Technology | Alkaloids | Plants | Liver | Cytochrome P-450 | Protein binding | Index Medicus
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9. Full Text Modulating therapeutic activity and toxicity of pyrrolobenzodiazepine antibody-drug conjugates with self-immolative disulfide linkers
by Pillow, Thomas H and Schutten, Melissa and Yu, Shang-Fan and Ohri, Rachana and Sadowsky, Jack and Poon, Kirsten Achilles and Solis, Willy and Zhong, Fiona and Del Rosario, Geoffrey and Go, Mary Ann T and Lau, Jeffrey and Yee, Sharon and He, Jintang and Liu, Luna and Ng, Carl and Xu, Keyang and Leipold, Douglas D and Kamath, Amrita V and Zhang, Donglu and Masterson, Luke and Gregson, Stephen J and Howard, Philip W and Fang, Fan and Chen, Jinhua and Gunzner-Toste, Janet and Kozak, Katherine K and Spencer, Susan and Polakis, Paul and Polson, Andrew G and Flygare, John A and Junutula, Jagath R
Molecular cancer therapeutics, ISSN 1535-7163, 05/2017, Volume 16, Issue 5, pp. 871 - 878
Life Sciences & Biomedicine | Oncology | Science & Technology | Antibodies - chemistry | Humans | Antineoplastic Agents - administration & dosage | Immunoconjugates - administration & dosage | Pyrroles - immunology | Disulfides - chemistry | Pyrroles - administration & dosage | Antibodies - immunology | Cell Survival - drug effects | Antineoplastic Agents - immunology | Antineoplastic Agents - chemistry | Immunoconjugates - chemistry | Neoplasms - drug therapy | Benzodiazepines - immunology | Xenograft Model Antitumor Assays | Antibodies - administration & dosage | Animals | Disulfides - immunology | Neoplasms - immunology | Benzodiazepines - chemistry | Cell Line, Tumor | Pyrroles - chemistry | Benzodiazepines - administration & dosage | Cell Proliferation - drug effects | Mice | Neoplasms - pathology | Drugs | Conjugates | Cysteine | Effectiveness | Toxicity | Xenografts | Rats | Cytotoxicity | Safety | Cancer | Index Medicus
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10. Full Text Toxicity of statins on rat skeletal muscle mitochondria
by Kaufmann, P and Török, M and Zahno, A and Waldhauser, K M and Brecht, K and Krähenbühl, S
Cellular and molecular life sciences : CMLS, ISSN 1420-682X, 10/2006, Volume 63, Issue 19, pp. 2415 - 2425
Life Sciences | Biochemistry, general | Life Sciences, general | statins | mitochondria | β-oxidation | apoptosis | Rhabdomyolysis | Biomedicine general | respiratory chain | Cell Biology | Mitochondria | Respiratory chain | Statins | Apoptosis | Biochemistry & Molecular Biology | Life Sciences & Biomedicine | Science & Technology | Membrane Potentials - drug effects | Hydroxymethylglutaryl-CoA Reductase Inhibitors - toxicity | Apoptosis - drug effects | Mitochondrial Membranes - physiology | Cytochromes c - metabolism | Muscle, Skeletal - ultrastructure | Rats | Indoles - toxicity | Pravastatin - toxicity | Oxygen - metabolism | Mitochondrial Membranes - drug effects | Atorvastatin Calcium | Heptanoic Acids - toxicity | Animals | Pyridines - toxicity | Pyrroles - toxicity | Muscle, Skeletal - drug effects | Mitochondria, Muscle - ultrastructure | Mitochondria, Muscle - drug effects | Apoptosis - physiology | DNA Fragmentation - drug effects | Fatty Acids, Monounsaturated - toxicity | Fatty Acids - metabolism | Simvastatin - toxicity | Cardiovascular agents | Skeletal system | Toxicity | Rodents | Index Medicus
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11.