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Tetrahedron Letters, ISSN 0040-4039, 08/2019, Volume 60, Issue 35, p. 150989
This communication details the first total synthesis of Punicagranine, a new pyrrolizine alkaloid isolated from the peels of the pomengranate, , the basis for... 
1,3-Dipolar cycloaddition | Pyrrolizine | Punicagranine | Total synthesis | CHEMISTRY, ORGANIC | POMEGRANATE
Journal Article
Organic Letters, ISSN 1523-7060, 04/2017, Volume 19, Issue 7, pp. 1586 - 1589
A concise, atom-economic strategy for the synthesis of pyrrolizines with amino and keto substituents has been developed. It includes the following key steps:... 
2-(PYRROL-1-YL)BENZALDEHYDES | SUBSTITUTED PYRROLES | 3H-PYRROLIZINES | EFFICIENT SYNTHESIS | CHEMISTRY, ORGANIC | POLYSUBSTITUTED PYRROLES | INDOLIZINE DERIVATIVES | PROPARGYLIC BETA-ENAMINONES | PYRROLIZINE DERIVATIVES | PHOSPHORUS-COMPOUNDS | ACTIVE SURFACES
Journal Article
Research on Chemical Intermediates, ISSN 0922-6168, 10/2017, Volume 43, Issue 10, pp. 5337 - 5344
The organocatalyst, piperidinium acetate formed in situ, was utilized as an efficient catalyst for one-pot synthesis of 5,6-disubstituted 3H-pyrrolizines with... 
Piperidinium acetate | One-pot | 3H-Pyrrolizine | DFT calculation | Organocatalyst | DESIGN | EFFICIENT SYNTHESIS | AGENTS | INHIBITORS | CHEMISTRY, MULTIDISCIPLINARY | PYRROLIZINE DERIVATIVES | Toluene
Journal Article
RSC Advances, ISSN 2046-2069, 2018, Volume 8, Issue 72, pp. 41226 - 41236
Novel spiropyrrolidine heterocyclic hybrids were synthesized for the first time in a sustainable fashion employing a 1,3-dipolar cycloaddition strategy to form... 
CHOLINESTERASE INHIBITORY-ACTIVITY | DIASTEREOSELECTIVE SYNTHESIS | 1,3-DIPOLAR CYCLOADDITION | AZOMETHINE YLIDES | GENERATION | IONIC LIQUIDS | DERIVATIVES | CHEMISTRY, MULTIDISCIPLINARY | PYRROLIZINE | HYBRIDS | SPIROOXINDOLES
Journal Article
Bioorganic Chemistry, ISSN 0045-2068, 01/2020, Volume 94, p. 103371
Two new series of ethyl benzoate bearing pyrrolizine and indolizine moieties – were synthesized and evaluated for their anti-inflammatory and anticancer... 
Cytotoxicity | Cell cycle analysis | Pyrrolizine | Indolizine | Anti-inflammatory | Apoptosis
Journal Article
European Journal of Medicinal Chemistry, ISSN 0223-5234, 01/2020, Volume 185, p. 111780
Two new series of pyrrolizine-5-carboxamides were synthesized and evaluated for their anticancer and anti-inflammatory activities. The new compounds exhibited... 
Cytotoxicity | Cell cycle analysis | Pyrrolizine | Kinase | COX | Apoptosis | CHEMISTRY, MEDICINAL | CYCLOOXYGENASE-2 | KINASE INHIBITORS | ANTITUMOR-ACTIVITY | CANCER | DISCOVERY | INFLAMMATION | GROWTH | RESISTANCE | BINDING | DERIVATIVES
Journal Article
Tetrahedron Letters, ISSN 0040-4039, 07/2016, Volume 57, Issue 29, pp. 3226 - 3230
We have designed and synthesized the original example of stable 3 -pyrrolizine fused diazaborepin using boron–amine (B–N) chemistry. 3 -Pyrrolizine fused... 
Diazaborepin | Piperidinium acetate | 3H-Pyrrolizine | BF2 complex | Borepin | complex | BORONDIPYRROMETHENE | BORON | ANALOGS | COMPLEXES | CHEMISTRY, ORGANIC | STATE | BODIPY DYES | FLUORESCENCE | ACCESS
Journal Article
Tetrahedron Letters, ISSN 0040-4039, 05/2019, Volume 60, Issue 18, pp. 1231 - 1233
A novel pyrrolizine alkaloid, 5-(furan-3-carbonyl)-2,3-dihydro-1 -pyrrolizine-7-carboxylic acid, was isolated from the peels of . Its structure was elucidated... 
Punica granatum | Anti-inflammatory activity | Pyrrolizine alkaloid | Punicagranine | CHEMISTRY, ORGANIC | POMEGRANATE | Medical colleges | Alkaloids | Furans | Anti-inflammatory drugs | Mitogens | Nitric oxide
Journal Article
Tetrahedron, ISSN 0040-4020, 06/2007, Volume 63, Issue 25, pp. 5608 - 5613
Journal Article
JOURNAL OF ORGANIC CHEMISTRY, ISSN 0022-3263, 11/2019, Volume 84, Issue 21, pp. 13707 - 13720
A straightforward protocol toward pharmacologically relevant (het)areno[x,y-b]pyrrolo[1,2-d][1,4]-diazepines in good to high yields has been described. The... 
CHEMISTRY, ORGANIC | THERAPEUTIC EFFICACY | PHARMACOKINETIC PROPERTIES | BROMOPYRROLE ALKALOIDS | PYRROLIZINES | DERIVATIVES
Journal Article
JOURNAL OF MEDICINAL CHEMISTRY, ISSN 0022-2623, 08/2009, Volume 52, Issue 15, pp. 4968 - 4972
We synthesized and evaluated inhibitors for the microsomal prostaglandin E-2 synthase-1 (mPGES-1), based on the arylpyrrolizine scaffold. In a cell free... 
CHEMISTRY, MEDICINAL | ACIDS | ANTIINFLAMMATORY 2,3-DIHYDRO-1H-PYRROLIZINES | CYCLOOXYGENASE | LICOFELONE
Journal Article
ORGANIC LETTERS, ISSN 1523-7060, 01/2019, Volume 21, Issue 2, pp. 519 - 523
We describe herein an organocatalytic, diastereo- and enantioselective [6 + 2]-cycloaddition toward the synthesis of densely substituted... 
2-INDOLYLMETHANOLS | INDOL-2-YL CARBINOLS | CYCLOADDITIONS | CONSTRUCTION | CHEMISTRY, ORGANIC | DUAL INHIBITORS | CHIRAL PYRROLIZINES | CYCLIZATION | INDOLES | TRICYCLOPENTANOIDS | ENAMIDES
Journal Article
Journal of Heterocyclic Chemistry, ISSN 0022-152X, 06/2019, Volume 56, Issue 6, pp. 1748 - 1756
The diastereoselective synthesis of novel series of dispiropyrrolidines has been achieved by a one‐pot three‐component [3 + 2] cycloaddition reaction of... 
ANTIMYCOBACTERIAL ACTIVITY | SPIROOXINDOLE DERIVATIVES | ANTICANCER | SPIROPYRROLIZIDINES | CHEMISTRY, ORGANIC | PYRROLIDINE DERIVATIVES | AGENTS | STEREOSELECTIVE-SYNTHESIS | FACILE | DISCOVERY | PYRROLIZINE | Schiff bases
Journal Article
Journal of the American Chemical Society, ISSN 0002-7863, 09/2006, Volume 128, Issue 35, pp. 11496 - 11504
The synthesis, structure, and anion binding properties of chromogenic octamethylcalix[4]pyrroles (OMCPs) and their N-confused octamethylcalix[4]pyrrole isomers... 
EXPANDED CALIXPYRROLES | RECOGNITION | CAVITY | 5-AMINO-3-IMINO-1,2,6,7-TETRACYANO-3H-PYRROLIZINE | CALIX PYRROLES | CONDENSATION | AGENTS | SENSORS | COMPLEXATION | CHEMISTRY, MULTIDISCIPLINARY | RECEPTOR MODELS | Anions | Chemical properties | Research | Structure | Hydrogen bonding | Pyrrole
Journal Article
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