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Plant Cell, ISSN 1040-4651, 12/2017, Volume 29, Issue 12, pp. 3234 - 3254
Methylglyoxal (MGO) and glyoxal (GO) are toxic reactive carbonyl species generated as by-products of glycolysis. The pre-emption pathway for detoxification of... 
ARABIDOPSIS-THALIANA | PROTEIN | BIOCHEMISTRY & MOLECULAR BIOLOGY | ESCHERICHIA-COLI | GLYCATION | D-LACTATE DEHYDROGENASE | PLANT SCIENCES | CELL BIOLOGY | SUBSTRATE-SPECIFICITY | ENCODING GENES | GENOME-WIDE ANALYSIS | METHYLGLYOXAL | GLYOXALASE-I | Inactivation, Metabolic | Arabidopsis - enzymology | Glutathione - metabolism | Eukaryotic Cells - metabolism | RNA, Messenger - metabolism | Arabidopsis Proteins - metabolism | Saccharomyces cerevisiae - metabolism | Protoplasts - metabolism | Pyruvaldehyde - metabolism | Isoenzymes - metabolism | Gene Expression Regulation, Plant | Free Radicals - metabolism | Plant Cells - metabolism | Lactoylglutathione Lyase - metabolism | Stress, Physiological - genetics | Alternative Splicing - genetics | Arabidopsis - cytology | RNA, Messenger - genetics | Mutation - genetics | Subcellular Fractions - metabolism | Chloroplasts - metabolism | Arabidopsis - metabolism | Arabidopsis - genetics | Metals - metabolism | Plant Leaves - metabolism | Models, Biological | Cytosol - metabolism | Sugars - metabolism | Arabidopsis thaliana | Glucose metabolism | Defense industry | Germination | Glutamine | Alternative splicing | Yeast | Transcription | Splicing | Detoxification | Byproducts | Chemical reactions | Homology | Cytosol | Seedlings | Mitochondria | Developmental stages | Chloroplasts | Coding | Compartments | Isoforms | Glycolysis | Biocompatibility | Lactoylglutathione lyase | Pyruvaldehyde | Species | Sugar | Carbonyls | Index Medicus
Journal Article
Ecotoxicology and Environmental Safety, ISSN 0147-6513, 01/2018, Volume 147, pp. 990 - 1001
Journal Article
Journal Article
Journal of Biological Chemistry, ISSN 0021-9258, 03/2016, Volume 291, Issue 13, pp. 7060 - 7069
Mycobacterium tuberculosis (Mtb) displays a high degree of metabolic plasticity to adapt to challenging host environments. Genetic evidence suggests that Mtb... 
BACTERIA | tricarboxylic acid cycle (TCA cycle) (Krebs cycle) | PHOSPHORYLATION | ACETYLATION | fatty acid metabolism | BIOCHEMISTRY & MOLECULAR BIOLOGY | ESCHERICHIA-COLI | allosteric regulation | microbial pathogenesis | SACCHAROMYCES-CEREVISIAE | DEHYDROGENASE | bacterial metabolism | Mycobacterium tuberculosis | METABOLISM | pyruvate kinase | GROWTH | PHOSPHOENOLPYRUVATE | METHYLGLYOXAL | Fatty Acids, Volatile - pharmacology | Allosteric Regulation | Tuberculosis - microbiology | Isocitrate Dehydrogenase - antagonists & inhibitors | Glycolysis - drug effects | Mycobacterium tuberculosis - drug effects | Glycolysis - genetics | Pyruvaldehyde - metabolism | Gene Deletion | Aconitic Acid - metabolism | Female | Adenosine Monophosphate - pharmacology | Culture Media - chemistry | Ketoglutaric Acids - metabolism | Mycobacterium tuberculosis - metabolism | Carbon - metabolism | Gene Expression | Tuberculosis - mortality | Glutamic Acid - pharmacology | Pyruvate Kinase - metabolism | Adenosine Monophosphate - metabolism | Bacterial Proteins - genetics | Glucose-6-Phosphate - pharmacology | Isocitrate Dehydrogenase - genetics | Mice, SCID | Phosphoenolpyruvate - metabolism | Animals | Survival Analysis | Glucose - metabolism | Bacterial Proteins - metabolism | Isocitrate Dehydrogenase - metabolism | Citric Acid - metabolism | Glutamic Acid - metabolism | Mice | Enzyme Activation | Glucose-6-Phosphate - metabolism | Pyruvate Kinase - genetics | Mycobacterium tuberculosis - genetics | Index Medicus | Microbiology
Journal Article
Nature, ISSN 0028-0836, 2015, Volume 520, Issue 7547, pp. 363 - 367
Journal Article
International Journal of Molecular Sciences, ISSN 1661-6596, 12/2015, Volume 16, Issue 12, pp. 30117 - 30132
Journal Article
Arteriosclerosis, Thrombosis, and Vascular Biology, ISSN 1079-5642, 04/2010, Volume 30, Issue 4, pp. 766 - 772
OBJECTIVE—The goal of this study was to investigate the effects of nonenzymatic glycation on the antiinflammatory properties of apolipoprotein (apo) A-I.... 
HDL | NF-κB | Reactive oxygen species | ApoA-I | Neutrophils | Adhesion molecules | Inflammation | CELL-ADHESION MOLECULE-1 | NF-kappa B | inflammation | adhesion molecules | reactive oxygen species | ENDOTHELIAL-CELLS | GENE-EXPRESSION | KINETIC-ANALYSIS | PERIPHERAL VASCULAR DISEASE | PROTEINS | HEMATOLOGY | neutrophils | NF-KAPPA-B | END-PRODUCTS | apoA-I | CYTOKINE-INDUCED EXPRESSION | HIGH-DENSITY-LIPOPROTEINS | Carotid Arteries - metabolism | Phosphorylation | Reactive Oxygen Species - metabolism | Humans | Lipoproteins, HDL - metabolism | NF-kappa B - metabolism | Diabetes Mellitus, Type 2 - metabolism | I-kappa B Proteins - metabolism | Neutrophil Infiltration | Phosphatidylcholines - metabolism | Anti-Inflammatory Agents - metabolism | Pyruvaldehyde - metabolism | Inflammation - metabolism | Time Factors | Diabetes Mellitus, Type 2 - immunology | Anti-Inflammatory Agents - administration & dosage | Active Transport, Cell Nucleus | Carotid Artery Injuries - metabolism | Disease Models, Animal | Diabetic Angiopathies - metabolism | Rabbits | NF-KappaB Inhibitor alpha | Infusions, Parenteral | Glycosylation | Inflammation - immunology | Apolipoprotein A-I - metabolism | Carotid Artery Injuries - prevention & control | Intercellular Adhesion Molecule-1 - metabolism | Animals | Diabetic Angiopathies - immunology | Carotid Arteries - immunology | Apolipoprotein A-I - administration & dosage | Carotid Artery Injuries - immunology | Inflammation - prevention & control | Protein Processing, Post-Translational | Vascular Cell Adhesion Molecule-1 - metabolism | Index Medicus
Journal Article
Free Radical Biology and Medicine, ISSN 0891-5849, 07/2013, Volume 60, pp. 7 - 16
This study was designed to evaluate the effects of dimerumic acid (DMA) on receptor for advanced glycation endproducts (RAGE) signal activation and THP-1... 
Dimerumic acid | Methylglyoxal | Nuclear factor-erythroid 2-related factor 2 | Free radicals | Diabetes | Receptor for advanced glycation endproducts | SPRAGUE-DAWLEY RATS | OXIDATIVE STRESS | STRESS-INDUCED CYTOTOXICITY | BIOCHEMISTRY & MOLECULAR BIOLOGY | ANGIOTENSIN-II | IN-VITRO | ANTIOXIDANT | MONASCUS-ANKA | ENDOCRINOLOGY & METABOLISM | NATURALLY-OCCURRING FLAVONOIDS | END-PRODUCTS | EXPRESSION | Diabetes Mellitus - pathology | Tumor Necrosis Factor-alpha - metabolism | Inflammation - pathology | Leukocytes, Mononuclear - metabolism | Antioxidants - metabolism | Humans | Male | Pyruvaldehyde - metabolism | Inflammation - metabolism | Liver - drug effects | Inflammation - drug therapy | Hydroxamic Acids - pharmacology | Receptor for Advanced Glycation End Products | Pyruvaldehyde - pharmacology | Leukocytes, Mononuclear - drug effects | Lactic Acid - metabolism | Liver - metabolism | Diabetes Mellitus - drug therapy | Diabetes Mellitus - metabolism | Diketopiperazines - pharmacology | Glycation End Products, Advanced - drug effects | Insulin - metabolism | Animals | Glycation End Products, Advanced - metabolism | NF-E2-Related Factor 2 - metabolism | Glucose - metabolism | Mice | Oxidative Stress - drug effects | Receptors, Immunologic - metabolism | Sulfur compounds | RNA | Aspartate | Inflammation | Glucose | Glutamate | Glucose tolerance tests | Dextrose | Antioxidants | Glucose metabolism | Hyperglycemia | Surface active agents | Ligases | Lactic acid | Index Medicus
Journal Article
Ecotoxicology, ISSN 0963-9292, 07/2017, Volume 26, Issue 5, pp. 675 - 690
Chromium (Cr) toxicity is hazardous to the seed germination, growth, and development of plants. gamma-aminobutyric acid (GABA) is a non-protein amino acid and... 
Chromium | Methylglyoxal | Reactive oxygen species | Metal chelation | Phytoremediation | ABIOTIC STRESS | HEAVY-METAL DETOXIFICATION | MECHANISMS | DEFICIENT ARABIDOPSIS MUTANT | CROP PLANTS | SPINACH-CHLOROPLASTS | SIGNAL-TRANSDUCTION | ENVIRONMENTAL SCIENCES | GLUTATHIONE | INDUCED OXIDATIVE STRESS | ECOLOGY | HYDROGEN-PEROXIDE | TOXICOLOGY | Glutathione Peroxidase - metabolism | Reactive Oxygen Species - metabolism | Glutathione - metabolism | Glutathione Reductase - metabolism | Lactoylglutathione Lyase - metabolism | gamma-Aminobutyric Acid - metabolism | Antioxidants - metabolism | Mustard Plant - physiology | Adaptation, Physiological - physiology | Phytochelatins - metabolism | Chlorophyll - metabolism | Ascorbic Acid - metabolism | Hydrogen Peroxide - metabolism | Soil Pollutants - toxicity | Catalase - metabolism | Ascorbate Peroxidases - metabolism | Chromium - toxicity | Thiolester Hydrolases - metabolism | Superoxide Dismutase - metabolism | Physiological effects | Hydrogen peroxide | Ascorbic acid | Toxicity | Roots | L-Ascorbate peroxidase | Lipid peroxidation | Proline | Amino acids | Lipids | Superoxide dismutase | Antioxidants | Proteins | Leaves | γ-Aminobutyric acid | Catalase | Moisture content | Glutathione reductase | Water content | Hydroxyacylglutathione hydrolase | Peroxidase | Physiology | Shoots | Damage | Glutathione | Peroxidation | Glutathione peroxidase | Stresses | Chlorophyll | Germination | Tolerance | Uptake | Chlorophylls | Seedlings | Seed germination | Environmental stress | Brassica | Plant growth | Liquid oxygen | Mustard | Lipoxygenase | Lactoylglutathione lyase | Pyruvaldehyde | Index Medicus
Journal Article
Nature, ISSN 0028-0836, 2014, Volume 509, Issue 7500, pp. 361 - 365
T cells discriminate between foreign and host molecules by recognizing distinct microbial molecules, predominantly peptides and lipids(1-4). Riboflavin... 
RIBOFLAVIN | SYNTHASE | DESIGN | RECOGNITION | VITAMIN-B METABOLITES | BIOSYNTHESIS | MULTIDISCIPLINARY SCIENCES | SALMONELLA-TYPHIMURIUM | RECEPTOR | MR1 | T-Lymphocyte Subsets - immunology | Immunity, Mucosal - immunology | Pyrimidines - immunology | Vitamin B Complex - immunology | Glyoxal - metabolism | T-Lymphocyte Subsets - cytology | Minor Histocompatibility Antigens | Humans | Molecular Conformation | Antigens, Bacterial - immunology | Amino Sugars - immunology | Pyrimidines - chemistry | Pyrimidines - metabolism | Histocompatibility Antigens Class I - metabolism | Pyruvaldehyde - metabolism | Lymphocyte Activation - immunology | Riboflavin - metabolism | Uracil - immunology | Uracil - chemistry | Riboflavin - biosynthesis | Antigens, Bacterial - chemistry | Glyoxal - chemistry | Histocompatibility Antigens Class I - immunology | Models, Molecular | Riboflavin - immunology | Antigen Presentation - immunology | Histocompatibility Antigens Class I - chemistry | Immunity, Innate - immunology | Metabolic Networks and Pathways | Mucous Membrane - immunology | Amino Sugars - metabolism | Schiff Bases - chemistry | Ligands | Uracil - metabolism | Amino Sugars - chemistry | Pyruvaldehyde - chemistry | Vitamin B Complex - metabolism | Antigens, Bacterial - metabolism | Uracil - analogs & derivatives | Antigens | Immune response | Physiological aspects | Physiological research | Research | T cells | Properties | T cell receptors | Mutation | Metabolites | Bacteriology | Index Medicus
Journal Article
Journal of Biological Chemistry, ISSN 0021-9258, 10/2007, Volume 282, Issue 42, pp. 31038 - 31045
Methylglyoxal is a highly reactive dicarbonyl degradation product formed from triose phosphates during glycolysis. Methylglyoxal forms stable adducts primarily... 
DIABETIC-RETINOPATHY | ACTIVATION | ADVANCED GLYCATION | SP1 | BIOCHEMISTRY & MOLECULAR BIOLOGY | O-GLYCOSYLATION | MICE | 3 MAJOR PATHWAYS | EXPRESSION | HYPERGLYCEMIC DAMAGE | GLYOXALASE-I | Tumor Necrosis Factor-alpha - metabolism | Transcription, Genetic - drug effects | Kidney - pathology | Sweetening Agents - metabolism | Angiopoietin-2 - genetics | Protein Processing, Post-Translational - genetics | Diabetes Mellitus, Experimental - genetics | N-Acetylglucosaminyltransferases - genetics | Glycolysis - drug effects | Acetylglucosamine - metabolism | Glycolysis - genetics | Pyruvaldehyde - metabolism | Kidney - metabolism | Diabetic Angiopathies - pathology | Protein Processing, Post-Translational - drug effects | Arginine - genetics | Intercellular Adhesion Molecule-1 - biosynthesis | Vascular Cell Adhesion Molecule-1 - genetics | Response Elements - genetics | Diabetes Mellitus, Experimental - metabolism | Diabetic Angiopathies - genetics | Repressor Proteins - metabolism | Sp3 Transcription Factor - metabolism | Diabetic Angiopathies - metabolism | Sweetening Agents - pharmacology | Endothelial Cells - metabolism | Gene Expression Regulation - genetics | Sp3 Transcription Factor - genetics | Angiopoietin-2 - biosynthesis | Repressor Proteins - genetics | Glucose - pharmacology | Acetylglucosamine - genetics | N-Acetylglucosaminyltransferases - metabolism | Gene Expression Regulation - drug effects | Tumor Necrosis Factor-alpha - pharmacology | Animals | Intercellular Adhesion Molecule-1 - genetics | Diabetes Mellitus, Experimental - pathology | Glucose - metabolism | Vascular Cell Adhesion Molecule-1 - biosynthesis | Mice | Endothelial Cells - pathology | Arginine - metabolism | Cell Line, Transformed | Index Medicus
Journal Article
Journal of Pharmacology and Experimental Therapeutics, ISSN 0022-3565, 07/2012, Volume 342, Issue 1, pp. 196 - 204
Journal Article
Journal Article