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Journal Article
The New England journal of medicine, ISSN 0028-4793, 09/2019, Volume 381, Issue 10, pp. 933 - 944
In this study, approximately half the patients with red-cell pyruvate kinase deficiency who were treated with mitapivat had an improvement in their hemoglobin... 
Anemia, Hemolytic, Congenital Nonspherocytic/blood | Pyruvate Metabolism, Inborn Errors/blood | Clinical Trial, Phase II | Drug Administration Schedule | Follow-Up Studies | Administration, Oral | Humans | Catechols | Male | Sleep Initiation and Maintenance Disorders/chemically induced | Journal Article | Young Adult | Pyruvate Kinase/blood | Research Support, Non-U.S. Gov't | Adolescent | Headache/chemically induced | Hemoglobins/metabolism | Tyrphostins | Adult | Female | Medicine(all) | Multicenter Study | Mutation | Medicine, General & Internal | Life Sciences & Biomedicine | General & Internal Medicine | Science & Technology | Piperazines - administration & dosage | Pyruvate Metabolism, Inborn Errors - genetics | Pyruvate Metabolism, Inborn Errors - drug therapy | Pyruvate Kinase - blood | Quinolines - administration & dosage | Anemia, Hemolytic, Congenital Nonspherocytic - drug therapy | Sleep Initiation and Maintenance Disorders - chemically induced | Headache - chemically induced | Pyruvate Metabolism, Inborn Errors - blood | Hemoglobins - metabolism | Piperazines - adverse effects | Pyruvate Kinase - deficiency | Anemia, Hemolytic, Congenital Nonspherocytic - blood | Pyruvate Kinase - genetics | Quinolines - adverse effects | Anemia, Hemolytic, Congenital Nonspherocytic - genetics | Treatment outcome | Usage | Safety and security measures | Pyruvate kinase deficiency | Analysis | Hemoglobin | Drug therapy | Health aspects | Glycolytic enzymes | Headache | Pyruvate kinase | Anemia | Pyruvic acid | Glucose | Kinases | Investigations | Sleep disorders | Allosteric properties | Hemolytic anemia | Pharyngitis | Index Medicus | Abridged Index Medicus
Journal Article
Science (American Association for the Advancement of Science), ISSN 1095-9203, 11/2011, Volume 334, Issue 6060, pp. 1278 - 1283
Control of intracellular reactive oxygen species (ROS) concentrations is critical for cancer cell survival. We show that, in human lung cancer cells, acute... 
Antioxidants | Oxidative stress | Medical research | Cellular metabolism | REPORTS | Erythrocytes | Cell lines | Antibodies | Oxidation | Cell membranes | Hemoglobins | Science & Technology - Other Topics | Multidisciplinary Sciences | Science & Technology | Enzyme Activators - pharmacology | Neoplasm Transplantation | Protein Subunits | Reactive Oxygen Species - metabolism | Oxidative Stress | Glutathione - metabolism | Antioxidants - metabolism | Humans | Pyruvate Kinase - chemistry | Diamide - pharmacology | Transplantation, Heterologous | Neoplasms, Experimental - pathology | Mutant Proteins - antagonists & inhibitors | Cell Line | Oxidation-Reduction | Pyruvate Kinase - metabolism | Cell Survival | Mutant Proteins - genetics | Mutant Proteins - metabolism | Cysteine - chemistry | Pyruvate Kinase - antagonists & inhibitors | Animals | Mice, Nude | Mutant Proteins - chemistry | Acetylcysteine - pharmacology | Cell Line, Tumor | Glucose - metabolism | Mice | Neoplasms, Experimental - metabolism | Pentose Phosphate Pathway | Pyruvate Kinase - genetics | Amino Acid Substitution | Reactive oxygen species | Enzyme inhibitors | Pyruvate kinase | Lung cancer | Cancer cells | Physiological aspects | Oxidation-reduction reaction | Research | Health aspects | Enzymes | Biochemistry | Cellular biology | Kinases | Index Medicus
Journal Article
Journal Article