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Journal Article
Science, ISSN 0036-8075, 12/2011, Volume 334, Issue 6060, pp. 1278 - 1283
Control of intracellular reactive oxygen species (ROS) concentrations is critical for cancer cell survival. We show that, in human lung cancer cells, acute... 
Antioxidants | Oxidative stress | Medical research | Cellular metabolism | REPORTS | Erythrocytes | Cell lines | Antibodies | Oxidation | Cell membranes | Hemoglobins | CELLS | OXIDATIVE STRESS | PROTEIN | METABOLISM | MULTIDISCIPLINARY SCIENCES | ROS | TUMOR-SUPPRESSOR | ISOFORM | CANCER | Enzyme Activators - pharmacology | Neoplasm Transplantation | Protein Subunits | Reactive Oxygen Species - metabolism | Oxidative Stress | Glutathione - metabolism | Antioxidants - metabolism | Humans | Pyruvate Kinase - chemistry | Diamide - pharmacology | Transplantation, Heterologous | Neoplasms, Experimental - pathology | Mutant Proteins - antagonists & inhibitors | Cell Line | Oxidation-Reduction | Pyruvate Kinase - metabolism | Cell Survival | Mutant Proteins - genetics | Mutant Proteins - metabolism | Cysteine - chemistry | Pyruvate Kinase - antagonists & inhibitors | Animals | Mice, Nude | Mutant Proteins - chemistry | Acetylcysteine - pharmacology | Cell Line, Tumor | Glucose - metabolism | Mice | Neoplasms, Experimental - metabolism | Pentose Phosphate Pathway | Pyruvate Kinase - genetics | Amino Acid Substitution | Reactive oxygen species | Enzyme inhibitors | Pyruvate kinase | Lung cancer | Cancer cells | Physiological aspects | Oxidation-reduction reaction | Research | Health aspects | Enzymes | Biochemistry | Cellular biology | Kinases
Journal Article
Journal Article
JOURNAL OF BIOLOGICAL CHEMISTRY, ISSN 0021-9258, 08/2018, Volume 293, Issue 34, pp. 13204 - 13213
Journal Article
Journal Article
Nature Genetics, ISSN 1061-4036, 02/2018, Volume 50, Issue 2, pp. 219 - 228
The mechanisms by which mitochondrial metabolism supports cancer anabolism remain unclear. Here, we found that genetic and pharmacological inactivation of... 
OXIDATIVE STRESS | METABOLIC SWITCH | EPITHELIAL-CELLS | TCA CYCLE | STEROL REGULATORY ELEMENT | MITOCHONDRIA | GENETICS & HEREDITY | ZINC INHIBITION | LIPOPROTEIN RECEPTOR PROMOTER | NUCLEAR-PROTEIN | HISTONE ACETYLATION | Pyruvate Dehydrogenase Complex - metabolism | Prostatic Neoplasms - metabolism | Prostatic Neoplasms - pathology | Humans | Protein Processing, Post-Translational - genetics | Cells, Cultured | Cytoplasm - metabolism | Male | Cytoplasm - pathology | Pyruvate Dehydrogenase (Lipoamide) - metabolism | Mice, Knockout | Cell Compartmentation - physiology | Pyruvate Dehydrogenase Complex - physiology | Animals | Cell Nucleus - metabolism | Prostatic Neoplasms - genetics | Cell Nucleus - genetics | Lipogenesis - genetics | Cell Nucleus - pathology | Cell Line, Tumor | Cytoplasm - genetics | Mice | Pyruvate Dehydrogenase (Lipoamide) - genetics | Phosphatases | Pyruvate dehydrogenase complex | Genetic aspects | Research | Genetic transcription | Diagnosis | Prostate cancer | Animal models | Phosphorylation | Dehydrogenases | Xenotransplantation | Pyruvic acid | Lipids | Biosynthesis | Regulatory sequences | Kinases | Dehydrogenase | Inactivation | Datasets | Proteins | Mitochondria | Cell growth | Xenografts | Tumorigenesis | Acetylation | Lipogenesis | Deactivation | Pyruvate dehydrogenase (lipoamide) | Pharmacology | Metabolism | Gene expression | Citric acid | Respiration | Prostate | Cancer | Apoptosis | Tumors
Journal Article
Journal Article