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Journal Article
Journal of Biological Chemistry, ISSN 0021-9258, 2017, Volume 292, Issue 37, pp. 15561 - 15576
Preferential expression of the low-activity (dimeric) M2 isoform of pyruvate kinase (PK) over its constitutively active splice variant M1 isoform is considered... 
LUNG-CANCER | METABOLISM | TUMOR SUPPRESSION | PKM2 | BIOCHEMISTRY & MOLECULAR BIOLOGY | GROWTH | PREDICTING SUBCELLULAR-LOCALIZATION | HIGH-TITER LENTIVIRUS | ISOFORM | LKB1 | GENE-TRANSCRIPTION | Mitochondrial Dynamics | AMP-Activated Protein Kinases - metabolism | Humans | Lung Neoplasms - metabolism | Pyruvate Kinase - chemistry | Lung Neoplasms - pathology | Neoplasm Proteins - antagonists & inhibitors | Isoenzymes - chemistry | Neoplasm Proteins - metabolism | Autophagy | Recombinant Fusion Proteins - metabolism | Thyroid Hormones - chemistry | Organelle Biogenesis | RNA Interference | Isoenzymes - metabolism | Adenosine Triphosphate - metabolism | Carcinoma - enzymology | Carrier Proteins - chemistry | Membrane Proteins - metabolism | Carcinoma - pathology | Neoplasm Proteins - genetics | Dimerization | A549 Cells | Lung Neoplasms - enzymology | Pyruvate Kinase - metabolism | Isoenzymes - genetics | Membrane Proteins - genetics | AMP-Activated Protein Kinases - antagonists & inhibitors | Carrier Proteins - antagonists & inhibitors | Neoplasm Proteins - chemistry | Recombinant Fusion Proteins - chemistry | Thyroid Hormones - genetics | Protein Transport | Carrier Proteins - genetics | Pyruvate Kinase - antagonists & inhibitors | Carrier Proteins - metabolism | Energy Metabolism | Membrane Proteins - antagonists & inhibitors | Membrane Proteins - chemistry | Thyroid Hormones - metabolism | Cell Line, Tumor | Carcinoma - metabolism | Mutation | Pyruvate Kinase - genetics | AMP-Activated Protein Kinases - genetics | Isoenzymes - antagonists & inhibitors | Amino Acid Substitution | Apoptosis | cancer metabolism | cancer therapy | pyruvate kinase M1 | mitochondria | pyruvate kinase M2 | cancer biology | Metabolism | mitochondrial oxidative phosphorylation | energy metabolism | Warburg effect
Journal Article
Nature, ISSN 0028-0836, 06/2017, Volume 546, Issue 7658, pp. 426 - 430
D-type cyclins (D1, D2 and D3) and their associated cyclin-dependent kinases (CDK4 and CDK6) are components of the core cell cycle machinery that drives cell... 
FLUX ANALYSIS | SITE | CATABOLISM | PYRUVATE-KINASE | GLUTAMINE | PHOSPHOFRUCTOKINASES | MULTIDISCIPLINARY SCIENCES | CDK4/6 INHIBITION | PROTEIN-PHOSPHORYLATION | CONFIDENCE | Cyclin-Dependent Kinase 6 - antagonists & inhibitors | Neoplasms - metabolism | Pentose Phosphate Pathway - drug effects | Precursor T-Cell Lymphoblastic Leukemia-Lymphoma - pathology | Reactive Oxygen Species - metabolism | Apoptosis - drug effects | Humans | Glycolysis - drug effects | Aminopyridines - therapeutic use | Female | Purines - therapeutic use | Phosphorylation - drug effects | Cyclin-Dependent Kinase 4 - antagonists & inhibitors | Precursor T-Cell Lymphoblastic Leukemia-Lymphoma - metabolism | Cyclin D3 - metabolism | Cell Survival - drug effects | Pyruvate Kinase - metabolism | Purines - pharmacology | Reactive Nitrogen Species - metabolism | Neoplasms - enzymology | Cyclin-Dependent Kinase 6 - metabolism | Precursor T-Cell Lymphoblastic Leukemia-Lymphoma - enzymology | Cyclin-Dependent Kinase 4 - metabolism | Serine - metabolism | Neoplasms - drug therapy | Xenograft Model Antitumor Assays | Animals | Aminopyridines - pharmacology | Cell Line, Tumor | Mice | Oxidative Stress - drug effects | Cell Cycle - drug effects | Neoplasms - pathology | Phosphofructokinase-1 - metabolism | Phosphates | Reactive oxygen species | Phosphorylation | Brain cancer | Clinical trials | Catalytic activity | Kinases | Cyclin-dependent kinase 6 | Machinery | Cyclin-dependent kinase 4 | Cyclin D3 | Proteins | Antioxidants | Pathways | Metabolites | Pentose | Xenografts | Cell cycle | Inhibition | NADP | Cyclin D | Catalysis | Phosphofructokinase | Glutathione | Pentose phosphate | Enzymes | Medical research | Oxygen | Cell survival | Pyruvate kinase | Cyclin-dependent kinases | Metabolism | Survival | Cyclins | Intermediates | Cell death | Glycolysis | Scientific imaging | Mass spectrometry | Tumors | Apoptosis | Cancer | 6-Phosphofructokinase
Journal Article
Trends in Biochemical Sciences, ISSN 0968-0004, 04/2018, Volume 43, Issue 4, pp. 301 - 310
Journal Article
Journal of Cell Science, ISSN 0021-9533, 2015, Volume 128, Issue 9, pp. 1655 - 1660
Journal Article
Nature Chemical Biology, ISSN 1552-4450, 2012, Volume 8, Issue 10, pp. 839 - 847
Journal Article
Journal Article