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Science, ISSN 0036-8075, 12/2011, Volume 334, Issue 6060, pp. 1278 - 1283
Control of intracellular reactive oxygen species (ROS) concentrations is critical for cancer cell survival. We show that, in human lung cancer cells, acute... 
Antioxidants | Oxidative stress | Medical research | Cellular metabolism | REPORTS | Erythrocytes | Cell lines | Antibodies | Oxidation | Cell membranes | Hemoglobins | CELLS | OXIDATIVE STRESS | PROTEIN | METABOLISM | MULTIDISCIPLINARY SCIENCES | ROS | TUMOR-SUPPRESSOR | ISOFORM | CANCER | Enzyme Activators - pharmacology | Neoplasm Transplantation | Protein Subunits | Reactive Oxygen Species - metabolism | Oxidative Stress | Glutathione - metabolism | Antioxidants - metabolism | Humans | Pyruvate Kinase - chemistry | Diamide - pharmacology | Transplantation, Heterologous | Neoplasms, Experimental - pathology | Mutant Proteins - antagonists & inhibitors | Cell Line | Oxidation-Reduction | Pyruvate Kinase - metabolism | Cell Survival | Mutant Proteins - genetics | Mutant Proteins - metabolism | Cysteine - chemistry | Pyruvate Kinase - antagonists & inhibitors | Animals | Mice, Nude | Mutant Proteins - chemistry | Acetylcysteine - pharmacology | Cell Line, Tumor | Glucose - metabolism | Mice | Neoplasms, Experimental - metabolism | Pentose Phosphate Pathway | Pyruvate Kinase - genetics | Amino Acid Substitution | Reactive oxygen species | Enzyme inhibitors | Pyruvate kinase | Lung cancer | Cancer cells | Physiological aspects | Oxidation-reduction reaction | Research | Health aspects | Enzymes | Biochemistry | Cellular biology | Kinases | Index Medicus
Journal Article
Proceedings of the National Academy of Sciences of the United States of America, ISSN 0027-8424, 5/2012, Volume 109, Issue 18, pp. 6904 - 6909
Journal Article
Circulation, ISSN 0009-7322, 12/2017, Volume 136, Issue 25, pp. 2468 - 2485
BACKGROUND: An emerging metabolic theory of pulmonary hypertension (PH) suggests that cellular and mitochondrial metabolic dysfunction underlies the pathology... 
hypoxia | splicing factors | mitochondria | pyruvate kinase | TEEP-46 | metabolism | shikonin | INFLAMMATORY PHENOTYPE | CARDIAC & CARDIOVASCULAR SYSTEMS | CANCER-CELL-GROWTH | ROS PRODUCTION | ISOFORM EXPRESSION | COLON-CANCER | INHIBITION | PYRUVATE-KINASE | COLORECTAL-CANCER | ARTERIAL-HYPERTENSION | PERIPHERAL VASCULAR DISEASE | DYSFUNCTION | Endothelium, Vascular - cytology | Cell Proliferation | MicroRNAs - antagonists & inhibitors | Alternative Splicing | Humans | MicroRNAs - metabolism | Polypyrimidine Tract-Binding Protein - antagonists & inhibitors | Protein Isoforms - metabolism | RNA Interference | Cattle | Interleukin-1beta - metabolism | Macrophages - immunology | Fibroblasts - metabolism | Pyruvate Kinase - metabolism | Mice, Inbred C57BL | Heterogeneous-Nuclear Ribonucleoproteins - metabolism | Heterogeneous-Nuclear Ribonucleoproteins - antagonists & inhibitors | Naphthoquinones - pharmacology | Hypertension, Pulmonary - metabolism | Polypyrimidine Tract-Binding Protein - metabolism | Macrophages - cytology | Heterogeneous-Nuclear Ribonucleoproteins - genetics | Macrophages - metabolism | Pyruvate Kinase - antagonists & inhibitors | Animals | Fibroblasts - drug effects | Glycolysis | Histone Deacetylase Inhibitors - pharmacology | Fibroblasts - cytology | Mice | MicroRNAs - genetics | Antagomirs - metabolism | Hypertension, Pulmonary - pathology | Pyruvate Kinase - genetics | Protein Isoforms - antagonists & inhibitors | Polypyrimidine Tract-Binding Protein - genetics | Protein Isoforms - genetics | Index Medicus | Abridged Index Medicus
Journal Article
Journal of Biological Chemistry, ISSN 0021-9258, 2017, Volume 292, Issue 37, pp. 15561 - 15576
Preferential expression of the low-activity (dimeric) M2 isoform of pyruvate kinase (PK) over its constitutively active splice variant M1 isoform is considered... 
LUNG-CANCER | METABOLISM | TUMOR SUPPRESSION | PKM2 | BIOCHEMISTRY & MOLECULAR BIOLOGY | GROWTH | PREDICTING SUBCELLULAR-LOCALIZATION | HIGH-TITER LENTIVIRUS | ISOFORM | LKB1 | GENE-TRANSCRIPTION | Mitochondrial Dynamics | AMP-Activated Protein Kinases - metabolism | Humans | Lung Neoplasms - metabolism | Pyruvate Kinase - chemistry | Lung Neoplasms - pathology | Neoplasm Proteins - antagonists & inhibitors | Isoenzymes - chemistry | Neoplasm Proteins - metabolism | Autophagy | Recombinant Fusion Proteins - metabolism | Thyroid Hormones - chemistry | Organelle Biogenesis | RNA Interference | Isoenzymes - metabolism | Adenosine Triphosphate - metabolism | Carcinoma - enzymology | Carrier Proteins - chemistry | Membrane Proteins - metabolism | Carcinoma - pathology | Neoplasm Proteins - genetics | Dimerization | A549 Cells | Lung Neoplasms - enzymology | Pyruvate Kinase - metabolism | Isoenzymes - genetics | Membrane Proteins - genetics | AMP-Activated Protein Kinases - antagonists & inhibitors | Carrier Proteins - antagonists & inhibitors | Neoplasm Proteins - chemistry | Recombinant Fusion Proteins - chemistry | Thyroid Hormones - genetics | Protein Transport | Carrier Proteins - genetics | Pyruvate Kinase - antagonists & inhibitors | Carrier Proteins - metabolism | Energy Metabolism | Membrane Proteins - antagonists & inhibitors | Membrane Proteins - chemistry | Thyroid Hormones - metabolism | Cell Line, Tumor | Carcinoma - metabolism | Mutation | Pyruvate Kinase - genetics | AMP-Activated Protein Kinases - genetics | Isoenzymes - antagonists & inhibitors | Amino Acid Substitution | Apoptosis | Index Medicus | cancer metabolism | cancer therapy | pyruvate kinase M1 | mitochondria | pyruvate kinase M2 | cancer biology | Metabolism | mitochondrial oxidative phosphorylation | energy metabolism | Warburg effect
Journal Article
Nature Communications, ISSN 2041-1723, 10/2016, Volume 7, Issue 1, pp. 13280 - 13280
Sepsis, severe sepsis and septic shock are the main cause of mortality in non-cardiac intensive care units. Immunometabolism has been linked to sepsis;... 
IL-1-BETA PRODUCTION | MACROPHAGES | MULTIDISCIPLINARY SCIENCES | PYRUVATE-KINASE M2 | LACTATE | HMGB1 RELEASE | SEPTIC SHOCK | INTRACELLULAR LPS | SEPSIS | PKR ACTIVATION | INNATE IMMUNITY | Interleukin-18 - immunology | Phosphorylation | eIF-2 Kinase - metabolism | Humans | Male | HMGB1 Protein - immunology | HMGB1 Protein - secretion | DNA-Binding Proteins - metabolism | Signal Transduction - immunology | Macrophages - secretion | Female | Membrane Proteins - metabolism | Carrier Proteins - immunology | Macrophages - immunology | Disease Models, Animal | eIF-2 Kinase - genetics | Interleukin-1beta - secretion | Sepsis - immunology | DNA-Binding Proteins - immunology | Membrane Proteins - genetics | NLR Family, Pyrin Domain-Containing 3 Protein - metabolism | Coinfection - immunology | Carrier Proteins - antagonists & inhibitors | Interleukin-1beta - immunology | Membrane Proteins - immunology | Naphthoquinones - pharmacology | Thyroid Hormones - genetics | eIF-2 Kinase - antagonists & inhibitors | Mice, Knockout | Thyroid Hormones - immunology | Carrier Proteins - genetics | Coinfection - microbiology | Macrophages - metabolism | Animals | Carrier Proteins - metabolism | NLR Family, Pyrin Domain-Containing 3 Protein - immunology | Membrane Proteins - antagonists & inhibitors | Thyroid Hormones - metabolism | Inflammasomes - immunology | Myeloid Cells - metabolism | Interleukin-18 - secretion | Mice | Mice, Inbred BALB C | Glycolysis - immunology | Sepsis - microbiology | Index Medicus
Journal Article
Journal of Agricultural and Food Chemistry, ISSN 0021-8561, 11/2018, Volume 66, Issue 46, pp. 12439 - 12452
Journal Article
Nature, ISSN 0028-0836, 2013, Volume 498, Issue 7452, pp. 109 - 112
Journal Article
Nature Communications, ISSN 2041-1723, 2014, Volume 5, Issue 1, pp. 5566 - 5566
Pyruvate kinase M2 (PKM2) is expressed at high levels during embryonic development and tumour progression and is important for cell growth. However, it is not... 
ACTIVATION | INHIBITION | METABOLISM | MULTIDISCIPLINARY SCIENCES | PYRUVATE-KINASE M2 | DEGRADATION | ISOFORM | BETA-CATENIN | PROMOTES | LIGHT-CHAIN PHOSPHORYLATION | GENE-TRANSCRIPTION | Cell Cycle - genetics | Phosphorylation | Proto-Oncogene Proteins p21(ras) | Aurora Kinase B - metabolism | Myosin Light Chains - genetics | Humans | Gene Expression Regulation, Neoplastic | ras Proteins - metabolism | rho-Associated Kinases - antagonists & inhibitors | Receptor, Epidermal Growth Factor - metabolism | RNA Interference | rho-Associated Kinases - metabolism | Cell Transformation, Neoplastic - genetics | Cytokinesis - physiology | Membrane Proteins - metabolism | Cardiac Myosins - metabolism | Proto-Oncogene Proteins B-raf - metabolism | Amides - pharmacology | Proto-Oncogene Proteins - metabolism | Cell Proliferation - genetics | Pyruvate Kinase - metabolism | Membrane Proteins - genetics | Cardiac Myosins - genetics | HCT116 Cells | Carrier Proteins - antagonists & inhibitors | Brain Neoplasms - genetics | Thyroid Hormones - genetics | Carrier Proteins - genetics | Leupeptins - pharmacology | Pyruvate Kinase - antagonists & inhibitors | Animals | Carrier Proteins - metabolism | Membrane Proteins - antagonists & inhibitors | Mitosis - physiology | Mice, Nude | Thyroid Hormones - metabolism | Cell Line, Tumor | Mice | Myosin Light Chains - metabolism | Pyridines - pharmacology | RNA, Small Interfering | Pyruvate Kinase - genetics | Index Medicus
Journal Article