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Plant Physiology, ISSN 0032-0889, 10/2001, Volume 127, Issue 2, pp. 615 - 623
In contrast to peas (Pisum sativum), where mitochondrial lipoamide dehydrogenase is encoded by a single gene and shared between the α-ketoacid dehydrogenase... 
Peas | Mitochondria | Dehydrogenases | Messenger RNA | Biochemical Processes and Macromolecular Structures | RNA | Complementary DNA | Genes | Plant roots | Amino acids | Plants | GLYCINE DECARBOXYLASE COMPLEX | CLONING | PEA-LEAF MITOCHONDRIA | CONTAINING H-PROTEIN | AMINO-ACID-SEQUENCES | DIHYDROLIPOAMIDE DEHYDROGENASE | CLEAVAGE SYSTEM | PLANT-MITOCHONDRIA | MULTIENZYME COMPLEX | PISUM-SATIVUM | PLANT SCIENCES | Mitochondria - enzymology | Arabidopsis - enzymology | Multienzyme Complexes - metabolism | Plant Roots - genetics | DNA, Mitochondrial | Amino Acid Oxidoreductases - metabolism | DNA, Plant | Amino Acid Oxidoreductases - genetics | Arabidopsis Proteins - metabolism | Mitochondria - genetics | Plants, Genetically Modified | Gene Expression Regulation, Plant | Plant Leaves - enzymology | Pyruvate Dehydrogenase (Lipoamide) - genetics | Arabidopsis Proteins - genetics | Peas - enzymology | Signal Transduction | Glycine Dehydrogenase (Decarboxylating) | Multienzyme Complexes - genetics | Pyruvate Dehydrogenase (Lipoamide) - metabolism | Arabidopsis - genetics | Plant Leaves - genetics | Dihydrolipoamide Dehydrogenase - genetics | Plant Roots - enzymology | Dihydrolipoamide Dehydrogenase - metabolism | Peas - genetics | DNA, Complementary | Genetic aspects | Oxidoreductases | Research | Arabidopsis | Phytochemistry | Plant genetics
Journal Article
Molecular Cell, ISSN 1097-2765, 02/2014, Volume 53, Issue 4, pp. 534 - 548
Journal Article
Nature, ISSN 0028-0836, 2013, Volume 498, Issue 7452, pp. 109 - 112
Journal Article
Journal of Clinical Investigation, ISSN 0021-9738, 04/2015, Volume 125, Issue 4, pp. 1579 - 1590
Metabolic reprogramming is implicated in macrophage activation, but the underlying mechanisms are poorly understood. Here, we demonstrate that the NOTCH1... 
MEDICINE, RESEARCH & EXPERIMENTAL | GENE | CELL ACTIVATION | NITRIC-OXIDE SYNTHASE | INFLAMMATION | ALCOHOLIC LIVER-DISEASE | TRANSCRIPTION | ROS | DIFFERENTIATION | HYPOXIA | PYRUVATE-DEHYDROGENASE COMPLEX | Up-Regulation | Macrophage Activation - genetics | Reactive Oxygen Species - metabolism | Electron Transport - genetics | Liver Failure, Acute - etiology | Male | Pyruvate Dehydrogenase (Lipoamide)-Phosphatase - antagonists & inhibitors | Fatty Liver, Alcoholic - metabolism | Inflammation - metabolism | Receptor, Notch1 - deficiency | Pyruvate Dehydrogenase (Lipoamide)-Phosphatase - metabolism | Transcription, Genetic | Fatty Liver, Alcoholic - pathology | Macrophage Activation - physiology | Protein Structure, Tertiary | Pyruvate Dehydrogenase Complex - metabolism | Cell Line | Mice, Inbred C57BL | Gene Expression Regulation | Oxidative Phosphorylation | Fatty Liver, Alcoholic - immunology | Inflammation - immunology | Liver Failure, Acute - metabolism | Mitochondria - metabolism | Mice, Knockout | Feedback, Physiological | Animals | Endotoxemia - complications | Liver Failure, Acute - immunology | Liver Failure, Acute - pathology | Glucose - metabolism | Myeloid Cells - metabolism | Signal Transduction - physiology | Mice | Pyruvate Dehydrogenase (Lipoamide)-Phosphatase - genetics | Myeloid Cells - pathology | Nitric Oxide - metabolism | Receptor, Notch1 - physiology | Cell metabolism | Genetic research | Genetic aspects | Genetic transcription | Research | Macrophages | Properties | Liver diseases | Cytokines | Microscopy | Pilot projects | Rodents | Mitochondrial DNA | Metabolism | Gene expression | Hepatology | Inflammation | Immunology
Journal Article
Nature Genetics, ISSN 1061-4036, 02/2018, Volume 50, Issue 2, pp. 219 - 228
The mechanisms by which mitochondrial metabolism supports cancer anabolism remain unclear. Here, we found that genetic and pharmacological inactivation of... 
OXIDATIVE STRESS | METABOLIC SWITCH | EPITHELIAL-CELLS | TCA CYCLE | STEROL REGULATORY ELEMENT | MITOCHONDRIA | GENETICS & HEREDITY | ZINC INHIBITION | LIPOPROTEIN RECEPTOR PROMOTER | NUCLEAR-PROTEIN | HISTONE ACETYLATION | Pyruvate Dehydrogenase Complex - metabolism | Prostatic Neoplasms - metabolism | Prostatic Neoplasms - pathology | Humans | Protein Processing, Post-Translational - genetics | Cells, Cultured | Cytoplasm - metabolism | Male | Cytoplasm - pathology | Pyruvate Dehydrogenase (Lipoamide) - metabolism | Mice, Knockout | Cell Compartmentation - physiology | Pyruvate Dehydrogenase Complex - physiology | Animals | Cell Nucleus - metabolism | Prostatic Neoplasms - genetics | Cell Nucleus - genetics | Lipogenesis - genetics | Cell Nucleus - pathology | Cell Line, Tumor | Cytoplasm - genetics | Mice | Pyruvate Dehydrogenase (Lipoamide) - genetics | Phosphatases | Pyruvate dehydrogenase complex | Genetic aspects | Research | Genetic transcription | Diagnosis | Prostate cancer | Animal models | Phosphorylation | Dehydrogenases | Xenotransplantation | Pyruvic acid | Lipids | Biosynthesis | Regulatory sequences | Kinases | Dehydrogenase | Inactivation | Datasets | Proteins | Mitochondria | Cell growth | Xenografts | Tumorigenesis | Acetylation | Lipogenesis | Deactivation | Pyruvate dehydrogenase (lipoamide) | Pharmacology | Metabolism | Gene expression | Citric acid | Respiration | Prostate | Cancer | Apoptosis | Tumors
Journal Article
FEBS Letters, ISSN 0014-5793, 10/2000, Volume 484, Issue 1, pp. 12 - 16
Journal Article
Journal Article
Biochemical and Biophysical Research Communications, ISSN 0006-291X, 03/2000, Volume 269, Issue 2, pp. 382 - 386
Journal Article
Nature Genetics, ISSN 1061-4036, 09/2018, Volume 50, Issue 9, pp. 1343 - 1343
Journal Article
Journal Article
Hepatology, ISSN 0270-9139, 05/2017, Volume 65, Issue 5, pp. 1670 - 1682
Journal Article
Biochemical and Biophysical Research Communications, ISSN 0006-291X, 08/1999, Volume 262, Issue 1, pp. 163 - 166
An infant with a neurodegenerative disorder accompanied by lactic acidemia is described. In muscle homogenate, the activity of lipoamide dehydrogenase (LAD),... 
SKELETAL-MUSCLE | PYRUVATE | PROTEIN | BIOPHYSICS | BIOCHEMISTRY & MOLECULAR BIOLOGY | COMPLEXES | DISEASE | SEQUENCE | COMPONENT | IDENTIFICATION | ALPHA-KETOGLUTARATE DEHYDROGENASE | HUMAN DIHYDROLIPOAMIDE DEHYDROGENASE | Ketoglutarate Dehydrogenase Complex - chemistry | Humans | Enzyme Precursors - genetics | Molecular Sequence Data | Infant | Male | Ketoglutarate Dehydrogenase Complex - metabolism | Pyruvate Dehydrogenase Complex - genetics | Ketoglutarate Dehydrogenase Complex - genetics | Muscles - pathology | Dihydrolipoamide Dehydrogenase - chemistry | Pyruvate Dehydrogenase Complex Deficiency Disease - genetics | Female | Pyruvate Dehydrogenase Complex Deficiency Disease - enzymology | Dimerization | Pyruvate Dehydrogenase Complex - metabolism | Amino Acid Sequence | Mitochondria, Muscle - enzymology | Neurodegenerative Diseases - pathology | Enzyme Precursors - chemistry | Protein Structure, Secondary | Dihydrolipoamide Dehydrogenase - deficiency | Neurodegenerative Diseases - genetics | Ketoglutarate Dehydrogenase Complex - deficiency | Enzyme Precursors - metabolism | Phenotype | Muscles - enzymology | Pyruvate Dehydrogenase Complex - chemistry | Dihydrolipoamide Dehydrogenase - genetics | Pyruvate Dehydrogenase Complex Deficiency Disease - pathology | Dihydrolipoamide Dehydrogenase - metabolism | Lymphocytes - enzymology | Heterozygote | Mutation | Amino Acid Substitution | Neurodegenerative Diseases - enzymology | Thiols
Journal Article