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British Journal of Haematology, ISSN 0007-1048, 11/2009, Volume 147, Issue 3, pp. 275 - 275
Journal Article
The New England Journal of Medicine, ISSN 0028-4793, 09/2019, Volume 381, Issue 10, pp. 933 - 944
In this study, approximately half the patients with red-cell pyruvate kinase deficiency who were treated with mitapivat had an improvement in their hemoglobin... 
Anemia, Hemolytic, Congenital Nonspherocytic/blood | Pyruvate Metabolism, Inborn Errors/blood | Clinical Trial, Phase II | Drug Administration Schedule | Follow-Up Studies | Administration, Oral | Humans | Catechols | Male | Sleep Initiation and Maintenance Disorders/chemically induced | Journal Article | Young Adult | Pyruvate Kinase/blood | Research Support, Non-U.S. Gov't | Adolescent | Headache/chemically induced | Hemoglobins/metabolism | Tyrphostins | Adult | Female | Medicine(all) | Multicenter Study | Mutation | MEDICINE, GENERAL & INTERNAL | BLOOD-CELL | PK DEFICIENCY | RED-CELL DISTORTION | EXTREME HEMOLYSIS | Piperazines - administration & dosage | Pyruvate Metabolism, Inborn Errors - genetics | Pyruvate Metabolism, Inborn Errors - drug therapy | Pyruvate Kinase - blood | Quinolines - administration & dosage | Anemia, Hemolytic, Congenital Nonspherocytic - drug therapy | Sleep Initiation and Maintenance Disorders - chemically induced | Headache - chemically induced | Pyruvate Metabolism, Inborn Errors - blood | Hemoglobins - metabolism | Piperazines - adverse effects | Pyruvate Kinase - deficiency | Anemia, Hemolytic, Congenital Nonspherocytic - blood | Pyruvate Kinase - genetics | Quinolines - adverse effects | Anemia, Hemolytic, Congenital Nonspherocytic - genetics | Treatment outcome | Usage | Safety and security measures | Pyruvate kinase deficiency | Analysis | Hemoglobin | Drug therapy | Health aspects | Glycolytic enzymes | Headache | Pyruvate kinase | Anemia | Pyruvic acid | Glucose | Kinases | Investigations | Sleep disorders | Allosteric properties | Hemolytic anemia | Pharyngitis
Journal Article
Nature (London), ISSN 1476-4687, 2018, Volume 565, Issue 7737, pp. 96 - 100
Endothelial nitric oxide synthase (eNOS) is protective against kidney injury, but the molecular mechanisms of this protection are poorly understood(1,2).... 
GLYCOLYSIS | INHIBITION | MULTIDISCIPLINARY SCIENCES | PYRUVATE-KINASE M2 | REPERFUSION INJURY | NITRIC-OXIDE | ISOFORM | PATHOLOGY | PROMOTES | NITROSYLATION | REVEALS | Metabolic Engineering | Aldehyde Reductase - genetics | Humans | Protein Multimerization | Male | HEK293 Cells | Aldehyde Reductase - metabolism | Female | Kidney Tubules, Proximal - enzymology | Nitric Oxide Synthase Type III - metabolism | Cell Line | Aldehyde Reductase - deficiency | Oxidation-Reduction | Oxidoreductases - metabolism | Pyruvate Kinase - metabolism | Acute Kidney Injury - enzymology | Coenzyme A - metabolism | Acute Kidney Injury - prevention & control | Pyruvate Kinase - deficiency | Pyruvate Kinase - antagonists & inhibitors | Animals | Glycolysis | Mice | Mutation | Pentose Phosphate Pathway | Pyruvate Kinase - genetics | Physiological aspects | Care and treatment | Nitrosoamines | Acute renal failure | Phosphates | Glucose metabolism | Nitric oxide | Resveratrol | Mass spectrometry | Sugars | Monosaccharides | Endothelium | Baking yeast | Homology | Pyruvic acid | Cardiovascular disease | Proximal tubules | Gene deletion | Kinases | Proteins | Clonal deletion | Pentose | Physiology | Pentose phosphate | Enzymes | Kidneys | Pyruvate kinase | Tubules | Mass spectroscopy | Metabolism | Mammals | Biological activity | Nitric-oxide synthase | Injury prevention | Molecular modelling | Protein S | Scientific imaging | Conjugation | Reductase
Journal Article
Journal Article
Nature (London), ISSN 1476-4687, 2019, Volume 566, Issue 7743, pp. 279 - 283
Adaptation to the environment and extraction of energy are essential for survival. Some species have found niches and specialized in using a particular source... 
INSULIN | THERMOGENESIS | PYRUVATE-DEHYDROGENASE KINASE | LACTATE PRODUCTION | METABOLISM | GLUCOSE | MULTIDISCIPLINARY SCIENCES | IN-VIVO | DIFFERENTIATION | CELL | ADIPOSE-TISSUE | Mitochondria - enzymology | Phosphorylation | Humans | Male | Muscle Fibers, Skeletal - metabolism | Forkhead Transcription Factors - metabolism | Lactic Acid - biosynthesis | Pyruvate Dehydrogenase (Lipoamide)-Phosphatase - metabolism | Pyruvic Acid - metabolism | Female | Forkhead Transcription Factors - deficiency | Protein-Serine-Threonine Kinases - metabolism | Pyruvate Dehydrogenase Complex - metabolism | Aerobiosis | Oxidation-Reduction | Lactic Acid - metabolism | Mice, Inbred C57BL | Cells, Cultured | Mitochondria - metabolism | Forkhead Transcription Factors - genetics | Animals | Pyruvate Dehydrogenase Complex - chemistry | Glycolysis | Mice | 3T3 Cells | Health aspects | Transcription factors | Regulators | Dehydrogenases | Pyruvic acid | Genomes | Adipocytes | Glucose | Kinases | Dehydrogenase | Experiments | Mitochondria | Bioenergetics | Forkhead protein | Nutrients | Oxidation | Catalysis | Bioinformatics | Phosphofructokinase | Adaptation | Enzymes | Phenotypes | Starvation | Pyruvate kinase | Pyruvate dehydrogenase (lipoamide) | Lactate dehydrogenase | Metabolism | Gene expression | Hexokinase | L-Lactate dehydrogenase | Substrates | Musculoskeletal system | Thermogenesis | In vivo methods and tests | Lactic acid | Niches | Other Basic Medicine | Biokemi och molekylärbiologi | Cell and Molecular Biology | Annan medicinsk grundvetenskap | Biochemistry and Molecular Biology | Cellbiologi | Cell- och molekylärbiologi | Cell Biology
Journal Article
Science (American Association for the Advancement of Science), ISSN 1095-9203, 2011, Volume 334, Issue 6060, pp. 1278 - 1283
Control of intracellular reactive oxygen species (ROS) concentrations is critical for cancer cell survival. We show that, in human lung cancer cells, acute... 
Antioxidants | Oxidative stress | Medical research | Cellular metabolism | REPORTS | Erythrocytes | Cell lines | Antibodies | Oxidation | Cell membranes | Hemoglobins | CELLS | OXIDATIVE STRESS | PROTEIN | METABOLISM | MULTIDISCIPLINARY SCIENCES | ROS | TUMOR-SUPPRESSOR | ISOFORM | CANCER | Enzyme Activators - pharmacology | Neoplasm Transplantation | Protein Subunits | Reactive Oxygen Species - metabolism | Oxidative Stress | Glutathione - metabolism | Antioxidants - metabolism | Humans | Pyruvate Kinase - chemistry | Diamide - pharmacology | Transplantation, Heterologous | Neoplasms, Experimental - pathology | Mutant Proteins - antagonists & inhibitors | Cell Line | Oxidation-Reduction | Pyruvate Kinase - metabolism | Cell Survival | Mutant Proteins - genetics | Mutant Proteins - metabolism | Cysteine - chemistry | Pyruvate Kinase - antagonists & inhibitors | Animals | Mice, Nude | Mutant Proteins - chemistry | Acetylcysteine - pharmacology | Cell Line, Tumor | Glucose - metabolism | Mice | Neoplasms, Experimental - metabolism | Pentose Phosphate Pathway | Pyruvate Kinase - genetics | Amino Acid Substitution | Reactive oxygen species | Enzyme inhibitors | Pyruvate kinase | Lung cancer | Cancer cells | Physiological aspects | Oxidation-reduction reaction | Research | Health aspects | Enzymes | Biochemistry | Cellular biology | Kinases
Journal Article
Biotechnology and bioengineering, ISSN 1097-0290, 2018, Volume 115, Issue 9, pp. 2315 - 2327
Lactate is one of the key waste metabolites of mammalian cell culture. High lactate levels are caused by high aerobic glycolysis, also known as the Warburg... 
fed batch | lactate | monoclonal antibody | pyruvate dehydrogenase kinase | Chinese hamster ovary cells | Warburg effect | LACTATE-DEHYDROGENASE | ALLOSTERIC REGULATION | FED-BATCH | DICHLOROACETATE | MAMMALIAN-CELLS | PYRUVATE-DEHYDROGENASE | FLUX ANALYSIS | SKELETAL-MUSCLE 6-PHOSPHOFRUCTO-1-KINASE | METABOLISM | HAMSTER OVARY CELLS | BIOTECHNOLOGY & APPLIED MICROBIOLOGY | Pyruvate Dehydrogenase Complex - metabolism | Pyruvates - metabolism | Recombinant Proteins - metabolism | Aerobiosis | Antibodies - metabolism | Cricetulus | Cell Survival | Technology, Pharmaceutical - methods | Recombinant Proteins - genetics | Metabolic Flux Analysis | Cell Culture Techniques - methods | Acetyl Coenzyme A - metabolism | Animals | Lactates - metabolism | Bioreactors | Biological Products - metabolism | Glycolysis | Antibodies - genetics | Culture Media - chemistry | CHO Cells | Lactates | Glucose metabolism | Enzymes | Production management | Analysis | Monoclonal antibodies | Cells | Tricarboxylic acid cycle | Cell culture | Dichloroacetic acid | Media (culture) | Dehydrogenases | Pyruvic acid | Glucose | Kinases | Dehydrogenase | Cell density | Proteins | Metabolic flux | Metabolites | Fed batch | Coenzyme A | Productivity | Pyruvate dehydrogenase (lipoamide) | Glycosylation | Fluxes | Sodium chloride | Feeding | Sodium lactate | Sodium | Proteomics | Lactic acid
Journal Article