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Journal of the American Academy of Dermatology, ISSN 0190-9622, 08/2019, Volume 81, Issue 2, pp. 313 - 324
Journal Article
Journal Article
Scientific Reports, ISSN 2045-2322, 2015, Volume 5, Issue 1, pp. 7762 - 7762
Journal Article
PLoS ONE, ISSN 1932-6203, 05/2014, Volume 9, Issue 5, p. e98032
Severe influenza is characterized by cytokine storm and multiorgan failure with metabolic energy disorders and vascular hyperpermeability. In the regulation of... 
A VIRUS | RAT LUNGS | PROTEIN-KINASE | INFLAMMATION | MULTIDISCIPLINARY SCIENCES | GENE-EXPRESSION | TRYPSIN-I | PROLIFERATOR-ACTIVATED RECEPTOR | IDENTIFICATION | BLOOD-BRAIN-BARRIER | CARNITINE PALMITOYLTRANSFERASE-II | Protein Kinases - metabolism | Metabolic Diseases - enzymology | Orthomyxoviridae Infections - complications | Metabolic Diseases - drug therapy | Orthomyxoviridae Infections - enzymology | Pyruvic Acid - metabolism | Female | Phosphorylation - drug effects | Real-Time Polymerase Chain Reaction | Enzyme-Linked Immunosorbent Assay | Oxidation-Reduction | Mice, Inbred C57BL | Quaternary Ammonium Compounds - therapeutic use | RNA, Messenger - genetics | Influenza A Virus, H1N1 Subtype - pathogenicity | Reverse Transcriptase Polymerase Chain Reaction | Blotting, Western | Animals | Metabolic Diseases - etiology | Protein Kinase Inhibitors - therapeutic use | Multiple Organ Failure - etiology | Lipid Metabolism - drug effects | Multiple Organ Failure - enzymology | Glucose - metabolism | Mice | Orthomyxoviridae Infections - virology | Multiple Organ Failure - drug therapy | Glucose metabolism | Synthesis | Cytokines | Influenza | Liver | Physiological aspects | Muscles | Glucose | Health aspects | Fatty acids | Dextrose | Heart | Tricarboxylic acid cycle | Regulations | Energy metabolism | Dichloroacetic acid | Dehydrogenases | Disorders | Dehydrogenase | Lipid metabolism | Failure | Enzymes | Pathogens | Gene expression | Metabolism | Energy balance | Chemistry | Inhibitors | Metabolic disorders | Homeostasis | Pyruvic acid | Viruses | Lipids | Infections | Kinases | Metabolites | Rodents | Influenza A | Tumor necrosis factor-TNF | Edema | Research & development--R&D | Oral administration | Organs | Pharmacology | Chemical compounds | Skeletal muscle | Trypsin | Brain research | Lungs | Decarboxylation | Glycolysis | Diabetes | Laboratory animals | ATP | Research & development | R&D
Journal Article
Molecular Nutrition & Food Research, ISSN 1613-4125, 11/2017, Volume 61, Issue 11, pp. 1700466 - n/a
It is difficult for polysaccharides to be directly absorbed through the intestine, which implies other utilization mechanisms involved in the bioactivity... 
Immunomodulatory activities | Intestinal microbiome | Short‐chain fatty acid | Multi‐omics | Longan polysaccharide | Short-chain fatty acid | Multi-omics | FOOD SCIENCE & TECHNOLOGY | GUT | HEALTH | Metabolomics | Intestinal Mucosa - metabolism | Immunity, Mucosal | Male | Dysbiosis - microbiology | Fatty Acids, Volatile - metabolism | Dysbiosis - immunology | Feces - microbiology | Intestinal Mucosa - immunology | Malpighiaceae - growth & development | China | Biomarkers - metabolism | Polysaccharides - therapeutic use | Malpighiaceae - chemistry | Fruit - chemistry | Immunomodulation | Mice, Inbred C57BL | Computational Biology | Intestinal Mucosa - microbiology | Random Allocation | Fermentation | Prebiotics | Fruit - growth & development | Ethnopharmacology | Animals | Feces - chemistry | Dysbiosis - pathology | Gastrointestinal Microbiome - immunology | Dysbiosis - prevention & control | Medicine, Traditional | Plant Extracts - therapeutic use | Intestinal Mucosa - pathology | Polysaccharides | Metabolites | Microbiota (Symbiotic organisms) | Analysis | Acetic acid | Saturated fatty acids | Fructose | Organic acids | Immune response | Taxonomy | Propionic acid | Pyruvic acid | Longan | Mannose | Immunity | Fatty acids | Biological activity | Butyric acid | Microorganisms | Intestine | Network analysis | Succinic acid | Intestinal microflora | Saccharides | Immune system
Journal Article
PLoS ONE, ISSN 1932-6203, 07/2017, Volume 12, Issue 7, pp. e0182166 - e0182166
Pyruvate kinase M2 (PKM2) regulates glycolysis and oxidative phosphorylation; however, the role of PKM2 in ovarian cancer remains largely unknown. We... 
APOPTOSIS | SHIKONIN | ENERGY | METABOLISM | STATISTICS | MULTIDISCIPLINARY SCIENCES | ISOFORM | ANTITUMOR-ACTIVITY | TUMOR-GROWTH | CELL | DERIVATIVES | Immunohistochemistry | Prognosis | Tissue Array Analysis | Humans | Ovarian Neoplasms - pathology | Positron-Emission Tomography | Female | Ovarian Neoplasms - drug therapy | Cell Survival - drug effects | Pyruvate Kinase - metabolism | Ovarian Neoplasms - diagnosis | Lactic Acid - metabolism | Biomarkers - analysis | Enzyme Inhibitors - pharmacology | Naphthoquinones - therapeutic use | Naphthoquinones - pharmacology | Mice, SCID | Enzyme Inhibitors - therapeutic use | Ovarian Neoplasms - enzymology | Xenograft Model Antitumor Assays | Disease-Free Survival | Pyruvate Kinase - antagonists & inhibitors | Animals | Cell Line, Tumor | Glucose - metabolism | Genetic aspects | Research | Pyruvate kinase | Ovarian cancer | Phosphorylation | Ovarian carcinoma | Laboratories | Toxicity | Pathogenesis | Physicians | Clinical trials | Acidification | Pyruvic acid | Malignancy | Multivariate analysis | Kinases | Confidence intervals | Shikonin | Xenografts | Cell cycle | Inhibition | Enzymes | Medical research | Adenosine | Gynecology | Oxygen consumption | Breast cancer | Metabolism | Patients | Obstetrics | Medicine | Studies | Hospitals | Inhibitors | Oxidative phosphorylation | Stem cells | Epigenetics | Glycolysis | Cell migration | Cancer | Apoptosis | Index Medicus
Journal Article
Journal Article
PLoS ONE, ISSN 1932-6203, 04/2014, Volume 9, Issue 4, pp. e94079 - e94079
Shikonin, a small-molecule natural product which inhibits the activity of pyruvate kinase M2 (PKM2), has been studied as an anti-cancer drug candidate in human... 
TRANSFORMATION | IN-VITRO | INHIBITION | PYRUVATE-KINASE | PHOSPHORYLATION | MULTIDISCIPLINARY SCIENCES | TRANSCRIPTION | INDUCTION | NF-KAPPA-B | AP-1 | PACLITAXEL | Adenocarcinoma - pathology | Paclitaxel - pharmacology | Apoptosis - drug effects | Humans | Naphthoquinones - therapeutic use | Naphthoquinones - pharmacology | Antineoplastic Agents - therapeutic use | Adenocarcinoma - drug therapy | Breast Neoplasms - drug therapy | Paclitaxel - therapeutic use | Animals | Drug Interactions | Heterografts | Breast Neoplasms - pathology | Mice, Nude | Cell Line, Tumor | Female | Antineoplastic Agents - pharmacology | Mice | Antineoplastic Agents, Phytogenic - pharmacology | Antineoplastic Agents, Phytogenic - therapeutic use | Drug Therapy, Combination | Chemotherapy | Analysis | Cancer cells | Development and progression | Breast cancer | Drug therapy | Health aspects | Apoptosis | Cancer | Adenocarcinoma | Health sciences | Neurosciences | Phosphorylation | Target recognition | Toxicity | Cytotoxicity | Pyruvic acid | AKT protein | Kinases | Drug resistance | Cancer therapies | Proteins | Toxicology | Shikonin | Cell cycle | Paclitaxel | Xenografts | Biocompatibility | Sensitizing | Pyruvate kinase | Taxol | Extracellular signal-regulated kinase | Pharmacology | Metabolism | Ribosomal protein S6 kinase | Index Medicus | Breast
Journal Article