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1. Full Text Common variants at ten loci influence QT interval duration in the QTGEN Study
by Newton-Cheh, Christopher and Kors, Jan A and de Bakker, Paul I W and Witteman, Jacqueline C M and Estrada, Karol and Heckbert, Susan R and Uitterlinden, André G and Smith, Nicholas L and Eijgelsheim, Mark and Lumley, Thomas and Ch Stricker, Bruno H and O'Donnell, Christopher J and Rice, Kenneth M and Sotoodehnia, Nona and Larson, Martin G and Yin, Xiaoyan and Noseworthy, Peter A and Bis, Joshua C and Hofman, Albert and Marciante, Kristin and Rotter, Jerome I and Rivadeneira, Fernando and Psaty, Bruce M
Nature Genetics, ISSN 1061-4036, 04/2009, Volume 41, Issue 4, pp. 399 - 406
QT interval duration, reflecting myocardial repolarization on the electrocardiogram, is a heritable risk factor for sudden cardiac death and drug-induced... 
HEART | FRAMINGHAM | KCNH2 | NOS1 REGULATOR NOS1AP | GENETICS & HEREDITY | SUDDEN CARDIAC DEATH | SCN5A | POLYMORPHISM | PHOSPHOLAMBAN GENE | GENOME-WIDE ASSOCIATION | REPOLARIZATION | European Continental Ancestry Group - genetics | Genetic Predisposition to Disease - genetics | Meta-Analysis as Topic | Arrhythmias, Cardiac - chemically induced | KCNQ1 Potassium Channel - genetics | Humans | Risk Factors | Chromosome Mapping | Electroencephalography | ERG1 Potassium Channel | Ether-A-Go-Go Potassium Channels - genetics | Death, Sudden, Cardiac | Genetic Variation | Muscle Proteins - genetics | Adaptor Proteins, Signal Transducing - genetics | Polymorphism, Single Nucleotide - genetics | Adult | Aged | Sodium Channels - genetics | Genome, Human | Arrhythmias, Cardiac - genetics | NAV1.5 Voltage-Gated Sodium Channel | Potassium Channels, Voltage-Gated - genetics | Complications and side effects | Genetic variation | Cardiac arrest | Long QT syndrome | Genetic aspects | Research | Risk factors | Studies | Confidence intervals | Cardiac arrhythmia | Technological change | Quality control | Data base management | Kidney diseases | Neurological disorders | Family physicians | Index Medicus
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2. Full Text Common variants at ten loci modulate the QT interval duration in the QTSCD Study
by Najjar, Samer S and Fuchsberger, Christian and Pütz, Benno and Perz, Siegfried and Crisponi, Laura and Steinbeck, Gerhard and Ehret, Georg B and Hicks, Andrew A and Sinner, Moritz F and Orrú, Marco and Köttgen, Anna and Marroni, Fabio and Müller, Martina and Usala, Gianluca and Kao, W H Linda and Pramstaller, Peter P and Kääb, Stefan and Gieger, Christian and Li, Man and Scuteri, Angelo and Uda, Manuela and Barbalic, Maja and Gateva, Vesela and Pattaro, Cristian and Erbel, Raimund and Sanna, Serena and Möhlenkamp, Stefan and Dei, Mariano and Wichmann, H-Erich and Meitinger, Thomas and Chakravarti, Aravinda and Abecasis, Gonçalo R and Lakatta, Edward and Schlessinger, David and Pfeufer, Arne and Jöckel, Karl-Heinz and Müller-Myhsok, Bertram and Boerwinkle, Eric and Arking, Dan E and Prineas, Ronald J and Mühleisen, Thomas W and Naitza, Silvia and Coresh, Josef and Happle, Christine
Nature Genetics, ISSN 1061-4036, 04/2009, Volume 41, Issue 4, pp. 407 - 414
The QT interval, a measure of cardiac repolarization, predisposes to ventricular arrhythmias and sudden cardiac death ( SCD) when prolonged or shortened. A... 
HEALTHY POPULATION | NOS1 REGULATOR NOS1AP | HEART-FAILURE | DISEASE | MUTATION | GENETICS & HEREDITY | SUDDEN CARDIAC DEATH | RISK | GENETIC VARIANT | ASSOCIATION | REPOLARIZATION | Heart - physiopathology | Reproducibility of Results | KCNQ1 Potassium Channel - genetics | Heart - physiology | Humans | Ion Channels - genetics | Potassium Channels, Inwardly Rectifying - genetics | Chromosome Mapping | ERG1 Potassium Channel | Ether-A-Go-Go Potassium Channels - genetics | Genetic Variation | Muscle Proteins - genetics | Electrophysiology - methods | Electrocardiography | Long QT Syndrome - genetics | Sodium Channels - genetics | Arrhythmias, Cardiac - genetics | NAV1.5 Voltage-Gated Sodium Channel | Complications and side effects | Genetic variation | Cardiac arrest | Long QT syndrome | Genetic aspects | Research | Risk factors | Studies | Cardiac arrhythmia | Data analysis | Genes | Nitric oxide | Aging | Standard deviation | Gene loci | Medical ethics | Index Medicus
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3. Full Text Polymorphisms in the NOS1AP Gene Modulate QT Interval Duration and Risk of Arrhythmias in the Long QT Syndrome
by Tomás, Marta, PhD and Napolitano, Carlo, MD, PhD and De Giuli, Luciana, PhD and Bloise, Raffaella, MD and Subirana, Isaac, MS and Malovini, Alberto, MS and Bellazzi, Riccardo, PhD and Arking, Dan E., PhD and Marban, Eduardo, MD, PhD and Chakravarti, Aravinda, PhD and Spooner, Peter M., PhD and Priori, Silvia G., MD, PhD
JACC (Journal of the American College of Cardiology), ISSN 0735-1097, 2010, Volume 55, Issue 24, pp. 2745 - 2752
Objectives We investigated the role of nitric oxide 1 adaptor protein ( NOS1AP ) as a genetic modifier of long QT syndrome (LQTS). Background LQTS risk... 
Cardiovascular | Internal Medicine | genetics | risk stratification | long QT syndrome | single nucleotide polymorphisms | cardiac arrhythmias | POPULATION | CARDIAC & CARDIOVASCULAR SYSTEMS | VARIANTS | REGULATOR NOS1AP | NITRIC-OXIDE SYNTHASE | REPOLARIZATION | HEART | COMMON POLYMORPHISM | SUDDEN CARDIAC DEATH | ASSOCIATION | CAPON | Genetic Predisposition to Disease | Prognosis | Prospective Studies | Follow-Up Studies | Long QT Syndrome - epidemiology | Humans | Risk Factors | Genotype | Male | Incidence | Long QT Syndrome - physiopathology | Polymorphism, Genetic | DNA - genetics | Time Factors | Adaptor Proteins, Signal Transducing - genetics | Polymerase Chain Reaction | Electrocardiography | Long QT Syndrome - genetics | Adult | Female | Heart | Haplotypes | Cardiac arrhythmia | Heart attacks | Biomedical research | Genes | Studies | Heart rate | Nitric oxide | Long QT syndrome | Mutation | Deoxyribonucleic acid--DNA | Index Medicus | Abridged Index Medicus
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4. Full Text Common genetic variation in KCNH2 is associated with QT interval duration: The Framingham heart study
by Newton-Cheh, Christopher and Guo, Chao-Yu and Larson, Martin G and Musone, Stacy L and Surti, Aarti and Camargo, Amy L and Drake, Jared A and Benjamin, Emelia J and Levy, Daniel and D'Agostino Sr, Ralph B and Hirschhorn, Joel N and O'Donnell, Christopher J
Circulation, ISSN 0009-7322, 09/2007, Volume 116, Issue 10, pp. 1128 - 1136
Background-QT prolongation is associated with increased risk of sudden cardiac death in the general population and in people exposed to QT-prolonging drugs.... 
Electrocardiography | Genetics | Ion channels | Long-QT syndrome | Arrhythmia | CARDIAC & CARDIOVASCULAR SYSTEMS | FUNCTIONAL-CHARACTERIZATION | PROLONGATION | POLYMORPHISM | ion channels | long-QT syndrome | electrocardiography | genetics | HEALTHY POPULATION | HERG | RISK-FACTOR | EXONIC SPLICING ENHANCERS | arrhythmia | DISEASE | SUDDEN CARDIAC DEATH | CARDIOVASCULAR MORTALITY | PERIPHERAL VASCULAR DISEASE | HEMATOLOGY | Prospective Studies | Humans | Middle Aged | Molecular Sequence Data | Male | ERG1 Potassium Channel | Ether-A-Go-Go Potassium Channels - genetics | Haplotypes - genetics | Base Sequence | Long QT Syndrome - genetics | Adult | Female | Polymorphism, Genetic - genetics | Genetic Variation - genetics | Genetic Linkage - genetics | Gene mutations | Cardiac arrest | Long QT syndrome | Causes of | Physiological aspects | Genetic aspects | Research | Risk factors | Index Medicus | Abridged Index Medicus
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5. Full Text QT interval variability index and QT interval duration during different sleep stages in patients with obstructive sleep apnea
by Viigimae, Moonika and Karai, Deniss and Pilt, Kristjan and Pirn, Peeter and Huhtala, Heini and Polo, Olli and Meigas, Kalju and Kaik, Jyri
Sleep Medicine, ISSN 1389-9457, 09/2017, Volume 37, pp. 160 - 167
The aim of the study was to investigate the impact of obstructive sleep apnea (OSA) on the QT interval variability and duration in patients during different... 
Heart rate-corrected QT interval | QT interval variability | QT interval variability index | Obstructive sleep apnea | MORTALITY | CARDIOMYOPATHY | RISK | RANDOMIZED CONTROLLED-TRIAL | CLINICAL NEUROLOGY | SUDDEN CARDIAC DEATH | PRESSURE THERAPY WITHDRAWAL | REPOLARIZATION LABILITY | HEART-RATE | HYPERTENSION | AUTONOMIC NERVOUS-SYSTEM | Cardiovascular Physiological Phenomena | Sleep Apnea, Obstructive - physiopathology | Humans | Middle Aged | Male | Polysomnography | Young Adult | Time Factors | Sex Factors | Electrocardiography | Sleep Stages - physiology | Adult | Female | Aged | Care and treatment | Sleep apnea syndromes | Heart beat | Analysis | Index Medicus
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6. Full Text Sex-Steroid Hormones and Electrocardiographic QT-Interval Duration: Findings From the Third National Health and Nutrition Examination Survey and the Multi-Ethnic Study of Atherosclerosis
by Zhang, Yiyi and Ouyang, Pamela and Post, Wendy S and Dalal, Darshan and Vaidya, Dhananjay and Blasco-Colmenares, Elena and Soliman, Elsayed Z and Tomaselli, Gordon F and Guallar, Eliseo
American Journal of Epidemiology, ISSN 0002-9262, 2011, Volume 174, Issue 4, pp. 403 - 411
The association between physiologic levels of sex hormones and QT-interval duration in humans was evaluated using data from 727 men enrolled in the Third... 
Electrocardiography | gonadal sex hormones | testosterone | estradiol | MENSTRUAL-CYCLE | DE-POINTES | POTASSIUM CURRENTS | CARDIAC REPOLARIZATION | PROLONGATION | electrocardiography | VENTRICULAR REPOLARIZATION | PUBLIC, ENVIRONMENTAL & OCCUPATIONAL HEALTH | REPLACEMENT THERAPY | ESTROGEN | POSTMENOPAUSAL WOMEN | United States - epidemiology | Cross-Sectional Studies | Nutrition Surveys | Long QT Syndrome - epidemiology | Humans | Middle Aged | Male | Atherosclerosis - ethnology | Gonadal Steroid Hormones - blood | Atherosclerosis - epidemiology | Atherosclerosis - blood | Long QT Syndrome - ethnology | Health Surveys | Radioimmunoassay | Postmenopause | Female | Aged | Testosterone - blood | Long QT Syndrome - blood | Electrocardiogram | Atherosclerosis | Physiological aspects | Development and progression | Hormones, Sex | Research | Health aspects | Health surveys | Steroid hormones | Heart rate | Testosterone | Mens health | Medical research | Index Medicus | Original Contributions
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7. Full Text NOS1AP Polymorphisms Modify QTc Interval Duration But Not Cardiac Arrest Risk in Hypertrophic Cardiomyopathy
by EARLE, NIKKI and INGLES, JODIE and BAGNALL, RICHARD D and GRAY, BELINDA and CRAWFORD, JACKIE and SMITH, WARREN and SHELLING, ANDREW N and LOVE, DONALD R and SEMSARIAN, CHRIS and SKINNER, JONATHAN R
Journal of Cardiovascular Electrophysiology, ISSN 1045-3873, 12/2015, Volume 26, Issue 12, pp. 1346 - 1351
Arrhythmic SNPs and Risk of Cardiac Arrest in HCM IntroductionThe accurate prediction of the risk of sudden cardiac death (SCD) in hypertrophic cardiomyopathy... 
QTc interval | sudden death | hypertrophic cardiomyopathy | single nucleotide polymorphisms | DIAGNOSIS | CARDIAC & CARDIOVASCULAR SYSTEMS | PROTEIN | CARDIOLOGY | SUDDEN-DEATH | GUIDELINES | SOCIETY | REPOLARIZATION | TASK-FORCE | GENETIC-VARIATIONS | ASSOCIATION | Cardiomyopathy, Hypertrophic - genetics | Long QT Syndrome - epidemiology | Humans | Middle Aged | Heart Arrest - epidemiology | Heart Arrest - genetics | Male | Risk | Treatment Outcome | Death, Sudden, Cardiac | Long QT Syndrome - physiopathology | DNA - genetics | Cardiomyopathy, Hypertrophic - physiopathology | Defibrillators, Implantable | Adaptor Proteins, Signal Transducing - genetics | Electrocardiography | Heart Arrest - etiology | Long QT Syndrome - genetics | Female | Aged | Polymorphism, Single Nucleotide | Cardiomyopathy, Hypertrophic - epidemiology | Cohort Studies | New Zealand - epidemiology | Heart | Cardiomyopathy, Hypertrophic | Implants, Artificial | Prosthesis | Cardiac arrest | Genetic aspects | Single nucleotide polymorphisms | Chromosomes | Risk factors | Confidence intervals | Cardiac arrhythmia | Heart attacks | Defibrillators | Multivariate analysis | Cardiomyopathy | Index Medicus
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8. Full Text Facilitating assessment of QT interval duration during ventricular pacing
by Chiladakis, John A and Kalogeropoulos, Andreas and Zagkli, Fani and Koutsogiannis, Nikolaos and Chouchoulis, Konstantinos and Alexopoulos, Dimitrios
Europace, ISSN 1099-5129, 06/2013, Volume 15, Issue 6, pp. 907 - 914
We aimed to facilitate the assessment of the QT interval duration during conventional right ventricular pacing (VP) by uncovering relationships with the... 
Ventricular pacing | QT interval | GENERAL-POPULATION | CARDIAC & CARDIOVASCULAR SYSTEMS | MEN | PROLONGATION | HEART-RATE | Long QT Syndrome - prevention & control | Reproducibility of Results | Prevalence | Risk Assessment | Long QT Syndrome - epidemiology | Humans | Middle Aged | Cardiac Resynchronization Therapy - statistics & numerical data | Male | Treatment Outcome | Greece - epidemiology | Electrocardiography - statistics & numerical data | Long QT Syndrome - diagnosis | Sensitivity and Specificity | Diagnosis, Computer-Assisted - methods | Diagnosis, Computer-Assisted - trends | Aged, 80 and over | Adult | Female | Aged | Electrocardiography - methods | Index Medicus
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9. Full Text Invited Commentary: Sex-Steroid Hormones and QT-Interval Duration
by van Noord, Charlotte and Rodenburg, Eline M and Stricker, Bruno H. C
American Journal of Epidemiology, ISSN 0002-9262, 2011, Volume 174, Issue 4, pp. 412 - 415
In this issue of the Journal, Zhang et al. (Am J Epidemiol. 2011;174(4):403-411) make a substantial contribution to research in the area of hormonal influences... 
long QT syndrome | testosterone | Gonadal steroid hormones | TORSADES-DE-POINTES | POTASSIUM CHANNELS | HEART-FAILURE | PROLONGATION | VENTRICULAR REPOLARIZATION | CARDIOVASCULAR DRUGS | FEMALE GENDER | PUBLIC, ENVIRONMENTAL & OCCUPATIONAL HEALTH | RISK-FACTOR | SUDDEN CARDIAC DEATH | gonadal steroid hormones | Arrhythmias, Cardiac - epidemiology | United States - epidemiology | Nutrition Surveys | Long QT Syndrome - epidemiology | Death, Sudden, Cardiac - epidemiology | Humans | Risk Factors | Arrhythmias, Cardiac - ethnology | Male | Atherosclerosis - ethnology | Gonadal Steroid Hormones - blood | Atherosclerosis - epidemiology | Atherosclerosis - blood | Long QT Syndrome - ethnology | Health Surveys | Sex Factors | Electrocardiography | Postmenopause | Female | Arrhythmias, Cardiac - blood | Testosterone - blood | Long QT Syndrome - blood | Death, Sudden, Cardiac - ethnology | Physiological aspects | Development and progression | Hormones, Sex | Health aspects | Steroid hormones | Atherosclerosis | Long QT syndrome | Testosterone | Mens health | Cardiac arrhythmia | Index Medicus
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10. Full Text Clinical Correlates and Heritability of QT Interval Duration in Blacks: The Jackson Heart Study
by Akylbekova, Ermeg L and Crow, Richard S and Johnson, William D and Buxbaum, Sarah G and Njemanze, Stephanie and Fox, Ervin and Sarpong, Daniel F and Taylor, Herman A and Newton-Cheh, Christopher
Circulation: Arrhythmia and Electrophysiology, ISSN 1941-3149, 08/2009, Volume 2, Issue 4, pp. 427 - 432
BACKGROUND—Electrocardiographic QT interval prolongation is a risk factor for sudden cardiac death and drug-induced arrhythmia. The clinical correlates and... 
QT interval | Genetics | Jackson heart study | Heritability | Jackson Heart Study | UNITED-STATES | CORRECTED QT | CARDIAC & CARDIOVASCULAR SYSTEMS | QUANTITATIVE-TRAIT | DISEASE MORTALITY | FAMILY-HISTORY | LEFT-VENTRICULAR HYPERTROPHY | heritability | GENERAL-POPULATION | genetics | SUDDEN CARDIAC DEATH | LINKAGE ANALYSIS | AFRICAN-AMERICANS | Multivariate Analysis | Heart Failure - ethnology | Prevalence | Humans | Middle Aged | Mississippi - epidemiology | Risk Factors | Linear Models | Male | African Continental Ancestry Group - statistics & numerical data | Long QT Syndrome - ethnology | Aged, 80 and over | Long QT Syndrome - genetics | Adult | Female | Genetic Predisposition to Disease - ethnology | Aged | African Continental Ancestry Group - genetics | Death, Sudden, Cardiac - ethnology | Index Medicus
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11. Full Text Genetically predicted testosterone and electrocardiographic QT interval duration in Chinese: A Mendelian randomization analysis in the Guangzhou Biobank Cohort Study
by Zhao, Jie and Jiang, Chaoqiang and Lam, Tai Hing and Liu, Bin and Cheng, Kar Keung and Xu, Lin and Long, Mei Jing and Zhang, Weisen and Leung, Gabriel M and Schooling, C.Mary
International Journal of Epidemiology, ISSN 0300-5771, 05/2015, Volume 44, Issue 2, pp. 613 - 620
Background QT interval prolongation, a predictor of cardiac arrhythmias, and elevated heart rate are associated with higher risk of cardiovascular mortality.... 
QT interval | Testosterone | Mendelian randomization | PROSTATE | RISK-FACTORS | testosterone | SEX-HORMONES | BLOOD-PRESSURE | OLDER CHINESE | PUBLIC, ENVIRONMENTAL & OCCUPATIONAL HEALTH | THERAPY | MEN | HEART-RATE | SERUM TESTOSTERONE | GENOME-WIDE ASSOCIATION | China - ethnology | Age Distribution | Heart Rate - genetics | Humans | Middle Aged | Male | Testosterone - genetics | Aromatase - genetics | Hong Kong - epidemiology | Mendelian Randomization Analysis | Aged, 80 and over | Electrocardiography | Polymorphism, Single Nucleotide - genetics | Aged | Cohort Studies | Index Medicus
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12. Full Text Identification of a common variant at the NOS1AP locus strongly associated to QT-interval duration
by Eijgelsheim, Mark and Aarnoudse, Adrianus L.H.J and Rivadeneira, Fernando and Kors, Jan A and Witteman, Jacqueline C. M and Hofman, Albert and van Duijn, Cornelia M and Uitterlinden, André G and Stricker, Bruno H.C
Human Molecular Genetics, ISSN 0964-6906, 1/2009, Volume 18, Issue 2, pp. 347 - 357
QT-interval prolongation is an electrophysiologic phenomenon associated with sudden cardiac death. The QT-interval in the general population is ∼35% heritable.... 
TRANSCRIPTION FACTORS | HAPLOTYPE RECONSTRUCTION | HEALTHY POPULATION | RISK-FACTOR | MYOCARDIAL-INFARCTION | SUDDEN-DEATH | BIOCHEMISTRY & MOLECULAR BIOLOGY | GENETICS & HEREDITY | ANTIPSYCHOTIC-DRUGS | WHOLE-GENOME ASSOCIATION | C-MYB | PRIMARY CARDIAC-ARREST | European Continental Ancestry Group - genetics | Genome-Wide Association Study | Prospective Studies | Humans | Middle Aged | Genotype | Male | Long QT Syndrome - physiopathology | Adaptor Proteins, Signal Transducing - genetics | Electrocardiography | Long QT Syndrome - genetics | Female | Aged | Polymorphism, Single Nucleotide | Index Medicus
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