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1. Full Text Quinolinic acid, the inescapable neurotoxin
by Guillemin, Gilles J
FEBS Journal, ISSN 1742-464X, 04/2012, Volume 279, Issue 8, pp. 1356 - 1365
Over the last two decades, evidence for the involvement of quinolinic acid (QUIN) in neuroinflammatory diseases has been exponentially increasing. Within the... 
neurodegeneration | quinolinic acid | kynurenine pathway | neuroinflammation | HUMAN MICROGLIA | OXIDATIVE STRESS | TRYPTOPHAN-METABOLISM | ALZHEIMERS-DISEASE | BIOCHEMISTRY & MOLECULAR BIOLOGY | INDOLEAMINE 2,3-DIOXYGENASE | KYNURENINE PATHWAY ENZYMES | HUMAN ASTROCYTES | INHIBITS GLUTAMATE UPTAKE | RAT-BRAIN | HUNTINGTONS-DISEASE | Neurotoxicity Syndromes - etiology | Quinolinic Acid - adverse effects | Animals | Humans | Neurotoxins - adverse effects | Methyl aspartate | Nervous system diseases | Index Medicus
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2. Full Text Involvement of the kynurenine pathway in human glioma pathophysiology
by Adams, Seray and Teo, Charles and McDonald, Kerrie L and Zinger, Anna and Bustamante, Sonia and Lim, Chai K and Sundaram, Gayathri and Braidy, Nady and Brew, Bruce J and Guillemin, Gilles J
PLoS ONE, ISSN 1932-6203, 10/2014, Volume 9, Issue 11, p. e112945
The kynurenine pathway (KP) is the principal route of L-tryptophan (TRP) catabolism leading to the production of kynurenine (KYN), the neuroprotectants,... 
QUINOLINIC ACID | INHIBITION | METABOLISM | AMINOTRANSFERASE | MULTIDISCIPLINARY SCIENCES | INDOLEAMINE 2,3-DIOXYGENASE | T-CELL | TUMORAL IMMUNE RESISTANCE | TRYPTOPHAN DEGRADATION | IDO EXPRESSION | BRAIN | Immunohistochemistry | Indoleamine-Pyrrole 2,3,-Dioxygenase - genetics | Indoleamine-Pyrrole 2,3,-Dioxygenase - metabolism | Kynurenic Acid - blood | Gene Expression - drug effects | Humans | Kynurenine - biosynthesis | Brain Neoplasms - physiopathology | Picolinic Acids - blood | Quinolinic Acid - blood | Chromatography, High Pressure Liquid | Glial Fibrillary Acidic Protein - metabolism | Kynurenic Acid - metabolism | Carboxy-Lyases - genetics | Tryptophan - metabolism | Brain Neoplasms - metabolism | Picolinic Acids - metabolism | Antigens, CD - metabolism | Glioma - metabolism | Glioma - genetics | Kynurenine - blood | Tryptophan - blood | Carboxy-Lyases - metabolism | Tumor Cells, Cultured | Astrocytes - drug effects | Disaccharides | Cells, Cultured | Brain Neoplasms - genetics | Biosynthetic Pathways | Reverse Transcriptase Polymerase Chain Reaction | Glucuronates | Tryptophan Oxygenase - metabolism | Tryptophan Oxygenase - genetics | Antigens, Differentiation, Myelomonocytic - metabolism | Quinolinic Acid - metabolism | CD11b Antigen - metabolism | Glioma - physiopathology | Interferon-gamma - pharmacology | Astrocytes - metabolism | Tryptophan | Niacinamide | Methyl aspartate | Enzymes | Metabolites | Gliomas | NADPH | Neuroprotection | Brain | Brain tumors | Brain cancer | Glioblastoma | Tryptophan 2,3-dioxygenase | Immunity | DNA repair | Picolinic acid | Rodents | Glioma cells | L-Tryptophan | Kynurenic acid | Quinolinic acid | Deoxyribonucleic acid--DNA | Pyridines | Medical research | Hydroxylase | Adenine | Kynurenine-oxoglutarate transaminase | NAD | Acids | γ-Interferon | Nicotinamide adenine dinucleotide | Catabolism | Nicotinamide | Interferon | Tumors | Deoxyribonucleic acid | DNA
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3. Full Text Ciliary neurotrophic factor protects striatal neurons against excitotoxicity by enhancing glial glutamate uptake
by Beurrier, Corinne and Faideau, Mathilde and Bennouar, Khaled-Ezaheir and Escartin, Carole and Kerkerian-Le Goff, Lydia and Bonvento, Gilles and Gubellini, Paolo
PLoS ONE, ISSN 1932-6203, 01/2010, Volume 5, Issue 1, p. e8550
Ciliary neurotrophic factor (CNTF) is a potent neuroprotective cytokine in different animal models of glutamate-induced excitotoxicity, although its action... 
FACTOR-RECEPTOR | QUINOLINIC ACID | CNTF | IN-VIVO | BIOLOGY | CENTRAL-NERVOUS-SYSTEM | REACTIVE GLIOSIS | GENE-TRANSFER | HUNTINGTONS-DISEASE | RAT MODEL | RAFT MICRODOMAINS | Ciliary Neurotrophic Factor - physiology | Rats | Evoked Potentials - physiology | Corpus Striatum - cytology | Corpus Striatum - metabolism | Evoked Potentials - drug effects | Quinolinic Acid - pharmacology | Amino Acid Transport System X-AG - antagonists & inhibitors | Animals | Corpus Striatum - drug effects | Glutamic Acid - metabolism | Neurons - metabolism | In Vitro Techniques | Neurons - drug effects | Aspartic Acid - pharmacology | Nervous system diseases | Cytokines | Neurons | Amino acids | Ciliary neurotrophic factor | Comparative analysis | Glutamate | Huntingtons disease | Neuroprotection | Animal models | Glutamic acid receptors | Recovery | Neuronal-glial interactions | Overflow | Neurotoxicity | Neurodegeneration | Rodents | Neostriatum | Trends | Quinolinic acid | Excitation | Localization | Enzymes | Dopamine | Neurodegenerative diseases | Medical treatment | Cortex | Data processing | Spiny neurons | Neurological diseases | Brain research | Excitotoxicity | Cocaine | Glutamatergic transmission | Alzheimers disease | Neurons and Cognition | Evoked Potentials | Neurobiology | Amino Acid Transport System X-AG | Aspartic Acid | Quinolinic Acid | Glutamic Acid | Life Sciences | Ciliary Neurotrophic Factor | Corpus Striatum
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4. Full Text Connecting inflammation with glutamate agonism in suicidality
by Erhardt, Sophie and Lim, Chai K and Linderholm, Klas R and Janelidze, Shorena and Lindqvist, Daniel and Samuelsson, Martin and Lundberg, Kristina and Postolache, Teodor T and Träskman-Bendz, Lil and Guillemin, Gilles J and Brundin, Lena and Psykiatri and Närsjukvården i centrala Östergötland and Linköpings universitet and Institutionen för klinisk och experimentell medicin and Östergötlands Läns Landsting and Psykiatriska kliniken and Hälsouniversitetet
Neuropsychopharmacology, ISSN 0893-133X, 04/2013, Volume 38, Issue 5, pp. 743 - 752
The NMDA-receptor antagonist ketamine has proven efficient in reducing symptoms of suicidality, although the mechanisms explaining this effect have not been... 
cytokine | quinolinic acid | depression | glutamate | suicide | PSYCHIATRY | RESISTANT DEPRESSION | ADD-ON TRIAL | D-ASPARTATE ANTAGONIST | NEUROSCIENCES | HIPPOCAMPAL VOLUME | EMERGENCY-DEPARTMENT | DOUBLE-BLIND | PHARMACOLOGY & PHARMACY | CENTRAL-NERVOUS-SYSTEM | KYNURENIC ACID | MAJOR DEPRESSIVE DISORDER | Encephalitis - psychology | Excitatory Amino Acid Agonists - cerebrospinal fluid | Kynurenine - cerebrospinal fluid | Quinolinic Acid - cerebrospinal fluid | Excitatory Amino Acid Agonists - therapeutic use | Follow-Up Studies | Somatosensory Disorders - complications | Spinal Puncture | Humans | Middle Aged | Male | Mental Disorders - complications | Kynurenic Acid - cerebrospinal fluid | Mental Disorders - psychology | Young Adult | Psychiatric Status Rating Scales | Tritium - cerebrospinal fluid | Encephalitis - cerebrospinal fluid | Suicide - psychology | Adult | Female | Aged | Retrospective Studies | Interleukin-6 - metabolism | Brain | Glutamic acid | Glutamic acid receptors (ionotropic) | Depression | Mass spectroscopy | N-Methyl-D-aspartic acid receptors | Glutamic acid receptors | Inflammation | Cerebrospinal fluid | High-performance liquid chromatography | Suicide | Interleukin 6 | Gas chromatography | Ketamine | Glutamatergic transmission | Kynurenic acid | Quinolinic acid | Neurotransmission | Original | Medical and Health Sciences | Medicin och hälsovetenskap | MEDICIN | MEDICINE
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5. Quinolinic acid and the kynurenines
by Stone, Trevor W
1989, ISBN 9780849365928, 307
Kynurenine | Quinolinic acid | Derivatives
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6. Full Text Reduction of kynurenic acid to quinolinic acid ratio in both the depressed and remitted phases of major depressive disorder
by Savitz, Jonathan and Drevets, Wayne C and Wurfel, Brent E and Ford, Bart N and Bellgowan, Patrick S.F and Victor, Teresa A and Bodurka, Jerzy and Teague, T. Kent and Dantzer, Robert
Brain, Behavior, and Immunity, ISSN 0889-1591, 2015, Volume 46, pp. 55 - 59
Highlights • There was no significant difference in CRP and IL-1RA across groups. • There was no significant difference in activation of the kynurenine pathway... 
Psychiatry | Allergy and Immunology | Kynurenine | Remission | Anhedonia | Inflammation | Kynurenic acid | Quinolinic acid | Major depressive disorder | C-REACTIVE PROTEIN | CYTOKINES | ABNORMALITIES | PSYCHIATRY | STATE | SCHIZOPHRENIA | ANTIDEPRESSANT MEDICATION | IMMUNOLOGY | BIPOLAR DISORDER | NEUROSCIENCES | PLASMA-LEVELS | PATHWAY | SERUM-LEVELS | Depressive Disorder, Major - blood | Depressive Disorder, Major - metabolism | Humans | Middle Aged | Quinolinic Acid - blood | Male | Kynurenic Acid - metabolism | Young Adult | Tandem Mass Spectrometry | Adolescent | Chromatography, Liquid | Adult | Female | Depression, Mental | Organic acids | Index Medicus
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7. Full Text A validated liquid chromatography‐high resolution‐tandem mass spectrometry method for the simultaneous quantitation of tryptophan, kynurenine, kynurenic acid, and quinolinic acid in human plasma
by Arnhard, Kathrin and Pitterl, Florian and Sperner‐Unterweger, Barbara and Fuchs, Dietmar and Koal, Therese and Oberacher, Herbert
ELECTROPHORESIS, ISSN 0173-0835, 05/2018, Volume 39, Issue 9-10, pp. 1171 - 1180
Tryptophan (TRP) catabolism via the kynurenine pathway is considered to represent a major link between inflammation and various diseases, including... 
Tryptophan | Tandem mass spectrometry | Liquid chromatography | Metabolite profiling | High‐resolution mass spectrometry | High-resolution mass spectrometry | CHEMISTRY, ANALYTICAL | CATABOLISM | QUANTIFICATION | INDOLEAMINE 2,3-DIOXYGENASE | ACQUISITION | BIOCHEMICAL RESEARCH METHODS | HUMAN SERUM | IDENTIFICATION | SEROTONIN | RAT-BRAIN | PATHWAY METABOLITES | HPLC | Isotope Labeling - methods | Kynurenine - blood | Limit of Detection | Chromatography, High Pressure Liquid - methods | Kynurenic Acid - blood | Tryptophan - blood | Humans | Metabolome | Quinolinic Acid - blood | Tandem Mass Spectrometry - methods | Nervous system diseases | Multiple sclerosis | Metabolites | Nitriles | Precipitation (Meteorology) | Mass spectrometry | Methods | Plasma | Spectroscopy | Ammonium acetate | Schizophrenia | Ions | Workflow | Calibration | Chromatography | Blood plasma | Proteins | Acids | Acetonitrile | Catabolism | Scientific imaging | Fitness | Charcoal | Immune system
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8. Full Text Quinolinic acid: neurotoxicity
by Guillemin, Gilles J
FEBS Journal, ISSN 1742-464X, 04/2012, Volume 279, Issue 8, pp. 1355 - 1355
This minireview series reviews some of the most recent findings about quinolinic acid’s cellular toxicity and its implications in diseases such as HIV... 
BIOCHEMISTRY & MOLECULAR BIOLOGY | Neurotoxicity Syndromes - etiology | Quinolinic Acid - adverse effects | Animals | Humans
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9. Full Text Nicotinic acid, nicotinamide, and nicotinamide riboside: A molecular evaluation of NAD+ precursor vitamins in human nutrition
by Bogan, Katrina L and Brenner, Charles
Annual Review of Nutrition, ISSN 0199-9885, 2008, Volume 28, Issue 1, pp. 115 - 130
Although baseline requirements for nicotinamide adenine dinucleotide (NAD(+)) synthesis can be met either with dietary tryptophan or with less than 20 mg of... 
Sirtuins | Poly(ADP-ribose) polymerase | Wallerian degeneration | High-density lipoprotein cholesterol | Cyclic ADP-ribose synthase | PERFUSED RAT INTESTINE | cyclic ADP-ribose synthase | sirtuins | poly(ADP-ribose) polymerase | SACCHAROMYCES-CEREVISIAE | LIFE-SPAN EXTENSION | QUINOLINIC ACID | NUTRITION & DIETETICS | HUMAN-BRAIN TISSUE | high-density lipoprotein cholesterol | COLONY-ENHANCING FACTOR | ADENINE-DINUCLEOTIDE | CYCLIC ADP RIBOSE | CALORIE RESTRICTION | Niacinamide - analogs & derivatives | Nutritional Requirements | Dyslipidemias - drug therapy | Niacinamide - metabolism | Caloric Restriction | Humans | Candida glabrata - metabolism | Niacin - metabolism | Dyslipidemias - blood | Animals | NAD - biosynthesis | Dietary Supplements | NAD - metabolism
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10. Full Text Uridine monophosphate synthetase enables eukaryotic de novo NAD+ biosynthesis from quinolinic acid
by McReynolds, Melanie R and Wang, Wenqing and Holleran, Lauren M and Hanna-Rose, Wendy
Journal of Biological Chemistry, ISSN 0021-9258, 2017, Volume 292, Issue 27, pp. 11147 - 11153
NAD(+) biosynthesis is an attractive and promising therapeutic target for influencing health span and obesity-related phenotypes as well as tumor growth. Full... 
SALVAGE | CAENORHABDITIS-ELEGANS | METABOLISM | NICOTINAMIDE | PATHWAY | REPRODUCTIVE DEVELOPMENT | BIOCHEMISTRY & MOLECULAR BIOLOGY | C-ELEGANS | VITAMINS | Orotidine-5'-Phosphate Decarboxylase - metabolism | NAD - genetics | Caenorhabditis elegans - genetics | Tryptophan - genetics | Caenorhabditis elegans Proteins - metabolism | Multienzyme Complexes - metabolism | Orotate Phosphoribosyltransferase - genetics | Multienzyme Complexes - genetics | Tryptophan - metabolism | Orotidine-5'-Phosphate Decarboxylase - genetics | Animals | Quinolinic Acid - metabolism | NAD - biosynthesis | Orotate Phosphoribosyltransferase - metabolism | Mutation | Caenorhabditis elegans Proteins - genetics | Caenorhabditis elegans - enzymology | Caenorhabditis elegans (C. elegans) | metabolic tracer | metabolism | NAD biosynthesis | Accelerated Communications | tryptophan
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11. Full Text Comparison of the Toxic Effects of Quinolinic Acid and 3-Nitropropionic Acid in C. elegans: Involvement of the SKN-1 Pathway
by Kotlar, Ilan and Colonnello, Aline and Aguilera-González, María Fernanda and Avila, Daiana Silva and de Lima, María Eduarda and García-Contreras, Rodolfo and Ortíz-Plata, Alma and Soares, Félix Alexandre Antunes and Aschner, Michael and Santamaría, Abel
Neurotoxicity Research, ISSN 1029-8428, 2/2018, Volume 33, Issue 2, pp. 259 - 267
The tryptophan metabolite, quinolinic acid (QUIN), and the mitochondrial toxin 3-nitropropionic acid (3-NP) are two important tools for toxicological research... 
Neurochemistry | Neurosciences | VC1772 | Neurobiology | SKN-1 | Cell Biology | Neurology | Biomedicine | Excitotoxicity | NMDA | VP596 | Huntington’s disease | Pharmacology/Toxicology | OXIDATIVE STRESS | Huntington's disease | NEUROSCIENCES | DAMAGE | PATHOGENESIS | CAENORHABDITIS-ELEGANS | DOPAMINERGIC NEURODEGENERATION | ANTIOXIDANT | ANIMAL-MODEL | ENERGY-METABOLISM | HUNTINGTONS-DISEASE | Nitro Compounds - toxicity | DNA-Binding Proteins - drug effects | Caenorhabditis elegans Proteins - metabolism | Mitochondria - drug effects | Propionates - toxicity | Transcription Factors - drug effects | Transcription Factors - metabolism | Caenorhabditis elegans | Antihypertensive Agents - toxicity | Animals | Caenorhabditis elegans Proteins - drug effects | Corpus Striatum - drug effects | Neurotoxicity Syndromes - metabolism | Quinolinic Acid - toxicity | Oxidative Stress - drug effects | Disease Models, Animal | Tryptophan | Comparative analysis | Glutathione transferase | Nematoda | Index Medicus
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12. Full Text Cinnabarinic acid and xanthurenic acid: Two kynurenine metabolites that interact with metabotropic glutamate receptors
by Fazio, Francesco and Lionetto, Luana and Curto, Martina and Iacovelli, Luisa and Copeland, Caroline S and Neale, Stuart A and Bruno, Valeria and Battaglia, Giuseppe and Salt, Thomas E and Nicoletti, Ferdinando
Neuropharmacology, ISSN 0028-3908, 01/2017, Volume 112, Issue Pt B, pp. 365 - 372
Cinnabarinic and xanthurenic acids are kynurenine metabolites generated by oxidative dimerization of 3-hydroxyanthranilic acid and transamination of... 
Schizophrenia | Metabotropic glutamate receptors | Neuroinflammation | Xanthurenic acid | Cinnabarinic acid | POSITIVE ALLOSTERIC MODULATOR | SYNAPTIC-TRANSMISSION | IDENTIFICATION | NEUROSCIENCES | QUINOLINIC ACID | ENDOGENOUS AGONIST | ARYL-HYDROCARBON RECEPTOR | 3-HYDROXYANTHRANILIC ACID | PATHWAY | AMINOTRANSFERASE | PHARMACOLOGY & PHARMACY | RAT-BRAIN | Oxazines - metabolism | Animals | Xanthurenates - metabolism | Humans | Receptors, Metabotropic Glutamate - metabolism | Kynurenine - metabolism | Xanthurenates - pharmacology | Oxazines - pharmacology | Physiological aspects | Tryptophan | Metabolites | Glutamate
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