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Aging Cell, ISSN 1474-9718, 08/2015, Volume 14, Issue 4, pp. 644 - 658
Summary The healthspan of mice is enhanced by killing senescent cells using a transgenic suicide gene. Achieving the same using small molecules would have a... 
dasatinib | plasminogen‐activated inhibitor | dependence receptors | quercetin | ephrins | PI3K delta | p21 | Dasatinib | Dependence receptors | Ephrins | Plasminogen-activated inhibitor | Quercetin | P21 | ENDOTHELIAL DYSFUNCTION | PLASMINOGEN-ACTIVATOR INHIBITOR-1 | EXPRESSION PROFILES | plasminogen-activated inhibitor | CELLULAR SENESCENCE | CANCER-THERAPY | CELL BIOLOGY | GERIATRICS & GERONTOLOGY | LUNG-CANCER | SET ENRICHMENT ANALYSIS | GENE-EXPRESSION | IONIZING-RADIATION | TUMOR-GROWTH | Carotid Arteries - drug effects | Endonucleases - genetics | Plasminogen Activator Inhibitor 2 - genetics | Transcriptome | Gene Expression Profiling | Adipocytes - drug effects | Aging - genetics | Osteoporosis - metabolism | Ephrins - metabolism | Plasminogen Activator Inhibitor 2 - metabolism | Cyclin-Dependent Kinase Inhibitor p21 - metabolism | Osteoporosis - genetics | Intervertebral Disc - pathology | Fibroblasts - metabolism | Endothelial Cells - metabolism | Intervertebral Disc - chemistry | Fibroblasts - pathology | Mesenchymal Stem Cells - pathology | Mice, Knockout | Dasatinib - pharmacology | Osteoporosis - pathology | Ephrins - genetics | Fibroblasts - drug effects | Mice | Endothelial Cells - pathology | bcl-X Protein - metabolism | Aging - metabolism | Aging - drug effects | bcl-X Protein - genetics | Cellular Senescence - drug effects | Phosphatidylinositol 3-Kinases - metabolism | Endonucleases - metabolism | DNA-Binding Proteins - metabolism | Cyclin-Dependent Kinase Inhibitor p21 - genetics | Mesenchymal Stem Cells - drug effects | Mesenchymal Stem Cells - metabolism | Heart - physiopathology | Cellular Senescence - genetics | Osteoporosis - prevention & control | DNA-Binding Proteins - genetics | Adipocytes - pathology | Aging - pathology | Phosphatidylinositol 3-Kinases - genetics | Animals | Quercetin - pharmacology | Adipocytes - metabolism | Heart - drug effects | Carotid Arteries - pathology | Intervertebral Disc - drug effects | Drug Combinations | Endothelial Cells - drug effects | Original
Journal Article
Journal Article
Neurotoxicology, ISSN 0161-813X, 06/2012, Volume 33, Issue 3, pp. 482 - 490
► Rutin inhibits Aβ42 fibrillization and attenuates Aβ42-induced cytotoxicity. ► Rutin decreases the formation of active oxygen species (ROS). ► Rutin... 
Aggregation | Reactive oxygen species | Nitric oxide | β-Amyloid | Proinflammatory cytokines | Rutin | Alzheimer's disease | TEA EPIGALLOCATECHIN-3-GALLATE EGCG | INDUCED MITOCHONDRIAL DYSFUNCTION | CELLS | PROTEIN | ALZHEIMERS-DISEASE | NEUROSCIENCES | PEPTIDE | OLIGOMERS | QUERCETIN | MOUSE MODEL | beta-Amyloid | PHARMACOLOGY & PHARMACY | TOXICOLOGY | TRANSGENIC MICE | Tumor Necrosis Factor-alpha - metabolism | Neurons - pathology | Reactive Oxygen Species - metabolism | Glutathione - metabolism | Humans | Rutin - pharmacology | Dose-Response Relationship, Drug | Neuroprotective Agents - pharmacology | Time Factors | Interleukin-1beta - metabolism | Amyloid beta-Peptides - metabolism | Inflammation Mediators - metabolism | Neurons - metabolism | Neurons - drug effects | Superoxide Dismutase - metabolism | Cytoprotection | Malondialdehyde - metabolism | Glutathione Peroxidase - metabolism | Peptide Fragments - metabolism | Cytokines - metabolism | Anti-Inflammatory Agents - pharmacology | Down-Regulation | Neurons - immunology | Mitochondria - metabolism | Antioxidants - pharmacology | Mitochondria - drug effects | Mitochondria - pathology | Catalase - metabolism | Cell Line, Tumor | Oxidative Stress - drug effects | Nitric Oxide - metabolism | Nitric Oxide Synthase Type II - metabolism | Index Medicus | Oxidative stress | oxides | Cytotoxicity | Superoxide dismutase | beta -Amyloid | rutin | Neuroblastoma cells | Prevention | Fibrillogenesis | Mitochondria | Neurotoxicity | Catalase | Etiology | Interleukin 1 | Glutathione peroxidase | Oxygen | Deposits | Cytokines | Neurodegenerative diseases | Inflammation | Malondialdehyde | Nitric-oxide synthase | Microglia | Diets | Flavonoids | Tumor necrosis factor- alpha
Journal Article
Arteriosclerosis, Thrombosis, and Vascular Biology, ISSN 1079-5642, 04/2010, Volume 30, Issue 4, pp. 749 - 757
OBJECTIVE—Animal and clinical studies have suggested that polyphenols in fruits, red wine, and tea may delay the development of atherosclerosis through their... 
Endothelial dysfunction | Soluble P-selectin | Oxidative stress | Polyphenol | Inflammation | Endothelin-1 | polyphenol | endothelial dysfunction | soluble P-selectin | inflammation | NITRIC-OXIDE | PERIPHERAL VASCULAR DISEASE | BLACK TEA CONSUMPTION | SMOOTH-MUSCLE-CELLS | HEME OXYGENASE-1 | RED WINE | endothelin-1 | HEMATOLOGY | E-DEFICIENT MICE | NF-KAPPA-B | oxidative stress | CORONARY-ARTERY-DISEASE | Inflammation - pathology | Heme Oxygenase-1 - metabolism | Apolipoproteins E - deficiency | Cholesterol - blood | Endothelium, Vascular - drug effects | Male | Aorta - metabolism | F2-Isoprostanes - metabolism | Lignans - pharmacology | Aortic Diseases - metabolism | Inflammation - metabolism | Leukotriene B4 - metabolism | Aortic Diseases - prevention & control | Dioxoles - pharmacology | Polyphenols | Anti-Inflammatory Agents - administration & dosage | Disease Models, Animal | Phenols - pharmacology | Biomarkers - metabolism | Atherosclerosis - pathology | Anti-Inflammatory Agents - pharmacology | Atherosclerosis - physiopathology | Atherosclerosis - metabolism | Mice, Knockout | Aorta - pathology | Diet | Endothelium, Vascular - metabolism | Inflammation - prevention & control | Mice | Oxidative Stress - drug effects | Biflavonoids - pharmacology | Chlorogenic Acid - pharmacology | Nitrates - urine | Superoxides - metabolism | Flavonoids - administration & dosage | Flavonoids - pharmacology | Membrane Proteins - metabolism | Aorta - physiopathology | Nitric Oxide Synthase Type III - metabolism | Catechin - pharmacology | Fatty Acids - metabolism | Nitrites - urine | Aorta - drug effects | Mice, Inbred C57BL | Endothelium, Vascular - physiopathology | Aortic Diseases - physiopathology | Animals | Quercetin - pharmacology | Apolipoproteins E - genetics | Endothelin-1 - urine | P-Selectin - blood | Phenols - administration & dosage | Nitric Oxide - metabolism | Atherosclerosis - prevention & control | Inflammation - physiopathology
Journal Article
American Journal of Physiology - Heart and Circulatory Physiology, ISSN 0363-6135, 2017, Volume 312, Issue 1, pp. H128 - H140
Duchenne Muscular Dystrophy (DMD) is associated with progressive cardiac pathology; however, the SIRT1/PGC1-alpha activator quercetin may cardioprotect... 
Polyphenol | Duchenne muscular dystrophy | Utrophin | RESVERATROL | CARDIAC & CARDIOVASCULAR SYSTEMS | PHYSIOLOGY | PGC-1-ALPHA | PATHOLOGY | polyphenol | utrophin | PREVENTS | MDX MICE | SKELETAL-MUSCLE | MUSCLE MITOCHONDRIAL BIOGENESIS | CARDIAC-HYPERTROPHY | PERIPHERAL VASCULAR DISEASE | DUCHENNE MUSCULAR-DYSTROPHY | EXPRESSION | Utrophin - metabolism | Phosphorylation | Muscular Dystrophy, Animal - physiopathology | Mitochondria, Muscle - metabolism | Transforming Growth Factor beta1 - metabolism | Utrophin - genetics | Citrate (si)-Synthase - drug effects | NF-kappa B - metabolism | Motor Activity | Receptors, IgG - metabolism | Matrix Metalloproteinase 9 - metabolism | Myocardium - metabolism | Mice, Inbred mdx | Muscular Dystrophy, Animal - metabolism | Peroxisome Proliferator-Activated Receptor Gamma Coactivator 1-alpha - metabolism | Transforming Growth Factor beta1 - drug effects | Antigens, Differentiation - metabolism | Citrate (si)-Synthase - metabolism | Superoxide Dismutase - metabolism | Cytochromes c - drug effects | Disease Models, Animal | Heart - physiopathology | Sarcoglycans - metabolism | Peroxisome Proliferator-Activated Receptor Gamma Coactivator 1-alpha - drug effects | Cytochromes c - metabolism | Myocardium - pathology | Cyclooxygenase 2 - drug effects | Antioxidants - pharmacology | Electron Transport Chain Complex Proteins - drug effects | Receptors, IgG - drug effects | Food, Fortified | NF-KappaB Inhibitor alpha - drug effects | Superoxide Dismutase - drug effects | Blotting, Western | Fibronectins - metabolism | Heart - diagnostic imaging | Magnetic Resonance Imaging | Animals | Quercetin - pharmacology | Electron Transport Chain Complex Proteins - metabolism | NF-KappaB Inhibitor alpha - metabolism | Cyclooxygenase 2 - metabolism | Antigens, Differentiation - drug effects | Heart - drug effects | Mice | Mitochondria, Muscle - drug effects | Muscular Dystrophy, Duchenne | NF-kappa B - drug effects
Journal Article
Journal of nutrition, ISSN 0022-3166, 2008, Volume 138, Issue 8, pp. 1417 - 1420
Journal Article
Food Research International, ISSN 0963-9969, 10/2017, Volume 100, Issue Pt 3, pp. 411 - 422
Indigenous African leafy vegetables vary enormously in their secondary plant metabolites whereat genus and the species have a great impact. In African... 
Glucosinolates | Carotenoids | Flavonoid glycosides | Indigenous African leafy vegetables | Hydroxycinnamic acids | ANTIOXIDANT ACTIVITY | UV-B RADIATION | FOOD SCIENCE & TECHNOLOGY | OLERACEA VAR. SABELLICA | SOLANUM-LYCOPERSICON | ENZYMATIC-SYNTHESIS | AMARANTHUS SPP | PHENOLIC CONSTITUENTS | IN-VITRO | CHLOROGENIC ACID | OCCURRING FLAVONOID GLYCOSIDES | Africa, Eastern | Vigna - chemistry | Carotenoids - analysis | Vitamin A - chemistry | Antioxidants - chemistry | Coumaric Acids - chemistry | Antioxidants - metabolism | Chromatography, High Pressure Liquid | Glucosinolates - chemistry | Vitamin A - metabolism | Vegetables - chemistry | Amaranthus - metabolism | Amaranthus - chemistry | Vegetables - metabolism | Antioxidants - analysis | Glycosides - chemistry | Cleome - chemistry | Brassica - chemistry | Plant Leaves - chemistry | Vigna - metabolism | Glucosinolates - analysis | Glycosides - analysis | Quercetin - chemistry | Brassica - metabolism | Coumaric Acids - analysis | Coumaric Acids - metabolism | Quercetin - analysis | Cleome - metabolism | Phenols - metabolism | Vitamin A - analysis | Solanum - metabolism | Solanum - chemistry | Phenols - analysis | Glycosides - metabolism | Carotenoids - metabolism | Phenols - chemistry | Carotenoids - chemistry | Quercetin - metabolism | Vitamin A | Vegetables | Plant metabolites | Beta carotene | Antioxidants | Flavonoids | Flavones | Bioflavonoids | Plants | Derivatives (Financial instruments)
Journal Article