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Journal Article
Toxicology and Applied Pharmacology, ISSN 0041-008X, 08/2016, Volume 305, pp. 55 - 65
Journal Article
Journal of Immunology, ISSN 0022-1767, 04/2011, Volume 186, Issue 8, pp. 4794 - 4804
Endosomal TLRs play an important role in innate immune response as well as in autoimmune processes. In the therapy of systemic lupus erythematosus,... 
IMMUNOSTIMULATORY CPG-OLIGODEOXYNUCLEOTIDES | CELLS | SYSTEMIC-LUPUS-ERYTHEMATOSUS | ACTIVATION | DNA | COMPLEXES | TOLL-LIKE RECEPTORS | H+-ATPASE | IFN-ALPHA INDUCER | IMMUNOLOGY | NUCLEIC-ACIDS | Humans | Toll-Like Receptor 9 - genetics | Toll-Like Receptor 3 - antagonists & inhibitors | Endosomes - metabolism | Quinolines - pharmacology | Chloroquine - pharmacology | Quinacrine - pharmacology | Transfection | Hydrogen-Ion Concentration - drug effects | HEK293 Cells | Toll-Like Receptors - antagonists & inhibitors | Toll-Like Receptor 3 - genetics | Culture Media - chemistry | Imidazoles - metabolism | Toll-Like Receptor 8 - agonists | Binding, Competitive | Toll-Like Receptor 7 - agonists | Toll-Like Receptor 7 - genetics | Cell Line | Antimalarials - metabolism | Toll-Like Receptor 7 - metabolism | Toll-Like Receptor 9 - antagonists & inhibitors | Cytokines - metabolism | Cells, Cultured | Imidazoles - pharmacology | Nucleic Acids - metabolism | Toll-Like Receptor 3 - metabolism | Toll-Like Receptors - agonists | Antimalarials - pharmacology | Quinolines - metabolism | Animals | Toll-Like Receptors - genetics | Culture Media - pharmacology | Toll-Like Receptor 8 - genetics | Endosomes - chemistry | Toll-Like Receptor 9 - metabolism | Toll-Like Receptor 8 - metabolism | Serum - chemistry | Index Medicus | Abridged Index Medicus
Journal Article
Protein Science, ISSN 0961-8368, 01/2013, Volume 22, Issue 1, pp. 22 - 34
A variety of antiprion compounds have been reported that are effective in ex vivo and in vivo treatment experiments. However, the molecular mechanisms for most... 
anti‐prion compounds | action mechanism | medical chaperones | prion protein | Action mechanism | Anti-prion compounds | Medical chaperones | Prion protein | BIOCHEMISTRY & MOLECULAR BIOLOGY | INFECTIVITY | CONFORMATIONS | SCRAPIE | REPLICATION | INHIBITION | PRPSC | DISEASE | TRANSMISSIBLE SPONGIFORM ENCEPHALOPATHY | ACCUMULATION | anti-prion compounds | DERIVATIVES | Surface Plasmon Resonance | Carbazoles - chemistry | Molecular Chaperones - metabolism | Nitriles - pharmacology | Protein Conformation - drug effects | Molecular Chaperones - chemistry | Aminopyridines - chemistry | Pentosan Sulfuric Polyester - chemistry | Pentosan Sulfuric Polyester - pharmacology | Quinacrine - pharmacology | Piperidines - pharmacology | Quinacrine - chemistry | Molecular Structure | Catechin - pharmacology | Binding Sites - drug effects | Molecular Chaperones - pharmacology | Amides - pharmacology | Prions - metabolism | Piperidines - chemistry | Magnetic Resonance Spectroscopy | Congo Red - pharmacology | Prions - chemistry | Prions - antagonists & inhibitors | Animals | Aminopyridines - pharmacology | Nitriles - chemistry | Amides - chemistry | Catechin - analogs & derivatives | Mice | Carbazoles - pharmacology | Congo Red - chemistry | Catechin - chemistry | Nuclear magnetic resonance spectroscopy | Universities and colleges | Chemical properties | Precipitation (Meteorology) | Prions | Protein binding | Proteins | Binding sites | Index Medicus
Journal Article
Cancer Biology & Therapy, ISSN 1538-4047, 08/2011, Volume 12, Issue 3, pp. 229 - 238
Quinacrine has been widely explored in treatment of malaria, giardiasis, and rheumatic diseases. We find that quinacrine stabilizes p53 and induces... 
Proteins | Binding | Landes | Calcium | Biology | Bioscience | Cell | Cycle | Organogenesis | Cancer | Tumor xenograft | Quinacrine | TRAIL | Sorafenib | Hepatocellular carcinoma | Apoptosis | p53 | sorafenib | INDUCED APOPTOSIS | tumor xenograft | apoptosis | DEATH | AUTOPHAGY | quinacrine | THERAPY | ONCOLOGY | PLEURAL EFFUSIONS | DRUGS | NF-KAPPA-B | hepatocellular carcinoma | Niacinamide - analogs & derivatives | Microtubule-Associated Proteins - metabolism | Humans | Cytoplasm - metabolism | Deoxycytidine - pharmacology | Phenylurea Compounds | Receptors, TNF-Related Apoptosis-Inducing Ligand - metabolism | Proto-Oncogene Proteins c-bcl-2 - metabolism | Benzenesulfonates - pharmacology | Genes, p53 | Quinacrine - pharmacology | Carcinoma, Hepatocellular - drug therapy | Cell Nucleus - metabolism | TNF-Related Apoptosis-Inducing Ligand - pharmacology | Female | Liver Neoplasms - pathology | Antineoplastic Agents - pharmacology | Cell Death - drug effects | Tumor Cells, Cultured | Camptothecin - analogs & derivatives | Liver Neoplasms - drug therapy | Etoposide - pharmacology | Drug Synergism | Xenograft Model Antitumor Assays | Irinotecan | Animals | Myeloid Cell Leukemia Sequence 1 Protein | Carcinoma, Hepatocellular - pathology | Fluorouracil - pharmacology | Mice | Pyridines - pharmacology | RNA, Small Interfering | Cell Nucleus - drug effects | Camptothecin - pharmacology | Cytoplasm - drug effects | Deoxycytidine - analogs & derivatives | Doxorubicin - pharmacology | Quinacrine - pharmacokinetics | Index Medicus
Journal Article
European Urology, ISSN 0302-2838, 2016, Volume 71, Issue 3, pp. 319 - 327
Journal Article
American Journal of Physiology - Heart and Circulatory Physiology, ISSN 0363-6135, 05/2008, Volume 294, Issue 5, pp. 2363 - 2370
The perivascular sensory nerve (PvN) Ca2+-sensing receptor (CaR) is implicated in Ca2+-induced relaxation of isolated, phenylephrine (PE)-contracted mesenteric... 
sensing receptor | Arachidonic acid | Vasorelaxation | Ca | arachidonic acid | BKCA CHANNELS | CARDIAC & CARDIOVASCULAR SYSTEMS | PHYSIOLOGY | NERVE CA2+ RECEPTOR | DIETARY CALCIUM | BLOOD-PRESSURE REGULATION | Ca2+-sensing receptor | CORONARY-ARTERIES | SPONTANEOUSLY HYPERTENSIVE RATS | SMOOTH-MUSCLE | vasorelaxation | ARACHIDONIC-ACID MONOOXYGENASES | IN-VIVO | PERIPHERAL VASCULAR DISEASE | HYPERPOLARIZING FACTORS | Lipoprotein Lipase - antagonists & inhibitors | Cytochrome P-450 Enzyme Inhibitors | Rats, Wistar | Calcium - metabolism | Cytochrome P-450 Enzyme System - metabolism | Male | Mesenteric Arteries - drug effects | 8,11,14-Eicosatrienoic Acid - metabolism | Receptors, Calcium-Sensing - metabolism | Vasodilation | Dose-Response Relationship, Drug | Arachidonic Acids - metabolism | Quinacrine - pharmacology | Phenylephrine - pharmacology | Piperidines - pharmacology | Potassium Channels, Calcium-Activated - metabolism | Lipoprotein Lipase - metabolism | Phospholipase A2 Inhibitors | Endocannabinoids | Potassium Channel Blockers - pharmacology | Pyrazoles - pharmacology | Vasoconstrictor Agents - pharmacology | Vasodilator Agents - pharmacology | Acetylcholine - pharmacology | Enzyme Inhibitors - pharmacology | Rats | Phospholipases A2 - metabolism | Glycerides - metabolism | Mesenteric Arteries - metabolism | Arachidonic Acids - pharmacology | Peptides - pharmacology | Receptor, Cannabinoid, CB1 - metabolism | Animals | Signal Transduction - drug effects | Miconazole - pharmacology | Potassium Channels, Calcium-Activated - antagonists & inhibitors | Receptor, Cannabinoid, CB1 - antagonists & inhibitors | Mesenteric Arteries - enzymology | Index Medicus
Journal Article
BMC Neuroscience, ISSN 1471-2202, 05/2012, Volume 13, Issue 1, pp. 53 - 53
Background: ATP is an extracellular signaling molecule with many ascribed functions in sensory systems, including the olfactory epithelium. The mechanism(s) by... 
SYSTEM | CELLS | IN-VITRO | NEUROTRANSMISSION | PURINERGIC RECEPTOR ACTIVATION | ACETYLCHOLINE-RELEASE | NEURONS | NEUROMUSCULAR-JUNCTION | CONNEXIN HEMICHANNELS | EXPRESSION | NEUROSCIENCES | Gadolinium - pharmacology | Humans | Qb-SNARE Proteins - metabolism | Molecular Sequence Data | Phosphopyruvate Hydratase - metabolism | Exocytosis - drug effects | Adenosine Triphosphate - pharmacology | Drug Interactions | Transfection | Qc-SNARE Proteins - metabolism | Time Factors | Adenosine Triphosphate - metabolism | Quinacrine - metabolism | Ethylmaleimide - pharmacology | Sensory Receptor Cells - metabolism | Bromodeoxyuridine - metabolism | Pyridoxal Phosphate - analogs & derivatives | Organ Culture Techniques | Animals, Newborn | Receptors, Purinergic P2X2 - genetics | Calcium - pharmacology | Cytidine Triphosphate - pharmacology | Pyridoxal Phosphate - pharmacology | Uridine Triphosphate - pharmacology | Cells, Cultured | Enzyme Inhibitors - pharmacology | Adenosine Triphosphate - analogs & derivatives | Carbenoxolone - pharmacology | Microscopy, Confocal | Animals | Sensory Receptor Cells - drug effects | Analysis of Variance | Bacterial Toxins - pharmacology | Receptors, Purinergic P2X2 - metabolism | Mice | Olfactory Mucosa - cytology | Enterotoxins - pharmacology | Purinergic Agents - pharmacology | Infants (Newborn) | Luciferase | Central nervous system | Hostages | G proteins | Product introduction | Epithelium | Cell differentiation | Adenosine triphosphate | Probenecid | Colleges & universities | Homeostasis | ABC transporters | Life sciences | Cells | Adenosine triphosphatase | Manuscripts | Index Medicus
Journal Article
Gastroenterology, ISSN 0016-5085, 2008, Volume 135, Issue 2, pp. 632 - 641
Journal Article
European Journal of Pharmacology, ISSN 0014-2999, 09/2012, Volume 691, Issue 1-3, pp. 93 - 102
We previously reported that intracerebroventricularly (i.c.v.) administered (±)-epibatidine (a potent agonist of nicotinic acetylcholine receptors) (1, 5 and... 
Brain | Monoacylglycerol lipase | Diacylglycerol lipase | Adrenal medulla | (±)-Epibatidine | Phospholipase C | ARACHIDONIC-ACID RELEASE | SELECTIVE-INHIBITION | HUMAN-PLATELETS | DEPENDENT PROCESSES | (+)-Epibatidine | SPINAL-CORD | NICOTINIC ACETYLCHOLINE-RECEPTORS | PARAVENTRICULAR NUCLEUS | DIGLYCERIDE LIPASE | ADRENAL-MEDULLA | PHARMACOLOGY & PHARMACY | POLYMORPHONUCLEAR NEUTROPHILS | Rats, Wistar | Catecholamines - secretion | Brain - enzymology | Type C Phospholipases - metabolism | Male | Monoacylglycerol Lipases - metabolism | Paraventricular Hypothalamic Nucleus - cytology | Piperidines - pharmacology | Estrenes - pharmacology | Pyrrolidinones - pharmacology | Adrenal Medulla - drug effects | Neurons - drug effects | Lipoprotein Lipase - metabolism | Nicotinic Agonists - pharmacology | Pyridines - administration & dosage | Esterases - metabolism | Rats | Bridged Bicyclo Compounds, Heterocyclic - administration & dosage | Catecholamines - blood | Cyclohexanones - pharmacology | Arachidonic Acids - pharmacology | Brain - drug effects | Nicotinic Agonists - administration & dosage | Bridged Bicyclo Compounds, Heterocyclic - pharmacology | Organophosphonates - pharmacology | Adrenal Medulla - secretion | Animals | Neurons - enzymology | Pyridines - pharmacology | Benzodioxoles - pharmacology | Unsaturated fatty acids | Quinacrine | Neurons | Phospholipases | Indomethacin | Arachidonic acid | Lipase | Noradrenaline | Index Medicus
Journal Article
Journal Article