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Biochemistry, ISSN 0006-2960, 12/2014, Volume 53, Issue 49, pp. 7816 - 7823
Through a ligand-directed tosyl (LDT) chemistry strategy using the synthetic acetogenin ligand AL1, we succeeded in the pinpoint alkynylation (-C=CH) of Asp160... 
SITE | CYCLOADDITION | DOMAIN | SPACER | BIOCHEMISTRY & MOLECULAR BIOLOGY | ARCHITECTURE | DYNAMIC FUNCTION | PROTEINS | INHIBITORY-ACTION | NADH-UBIQUINONE OXIDOREDUCTASE | ACETOGENINS | Catalytic Domain - drug effects | NADH Dehydrogenase - antagonists & inhibitors | Mitochondria, Heart - metabolism | Molecular Weight | Benzoates - chemistry | Furans - pharmacology | Mitochondria, Heart - drug effects | Acetogenins - metabolism | Electron Transport Complex I - metabolism | Acetogenins - chemistry | Protein Subunits - metabolism | Tosyl Compounds - pharmacology | Pyrazoles - chemistry | Cattle | Furans - chemistry | Enzyme Inhibitors - chemistry | Indicators and Reagents - pharmacology | Indicators and Reagents - chemistry | Quinazolines - chemistry | Tosyl Compounds - antagonists & inhibitors | Pyrazoles - pharmacology | Electron Transport Complex I - antagonists & inhibitors | Click Chemistry | Enzyme Inhibitors - pharmacology | Mitochondria, Heart - enzymology | Models, Molecular | Tosyl Compounds - chemistry | NADH Dehydrogenase - chemistry | NADH Dehydrogenase - metabolism | Electron Transport Complex I - chemistry | Animals | Benzoates - pharmacology | Ligands | Protein Conformation | Protein Subunits - antagonists & inhibitors | Protein Subunits - chemistry | Aspartic Acid - chemistry | Quinazolines - pharmacology | Chemical reactions | Analysis | Proteomics | Index Medicus
Journal Article
JOURNAL OF ORGANIC CHEMISTRY, ISSN 0022-3263, 10/2011, Volume 76, Issue 20, pp. 8262 - 8269
A POCl3-mediated, direct amination reaction of heterocyclic amides/ureas with NH-heterocycles or N-substituted anilines is described. Compared to the existing... 
FUNCTIONALIZATION | FACILE SYNTHESIS | ACID | LIGANDS | AMINO | CUI | ARYLATION | CHEMISTRY, ORGANIC | ARYL | INHIBITORS | PALLADIUM-CATALYZED AMINATION | Azabicyclo Compounds - analysis | Erlotinib Hydrochloride | Hypnotics and Sedatives - chemistry | Chemistry, Pharmaceutical - methods | Humans | Hypnotics and Sedatives - analysis | Hypoglycemic Agents - analysis | Anticholesteremic Agents - chemistry | Heterocyclic Compounds - chemical synthesis | Piperazines - chemistry | Fluorobenzenes - chemistry | Thiazolidinediones - chemistry | Eszopiclone | Azabicyclo Compounds - chemistry | Pyrimidines - chemistry | Urea - chemistry | Prescription Drugs - analysis | Protein Kinase Inhibitors - chemistry | Thiazolidinediones - analysis | Amination | Protein Kinase Inhibitors - analysis | Urea - analogs & derivatives | Anticholesteremic Agents - analysis | Molecular Structure | Catalysis | Quinazolines - chemistry | Quinazolines - analysis | Pyrimidines - analysis | Sulfonamides - analysis | Sulfonamides - chemistry | Rosuvastatin Calcium | Hypoglycemic Agents - chemistry | Imatinib Mesylate | Phosphorus Compounds - chemistry | Heterocyclic Compounds - analysis | Piperazines - analysis | Amides - chemistry | Prescription Drugs - chemical synthesis | Aniline Compounds - chemistry | Benzamides | Fluorobenzenes - analysis | Hydrogen-Ion Concentration | Index Medicus
Journal Article
Journal of Biological Chemistry, ISSN 0021-9258, 2017, Volume 292, Issue 35, pp. 14496 - 14504
Monopolar spindle 1 (Mps1/TTK) is a protein kinase essential in mitotic checkpoint signaling, preventing anaphase until all chromosomes are properly attached... 
SPINDLE CHECKPOINT | DESIGN | KINETOCHORES | ACTIVATION | MOLECULAR-GRAPHICS | BIOCHEMISTRY & MOLECULAR BIOLOGY | VALIDATION | OPTIMIZATION | DRUG-RESISTANCE | MODEL | SELECTIVITY | Protein-Tyrosine Kinases - metabolism | Humans | Crystallography, X-Ray | Recombinant Fusion Proteins - metabolism | Antineoplastic Agents - metabolism | Cell Cycle Proteins - antagonists & inhibitors | Cell Cycle Proteins - chemistry | Protein Kinase Inhibitors - chemistry | Protein-Tyrosine Kinases - genetics | Pyrazoles - chemistry | Protein Processing, Post-Translational - drug effects | Quinazolines - metabolism | Adenosine Triphosphate - metabolism | Protein-Serine-Threonine Kinases - antagonists & inhibitors | Protein-Tyrosine Kinases - chemistry | Cell Cycle Proteins - genetics | Antineoplastic Agents - pharmacology | Molecular Structure | Phosphorylation - drug effects | Binding Sites | Quinazolines - chemistry | Protein-Serine-Threonine Kinases - metabolism | Pyrazoles - pharmacology | Recombinant Proteins - metabolism | Catalytic Domain | Purines - metabolism | Purines - pharmacology | Cell Cycle Proteins - metabolism | Protein-Serine-Threonine Kinases - genetics | Models, Molecular | Morpholines - pharmacology | Recombinant Proteins - chemistry | Morpholines - metabolism | Pyrazoles - metabolism | Recombinant Fusion Proteins - chemistry | Antineoplastic Agents - chemistry | Morpholines - chemistry | Point Mutation | Purines - chemistry | Ligands | Protein Kinase Inhibitors - pharmacology | Protein-Serine-Threonine Kinases - chemistry | Kinetics | Adenosine Triphosphate - chemistry | Quinazolines - pharmacology | Amino Acid Substitution | Protein Kinase Inhibitors - metabolism | Protein-Tyrosine Kinases - antagonists & inhibitors | Index Medicus | X-ray crystallography | Molecular Biophysics | protein drug interaction | fluorescence anisotropy | crystal structure | drug resistance | protein kinase
Journal Article
Journal of Controlled Release, ISSN 0168-3659, 05/2016, Volume 229, pp. 106 - 119
The present studies were aimed at formulating AZD2811-loaded polylactic acid-polyethylene glycol (PLA-PEG) nanoparticles with adjustable release rates without... 
Nanoparticles | Counterions | Drug release kinetics | In situ hydrophobic ion paring | PLA-PEG | Adjustable release rate | Prodrugs - administration & dosage | Acetanilides - administration & dosage | Nanoparticles - chemistry | Rats, Wistar | Cholic Acid - chemistry | Humans | Deoxycholic Acid - chemistry | Dioctyl Sulfosuccinic Acid - chemistry | Organophosphates - therapeutic use | Quinazolines - pharmacokinetics | Male | Naphthols - chemistry | Polyethylene Glycols - chemistry | Antineoplastic Agents - therapeutic use | Prodrugs - chemistry | Antineoplastic Agents - administration & dosage | Rats, Nude | Drug Delivery Systems | Nanoparticles - therapeutic use | Acetanilides - therapeutic use | Quinazolines - administration & dosage | Antineoplastic Agents - pharmacokinetics | Quinazolines - chemistry | Bone Marrow - drug effects | Organophosphates - administration & dosage | Organophosphates - pharmacokinetics | Antineoplastic Agents - chemistry | Neoplasms - drug therapy | Animals | Prodrugs - pharmacokinetics | Tumor Burden - drug effects | Mice, Nude | Quinazolines - therapeutic use | Acetanilides - chemistry | Bone Marrow - pathology | Cell Line, Tumor | Hydrophobic and Hydrophilic Interactions | Organophosphates - chemistry | Nanoparticles - administration & dosage | Prodrugs - therapeutic use | Acetanilides - pharmacokinetics | Neoplasms - pathology | Drugs | Monounsaturated fatty acids | Drug delivery systems | Patients' rights | Nuclear magnetic resonance spectroscopy | Product development | Raman spectroscopy | Biopolymers | Polyols | High performance liquid chromatography | Vehicles | Deoxycholic acid | Index Medicus
Journal Article
Biochemical Journal, ISSN 0264-6021, 09/2013, Volume 454, Issue 2, pp. 191 - 200
Activity of the aminoglycoside phosphotransferase APH(3')-Ia leads to resistance to aminoglycoside antibiotics in pathogenic Gram-negative bacteria, and... 
Aminoglycoside phosphotransferase APH(3')-Ia | Structure-based drug design | Protein kinase inhibitor | Antibiotic resistance | Crystal structure | structure-based drug design | COMPLEX | MECHANISM | CRYSTAL-STRUCTURE | BIOCHEMISTRY & MOLECULAR BIOLOGY | aminoglycoside phosphotransferase APH(3 ')-Ia | SENSITIVITY | MODEL | ENZYME | antibiotic resistance | TYROSINE | crystal structure | protein kinase inhibitor | PHOSPHOTRANSFERASE | SELECTIVITY | BINDING | Escherichia coli - drug effects | Molecular Conformation | Bacterial Proteins - chemistry | Kanamycin Kinase - metabolism | Isoenzymes - chemistry | Structure-Activity Relationship | Acinetobacter baumannii - enzymology | Pyrimidines - chemistry | Pyrimidines - metabolism | Microbial Sensitivity Tests | Protein Kinase Inhibitors - chemistry | Pyrazoles - chemistry | Quinazolines - metabolism | Isoenzymes - metabolism | Drug Design | Escherichia coli - metabolism | Drug Resistance, Bacterial - drug effects | Escherichia coli - growth & development | Binding Sites | Quinazolines - chemistry | Pyrazoles - pharmacology | Recombinant Proteins - metabolism | Bacterial Proteins - antagonists & inhibitors | Recombinant Proteins - antagonists & inhibitors | Anthracenes - chemistry | Isoenzymes - genetics | Recombinant Proteins - chemistry | Pyrazoles - metabolism | Pyrimidines - pharmacology | Kanamycin - pharmacology | Anthracenes - pharmacology | Kanamycin Kinase - antagonists & inhibitors | Kanamycin Kinase - chemistry | Kanamycin - metabolism | Kanamycin Kinase - genetics | Anthracenes - metabolism | Bacterial Proteins - metabolism | Kanamycin - chemistry | Anti-Bacterial Agents - pharmacology | Protein Kinase Inhibitors - pharmacology | Aminoglycosides - pharmacology | Quinazolines - pharmacology | Isoenzymes - antagonists & inhibitors | Protein Kinase Inhibitors - metabolism | Index Medicus | aminoglycoside phosphotransferase APH(3’)-Ia
Journal Article
Inorganic Chemistry, ISSN 0020-1669, 05/2016, Volume 55, Issue 9, pp. 4595 - 4605
Journal Article
Journal of Medicinal Chemistry, ISSN 0022-2623, 2014, Volume 57, Issue 16, pp. 6930 - 6948
Journal Article
Journal of Organic Chemistry, ISSN 0022-3263, 06/2014, Volume 79, Issue 12, pp. 5847 - 5851
Journal Article
Organic Letters, ISSN 1523-7060, 09/2011, Volume 13, Issue 17, pp. 4604 - 4607
Journal Article
Molecules, ISSN 1420-3049, 2018, Volume 23, Issue 6, p. 1488
Mono-polar spindle 1 (Mps1/TTK) represents a protein kinase reported to be vital for cell division processes and is generally regarded as an attractive target... 
C604Y | Mps1 | Molecular modeling | Resistance mechanisms | REVERSINE | VISUALIZATION | ACTIVATION | PROTEIN | CANCER CELLS | BIOCHEMISTRY & MOLECULAR BIOLOGY | KINASE | RECEPTOR | resistance mechanisms | CHEMISTRY, MULTIDISCIPLINARY | DYNAMICS SIMULATIONS | FREE-ENERGY CALCULATION | molecular modeling | SPINDLE-ASSEMBLY CHECKPOINT | Humans | Drug Resistance, Neoplasm | Antineoplastic Agents - chemistry | Molecular Dynamics Simulation | Morpholines - chemistry | Cell Cycle Proteins - antagonists & inhibitors | Cell Cycle Proteins - chemistry | Protein Kinase Inhibitors - chemistry | Pyrazoles - chemistry | Purines - chemistry | Drug Design | Protein-Serine-Threonine Kinases - antagonists & inhibitors | Protein-Tyrosine Kinases - chemistry | Protein Binding | Protein Conformation | Protein-Serine-Threonine Kinases - chemistry | Mutation | Binding Sites | Quinazolines - chemistry | Protein-Tyrosine Kinases - antagonists & inhibitors | Binding | Computer simulation | Cell division | Molecular dynamics | Hepatocellular carcinoma | Entropy | Breast cancer | Compounds | Kinases | Free energy | Proteins | Breast carcinoma | Molecular modelling | Colon cancer | Inhibitors | Energy | Protein kinase | Affinity | Colon | Cancer | Brain cancer | Colorectal cancer | Chromosomes | Adenosine triphosphate | Ligands | Binding sites | Index Medicus
Journal Article
Molecules, ISSN 1420-3049, 10/2014, Volume 19, Issue 10, pp. 15411 - 15439
Journal Article
Journal Article