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1. Full Text Quinidine interaction with Shab K.sup.+ channels: pore block and irreversible collapse of the K.sup.+ conductance
by Gomez-Lagunas, Froylan
Journal of Physiology, ISSN 0022-3751, 08/2010, Volume 588, Issue 15, p. 2691
Quinidine is a commonly used antiarrhythmic agent and a tool to study ion channels. Here it is reported that quinidine equilibrates within seconds across the... 
Quinidine
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2. Chiral Organocatalyzed Intermolecular Rauhut-Currier Reaction of Nitroalkenes with Ethyl Allenoate
by Shinobu Takizawa and Makoto Sako and Kenta Kishi and Masashi Shigenobu and Giang Vo-Thanh and Hiroaki Sasai
Chemical & Pharmaceutical Bulletin, ISSN 0009-2363, 11/2017, Volume 65, Issue 11, p. 997
An enantioselective intermolecular Rauhut-Currier (RC) reaction of nitroalkenes with ethyl allenoate has been established with quinidine-derived... 
Quinidine | Enantiomers
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3. Quinidine plasma level determination
by Bertrand, Lu Ann L and Toronto, Ont. University.Faculty of Pharmacy and Toronto, Ont. General Hospital.Pharmacy Residency Committee
1978, ix, 227 leaves.
Quinidine | Blood | Examination
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4. The role of quinidine in the pharmacological therapy of ventricular arrhythmias ‘quinidine’
by Bozic, Bojana and Uzelac, Teodora Vidonja and Kezic, Aleksandra and Bajcetic, Milica
Mini-Reviews in Medicinal Chemistry, ISSN 1389-5575, 04/2018, Volume 18, Issue 6, pp. 468 - 475
Historically, quinidine was the first medicine used in the therapy of heart arrhythmias. Studies in the early 20th century identified quinidine, a diastereomer... 
Heart | Ventricular arrhythmias | Repolarization | Alkaloid | Quinidine | Use | Brugada | LOW-DOSE QUINIDINE | DRUG-THERAPY | CHEMISTRY, MEDICINAL | quinidine | use | repolarization | MICRORNA THERAPEUTICS | heart | brugada | SHORT-QT-SYNDROME | BRUGADA-SYNDROME | ventricular arrhythmias | ELECTRICAL STORM | SUDDEN CARDIAC DEATH | ANTIARRHYTHMIC THERAPY | EARLY REPOLARIZATION SYNDROME | K+ CHANNEL | Arrhythmias, Cardiac - drug therapy | Ventricular Fibrillation - drug therapy | Anti-Arrhythmia Agents - adverse effects | Quinidine - adverse effects | Anti-Arrhythmia Agents - pharmacology | Brugada Syndrome - drug therapy | Humans | Quinidine - pharmacokinetics | Quinidine - pharmacology | Anti-Arrhythmia Agents - therapeutic use | Quinidine - therapeutic use | Anti-Arrhythmia Agents - pharmacokinetics | Index Medicus
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5. Full Text Quinidine therapy and therapeutic drug monitoring in four patients with KCNT1 mutations
by Yoshitomi, Shinsaku and Takahashi, Yukitoshi and Yamaguchi, Tokito and Oboshi, Taikan and Horino, Asako and Ikeda, Hiroko and Imai, Katsumi and Okanishi, Tohru and Nakashima, Mitsuko and Saitsu, Hirotomo and Matsumoto, Naomichi and Yoshimoto, Jun and Fujita, Takako and Ishii, Atsushi and Hirose, Shinichi and Inoue, Yushi
Epileptic Disorders, ISSN 1294-9361, 02/2019, Volume 21, Issue 1, pp. 48 - 54
Aims . Several recent studies have reported potassium sodium‐activated channel subfamily T member 1 ( KCNT1 ) mutations in epilepsy patients on quinidine... 
EIMFS | serum concentration | KCNT1 | quinidine | arrhythmia | migrating focal seizures | LOCALIZATION | NA+ | EPILEPSY | INFANCY | CLINICAL NEUROLOGY | POTASSIUM CHANNEL | Quinidine - blood | Anticonvulsants - blood | Arrhythmias, Cardiac - chemically induced | Epilepsies, Partial - drug therapy | Humans | Child, Preschool | Anticonvulsants - administration & dosage | Infant | Male | Quinidine - pharmacology | Quinidine - administration & dosage | Anticonvulsants - pharmacology | Nerve Tissue Proteins - genetics | Potassium Channels - genetics | Anticonvulsants - adverse effects | Quinidine - adverse effects | Electrocardiography | Female | Drug Monitoring | Child | Cardiac arrhythmia | Conduction | Arrhythmia | Epilepsy | Patients | Convulsions & seizures | Tachycardia | Sodium | Quinidine | Titration | Mutation | Ventricle | Drug dosages | Seizures
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6. Full Text [11 C]quinidine and [11 C]laniquidar PET imaging in a chronic rodent epilepsy model: Impact of epilepsy and drug-responsiveness
by Syvänen, Stina and Russmann, Vera and Verbeek, Joost and Eriksson, Jonas and Labots, Maaike and Zellinger, Christina and Seeger, Natalie and Schuit, Robert and Rongen, Marissa and van Kooij, Rolph and Windhorst, Albert D and Lammertsma, Adriaan A and de Lange, Elizabeth C and Voskuyl, Rob A and Koepp, Matthias and Potschka, Heidrun and Medicinska fakulteten and Geriatrik and Medicinska och farmaceutiska vetenskapsområdet and Uppsala universitet and Institutionen för folkhälso- och vårdvetenskap
Nuclear Medicine and Biology, ISSN 0969-8051, 2013, Volume 40, Issue 6, pp. 764 - 775
Abstract Introduction To analyse the impact of both epilepsy and pharmacological modulation of P-glycoprotein on brain uptake and kinetics of positron emission... 
Radiology | P-glycoprotein | [11C]quinidine | Positron emission tomography | [11C]laniquidar | Epilepsy | C]laniquidar | C]quinidine | [C-11]laniquidar | [C-11]quinidine | INCREASED EXPRESSION | RADIOTRACER | STATUS EPILEPTICUS | BLOOD-BRAIN-BARRIER | EPILEPTOGENESIS | RAT MODEL | ELECTRICAL-STIMULATION | HIGH-RESOLUTION | TRANSPORTER P-GLYCOPROTEIN | MULTIDRUG-RESISTANCE | RADIOLOGY, NUCLEAR MEDICINE & MEDICAL IMAGING | Phenobarbital - pharmacology | Quinidine - blood | Quinidine - chemistry | Quinolines - blood | Recurrence | ATP-Binding Cassette, Sub-Family B, Member 1 - metabolism | Epilepsy - diagnostic imaging | Epilepsy - metabolism | Male | Quinolines - pharmacology | Radiochemistry | Female | Disease Models, Animal | Quinidine - metabolism | Quinolines - chemistry | Gene Expression Regulation | Rats | Treatment Outcome | Benzazepines - blood | Positron-Emission Tomography - methods | Rats, Sprague-Dawley | Quinolines - metabolism | Phenobarbital - therapeutic use | Animals | Epilepsy - drug therapy | Quinolines - therapeutic use | Benzazepines - metabolism | Kinetics | Benzazepines - chemistry | Chronic Disease | Carbon Radioisotopes | Epilepsy - blood | PET imaging | Medical and Health Sciences | Medicin och hälsovetenskap
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7. Full Text Long-Term Follow-Up of Patients With Short QT Syndrome
by Giustetto, Carla, MD and Schimpf, Rainer, MD and Mazzanti, Andrea, MD and Scrocco, Chiara, MD and Maury, Philippe, MD and Anttonen, Olli, MD and Probst, Vincent, MD, PhD and Blanc, Jean-Jacques, MD and Sbragia, Pascal, MD and Dalmasso, Paola, MS and Borggrefe, Martin, MD and Gaita, Fiorenzo, MD
JACC (Journal of the American College of Cardiology), ISSN 0735-1097, 2011, Volume 58, Issue 6, pp. 587 - 595
Objectives The aim of this study was to investigate the clinical characteristics and the long-term course of a large cohort of patients with short QT syndrome... 
Cardiovascular | Internal Medicine | hydroquinidine | sudden death | implantable cardioverter defibrillator | arrhythmias | short-QT syndrome | channelopathies | CARDIAC & CARDIOVASCULAR SYSTEMS | TESTOSTERONE | CARDIOVERTER-DEFIBRILLATOR TREATMENT | INTERVAL SYNDROME | RISK | QUINIDINE | HERG | GENE | MUTATION | SUDDEN CARDIAC DEATH | SEX-DIFFERENCES | Arrhythmias, Cardiac - therapy | Follow-Up Studies | Anti-Arrhythmia Agents - pharmacology | Humans | Middle Aged | Quinidine - analogs & derivatives | Male | Treatment Outcome | Quinidine - pharmacology | ERG1 Potassium Channel | Ether-A-Go-Go Potassium Channels - genetics | Death, Sudden | Syncope - pathology | Defibrillators, Implantable | Adolescent | Adult | Female | Mutation | Electrocardiography - methods | Cohort Studies | Electrocardiography | Cardiology | Implants, Artificial | Prosthesis | Atrial fibrillation | Electrocardiogram | Studies | Cardiac arrhythmia | Families & family life | Variance analysis | Age | Methods
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8. Full Text Trial of dextromethorphan/quinidine to treat levodopa‐induced dyskinesia in Parkinson's disease
by Fox, Susan H and Metman, Leonard Verhagen and Nutt, John G and Brodsky, Matthew and Factor, Stewart A and Lang, Anthony E and Pope, Laura E and Knowles, Nadine and Siffert, João
Movement Disorders, ISSN 0885-3185, 06/2017, Volume 32, Issue 6, pp. 893 - 903
Background : Nondopaminergic pathways represent potential targets to treat levodopa‐induced dyskinesia in Parkinson's disease (PD). This pilot‐study... 
levodopa‐induced dyskinesia | Parkinson's disease | AVP‐923 | Unified Dyskinesia Rating Scale | dextromethorphan/quinidine | levodopa-induced dyskinesia | AVP-923 | DOPA-INDUCED DYSKINESIA | ABNORMAL INVOLUNTARY MOVEMENTS | CLINICAL NEUROLOGY | MOTOR FLUCTUATIONS | LIGANDS | AMANTADINE | SEROTONIN | QUALITY-OF-LIFE | RATING-SCALE | RECEPTORS | MODULATION | Outcome Assessment (Health Care) | Humans | Middle Aged | Male | Parkinson Disease - drug therapy | Enzyme Inhibitors - administration & dosage | Dyskinesia, Drug-Induced - drug therapy | Quinidine - adverse effects | Female | Dextromethorphan - adverse effects | Drug Therapy, Combination | Excitatory Amino Acid Antagonists - adverse effects | Dyskinesia, Drug-Induced - etiology | Dextromethorphan - pharmacology | Double-Blind Method | Enzyme Inhibitors - pharmacology | Excitatory Amino Acid Antagonists - administration & dosage | Excitatory Amino Acid Antagonists - pharmacology | Quinidine - pharmacology | Quinidine - administration & dosage | Antiparkinson Agents - adverse effects | Cross-Over Studies | Pilot Projects | Levodopa - adverse effects | Aged | Dextromethorphan - administration & dosage | Medicine, Experimental | Medical research | Dopa | Analysis | Movement disorders | Index Medicus
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9. Full Text AVP-786 for the treatment of agitation in dementia of the Alzheimer's type
by Garay, Ricardo P and Grossberg, George T
Expert Opinion on Investigational Drugs, ISSN 1354-3784, 01/2017, Volume 26, Issue 1, pp. 121 - 132
Introduction: Agitation is common and distressing in patients with Alzheimer-type dementia, but safe, effective treatments remain elusive. Psychological... 
AVP-786 | Agitation | quinidine | Alzheimer disease | dementia | AVP-923 | dextromethorphan | DEXTROMETHORPHAN BINDING-SITES | INJURY FOLLOWING TRANSIENT | RANDOMIZED CLINICAL-TRIAL | AMYOTROPHIC-LATERAL-SCLEROSIS | NICOTINIC ACETYLCHOLINE-RECEPTORS | GUINEA-PIG BRAIN | ATYPICAL ANTIPSYCHOTICS | REGULATED SIGMA SITES | CONDITIONED FEAR STRESS | PLACEBO-CONTROLLED TRIALS | PHARMACOLOGY & PHARMACY | Dextromethorphan - therapeutic use | Quinidine - chemistry | Alzheimer Disease - physiopathology | Brain - physiopathology | Humans | Alzheimer Disease - drug therapy | Deuterium - chemistry | Dextromethorphan - chemistry | Treatment Outcome | Psychomotor Agitation - drug therapy | Randomized Controlled Trials as Topic | Brain - metabolism | Psychomotor Agitation - etiology | Tissue Distribution | Animals | Quinidine - pharmacokinetics | Dextromethorphan - pharmacokinetics | Quinidine - therapeutic use | Drug Combinations
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10. Full Text The QUIDAM study: Hydroquinidine therapy for the management of Brugada syndrome patients at high arrhythmic risk
by Andorin, Antoine, MD and Gourraud, Jean-Baptiste, MD, PhD and Mansourati, Jacques, MD and Fouchard, Swanny, PhD and le Marec, Hervé, MD, PhD and Maury, Philippe, MD and Mabo, Philippe, MD, PhD and Hermida, Jean-Sylvain, MD and Deharo, Jean-Claude, MD and Delasalle, Béatrice, MS and Esnault, Simon, MD and Sadoul, Nicolas, MD and Davy, Jean-Marc, MD, PhD and Leenhardt, Antoine, MD and Klug, Didier, MD and Defaye, Pascal, MD and Babuty, Dominique, MD, PhD and Sacher, Frédéric, MD and Probst, Vincent, MD, PhD
Heart Rhythm, ISSN 1547-5271, 2017, Volume 14, Issue 8, pp. 1147 - 1154
Background Although the implantable cardioverter–defibrillator (ICD) remains the main therapy for Brugada syndrome (BrS), it does not reduce life-threatening... 
Cardiovascular | Repolarization | Implantable cardioverter–defibrillator | Brugada syndrome | Arrhythmia | Quinidine | CARDIAC & CARDIOVASCULAR SYSTEMS | CARDIOVERTER-DEFIBRILLATOR | VENTRICULAR-FIBRILLATION | MECHANISMS | QUINIDINE THERAPY | Implantable cardioverter-defibrillator | BUNDLE-BRANCH BLOCK | SUDDEN CARDIAC DEATH | TERM-FOLLOW-UP | ST-SEGMENT ELEVATION | ELECTROCARDIOGRAPHIC PARAMETERS | LONG | Ventricular Fibrillation - prevention & control | Prospective Studies | Double-Blind Method | Follow-Up Studies | Brugada Syndrome - physiopathology | Humans | Middle Aged | Quinidine - analogs & derivatives | Risk Factors | Male | Brugada Syndrome - complications | Anti-Arrhythmia Agents - therapeutic use | Ventricular Fibrillation - etiology | Cross-Over Studies | Heart Rate - drug effects | Time Factors | Defibrillators, Implantable | Electrocardiography | Ventricular Fibrillation - physiopathology | Adult | Female | Quinidine - therapeutic use | Brugada Syndrome - therapy | Medicine, Experimental | Medical research | Care and treatment | Implants, Artificial | Prosthesis | Life Sciences | Human health and pathology | Pharmacology | Pharmaceutical sciences | Cardiology and cardiovascular system
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11. Full Text Randomized, controlled trial of dextromethorphan/quinidine for pseudobulbar affect in multiple sclerosis
by Panitch, Hillel S and Thisted, Ronald A and Smith, Richard A and Wynn, Daniel R and Wymer, James P and Achiron, Anat and Vollmer, Timothy L and Mandler, Raul N and Dietrich, Dennis W and Fletcher, Malcolm and Pope, Laura E and Berg, James E and Miller, Ariel and Pseudobulbar Affect Multiple and Psuedobulbar Affect in Multiple Sclerosis Study Group and Pseudobulbar Affect in Multiple Sclerosis Study Group
Annals of Neurology, ISSN 0364-5134, 05/2006, Volume 59, Issue 5, pp. 780 - 787
Objective: To evaluate the efficacy and safety of DM/Q (capsules containing dextromethorphan [DM] and quinidine [Q]) compared with placebo, taken twice daily,... 
QUINIDINE | EMOTIONAL LABILITY | NEUROSCIENCES | CLINICAL NEUROLOGY | CLINICAL-TRIALS | LEVODOPA | Dextromethorphan - therapeutic use | Multiple Sclerosis - psychology | Affect - drug effects | Excitatory Amino Acid Antagonists - therapeutic use | Double-Blind Method | Excitatory Amino Acid Antagonists - pharmacokinetics | Humans | Middle Aged | Male | Pain Measurement - drug effects | Crying | Quinidine - adverse effects | Quinidine - pharmacokinetics | Quality of Life | Female | Laughter | Aged | Dextromethorphan - pharmacokinetics | Dextromethorphan - adverse effects | Quinidine - therapeutic use | Excitatory Amino Acid Antagonists - adverse effects | Drug Combinations | Multiple Sclerosis - drug therapy
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12. Full Text Synthesis and biological evaluation of fluoro-substituted 3,4-dihydroquinazoline derivatives for cytotoxic and analgesic effects
by Kim, Jin Han and Kim, Sun Young and Kim, Hyoung Ja and Jeong, Hui Rak and Jung, Da Woon and Yoon, Hong Bin and Lee, Kyung-Tae and Lee, Jae Yeol and Gadotti, Vinicius M and Huang, Junting and Zhang, Fang-Xiong and Zamponi, Gerald W
Bioorganic & Medicinal Chemistry, ISSN 0968-0896, 09/2017, Volume 25, Issue 17, pp. 4656 - 4664
As a bioisosteric strategy to overcome the poor metabolic stability of lead compound KYS05090S, a series of new fluoro-substituted 3,4-dihydroquinazoline... 
Liver microsomal stability | Bioisostere | Inflammatory pain | T-type calcium channel | 3,4-Dihydroquinazoline | Cytotoxic activity | CANCER-CELLS | APOPTOSIS | CHEMISTRY, MEDICINAL | STABILITY | BIOCHEMISTRY & MOLECULAR BIOLOGY | TUMOR | CHEMISTRY, ORGANIC | PROLIFERATION | CALCIUM-CHANNEL BLOCKERS | MEDICINAL CHEMISTRY | AGENT | NEUROPATHIC PAIN | ADENOCARCINOMA A549 CELLS | Quinazolines - chemical synthesis | Quinidine - chemistry | Quinidine - toxicity | Humans | Microsomes, Liver - metabolism | Quinidine - analogs & derivatives | Calcium Channels, T-Type - metabolism | Analgesics - chemical synthesis | Calcium Channels, T-Type - chemistry | HEK293 Cells | Inhibitory Concentration 50 | Calcium Channels, T-Type - genetics | Quinazolines - chemistry | Quinidine - chemical synthesis | Calcium Channel Blockers - chemical synthesis | A549 Cells | Cell Survival - drug effects | Drug Stability | Rats | Analgesics - toxicity | Calcium Channel Blockers - toxicity | Patch-Clamp Techniques | Animals | Quinazolines - toxicity | Analgesics - chemistry | Calcium Channel Blockers - chemistry | Fluorine - chemistry | Medical colleges | Calcium channels | Analysis | Liver | Resveratrol | Research institutes | Lung cancer, Non-small cell
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13. Full Text Long-term follow-up of asymptomatic Brugada patients with inducible ventricular fibrillation under hydroquinidine
by Bouzeman, Abdeslam and Traulle, Sarah and Messali, Anne and Extramiana, Fabrice and Denjoy, Isabelle and Narayanan, Kumar and Marijon, Eloi and Hermida, Jean-Sylvain and Leenhardt, Antoine
Europace, ISSN 1099-5129, 2014, Volume 16, Issue 4, pp. 572 - 577
To evaluate the long-term efficacy and safety of an electrophysiologically guided therapy, based on a strategy of treatment using hydroquinidine (HQ) among... 
Cardioverter defibrillator | Brugada syndrome | Primary prevention | Programmed ventricular stimulation | Sudden cardiac death | Hydroquinidine | ELECTROCARDIOGRAPHIC PATTERN | CARDIAC & CARDIOVASCULAR SYSTEMS | ST-SEGMENT-ELEVATION | RISK STRATIFICATION | PROGRAMMED ELECTRICAL-STIMULATION | NATURAL-HISTORY | QUINIDINE | INDIVIDUALS | IMPLANTABLE CARDIOVERTER-DEFIBRILLATOR | BUNDLE-BRANCH BLOCK | Brugada Syndrome - diagnosis | Prospective Studies | Follow-Up Studies | Ventricular Fibrillation - diagnosis | Brugada Syndrome - physiopathology | Humans | Middle Aged | Quinidine - analogs & derivatives | Male | Asymptomatic Diseases | Time Factors | Quinidine - adverse effects | Brugada Syndrome - drug therapy | Defibrillators, Implantable | Ventricular Fibrillation - physiopathology | Adult | Female | Quinidine - therapeutic use | France | Ventricular Fibrillation - prevention & control | Treatment Outcome | Anti-Arrhythmia Agents - therapeutic use | Electric Countershock - instrumentation | Anti-Arrhythmia Agents - adverse effects | Electrophysiologic Techniques, Cardiac
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14. Full Text Quinidine Revisited
by Yang, Felix, MD and Hanon, Sam, MD and Lam, Patrick, MD and Schweitzer, Paul, MD
American Journal of Medicine, The, ISSN 0002-9343, 2009, Volume 122, Issue 4, pp. 317 - 321
Abstract One of the earliest antiarrhythmic drugs developed, quinidine had a significant role in the treatment of many arrhythmias. After concerns for... 
Internal Medicine | Short QT syndrome | Arrhythmia | Brugada syndrome | Atrial fibrillation | Quinidine | Antiarrhythmic drug therapy | Idiopathic ventricular fibrillation | DIGOXIN-QUINIDINE | ATRIAL-FIBRILLATION | SHORT-QT-SYNDROME | MAINTENANCE | MEDICINE, GENERAL & INTERNAL | BRUGADA-SYNDROME | EARLY AFTERDEPOLARIZATIONS | ELECTRICAL STORM | IDIOPATHIC VENTRICULAR-FIBRILLATION | SINUS RHYTHM | ANTIARRHYTHMIC-DRUGS | Arrhythmias, Cardiac - drug therapy | Ventricular Fibrillation - drug therapy | Anti-Arrhythmia Agents - adverse effects | Quinidine - adverse effects | Humans | Quinidine - pharmacokinetics | Heart Diseases - drug therapy | Anti-Arrhythmia Agents - therapeutic use | Quinidine - therapeutic use | Anti-Arrhythmia Agents - pharmacokinetics | Index Medicus | Abridged Index Medicus
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15. Full Text Treatment of pseudobulbar affect in ALS with dextromethorphan/quinidine: A randomized trial
by Brooks, B.R and Thisted, R.A and Appel, S.H and Bradley, W.G and Olney, R.K and Berg, J.E and Pope, L.E and Smith, R.A and AVP-923 ALS Study Grp and AVP-923 ALS Study Group and for the AVP-923 ALS Study Group
Neurology, ISSN 0028-3878, 10/2004, Volume 63, Issue 8, pp. 1364 - 1370
Background: Patients with ALS commonly exhibit pseudobulbar affect. Methods: The authors conducted a multicenter, randomized, double-blind, controlled,... 
SIGMA-LIGANDS | AFFECTIVE LABILITY | INHIBITION | DOPAMINE RELEASE | GLUTAMATE | NEUROLOGY | SITES | PHENOTYPE | AMYOTROPHIC-LATERAL-SCLEROSIS | GUINEA-PIG BRAIN | CLINICAL NEUROLOGY | Cytochrome P-450 CYP2D6 Inhibitors | Quinidine - blood | Receptors, N-Methyl-D-Aspartate - antagonists & inhibitors | Amyotrophic Lateral Sclerosis - physiopathology | Humans | Middle Aged | Receptors, N-Methyl-D-Aspartate - metabolism | Male | Amyotrophic Lateral Sclerosis - drug therapy | Enzyme Inhibitors - administration & dosage | Quinidine - adverse effects | Adult | Female | Pseudobulbar Palsy - etiology | Dextromethorphan - adverse effects | Excitatory Amino Acid Antagonists - adverse effects | Pseudobulbar Palsy - drug therapy | Enzyme Inhibitors - adverse effects | Quinidine - metabolism | Double-Blind Method | Enzyme Inhibitors - metabolism | Excitatory Amino Acid Antagonists - administration & dosage | Treatment Outcome | Quinidine - administration & dosage | Metabolic Clearance Rate - physiology | Amyotrophic Lateral Sclerosis - complications | Dextromethorphan - blood | Pseudobulbar Palsy - physiopathology | Excitatory Amino Acid Antagonists - blood | Drug Interactions - physiology | Cytochrome P-450 CYP2D6 - metabolism | Aged | Glutamic Acid - metabolism | Metabolic Clearance Rate - drug effects | Drug Combinations | Dextromethorphan - administration & dosage
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16. Full Text Efficacy and Safety of Dextromethorphan/Quinidine at Two Dosage Levels for Diabetic Neuropathic Pain: A Double‐Blind, Placebo‐Controlled, Multicenter Study
by Shaibani, Aziz I and Pope, Laura E and Thisted, Ronald and Hepner, Adrian
Pain Medicine, ISSN 1526-2375, 02/2012, Volume 13, Issue 2, pp. 243 - 254
Objective.  To evaluate dextromethorphan coadministered with quinidine as treatment of diabetic peripheral neuropathic pain. Design.  In a 13‐week, phase 3,... 
Pain | Clinical Trial | Diabetic Peripheral Neuropathic Pain | Dextromethorphan/Quinidine | Numerical Pain Rating Scale | Dextromethorphan/quinidine | Diabetic peripheral neuropathic pain | Clinical trial | Numerical pain rating scale | CONTROLLED-TRIAL | PREGABALIN | Dextromethorphan | PREVALENCE | MEDICINE, GENERAL & INTERNAL | DULOXETINE | Quinidine | DEXTRORPHAN | PERIPHERAL NEUROPATHY | PSEUDOBULBAR AFFECT | BINDING-SITES | ANTAGONISTS | Excitatory Amino Acid Antagonists - metabolism | Double-Blind Method | Humans | Middle Aged | Excitatory Amino Acid Antagonists - administration & dosage | Dextromethorphan - metabolism | Male | Diabetic Neuropathies - drug therapy | Quinidine - administration & dosage | Quinidine - adverse effects | Aged, 80 and over | Placebos | Adult | Female | Aged | Dextromethorphan - adverse effects | Excitatory Amino Acid Antagonists - adverse effects | Drug Combinations | Dextromethorphan - administration & dosage | Diabetic Neuropathies - physiopathology | Medical colleges | Care and treatment | Stimulants | Analysis | Diabetes | Drug therapy, Combination | Drug therapy | Pain management
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17. Full Text Dimeric quinidine-catalyzed enantioselective aminooxygenation of oxindoles: An organocatalytic approach to 3-hydroxyoxindole derivatives
by Bui, Tommy and Candeias, Nuno R and Barbas, Carlos F
Journal of the American Chemical Society, ISSN 0002-7863, 04/2010, Volume 132, Issue 16, pp. 5574 - 5575
3-Hydroxyoxindoles are common structural motifs found in a vast array of natural and biologically active molecules. Most catalytic methods for the asymmetric... 
ISATINS | HYDROXYLATION | ASYMMETRIC ADDITION | 2-OXINDOLES | CHEMISTRY, MULTIDISCIPLINARY | ARYLBORONIC ACIDS | NITROALKENES | ACCESS | ALKALOIDS | Quinidine - chemistry | Nitroso Compounds - chemistry | Oxidation-Reduction | Stereoisomerism | Substrate Specificity | Catalysis | Dimerization | Indoles - chemistry | Benzene | Analysis | Indole | Quinidine | Substitution reactions | Chemical properties
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