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1. Full Text Quinidine interaction with Shab K.sup.+ channels: pore block and irreversible collapse of the K.sup.+ conductance
by Gomez-Lagunas, Froylan
The Journal of physiology, ISSN 0022-3751, 08/2010, Volume 588, Issue 15, p. 2691
Quinidine
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2. Full Text Synthesis of fluorhydrins by reaction of quinidine acetate, epiquinidine, and its acetate in superacid
by Chagnault, Vincent and Jouannetaud, Marie-Paule and Jacquesy, Jean-Claude and Marrot, Jérome
Tetrahedron, ISSN 0040-4020, 2006, Volume 62, Issue 43, pp. 10248 - 10254
Quinidine
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3. Full Text Synthesis of Novel (9S)‐Acyloxy Derivatives of Quinidine and Dihydroquinidine as Insecticidal Agents
by Che, Zhiping and Yang, Jinming and Sun, Di and Tian, Yuee and Liu, Shengming and Lin, Xiaomin and Jiang, Jia and Chen, Genqiang
Chemistry & biodiversity, ISSN 1612-1872, 04/2020, Volume 17, Issue 4, pp. e1900696 - n/a
acyloxy | quinidine | insecticidal activity | structural modification | dihydroquinidine | Biochemistry & Molecular Biology | Physical Sciences | Chemistry | Life Sciences & Biomedicine | Chemistry, Multidisciplinary | Science & Technology | Insecticides - pharmacology | Moths - growth & development | Quinidine - chemistry | Insecticides - chemistry | Animals | Insecticides - chemical synthesis | Larva - drug effects | Stereoisomerism | Quinidine - analogs & derivatives | Quinidine - pharmacology | Moths - drug effects | Quinidine - chemical synthesis | Natural products | Quinidine | Insecticides | In vivo methods and tests | Bans | Derivatives | Configurations | Index Medicus
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4. Full Text Novel, Potent, and Druglike Tetrahydroquinazoline Inhibitor That Is Highly Selective for Human Topoisomerase II α over β
by Ortega, Jose Antonio and Arencibia, Jose M and Minniti, Elirosa and Byl, Jo Ann W and Franco-Ulloa, Sebastian and Borgogno, Marco and Genna, Vito and Summa, Maria and Bertozzi, Sine Mandrup and Bertorelli, Rosalia and Armirotti, Andrea and Minarini, Anna and Sissi, Claudia and Osheroff, Neil and De Vivo, Marco
Journal of medicinal chemistry, ISSN 0022-2623, 11/2020, Volume 63, Issue 21, pp. 12873 - 12886
Pharmacology & Pharmacy | Life Sciences & Biomedicine | Chemistry, Medicinal | Science & Technology | Quinidine - metabolism | Cell Survival - drug effects | DNA Topoisomerases, Type II - metabolism | Quinidine - chemistry | Humans | Quinidine - analogs & derivatives | Half-Life | Quinidine - pharmacology | Topoisomerase II Inhibitors - pharmacology | DNA - metabolism | Topoisomerase II Inhibitors - metabolism | DNA - chemistry | Animals | Topoisomerase II Inhibitors - chemistry | Isoenzymes - metabolism | DNA Topoisomerases, Type II - chemistry | Cell Line, Tumor | Mice | DNA Cleavage | Isoenzymes - antagonists & inhibitors | Drug Screening Assays, Antitumor | Index Medicus
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5. Full Text Precision therapy for epilepsy due to KCNT1 mutations: A randomized trial of oral quinidine
by Mullen, Saul A and Carney, Patrick W and Roten, Annie and Ching, Michael and Lightfoot, Paul A and Churilov, Leonid and Nair, Umesh and Li, Melody and Berkovic, Samuel F and Petrou, Steven and Scheffer, Ingrid E
Neurology, ISSN 0028-3878, 01/2018, Volume 90, Issue 1, pp. e67 - e72
Clinical Neurology | Neurosciences & Neurology | Life Sciences & Biomedicine | Science & Technology | Quinidine - blood | Seizures - blood | Epilepsy, Frontal Lobe - blood | Anticonvulsants - blood | Epilepsy, Frontal Lobe - genetics | Seizures - genetics | Double-Blind Method | Humans | Middle Aged | Seizures - drug therapy | Anticonvulsants - therapeutic use | Nerve Tissue Proteins - genetics | Potassium Channels - genetics | Cross-Over Studies | Anticonvulsants - adverse effects | Quinidine - adverse effects | Treatment Failure | Adolescent | Adult | Gain of Function Mutation | Quinidine - therapeutic use | Epilepsy, Frontal Lobe - drug therapy | Precision Medicine
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6. Full Text AVP-786 for the treatment of agitation in dementia of the Alzheimer's type
by Garay, Ricardo P and Grossberg, George T
Expert opinion on investigational drugs, ISSN 1354-3784, 01/2017, Volume 26, Issue 1, pp. 121 - 132
AVP-786 | Agitation | quinidine | Alzheimer disease | dementia | AVP-923 | dextromethorphan | Life Sciences & Biomedicine | Pharmacology & Pharmacy | Science & Technology | Dextromethorphan - therapeutic use | Quinidine - chemistry | Alzheimer Disease - physiopathology | Brain - physiopathology | Humans | Alzheimer Disease - drug therapy | Deuterium - chemistry | Dextromethorphan - chemistry | Treatment Outcome | Psychomotor Agitation - drug therapy | Randomized Controlled Trials as Topic | Brain - metabolism | Psychomotor Agitation - etiology | Tissue Distribution | Animals | Quinidine - pharmacokinetics | Dextromethorphan - pharmacokinetics | Quinidine - therapeutic use | Drug Combinations | Index Medicus
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7. Full Text Trial of dextromethorphan/quinidine to treat levodopa‐induced dyskinesia in Parkinson's disease
by Fox, Susan H and Metman, Leonard Verhagen and Nutt, John G and Brodsky, Matthew and Factor, Stewart A and Lang, Anthony E and Pope, Laura E and Knowles, Nadine and Siffert, João
Movement disorders, ISSN 0885-3185, 06/2017, Volume 32, Issue 6, pp. 893 - 903
levodopa‐induced dyskinesia | Parkinson's disease | AVP‐923 | Unified Dyskinesia Rating Scale | dextromethorphan/quinidine | levodopa-induced dyskinesia | AVP-923 | Clinical Neurology | Neurosciences & Neurology | Life Sciences & Biomedicine | Science & Technology | Outcome Assessment (Health Care) | Humans | Middle Aged | Male | Parkinson Disease - drug therapy | Enzyme Inhibitors - administration & dosage | Dyskinesia, Drug-Induced - drug therapy | Quinidine - adverse effects | Female | Dextromethorphan - adverse effects | Drug Therapy, Combination | Excitatory Amino Acid Antagonists - adverse effects | Dyskinesia, Drug-Induced - etiology | Dextromethorphan - pharmacology | Double-Blind Method | Enzyme Inhibitors - pharmacology | Excitatory Amino Acid Antagonists - administration & dosage | Excitatory Amino Acid Antagonists - pharmacology | Quinidine - pharmacology | Quinidine - administration & dosage | Antiparkinson Agents - adverse effects | Cross-Over Studies | Pilot Projects | Levodopa - adverse effects | Aged | Dextromethorphan - administration & dosage | Medicine, Experimental | Medical research | Dopa | Analysis | Movement disorders | Index Medicus
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8. Full Text Atrial fibrillation in horses Part 2: Diagnosis, treatment and prognosis
by Decloedt, Annelies and Van Steenkiste, Glenn and Vera, Lisse and Buhl, Rikke and van Loon, Gunther
The veterinary journal (1997), ISSN 1090-0233, 02/2021, Volume 268
Arrhythmia | Quinidine | Equine | Transvenous electrical cardioversion | Cardiology
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9. Full Text Synthesis and biological evaluation of fluoro-substituted 3,4-dihydroquinazoline derivatives for cytotoxic and analgesic effects
by Kim, Jin Han and Jeong, Hui Rak and Jung, Da Woon and Yoon, Hong Bin and Kim, Sun Young and Kim, Hyoung Ja and Lee, Kyung-Tae and Gadotti, Vinicius M and Huang, Junting and Zhang, Fang-Xiong and Zamponi, Gerald W and Lee, Jae Yeol
Bioorganic & medicinal chemistry, ISSN 0968-0896, 09/2017, Volume 25, Issue 17, pp. 4656 - 4664
Liver microsomal stability | Bioisostere | Inflammatory pain | T-type calcium channel | 3,4-Dihydroquinazoline | Cytotoxic activity | Quinazolines - chemical synthesis | Quinidine - chemistry | Quinidine - toxicity | Humans | Microsomes, Liver - metabolism | Quinidine - analogs & derivatives | Calcium Channels, T-Type - metabolism | Analgesics - chemical synthesis | Calcium Channels, T-Type - chemistry | HEK293 Cells | Inhibitory Concentration 50 | Calcium Channels, T-Type - genetics | Quinazolines - chemistry | Quinidine - chemical synthesis | Calcium Channel Blockers - chemical synthesis | A549 Cells | Cell Survival - drug effects | Drug Stability | Rats | Analgesics - toxicity | Calcium Channel Blockers - toxicity | Patch-Clamp Techniques | Animals | Quinazolines - toxicity | Analgesics - chemistry | Calcium Channel Blockers - chemistry | Fluorine - chemistry | Medical colleges | Calcium channels | Analysis | Liver | Resveratrol | Research institutes | Lung cancer, Non-small cell | Index Medicus
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10. Full Text [11 C]quinidine and [11 C]laniquidar PET imaging in a chronic rodent epilepsy model: Impact of epilepsy and drug-responsiveness
by Syvänen, Stina and Russmann, Vera and Verbeek, Joost and Eriksson, Jonas and Labots, Maaike and Zellinger, Christina and Seeger, Natalie and Schuit, Robert and Rongen, Marissa and van Kooij, Rolph and Windhorst, Albert D and Lammertsma, Adriaan A and de Lange, Elizabeth C and Voskuyl, Rob A and Koepp, Matthias and Potschka, Heidrun
Nuclear medicine and biology, ISSN 0969-8051, 2013, Volume 40, Issue 6, pp. 764 - 775
Radiology | P-glycoprotein | [11C]quinidine | Positron emission tomography | [11C]laniquidar | Epilepsy | C]laniquidar | C]quinidine | Life Sciences & Biomedicine | Radiology, Nuclear Medicine & Medical Imaging | Science & Technology | Phenobarbital - pharmacology | Quinidine - blood | Quinidine - chemistry | Quinolines - blood | Recurrence | ATP-Binding Cassette, Sub-Family B, Member 1 - metabolism | Epilepsy - diagnostic imaging | Epilepsy - metabolism | Male | Quinolines - pharmacology | Radiochemistry | Female | Disease Models, Animal | Quinidine - metabolism | Quinolines - chemistry | Gene Expression Regulation | Rats | Treatment Outcome | Benzazepines - blood | Positron-Emission Tomography - methods | Rats, Sprague-Dawley | Quinolines - metabolism | Phenobarbital - therapeutic use | Animals | Epilepsy - drug therapy | Quinolines - therapeutic use | Benzazepines - metabolism | Kinetics | Benzazepines - chemistry | Chronic Disease | Carbon Radioisotopes | Epilepsy - blood | PET imaging | Index Medicus
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11. Full Text Quinidine in the treatment of KCNT1‐positive epilepsies
by Mikati, Mohamad A and Jiang, Yong‐hui and Carboni, Michael and Shashi, Vandana and Petrovski, Slave and Spillmann, Rebecca and Milligan, Carol J and Li, Melody and Grefe, Annette and McConkie, Allyn and Berkovic, Samuel and Scheffer, Ingrid and Mullen, Saul and Bonner, Melanie and Petrou, Steven and Goldstein, David
Annals of neurology, ISSN 0364-5134, 12/2015, Volume 78, Issue 6, pp. 995 - 999
Neurosciences | Clinical Neurology | Neurosciences & Neurology | Life Sciences & Biomedicine | Science & Technology | Humans | Enzyme Inhibitors - pharmacology | Child, Preschool | Male | Quinidine - pharmacology | Quinidine - administration & dosage | Nerve Tissue Proteins - genetics | Drug Resistant Epilepsy - drug therapy | Potassium Channels - genetics | Enzyme Inhibitors - administration & dosage | Drug Resistant Epilepsy - genetics | Female | Mutation | Child | Index Medicus
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12. Full Text Severe Malaria Treatment in the United States at the Precipice
by Krey, Rebecca A and Travassos, Mark A
Annals of internal medicine, ISSN 0003-4819, 09/2019, Volume 171, Issue 5, pp. 362 - 363
Medicine, General & Internal | Life Sciences & Biomedicine | General & Internal Medicine | Science & Technology | Severity of Illness Index | Malaria, Falciparum - drug therapy | Artesunate - therapeutic use | United States | Humans | Quinidine - analogs & derivatives | Male | Antimalarials - therapeutic use | Drug Approval | Young Adult | Patient Care Planning | Malaria, Falciparum - diagnosis | Quinidine - supply & distribution | Quinidine - therapeutic use | Antimalarials - supply & distribution | United States Food and Drug Administration | Prescription drugs | Hospitals | Malaria | Medical treatment | Public health | Index Medicus | Abridged Index Medicus
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13. Quantitative evaluation of the impact of active efflux by P-glycoprotein and breast cancer resistance protein at the blood-brain barrier on the predictability of the unbound concentrations of drugs in the brain using cerebrospinal fluid concentration as a surrogate
by Kodaira, Hiroshi and Kusuhara, Hiroyuki and Fujita, Takuya and Ushiki, Junko and Fuse, Eiichi and Sugiyama, Yuichi
The Journal of pharmacology and experimental therapeutics, ISSN 0022-3565, 12/2011, Volume 339, Issue 3, pp. 935 - 944
Life Sciences & Biomedicine | Pharmacology & Pharmacy | Science & Technology | ATP Binding Cassette Transporter, Sub-Family G, Member 2 | Erlotinib Hydrochloride | Humans | ATP-Binding Cassette, Sub-Family B, Member 1 - metabolism | Quinazolines - pharmacokinetics | Male | Neoplasm Proteins - metabolism | Antineoplastic Agents - metabolism | Brain - metabolism | Biological Transport, Active | Quinazolines - metabolism | Quinidine - pharmacokinetics | ATP-Binding Cassette Transporters - metabolism | Female | Antineoplastic Agents - pharmacokinetics | Quinazolines - cerebrospinal fluid | Quinidine - metabolism | Antineoplastic Agents - cerebrospinal fluid | Rats | Blood-Brain Barrier - drug effects | Quinidine - cerebrospinal fluid | Blood-Brain Barrier - metabolism | Mice, Knockout | Brain - drug effects | Animals | Dogs | ATP Binding Cassette Transporter, Sub-Family B - metabolism | Biomarkers | Protein Binding | Mice
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