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1. Full Text Determination of moxifloxacin in dried blood spots using LC–MS/MS and the impact of the hematocrit and blood volume
by Vu, D.H and Koster, R.A and Alffenaar, J.W.C and Brouwers, J.R.B.J and Uges, D.R.A
Journal of chromatography. B, Analytical technologies in the biomedical and life sciences, ISSN 1570-0232, 2011, Volume 879, Issue 15, pp. 1063 - 1070
Tuberculosis | Moxifloxacin | Pharmacokinetics | LC–MS/MS | Dried blood spot | Hematocrit | MYCOBACTERIUM-TUBERCULOSIS | PHASE-II | TANDEM MASS-SPECTROMETRY | CEREBROSPINAL-FLUID | QUANTITATIVE-ANALYSIS | UMCG Approved | LC-MS/MS | PLASMA | MULTIDRUG-RESISTANT TUBERCULOSIS | FILTER-PAPER | Biochemistry & Molecular Biology | Physical Sciences | Chemistry | Life Sciences & Biomedicine | Biochemical Research Methods | Chemistry, Analytical | Science & Technology | Fundamental and applied biological sciences. Psychology | Analytical, structural and metabolic biochemistry | General pharmacology | Analysis | Pharmacology. Drug treatments | Biological and medical sciences | Medical sciences | Fluoroquinolones | Quinolines - blood | Reproducibility of Results | Aza Compounds - therapeutic use | Drug Stability | Humans | Linear Models | Antitubercular Agents - blood | Blood Specimen Collection | Sensitivity and Specificity | Tuberculosis - drug therapy | Blood Volume | Aza Compounds - blood | Quinolines - therapeutic use | Tuberculosis - blood | Chromatography, Liquid - methods | Drug Monitoring | Tandem Mass Spectrometry - methods | Antitubercular Agents - therapeutic use | Antitubercular agents | Liquid chromatography | Mass spectrometry | Index Medicus | Blood volume | DBS | Spots | Bacteria | Disks | Time division multiplexing | Sampling | Blood
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2. Full Text Pgp‐Mediated Interaction Between (R)‐[11C]Verapamil and Tariquidar at the Human Blood–Brain Barrier: A Comparison With Rat Data
by Bauer, M and Zeitlinger, M and Karch, R and Matzneller, P and Stanek, J and Jäger, W and Böhmdorfer, M and Wadsak, W and Mitterhauser, M and Bankstahl, J P and Löscher, W and Koepp, M and Kuntner, C and Müller, M and Langer, Oliver
Clinical pharmacology and therapeutics, ISSN 0009-9236, 02/2012, Volume 91, Issue 2, pp. 227 - 233
Life Sciences & Biomedicine | Pharmacology & Pharmacy | Science & Technology | Biological and medical sciences | Pharmacology. Drug treatments | Medical sciences | Quinolines - blood | Brain - diagnostic imaging | Species Specificity | Humans | Rats | Verapamil - pharmacokinetics | Positron-Emission Tomography - methods | ATP-Binding Cassette, Sub-Family B, Member 1 - antagonists & inhibitors | Calcium Channel Blockers - pharmacology | Blood-Brain Barrier - drug effects | Quinolines - pharmacology | Brain - metabolism | Dose-Response Relationship, Drug | Positron-Emission Tomography - statistics & numerical data | Animals | Blood-Brain Barrier - diagnostic imaging | Carbon Radioisotopes | Dose-response relationship (Biochemistry) | Usage | PET imaging | Protease inhibitors | Drug interactions | Verapamil | Dosage and administration | Research | Index Medicus | Abridged Index Medicus
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3. Full Text Saliva versus Plasma Pharmacokinetics: Theory and Application of a Salivary Excretion Classification System
by Idkaidek, Nasir and Arafat, Tawfiq
Molecular pharmaceutics, ISSN 1543-8384, 08/2012, Volume 9, Issue 8, pp. 2358 - 2363
Salivary Excretion Classification System | effective permeability | pharmacokinetics | protein binding | bioequivalence | SimCYP | Pharmacology & Pharmacy | Life Sciences & Biomedicine | Medicine, Research & Experimental | Science & Technology | Research & Experimental Medicine | Quinolines - blood | Acetates - blood | Fluorobenzenes - pharmacokinetics | Hydrochlorothiazide - pharmacokinetics | Triazoles - blood | Piroxicam - blood | Azithromycin - blood | Humans | Losartan - blood | Saliva - secretion | Male | Naphthalenes - blood | Benzhydryl Compounds - blood | Fluorobenzenes - pharmacology | Quinolines - pharmacokinetics | Sulfonamides - blood | Azithromycin - pharmacokinetics | Tolterodine Tartrate | Female | Triazoles - pharmacokinetics | Naphthalenes - pharmacokinetics | Piroxicam - analogs & derivatives | Sitagliptin Phosphate | Hydrochlorothiazide - blood | Losartan - pharmacokinetics | Benzhydryl Compounds - pharmacokinetics | Metformin - blood | Cresols - blood | Phenylpropanolamine - blood | Metformin - pharmacokinetics | Rosuvastatin Calcium | Cloxacillin - pharmacokinetics | Pyrimidines - pharmacology | Sulfonamides - pharmacology | Sulfonamides - pharmacokinetics | Cinacalcet Hydrochloride | Cloxacillin - blood | Saliva - metabolism | Pyrazines - pharmacokinetics | Piroxicam - pharmacokinetics | Pyrimidines - pharmacokinetics | Cresols - pharmacokinetics | Anthraquinones - blood | Anthraquinones - pharmacokinetics | Phenylpropanolamine - pharmacokinetics | Pyrazines - blood | Acetates - pharmacokinetics | Index Medicus
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4. Full Text Comparability of [18F]THK5317 and [11C]PIB blood flow proxy images with [18F]FDG positron emission tomography in Alzheimer’s disease
by Rodriguez-Vieitez, Elena and Leuzy, Antoine and Chiotis, Konstantinos and Saint-Aubert, Laure and Wall, Anders and Nordberg, Agneta
Journal of cerebral blood flow and metabolism, ISSN 0271-678X, 2/2017, Volume 37, Issue 2, pp. 740 - 749
2-deoxy-2- | F]THK5317 positron emission tomography | early-phase | Alzheimer's disease | F]fluoro-D-glucose | early-phase carbon-11 Pittsburgh Compound-B | simplified reference tissue model R 1 | Endocrinology & Metabolism | Neurosciences | Neurosciences & Neurology | Life Sciences & Biomedicine | Hematology | Science & Technology | Aniline Compounds - analysis | Brain - diagnostic imaging | Fluorodeoxyglucose F18 - analysis | Cognitive Dysfunction - metabolism | Humans | Male | Positron-Emission Tomography - methods | Radiopharmaceuticals - analysis | Thiazoles - analysis | Quinolines - analysis | Brain - blood supply | Alzheimer Disease - metabolism | Glucose - metabolism | Female | Alzheimer Disease - diagnostic imaging | Cognitive Dysfunction - diagnostic imaging | Index Medicus | early-phase [18F]THK5317 positron emission tomography | 2-deoxy-2-[18F]fluoro-D-glucose | Alzheimer’s disease | Original | simplified reference tissue model R1 | Medicin och hälsovetenskap
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5. Full Text Residual Antimalarial Concentrations before Treatment in Patients with Malaria from Cambodia: Indication of Drug Pressure
by Eva Maria Hodel and Blaise Genton and Boris Zanolari and Thomas Mercier and Socheat Duong and Hans-Peter Beck and Piero Olliaro and Laurent Arthur Decosterd and Frédéric Ariey
The Journal of infectious diseases, ISSN 0022-1899, 10/2010, Volume 202, Issue 7, pp. 1088 - 1094
Statistical median | Malaria | Artemisinins | Antimalarials | Parasitism | Parasites | Dosage | Private sector | Falciparum malaria | Blood plasma | Infectious Diseases | Immunology | Life Sciences & Biomedicine | Microbiology | Science & Technology | Fundamental and applied biological sciences. Psychology | Infectious diseases | Parasitic diseases | Protozoal diseases | Biological and medical sciences | Human protozoal diseases | Medical sciences | Mefloquine - blood | Quinolines - blood | Cambodia | Humans | Middle Aged | Selection, Genetic | Antimalarials - blood | Child, Preschool | Chloroquine - blood | Male | Young Adult | Tandem Mass Spectrometry | Adolescent | Malaria, Falciparum - diagnosis | Quinine - blood | Chromatography, Liquid | Adult | Female | Child | Drug Resistance | Serum - chemistry | Care and treatment | Usage | Health promotion | Influence | Research | Drug resistance | Health aspects | Index Medicus | Abridged Index Medicus
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6. Full Text In vitro analysis of drugs that improve hyperglycemia-induced blood-brain barrier dysfunction
by Kayano, Ryoma and Morofuji, Yoichi and Nakagawa, Shinsuke and Fukuda, Shuji and Watanabe, Daisuke and Ozawa, Hiroki and Niwa, Masami and Matsuo, Takayuki
Biochemical and biophysical research communications, ISSN 0006-291X, 09/2018, Volume 503, Issue 3, pp. 1885 - 1890
Pitavastatin | Hyperglycemia | Blood-brain barrier | Candesartan | Biochemistry & Molecular Biology | Biophysics | Life Sciences & Biomedicine | Science & Technology | Reactive Oxygen Species - metabolism | Tetrazoles - pharmacology | Cilostazol - pharmacology | Rats, Wistar | Rats | Electric Impedance | Blood-Brain Barrier - drug effects | Hyperglycemia - drug therapy | Quinolines - pharmacology | Blood-Brain Barrier - metabolism | Hyperglycemia - metabolism | Propranolol - pharmacology | Animals | Eicosapentaenoic Acid - pharmacology | Benzimidazoles - pharmacology | Disease Models, Animal | Hypertension | Drugs | Diabetics | Comorbidity | Glucose | Risk factors | Dextrose | Unsaturated fatty acids | Analysis | Atherosclerosis | Diabetes | Omega-3 fatty acids | Index Medicus
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7. Full Text A Prediction Method for P-glycoprotein–Mediated Drug–Drug Interactions at the Human Blood–Brain Barrier From Blood Concentration–Time Profiles, Validated With PET Data
by Matsuda, Akihiro and Karch, Rudolf and Bauer, Martin and Traxl, Alexander and Zeitlinger, Markus and Langer, Oliver
Journal of pharmaceutical sciences, ISSN 0022-3549, 09/2017, Volume 106, Issue 9, pp. 2780 - 2786
P-glycoprotein | drug-drug interactions | ABC transporters | physiologically based pharmacokinetic model | blood–brain barrier | PET | Physical Sciences | Chemistry | Life Sciences & Biomedicine | Pharmacology & Pharmacy | Chemistry, Medicinal | Chemistry, Multidisciplinary | Science & Technology | Humans | ATP-Binding Cassette, Sub-Family B, Member 1 - metabolism | Capillary Permeability - drug effects | Verapamil - pharmacokinetics | Positron-Emission Tomography | ATP-Binding Cassette, Sub-Family B, Member 1 - antagonists & inhibitors | Anti-Arrhythmia Agents - pharmacokinetics | Neoplasm Proteins - metabolism | Blood-Brain Barrier - drug effects | ATP Binding Cassette Transporter, Sub-Family G, Member 2 - metabolism | Quinolines - pharmacology | Blood-Brain Barrier - metabolism | Quinolines - pharmacokinetics | Drug Interactions | Models, Biological | Computer Simulation | Index Medicus
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8. Full Text Functional Characterization of Mouse Organic Anion Transporting Peptide 1a4 in the Uptake and Efflux of Drugs Across the Blood-Brain Barrier
by Atsushi Ose and Hiroyuki Kusuhara and Chihiro Endo and Kimio Tohyama and Mari Miyajima and Satoshi Kitamura and Yuichi Sugiyama
Drug metabolism and disposition, ISSN 0090-9556, 01/2010, Volume 38, Issue 1, pp. 168 - 176
Life Sciences & Biomedicine | Pharmacology & Pharmacy | Science & Technology | Fluorobenzenes - pharmacokinetics | Gene Expression - genetics | Pyrimidines - blood | Humans | Ion Pumps - genetics | Fluorobenzenes - administration & dosage | Quinolines - administration & dosage | Pyrimidines - metabolism | Brain - metabolism | Quinolines - pharmacokinetics | Choroid Plexus - blood supply | ATP-Binding Cassette Transporters - genetics | Ochratoxins - administration & dosage | Cell Membrane - metabolism | Cerebral Cortex - drug effects | Capillaries - metabolism | Fluorobenzenes - metabolism | Tetrahydroisoquinolines - pharmacology | Organic Cation Transport Proteins - metabolism | Pravastatin - metabolism | Liver - metabolism | Rosuvastatin Calcium | Sulfonamides - pharmacokinetics | Blood-Brain Barrier - metabolism | Mice, Knockout | Brain - drug effects | Taurocholic Acid - administration & dosage | Pravastatin - administration & dosage | Enkephalin, D-Penicillamine (2,5)- - administration & dosage | Pyrimidines - pharmacokinetics | Mice | Kinetics | Organic Cation Transport Proteins - genetics | Pravastatin - pharmacokinetics | Sulfonamides - administration & dosage | Quinolines - blood | Digoxin - metabolism | Taurocholic Acid - metabolism | Choroid Plexus - metabolism | Taurocholic Acid - blood | Ochratoxins - pharmacokinetics | ATP-Binding Cassette, Sub-Family B, Member 1 - antagonists & inhibitors | Ochratoxins - metabolism | Cerebral Cortex - metabolism | Organic Anion Transporters - metabolism | Brain - blood supply | Sulfonamides - blood | Organic Anion Transporters - genetics | Transfection | Fluorobenzenes - blood | Enkephalin, D-Penicillamine (2,5)- - pharmacokinetics | Recombinant Proteins - metabolism | Cell Line | Pyrimidines - administration & dosage | Mice, Inbred C57BL | Recombinant Proteins - genetics | Blood-Brain Barrier - drug effects | Digoxin - pharmacokinetics | Quinolines - metabolism | Taurocholic Acid - pharmacokinetics | Liver - blood supply | Pharmaceutical Preparations - metabolism | Animals | Digoxin - administration & dosage | Enkephalin, D-Penicillamine (2,5)- - metabolism | Acridines - pharmacology | Sulfonamides - metabolism | Index Medicus
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9. Full Text Torcetrapib‐induced blood pressure elevation is independent of CETP inhibition and is accompanied by increased circulating levels of aldosterone
by Forrest, M J and Bloomfield, D and Briscoe, R J and Brown, P N and Cumiskey, A‐M and Ehrhart, J and Hershey, J C and Keller, W J and Ma, X and McPherson, H E and Messina, E and Peterson, L B and Sharif‐Rodriguez, W and Siegl, P K S and Sinclair, P J and Sparrow, C P and Stevenson, A S and Sun, S‐Y and Tsai, C and Vargas, H and Walker, M and West, S H and White, V and Woltmann, R F
British journal of pharmacology, ISSN 0007-1188, 08/2008, Volume 154, Issue 7, pp. 1465 - 1473
preclinical animal models | cholesteryl ester transfer protein inhibitor | aldosterone | Aldosterone | Cholesteryl ester transfer protein inhibitor | Preclinical animal models | Life Sciences & Biomedicine | Pharmacology & Pharmacy | Science & Technology | Cholesterol Ester Transfer Proteins - antagonists & inhibitors | Anticholesteremic Agents - toxicity | Muscle, Smooth, Vascular - metabolism | Species Specificity | Mice, Inbred C57BL | Aldosterone - blood | Rats | Male | Macaca mulatta | Adrenal Cortex - cytology | Rats, Sprague-Dawley | Oxazolidinones - toxicity | Animals | Dogs | Female | Models, Animal | Blood Pressure - drug effects | Mice | Adrenal Cortex - drug effects | Corticosterone - blood | Drug Evaluation, Preclinical | Quinolines - toxicity | Muscle, Smooth, Vascular - drug effects | Index Medicus | Research Papers
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10. Full Text Safety of bosutinib versus imatinib in the phase 3 BELA trial in newly diagnosed chronic phase chronic myeloid leukemia
by Gambacorti‐Passerini, Carlo and Cortes, Jorge E and Lipton, Jeff H and Dmoszynska, Anna and Wong, Raymond S and Rossiev, Victor and Pavlov, Dmitri and Gogat Marchant, Karin and Duvillié, Ladan and Khattry, Navin and Kantarjian, Hagop M and Brümmendorf, Tim H
American journal of hematology, ISSN 0361-8609, 10/2014, Volume 89, Issue 10, pp. 947 - 953
Life Sciences & Biomedicine | Hematology | Science & Technology | Muscle Cramp - blood | Piperazines - administration & dosage | Myalgia - blood | Myalgia - chemically induced | Humans | Middle Aged | Male | Alanine Transaminase - blood | Antineoplastic Agents - administration & dosage | Pain - chemically induced | Diarrhea - chemically induced | Quinolines - administration & dosage | Fever - chemically induced | Vomiting - blood | Muscle Cramp - chemically induced | Nitriles - administration & dosage | Benzamides - administration & dosage | Diarrhea - blood | Fever - blood | Antineoplastic Agents - adverse effects | Leukemia, Myelogenous, Chronic, BCR-ABL Positive - pathology | Female | Benzamides - adverse effects | Aniline Compounds - administration & dosage | Pain - blood | Leukemia, Myelogenous, Chronic, BCR-ABL Positive - blood | Pyrimidines - administration & dosage | Imatinib Mesylate | Piperazines - adverse effects | Vomiting - chemically induced | Aspartate Aminotransferases - blood | Pyrimidines - adverse effects | Aniline Compounds - adverse effects | Nitriles - adverse effects | Quinolines - adverse effects | Drug therapy | Leukemia | Index Medicus
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11. Full Text Investigation of the Importance of Multidrug Resistance-Associated Protein 4 (Mrp4/Abcc4) in the Active Efflux of Anionic Drugs Across the Blood–Brain Barrier
by Kanamitsu, Kayoko and Kusuhara, Hiroyuki and Schuetz, John D and Takeuchi, Kenji and Sugiyama, Yuichi
Journal of pharmaceutical sciences, ISSN 0022-3549, 09/2017, Volume 106, Issue 9, pp. 2566 - 2575
blood-brain barrier | P-glycoprotein | MRP | ABC transporters | cerebrospinal fluid | Physical Sciences | Chemistry | Life Sciences & Biomedicine | Pharmacology & Pharmacy | Chemistry, Medicinal | Chemistry, Multidisciplinary | Science & Technology | Central Nervous System - metabolism | Humans | 2,4-Dichlorophenoxyacetic Acid - chemistry | Ochratoxins - chemistry | Male | Thiophenes - metabolism | Ochratoxins - metabolism | Pravastatin - chemistry | Brain - metabolism | Uric Acid - chemistry | Biological Transport | Quinazolines - metabolism | Tetrahydroisoquinolines - chemistry | Adenosine Triphosphate - metabolism | Cyclic GMP - chemistry | Multidrug Resistance-Associated Proteins - genetics | Quinazolines - chemistry | Methotrexate - chemistry | 2,4-Dichlorophenoxyacetic Acid - metabolism | Acridines - chemistry | Methotrexate - metabolism | Uric Acid - metabolism | Acridines - metabolism | Pravastatin - metabolism | Mice, Inbred C57BL | Quinolines - chemistry | Blood-Brain Barrier - metabolism | Quinolines - metabolism | Animals | Cyclic GMP - metabolism | Tetrahydroisoquinolines - metabolism | Kinetics | Adenosine Triphosphate - chemistry | Thiophenes - chemistry | Multidrug Resistance-Associated Proteins - metabolism | Index Medicus | Blood–brain barrier
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