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Biochemical journal, ISSN 1470-8728, 06/2017, Volume 474, Issue 11, pp. 1867 - 1877
Until recently, one of the major limitations of hydrogen/deuterium exchange mass spectrometry (HDX-MS) was the peptide-level resolution afforded by proteolytic... 
Life Sciences & Biomedicine | Biochemistry & Molecular Biology | Science & Technology | Oligonucleotides - genetics | Oligonucleotides - chemistry | Class Ia Phosphatidylinositol 3-Kinase - metabolism | Electron Transport | Molecular Weight | Humans | Enzyme Inhibitors - chemistry | Oligonucleotides - antagonists & inhibitors | Signal Processing, Computer-Assisted | Binding Sites | Peptide Fragments - genetics | Drug Evaluation, Preclinical - methods | Triazines - metabolism | Triazines - pharmacology | Indazoles - chemistry | Enzyme Inhibitors - metabolism | Purines - metabolism | Enzyme Inhibitors - pharmacology | Models, Molecular | Indazoles - metabolism | Recombinant Fusion Proteins - chemistry | Sulfonamides - pharmacology | Indazoles - pharmacology | Oligonucleotides - metabolism | Peptide Fragments - chemistry | Class I Phosphatidylinositol 3-Kinases | Purines - chemistry | Peptide Fragments - antagonists & inhibitors | Protein Conformation | Quinazolinones - chemistry | Quinazolinones - metabolism | Phosphoinositide-3 Kinase Inhibitors | Phosphatidylinositol 3-Kinases - metabolism | Recombinant Fusion Proteins - metabolism | Quinolines - pharmacology | Antineoplastic Agents - metabolism | Tandem Mass Spectrometry | Class Ia Phosphatidylinositol 3-Kinase - chemistry | Deuterium Exchange Measurement | Triazines - chemistry | Antineoplastic Agents - pharmacology | Class Ia Phosphatidylinositol 3-Kinase - genetics | Quinazolinones - pharmacology | Peptide Fragments - metabolism | Reproducibility of Results | Sulfonamides - chemistry | Purines - pharmacology | Quinolines - chemistry | Phosphatidylinositol 3-Kinases - chemistry | Antineoplastic Agents - chemistry | Phosphatidylinositol 3-Kinases - genetics | Quinolines - metabolism | Sulfonamides - metabolism | Index Medicus | ETD | HDX-MS | PI3K
Journal Article
Journal Article
Journal Article
PloS one, ISSN 1932-6203, 04/2012, Volume 7, Issue 4, pp. e29828 - e29828
Chronic myeloid leukemia (CML) is caused by the kinase activity of the BCR-Abl fusion protein. The Abl inhibitors imatinib, nilotinib and dasatinib are... 
Science & Technology - Other Topics | Multidisciplinary Sciences | Science & Technology | Nitriles - pharmacology | Protein-Tyrosine Kinases - metabolism | Escherichia coli | Humans | Leukemia, Myelogenous, Chronic, BCR-ABL Positive - drug therapy | Leukemia, Myelogenous, Chronic, BCR-ABL Positive - genetics | Drug Resistance, Neoplasm | Piperazines - chemistry | Isomerism | Pyrimidines - chemistry | Quinolines - pharmacology | Protein Kinase Inhibitors - chemistry | Spectrophotometry, Infrared | X-Ray Diffraction | Protein-Tyrosine Kinases - chemistry | Binding Sites | Fusion Proteins, bcr-abl - chemistry | Leukemia, Myelogenous, Chronic, BCR-ABL Positive - enzymology | Protein Structure, Tertiary | Recombinant Proteins - metabolism | Dasatinib | Recombinant Proteins - antagonists & inhibitors | Aniline Compounds - pharmacology | Quinolines - chemistry | Models, Molecular | Recombinant Proteins - chemistry | Pyrimidines - pharmacology | Static Electricity | Imatinib Mesylate | Piperazines - pharmacology | Fusion Proteins, bcr-abl - antagonists & inhibitors | Nitriles - chemistry | Thiazoles - chemistry | Protein Kinase Inhibitors - pharmacology | Thiazoles - pharmacology | Aniline Compounds - chemistry | Benzamides | Mutation | Fusion Proteins, bcr-abl - metabolism | Protein-Tyrosine Kinases - antagonists & inhibitors | Tyrosine | Phenols | Phosphotransferases | BCR protein | Phosphorylation | Peptides | Leukemia | Clinical trials | Fluorescence | Infrared absorption | Spectroscopic analysis | Biochemistry | Kinases | Cancer therapies | Proteins | Sulfur | Fusion protein | Growth factors | Electric fields | Protein-tyrosine kinase | Crystal structure | Medical research | Enzymes | Imatinib | Chlorine | Myeloid leukemia | Abl protein | Chronic myeloid leukemia | Chemical compounds | Mutants | Gene amplification | Inhibitors | Resistant mutant | Binding sites | Index Medicus
Journal Article
Journal of the American Chemical Society, ISSN 0002-7863, 03/2010, Volume 132, Issue 11, pp. 3793 - 3807
The first systematic mechanism study of C−F reductive elimination from a transition metal complex is described. C−F bond formation from three different Pd(IV)... 
Temperature | Magnetic Resonance Spectroscopy | Oxidation-Reduction | Sulfonamides - chemistry | Pyridines - chemistry | Solvents - chemistry | Quinolines - chemistry | Carbon - chemistry | Fluorides - chemistry | Quantum Theory | Solutions | Ligands | Kinetics | Palladium - chemistry | Fluorine - chemistry | Palladium | Chemical properties | Fluorides | Structure | Sulfonamides | Pyridazine | Index Medicus
Journal Article
Chemical Society reviews, ISSN 1460-4744, 2011, Volume 40, Issue 3, pp. 1383 - 1403
Journal Article
Journal Article
Organic letters, ISSN 1523-7060, 09/2015, Volume 17, Issue 18, pp. 4404 - 4407
Dehydrogenation of (partially) saturated heterocycles provides an important route to heteroaromatic compounds. A heterogeneous cobalt oxide catalyst,... 
Amines - chemistry | Quinolines - chemical synthesis | Heterocyclic Compounds - chemistry | Nitrogen - chemistry | Oxidation-Reduction | Oxides - chemistry | Quinolines - chemistry | Heterocyclic Compounds - chemical synthesis | Molecular Structure | Catalysis | Carbon - chemistry | Cobalt - chemistry | Index Medicus
Journal Article
Journal of the American Chemical Society, ISSN 0002-7863, 04/2017, Volume 139, Issue 16, pp. 5724 - 5727
Journal Article