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1. Full Text Saliva versus Plasma Pharmacokinetics: Theory and Application of a Salivary Excretion Classification System
by Idkaidek, Nasir and Arafat, Tawfiq
Molecular pharmaceutics, ISSN 1543-8384, 08/2012, Volume 9, Issue 8, pp. 2358 - 2363
Salivary Excretion Classification System | effective permeability | pharmacokinetics | protein binding | bioequivalence | SimCYP | Pharmacology & Pharmacy | Life Sciences & Biomedicine | Medicine, Research & Experimental | Science & Technology | Research & Experimental Medicine | Quinolines - blood | Acetates - blood | Fluorobenzenes - pharmacokinetics | Hydrochlorothiazide - pharmacokinetics | Triazoles - blood | Piroxicam - blood | Azithromycin - blood | Humans | Losartan - blood | Saliva - secretion | Male | Naphthalenes - blood | Benzhydryl Compounds - blood | Fluorobenzenes - pharmacology | Quinolines - pharmacokinetics | Sulfonamides - blood | Azithromycin - pharmacokinetics | Tolterodine Tartrate | Female | Triazoles - pharmacokinetics | Naphthalenes - pharmacokinetics | Piroxicam - analogs & derivatives | Sitagliptin Phosphate | Hydrochlorothiazide - blood | Losartan - pharmacokinetics | Benzhydryl Compounds - pharmacokinetics | Metformin - blood | Cresols - blood | Phenylpropanolamine - blood | Metformin - pharmacokinetics | Rosuvastatin Calcium | Cloxacillin - pharmacokinetics | Pyrimidines - pharmacology | Sulfonamides - pharmacology | Sulfonamides - pharmacokinetics | Cinacalcet Hydrochloride | Cloxacillin - blood | Saliva - metabolism | Pyrazines - pharmacokinetics | Piroxicam - pharmacokinetics | Pyrimidines - pharmacokinetics | Cresols - pharmacokinetics | Anthraquinones - blood | Anthraquinones - pharmacokinetics | Phenylpropanolamine - pharmacokinetics | Pyrazines - blood | Acetates - pharmacokinetics | Index Medicus
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2. Full Text Application of physiologically based pharmacokinetic modeling to the understanding of bosutinib pharmacokinetics: Prediction of drug-drug and drug-disease interactions
by Ono, Chiho and Hsyu, Poe-Hirr and Abbas, Richat and Loi, Cho-Ming and Yamazaki, Shinji
Drug metabolism and disposition, ISSN 0090-9556, 04/2017, Volume 45, Issue 4, pp. 390 - 398
Life Sciences & Biomedicine | Pharmacology & Pharmacy | Science & Technology | Protein Kinase Inhibitors - pharmacokinetics | Rifampin - pharmacokinetics | Proto-Oncogene Proteins c-abl - antagonists & inhibitors | Administration, Oral | Area Under Curve | Humans | src-Family Kinases - antagonists & inhibitors | Leukemia, Myelogenous, Chronic, BCR-ABL Positive - drug therapy | Ketoconazole - pharmacokinetics | Cytochrome P-450 CYP3A Inhibitors - pharmacokinetics | Treatment Outcome | Aniline Compounds - pharmacokinetics | Quinolines - administration & dosage | Nitriles - pharmacokinetics | Nitriles - administration & dosage | Quinolines - pharmacokinetics | Protein Kinase Inhibitors - administration & dosage | Drug Interactions | Cytochrome P-450 CYP3A - metabolism | Models, Biological | Computer Simulation | Cytochrome P-450 CYP3A Inducers - pharmacokinetics | Aniline Compounds - administration & dosage | Index Medicus
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3. Full Text Pharmacokinetic/Pharmacodynamic (PK/PD) Indices of Antibiotics Predicted by a Semimechanistic PKPD Model: a Step toward Model-Based Dose Optimization
by Elisabet I. Nielsen and Otto Cars and Lena E. Friberg
Antimicrobial Agents and Chemotherapy, ISSN 0066-4804, 10/2011, Volume 55, Issue 10, pp. 4619 - 4630
Pharmacology & Pharmacy | Life Sciences & Biomedicine | Microbiology | Science & Technology | Biological and medical sciences | Medical sciences | Pharmacology. Drug treatments | Antibiotics. Antiinfectious agents. Antiparasitic agents | Fluoroquinolones | Aza Compounds - pharmacokinetics | Area Under Curve | Erythromycin - pharmacology | Escherichia coli - drug effects | Humans | Cefuroxime - pharmacology | Aza Compounds - pharmacology | Quinolines - pharmacology | Microbial Sensitivity Tests | Quinolines - pharmacokinetics | Anti-Bacterial Agents - therapeutic use | Gentamicins - pharmacology | Computer Simulation | Vancomycin - pharmacology | Streptococcus pyogenes - drug effects | Gentamicins - pharmacokinetics | Penicillin G - pharmacology | Erythromycin - pharmacokinetics | Cefuroxime - pharmacokinetics | Vancomycin - pharmacokinetics | Anti-Bacterial Agents - pharmacokinetics | Anti-Bacterial Agents - pharmacology | Anti-Bacterial Agents - administration & dosage | Penicillin G - pharmacokinetics | Index Medicus | Drugs | Subpopulations | Pharmacodynamics | Gentamicin | Benzylpenicillin | Erythromycin | Moxifloxacin | Regression analysis | Vancomycin | Drug development | Cefuroxime | Antibiotics | Minimum inhibitory concentration | Models | Pharmacokinetics | Experimental Therapeutics
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4. Full Text Pharmacokinetics-Pharmacodynamics of High-Dose Ivermectin with Dihydroartemisinin-Piperaquine on Mosquitocidal Activity and QT-Prolongation (IVERMAL)
by Smit, Menno R and Ochomo, Eric O and Waterhouse, David and Kwambai, Titus K and Abong'o, Bernard O and Bousema, T and Ward, Stephen A and Aljayyoussi, Ghaith
Clinical pharmacology and therapeutics, ISSN 0009-9236, 2019, Volume 105, Issue 2, pp. 388 - 401
Life Sciences & Biomedicine | Pharmacology & Pharmacy | Science & Technology | Artemisinins - pharmacokinetics | Humans | Long QT Syndrome - chemically induced | Male | Quinolines - pharmacology | Dose-Response Relationship, Drug | Quinolines - pharmacokinetics | Artemisinins - pharmacology | Drug Interactions | Adult | Female | Insecticides - pharmacology | Antimalarials - pharmacokinetics | Double-Blind Method | Long QT Syndrome - epidemiology | Ivermectin - pharmacokinetics | Treatment Outcome | Ivermectin - pharmacology | Kenya | Antimalarials - pharmacology | Anopheles | Animals | Malaria - drug therapy | Drug Combinations | Insecticides - pharmacokinetics | Index Medicus | Abridged Index Medicus | Clinical Trial | Research
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5. Full Text Transporter‐Mediated Hepatic Uptake Plays an Important Role in the Pharmacokinetics and Drug–Drug Interactions of Montelukast
by Varma, MV and Kimoto, E and Scialis, R and Bi, Y and Lin, J and Eng, H and Kalgutkar, AS and El‐Kattan, AF and Rodrigues, AD and Tremaine, LM
Clinical pharmacology and therapeutics, ISSN 0009-9236, 03/2017, Volume 101, Issue 3, pp. 406 - 415
Life Sciences & Biomedicine | Pharmacology & Pharmacy | Science & Technology | Organic Anion Transporters - antagonists & inhibitors | Cytochrome P-450 CYP2C8 - drug effects | Liver - metabolism | Rats | Gemfibrozil - pharmacology | Hepatocytes - metabolism | Organic Anion Transporters - metabolism | Quinolines - pharmacology | Haplorhini | Dose-Response Relationship, Drug | Quinolines - pharmacokinetics | Nucleic Acid Synthesis Inhibitors | Animals | Cytochrome P-450 CYP3A Inhibitors - metabolism | Models, Biological | Solute Carrier Organic Anion Transporter Family Member 1b1 - antagonists & inhibitors | Clarithromycin - pharmacokinetics | Acetates - pharmacology | Cytochrome P-450 CYP2C8 - metabolism | Rifampin - pharmacology | Acetates - pharmacokinetics | Care and treatment | Usage | Montelukast | Dosage and administration | Research | Drug therapy | Pharmacokinetics | Asthma | Index Medicus | Abridged Index Medicus
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6. Clinical Pharmacokinetics and Pharmacodynamics of Bosutinib
by Abbas, Richat and Hsyu, Poe-Hirr
Clinical pharmacokinetics, ISSN 0312-5963, 10/2016, Volume 55, Issue 10, pp. 1191 - 1204
Life Sciences & Biomedicine | Pharmacology & Pharmacy | Science & Technology | Nitriles - pharmacology | Area Under Curve | Humans | Leukemia, Myelogenous, Chronic, BCR-ABL Positive - drug therapy | Half-Life | Metabolic Clearance Rate | Nitriles - pharmacokinetics | Intestinal Absorption | Quinolines - pharmacology | Dose-Response Relationship, Drug | Quinolines - pharmacokinetics | Liver Failure - metabolism | Drug Interactions | Electrocardiography | Antineoplastic Agents - pharmacokinetics | Antineoplastic Agents - pharmacology | Protein Kinase Inhibitors - pharmacokinetics | Aniline Compounds - pharmacology | Clinical Trials as Topic | Renal Insufficiency - metabolism | Aniline Compounds - pharmacokinetics | Asian Continental Ancestry Group | Cytochrome P-450 CYP3A - metabolism | Protein Binding | Protein Kinase Inhibitors - pharmacology | Quinolines - therapeutic use | Aniline Compounds - therapeutic use | Nitriles - therapeutic use | Index Medicus
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7. Full Text Population Pharmacokinetic and Concentration—QTc Models for Moxifloxacin: Pooled Analysis of 20 Thorough QT Studies
by Florian, Jeffry A and Tornøe, Christoffer W and Brundage, Richard and Parekh, Ameeta and Garnett, Christine E
Journal of clinical pharmacology, ISSN 0091-2700, 08/2011, Volume 51, Issue 8, pp. 1152 - 1162
Population pharmacokinetics | QT prolongation | exposure—response modeling | thorough QT studies | ICH E14 | moxifloxacin | exposure-response modeling | Life Sciences & Biomedicine | Pharmacology & Pharmacy | Science & Technology | Fluoroquinolones | Aza Compounds - pharmacokinetics | Quinolines - blood | Drugs, Investigational - adverse effects | Anti-Infective Agents - blood | United States | Humans | Middle Aged | Drugs, Investigational - pharmacokinetics | Aza Compounds - adverse effects | Male | Metabolic Clearance Rate | Quinolines - administration & dosage | Drugs, Investigational - analysis | Intestinal Absorption | Delayed-Action Preparations - administration & dosage | Quinolines - pharmacokinetics | Young Adult | Delayed-Action Preparations - pharmacokinetics | Adult | Aza Compounds - blood | Female | United States Food and Drug Administration | Aza Compounds - administration & dosage | Anti-Infective Agents - adverse effects | Administration, Oral | Electrocardiography - drug effects | Clinical Trials as Topic | Animals | Anti-Infective Agents - administration & dosage | Delayed-Action Preparations - adverse effects | Models, Biological | Anti-Infective Agents - pharmacokinetics | Adolescent | Drugs, Investigational - administration & dosage | Aged | Quinolines - adverse effects | Physiological aspects | Moxifloxacin | Research | Demographic aspects | Pharmacokinetics | Index Medicus
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8. Full Text Safety and pharmacokinetics of lenvatinib in patients with advanced hepatocellular carcinoma
by Ikeda, Masafumi and Okusaka, Takuji and Mitsunaga, Shuichi and Ueno, Hideki and Tamai, Toshiyuki and Suzuki, Takuya and Hayato, Seiichi and Kadowaki, Tadashi and Okita, Kiwamu and Kumada, Hiromitsu
Clinical cancer research, ISSN 1078-0432, 03/2016, Volume 22, Issue 6, pp. 1385 - 1394
Life Sciences & Biomedicine | Oncology | Science & Technology | Carcinoma, Hepatocellular - mortality | Humans | Middle Aged | Male | Antineoplastic Agents - therapeutic use | Liver Neoplasms - mortality | Quinolines - pharmacokinetics | Neoplasm Metastasis | Carcinoma, Hepatocellular - drug therapy | Antineoplastic Agents - adverse effects | Phenylurea Compounds - adverse effects | Female | Liver Neoplasms - pathology | Antineoplastic Agents - pharmacokinetics | Phenylurea Compounds - pharmacokinetics | Kaplan-Meier Estimate | Liver Neoplasms - drug therapy | Phenylurea Compounds - therapeutic use | Treatment Outcome | Combined Modality Therapy | Magnetic Resonance Imaging | Retreatment | Carcinoma, Hepatocellular - pathology | Aged | Quinolines - therapeutic use | Neoplasm Staging | Quinolines - adverse effects | Index Medicus
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9. Full Text Population pharmacokinetics and exposure–overall survival analysis of the transforming growth factor-β inhibitor galunisertib in patients with pancreatic cancer
by Gueorguieva, Ivelina and Tabernero, Josep and Melisi, Davide and Macarulla, Teresa and Merz, Valeria and Waterhouse, Timothy H and Miles, Colin and Lahn, Michael M and Cleverly, Ann and Benhadji, Karim A
Cancer chemotherapy and pharmacology, ISSN 0344-5704, 11/2019, Volume 84, Issue 5, pp. 1003 - 1015
Pharmacodynamics | Medicine & Public Health | Anticancer drugs | Oncology | Cancer Research | Pharmacology/Toxicology | Pharmacokinetics | Randomized controlled trial | Pharmacology & Pharmacy | Life Sciences & Biomedicine | Science & Technology | Antineoplastic Combined Chemotherapy Protocols - administration & dosage | Deoxycytidine - administration & dosage | Humans | Middle Aged | Pancreatic Neoplasms - pathology | Antineoplastic Combined Chemotherapy Protocols - pharmacokinetics | Half-Life | Male | Quinolines - administration & dosage | Randomized Controlled Trials as Topic | Pancreatic Neoplasms - drug therapy | Young Adult | CA-19-9 Antigen - metabolism | Pyrazoles - administration & dosage | Survival Analysis | Aged, 80 and over | Adult | Female | Aged | Deoxycytidine - analogs & derivatives | Statistical analysis | Gemcitabine | Transforming growth factor | Exposure | Pharmacology | Dosage | Patients | Survival | Survival analysis | Pancreatic cancer | Growth factors | Cancer | Index Medicus
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10. Full Text Contrasting Effects of Acidic pH on the Extracellular and Intracellular Activities of the Anti-Gram-Positive Fluoroquinolones Moxifloxacin and Delafloxacin against Staphylococcus aureus
by Sandrine Lemaire and Paul M. Tulkens and Françoise Van Bambeke
Antimicrobial Agents and Chemotherapy, ISSN 0066-4804, 02/2011, Volume 55, Issue 2, pp. 649 - 658
Pharmacology & Pharmacy | Life Sciences & Biomedicine | Microbiology | Science & Technology | Infectious diseases | Bacterial diseases | Human bacterial diseases | Pharmacology. Drug treatments | Staphylococcal infections, streptococcal infections, pneumococcal infections | Biological and medical sciences | Medical sciences | Antibiotics. Antiinfectious agents. Antiparasitic agents | Fluoroquinolones - chemistry | Aza Compounds - pharmacokinetics | Anti-Infective Agents - pharmacology | Humans | Monocytes - metabolism | Aza Compounds - pharmacology | Fluoroquinolones - pharmacokinetics | Quinolines - pharmacology | Microbial Sensitivity Tests | Quinolines - pharmacokinetics | Anti-Infective Agents - chemistry | Staphylococcal Infections - microbiology | Culture Media - chemistry | Staphylococcus aureus - metabolism | Cell Line | Monocytes - microbiology | Quinolines - chemistry | Aza Compounds - chemistry | Macrophages - metabolism | Animals | Models, Biological | Anti-Infective Agents - pharmacokinetics | Fluoroquinolones - pharmacology | Mice | Staphylococcus aureus - drug effects | Hydrogen-Ion Concentration | Index Medicus | Susceptibility
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