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EUROPEAN JOURNAL OF MEDICINAL CHEMISTRY, ISSN 0223-5234, 08/2017, Volume 136, pp. 259 - 269
New alpha(1)-adrenoreceptor (alpha(1)-AR) antagonists related to prazosin and doxazosin were synthesized by replacing piperazine ring with (S)- or... 
APOPTOSIS | LOCALIZATION | DESIGN | CHEMISTRY, MEDICINAL | Antiproliferative activity | Quinone | ALPHA-1-ADRENOCEPTOR ANTAGONISTS | MECHANISMS | alpha-Adrenoreceptor antagonist | DNA fragmentation | GROWTH | Quinazoline | DOXAZOSIN | DERIVATIVES
Journal Article
European Journal of Medicinal Chemistry, ISSN 0223-5234, 08/2017, Volume 136, pp. 259 - 269
New α1-adrenoreceptor (α1-AR) antagonists related to prazosin and doxazosin were synthesized by replacing piperazine ring with (S)- or (R)-3-aminopiperidine.... 
α1-Adrenoreceptor antagonist | Quinazoline | Antiproliferative activity | Quinone | DNA fragmentation | Adrenoreceptor antagonist
Journal Article
Blood, ISSN 0006-4971, 12/2007, Volume 110, Issue 12, pp. 4055 - 4063
The BCR-ABL tyrosine kinase inhibitor imatinib represents the current frontline therapy in chronic myeloid leukemia. Because many patients develop imatinib... 
SELECTIVE INHIBITOR | DISCOIDIN DOMAIN RECEPTOR-1 | C-ABL | TYROSINE KINASE | PROTEIN-KINASE | CRYSTAL-STRUCTURE | INTRACELLULAR TARGETS | RESISTANCE | LEUKEMIA | IDENTIFICATION | HEMATOLOGY | Protein-Tyrosine Kinases - metabolism | Humans | Leukemia, Myelogenous, Chronic, BCR-ABL Positive - drug therapy | Drug Resistance, Neoplasm | Neoplasm Proteins - antagonists & inhibitors | Piperazines - chemistry | Thiazoles - therapeutic use | Neoplasm Proteins - metabolism | Pyrimidines - chemistry | Dose-Response Relationship, Drug | Protein Kinase Inhibitors - chemistry | Fusion Proteins, bcr-abl | Protein-Serine-Threonine Kinases - antagonists & inhibitors | Receptor Protein-Tyrosine Kinases - antagonists & inhibitors | Protein-Serine-Threonine Kinases - metabolism | Leukemia, Myelogenous, Chronic, BCR-ABL Positive - enzymology | Dasatinib | Quinone Reductases - metabolism | Piperazines - therapeutic use | Discoidin Domain Receptor 1 | Pyrimidines - pharmacology | Receptor Protein-Tyrosine Kinases - metabolism | Imatinib Mesylate | Piperazines - pharmacology | Protein Kinase Inhibitors - therapeutic use | Pyrimidines - therapeutic use | Quinone Reductases - antagonists & inhibitors | K562 Cells | Proteomics | Thiazoles - chemistry | Protein Kinase Inhibitors - pharmacology | Thiazoles - pharmacology | Benzamides | Drug Screening Assays, Antitumor | Protein-Tyrosine Kinases - antagonists & inhibitors
Journal Article
BioFactors, ISSN 0951-6433, 07/2019, Volume 45, Issue 4, pp. 616 - 626
Chlorogenic acid (CA), the ester of caffeic acid and quinic acid, is one of the most abundant polyphenols in coffee, and has multiple pharmacological... 
antioxidant | Nrf2 | chlorogenic acid | neuroprotection | oxidative stress | coffee | APOPTOSIS | KEAP1-NRF2-ARE PATHWAY | PHASE-II-ENZYMES | BIOCHEMISTRY & MOLECULAR BIOLOGY | DISCOVERY | IN-VITRO | ENDOCRINOLOGY & METABOLISM | THIOREDOXIN REDUCTASE | POLYPHENOL | NF-KAPPA-B | RNA, Small Interfering - genetics | NF-E2-Related Factor 2 - antagonists & inhibitors | Reactive Oxygen Species - metabolism | Chlorogenic Acid - pharmacology | Glutathione - metabolism | Neurons - cytology | Antioxidant Response Elements - drug effects | NAD(P)H Dehydrogenase (Quinone) - genetics | PC12 Cells | Glutathione - agonists | Neuroprotective Agents - pharmacology | Thioredoxins - genetics | Biphenyl Compounds - antagonists & inhibitors | NF-E2-Related Factor 2 - genetics | Thioredoxins - metabolism | Benzothiazoles - antagonists & inhibitors | Neurons - metabolism | Heme Oxygenase (Decyclizing) - metabolism | Neurons - drug effects | Heme Oxygenase (Decyclizing) - genetics | Signal Transduction | Gene Expression Regulation | Hydrogen Peroxide - pharmacology | Rats | Antioxidants - pharmacology | Sulfonic Acids - antagonists & inhibitors | Picrates - antagonists & inhibitors | Reactive Oxygen Species - antagonists & inhibitors | Animals | Cell Differentiation - drug effects | NF-E2-Related Factor 2 - metabolism | NAD(P)H Dehydrogenase (Quinone) - metabolism | Thioredoxin Reductase 1 - genetics | Oxidative Stress - drug effects | Hydrogen Peroxide - antagonists & inhibitors | RNA, Small Interfering - metabolism | Thioredoxin Reductase 1 - metabolism | Antioxidants | Polyphenols | Thioredoxin | Coffee | Index Medicus
Journal Article
European Journal of Medicinal Chemistry, ISSN 0223-5234, 08/2017, Volume 136, p. 259
New [alpha].sub.1-adrenoreceptor ([alpha].sub.1-AR) antagonists related to prazosin and doxazosin were synthesized by replacing piperazine ring with (S)- or... 
Drug discovery | Prostate cancer | Pharmacy | Quinone
Journal Article
Journal of Medicinal Chemistry, ISSN 0022-2623, 07/2010, Volume 53, Issue 13, pp. 5033 - 5043
Five resveratrol sulfate metabolites were synthesized and assessed for activities known to be mediated by resveratrol: inhibition of tumor necrosis factor... 
BREAST-CANCER | QUINONE REDUCTASE | CHEMISTRY, MEDICINAL | CANCER CHEMOPREVENTIVE ACTIVITY | NITRIC-OXIDE SYNTHASE | II DETOXIFICATION ENZYMES | MAMMARY CARCINOGENESIS | RAW 264.7 MACROPHAGES | NATURAL-PRODUCT PRESENT | NF-KAPPA-B | SMALL-MOLECULE ACTIVATORS | Antineoplastic Agents - chemical synthesis | Humans | Aromatase - metabolism | Nitric Oxide Synthase - antagonists & inhibitors | NF-kappa B - metabolism | Stilbenes - metabolism | Sulfuric Acid Esters - pharmacology | Stilbenes - chemistry | Stilbenes - pharmacology | Enzyme Inhibitors - chemical synthesis | Spectroscopy, Fourier Transform Infrared | Biphenyl Compounds - metabolism | Spectrometry, Mass, Electrospray Ionization | Biphenyl Compounds - antagonists & inhibitors | Sulfuric Acid Esters - chemical synthesis | Enzyme Inhibitors - chemistry | Inhibitory Concentration 50 | Antineoplastic Agents - pharmacology | Cell Survival - drug effects | NF-kappa B - antagonists & inhibitors | Magnetic Resonance Spectroscopy | Picrates - metabolism | Enzyme Inhibitors - pharmacology | Sulfuric Acid Esters - chemistry | Antineoplastic Agents - chemistry | NAD(P)H Dehydrogenase (Quinone) - antagonists & inhibitors | Macrophages - metabolism | Picrates - antagonists & inhibitors | Animals | Cyclooxygenase 2 - metabolism | HL-60 Cells | NAD(P)H Dehydrogenase (Quinone) - metabolism | Macrophages - drug effects | Mice | Nitric Oxide Synthase - metabolism | Cyclooxygenase 1 - metabolism
Journal Article
Nature Biotechnology, ISSN 1087-0156, 09/2007, Volume 25, Issue 9, pp. 1035 - 1044
Journal Article
Journal Article
Biochemical and Biophysical Research Communications, ISSN 0006-291X, 2010, Volume 394, Issue 3, pp. 439 - 442
Journal Article
Cancer Research, ISSN 0008-5472, 07/2005, Volume 65, Issue 14, pp. 6401 - 6408
Somatic mutations in the kinase domain of the epidermal growth factor receptor (EGFR), including L858R and exon 19 deletions, underlie responsiveness to... 
CELL LUNG-CANCER | SIGNAL-TRANSDUCTION | BRAF GENE | ONCOLOGY | PHOSPHATIDYLINOSITOL 3-KINASE | CYCLIN-D EXPRESSION | MOLECULAR CHAPERONE | TYROSINE KINASES | EGFR MUTATIONS | ANTITUMOR AGENT | HSP90 FUNCTION | Cyclin D1 - metabolism | Lung Neoplasms - drug therapy | NIH 3T3 Cells | Receptor, Epidermal Growth Factor - genetics | Antibiotics, Antineoplastic - pharmacology | Apoptosis - drug effects | Humans | Mitogen-Activated Protein Kinase 3 - antagonists & inhibitors | Lactams, Macrocyclic | Receptor, Epidermal Growth Factor - metabolism | Gene Deletion | Protein-Serine-Threonine Kinases - antagonists & inhibitors | Phosphorylation - drug effects | Protein-Serine-Threonine Kinases - metabolism | Quinones - pharmacology | Lung Neoplasms - genetics | Protein Structure, Tertiary | Proto-Oncogene Proteins - metabolism | Proto-Oncogene Proteins - antagonists & inhibitors | Lung Neoplasms - enzymology | Carcinoma, Non-Small-Cell Lung - genetics | Mitogen-Activated Protein Kinase 1 - antagonists & inhibitors | Benzoquinones | Proto-Oncogene Proteins c-akt | Animals | Mitogen-Activated Protein Kinase 3 - metabolism | HSP90 Heat-Shock Proteins - antagonists & inhibitors | Cysteine Proteinase Inhibitors - pharmacology | Cell Line, Tumor | HSP90 Heat-Shock Proteins - metabolism | Mice | Carcinoma, Non-Small-Cell Lung - drug therapy | Carcinoma, Non-Small-Cell Lung - enzymology | Mitogen-Activated Protein Kinase 1 - metabolism
Journal Article
PLoS ONE, ISSN 1932-6203, 05/2012, Volume 7, Issue 5, p. e36774
Background: Nuclear factor (erythroid-derived 2)-like 2 (Nrf2) is a key transcription factor regulating a plethora of detoxifying enzymes and antioxidant genes... 
HEXOSE-6-PHOSPHATE DEHYDROGENASE | OXIDATIVE STRESS | TRANSCRIPTION FACTOR NRF2 | 11-BETA-HYDROXYSTEROID DEHYDROGENASE TYPE-1 | TRANSFERASE A2 GENE | PATHWAY | MULTIDISCIPLINARY SCIENCES | RECEPTOR | INDUCTION | INDUCIBLE EXPRESSION | BASAL LEVEL | NF-E2-Related Factor 2 - antagonists & inhibitors | Receptors, Glucocorticoid - antagonists & inhibitors | Oligonucleotide Array Sequence Analysis | Oxidative Stress | Rats, Wistar | Antioxidants - metabolism | Humans | Transcriptional Activation - drug effects | Male | Receptors, Glucocorticoid - metabolism | NAD(P)H Dehydrogenase (Quinone) - genetics | Transfection | Liver - drug effects | Glucocorticoids - metabolism | HEK293 Cells | Thiocyanates - pharmacology | Female | NF-E2-Related Factor 2 - genetics | Isothiocyanates | Genes, Reporter | Recombinant Proteins - metabolism | Liver - metabolism | Hydrogen Peroxide - pharmacology | Rats | Recombinant Proteins - genetics | Sex Characteristics | Down-Regulation - drug effects | 11-beta-Hydroxysteroid Dehydrogenase Type 1 - antagonists & inhibitors | NAD(P)H Dehydrogenase (Quinone) - antagonists & inhibitors | 11-beta-Hydroxysteroid Dehydrogenase Type 1 - metabolism | Animals | NF-E2-Related Factor 2 - metabolism | Cell Line, Tumor | Glucocorticoids - pharmacology | NAD(P)H Dehydrogenase (Quinone) - metabolism | Hydrocortisone - pharmacology | Liver - cytology | Oxidative stress | Hydrogen peroxide | Biomedical research | Dehydrogenases | Glucocorticoids | Adrenal glands | Oxidative metabolism | Liver | Genes | Glands | Alcohol | Dimorphism | Hormones | Gender | Antioxidants | Toxicology | Immunology | Rodents | 11β-Hydroxysteroid dehydrogenase | Drug metabolism | Fibroblasts | Physiology | Sexual dimorphism | Trends | Localization | Product safety | NRF2 protein | Pharmaceutical sciences | Enzymes | Liver diseases | Pharmacology | Gene expression | Metabolism | Cortisone | In vivo methods and tests
Journal Article