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Free Radical Biology and Medicine, ISSN 0891-5849, 08/2012, Volume 53, Issue 4, pp. 817 - 827
The Keap1-Nrf2 system plays a critical role in cellular defense against electrophiles and reactive oxygen species. Keap1 possesses a number of cysteine... 
Keap1 | Reactive cysteine | Stress response | Nrf2 | OXIDATIVE STRESS | ACTIVATION | BIOCHEMISTRY & MOLECULAR BIOLOGY | CDDO-IM | PHASE-2 RESPONSE | ANTIOXIDANT | COVALENT MODIFICATION | ENDOCRINOLOGY & METABOLISM | GENE-EXPRESSION | NITRIC-OXIDE | CYSTEINE RESIDUES | Oxidants - pharmacology | Maleates - pharmacology | Cytoskeletal Proteins - genetics | Humans | Oleanolic Acid - analogs & derivatives | Transcriptional Activation - drug effects | Oleanolic Acid - pharmacology | NAD(P)H Dehydrogenase (Quinone) - genetics | Hydroquinones - pharmacology | Organoselenium Compounds - pharmacology | HEK293 Cells | Cytoskeletal Proteins - metabolism | NF-E2-Related Factor 2 - genetics | Glutamate-Cysteine Ligase - metabolism | Dimethyl Fumarate | Kelch-Like ECH-Associated Protein 1 | Macrophages, Peritoneal - drug effects | Isothiocyanates - pharmacology | Gene Expression | Mice, Transgenic | Imidazoles - pharmacology | Antioxidants - pharmacology | Azoles - pharmacology | Gene Expression Regulation - drug effects | Animals | Fumarates - pharmacology | NF-E2-Related Factor 2 - metabolism | Adaptor Proteins, Signal Transducing - genetics | NAD(P)H Dehydrogenase (Quinone) - metabolism | Glutamate-Cysteine Ligase - genetics | Mice | Oxidative Stress - drug effects | Adaptor Proteins, Signal Transducing - metabolism | Macrophages, Peritoneal - metabolism | Amino Acid Substitution | Purines | Cysteine | Dimethylformamide | Ligases | Quinone | Transplantation of organs, tissues, etc | Universities and colleges | Macrophages | Cystine | Index Medicus | stress response | reactive cysteine
Journal Article
Arteriosclerosis thrombosis and vascular biology, ISSN 1079-5642, 07/2010, Volume 30, Issue 7, pp. 1407 - U356
Objective-Endothelial cell senescence is an important contributor to vascular aging and is increased under diabetic conditions. Here we investigated whether... 
senescence | glucagon-like peptide 1 | endothelium | diabetes mellitus | reactive oxygen species | APOPTOSIS | TRANSCRIPTION | ATHEROSCLEROSIS | ZUCKER RAT | NEPHROPATHY | CARDIOVASCULAR-DISEASE | NITRIC-OXIDE | PERIPHERAL VASCULAR DISEASE | DYSFUNCTION | GLP-1 RECEPTOR | HEMATOLOGY | DIABETIC FATTY RATS | Diabetes Mellitus - enzymology | Diabetes Mellitus - pathology | Heme Oxygenase-1 - metabolism | Oxidants - pharmacology | Reactive Oxygen Species - metabolism | Nitriles - pharmacology | Humans | Cellular Senescence - drug effects | Male | Phosphatidylinositol 3-Kinases - metabolism | Dipeptidyl-Peptidase IV Inhibitors - pharmacology | Pyrrolidines - pharmacology | Dose-Response Relationship, Drug | Proto-Oncogene Proteins c-akt - metabolism | Cyclic AMP - metabolism | Adamantane - analogs & derivatives | Disease Models, Animal | Cyclic AMP-Dependent Protein Kinases - metabolism | Adamantane - pharmacology | Glucagon-Like Peptide 1 - metabolism | Signal Transduction | Cells, Cultured | Diabetes Mellitus - drug therapy | Hydrogen Peroxide - pharmacology | Rats | Receptors, Glucagon - metabolism | Hypoglycemic Agents - pharmacology | Peptides - pharmacology | Rats, Zucker | Animals | Glucagon-Like Peptide-1 Receptor | Cyclic AMP Response Element-Binding Protein - metabolism | NAD(P)H Dehydrogenase (Quinone) - metabolism | Venoms - pharmacology | DNA Damage | Enzyme Activation | Oxidative Stress - drug effects | Endothelial Cells - pathology | Endothelial Cells - enzymology | Endothelial Cells - drug effects | Index Medicus
Journal Article
Biochemical Pharmacology, ISSN 0006-2952, 2006, Volume 72, Issue 3, pp. 366 - 376
NRH:quinone oxidoreductase 2 (NQO2) is a cytosolic flavoprotein that utilizes NRH as electron donor. The present studies investigate the role of NQO2 in... 
Anti-tumor drugs | NRH:quinone oxidoreductase 2 | Metabolic activation | Quinones | Cytotoxicity | Mitomycin C | mitomycin C | anti-tumor drugs | CANCER-CHEMOTHERAPY | TISSUE-SPECIFIC EXPRESSION | NRH : quinone oxidoreductase 2 | OXIDOREDUCTASE-1 DEFICIENCY | MENADIONE TOXICITY | INCREASES SUSCEPTIBILITY | GENE | DT-DIAPHORASE | metabolic activation | SKIN CARCINOGENESIS | REDUCTASE | PHARMACOLOGY & PHARMACY | quinones | cytotoxicity | MOUSE SKIN | Cricetulus | Cross-Linking Reagents - pharmacology | DNA, Complementary - genetics | Hydroquinones - metabolism | Hydroquinones - pharmacology | Indolequinones - metabolism | Antineoplastic Agents - metabolism | Dose-Response Relationship, Drug | Mitomycins - pharmacology | Transfection | Antineoplastic Agents - pharmacology | Benzopyrenes - pharmacology | Quinones - pharmacology | CHO Cells | Quinones - metabolism | Cell Survival - drug effects | Quinone Reductases - metabolism | Cricetinae | Cells, Cultured | Indolequinones - pharmacology | Aziridines - pharmacology | Keratinocytes - cytology | Mice, Knockout | Mitomycin - pharmacology | Cross-Linking Reagents - metabolism | Vitamin K 3 - pharmacology | Vitamin K 3 - metabolism | Animals | Keratinocytes - drug effects | Keratinocytes - metabolism | Biotransformation - drug effects | Benzopyrenes - metabolism | Quinone Reductases - genetics | Mice | Aziridines - metabolism | Mitomycin - metabolism | Mitomycins - metabolism | Niacinamide | Mitomycin | Histidine | Hamsters | Quinone | Skin cancer | Index Medicus
Journal Article
Journal of Biological Chemistry, ISSN 0021-9258, 05/2004, Volume 279, Issue 19, pp. 20267 - 20276
Journal Article
Journal Article
Journal of Medicinal Chemistry, ISSN 0022-2623, 05/2012, Volume 55, Issue 10, pp. 4837 - 4846
Novel monocyclic cyanoenones examined to date display unique features regarding chemical reactivity as Michael acceptors and biological potency. Remarkably, in... 
CHEMISTRY, MEDICINAL | NITRIC-OXIDE PRODUCTION | CDDO | ACTIVE INHIBITORS | IKK-BETA | URSANE TRITERPENOIDS | MOUSE MACROPHAGES | DIRECT INHIBITION | NF-KAPPA-B | OLEANANE | 2-CYANO-3,12-DIOXOOLEAN-1,9-DIEN-28-OIC ACID | Alkynes - chemical synthesis | Anticarcinogenic Agents - chemical synthesis | Nitriles - pharmacology | Apoptosis - drug effects | Oleanolic Acid - analogs & derivatives | Oleanolic Acid - pharmacology | Anti-Inflammatory Agents, Non-Steroidal - chemistry | Nitriles - chemical synthesis | Anti-Inflammatory Agents, Non-Steroidal - pharmacology | Phenanthrenes - chemistry | Macrophages - secretion | I-kappa B Kinase - antagonists & inhibitors | Alkynes - pharmacology | Anti-Inflammatory Agents, Non-Steroidal - chemical synthesis | Anticarcinogenic Agents - pharmacology | Cytoprotection | Amides - pharmacology | Interleukin-1beta - secretion | Cell Line | Nitric Oxide - biosynthesis | Nitric Oxide - antagonists & inhibitors | Tumor Necrosis Factor-alpha - secretion | Thiophenes - pharmacology | Alkynes - chemistry | Macrophages - cytology | Phenanthrenes - pharmacology | NAD(P)H Dehydrogenase (Quinone) - biosynthesis | Animals | Anticarcinogenic Agents - chemistry | Lipopolysaccharides - pharmacology | Nitriles - chemistry | Oleanolic Acid - chemistry | Amides - chemistry | Cell Line, Tumor | Macrophages - drug effects | Mice | Thiophenes - chemistry | Index Medicus
Journal Article
Bioorganic & Medicinal Chemistry Letters, ISSN 0960-894X, 05/2018, Volume 28, Issue 8, pp. 1292 - 1297
Journal Article
Clinical and Experimental Pharmacology and Physiology, ISSN 0305-1870, 02/2008, Volume 35, Issue 2, pp. 211 - 216
1 The present study was conducted to investigate whether hydroxysafflor yellow A (HSYA) has a protective effect against heart injury after... 
nitric oxide | reperfusion injury | hydroxysafflor yellow A | heart | mitochondrial permeability transition pore | Heart | Hydroxysafflor yellow A | Mitochondrial permeability transition pore | Nitric oxide | Reperfusion injury | PHYSIOLOGY | MYOCYTES | CONTRACTILE DYSFUNCTION | MYOCARDIAL-ISCHEMIA | DAMAGE | NITRIC-OXIDE DONOR | CYCLOSPORINE-A | PHARMACOLOGY & PHARMACY | RAT-HEART | CARDIOPROTECTION | L-Lactate Dehydrogenase - metabolism | Phosphorylation | Mitochondria, Heart - metabolism | Mitochondrial Membrane Transport Proteins - antagonists & inhibitors | Mitochondria, Heart - pathology | Male | Mitochondria, Heart - drug effects | Membrane Potential, Mitochondrial - drug effects | Myocardial Reperfusion Injury - pathology | Chalcone - pharmacology | Chalcone - analogs & derivatives | Nitric Oxide Synthase Type II - antagonists & inhibitors | Chalcone - therapeutic use | Mitochondrial Swelling | Quinones - pharmacology | NG-Nitroarginine Methyl Ester - pharmacology | Cell Survival - drug effects | Mitochondrial Membrane Transport Proteins - metabolism | Enzyme Inhibitors - pharmacology | Nitric Oxide Synthase Type III | Quinones - therapeutic use | Rats | Atractyloside - pharmacology | Rats, Sprague-Dawley | Cardiovascular Agents - pharmacology | Cardiovascular Agents - therapeutic use | Myocardial Reperfusion Injury - metabolism | Myocytes, Cardiac - pathology | Animals | Myocytes, Cardiac - drug effects | Perfusion | Myocytes, Cardiac - metabolism | In Vitro Techniques | Nitric Oxide - metabolism | Myocardial Reperfusion Injury - prevention & control | Nitric Oxide Synthase Type II - metabolism | Cell Survival, drug effects | NG-Nitroarginine Methyl Ester, pharmacology | Myocytes, Cardiac, drug effects | Chalcone, therapeutic use | Enzyme Inhibitors, pharmacology | Cardiovascular Agents, therapeutic use | Myocardial Reperfusion Injury, prevention and control | Myocytes, Cardiac, pathology | Nitric Oxide Synthase Type II, metabolism | Chalcone, pharmacology | Mitochondrial Membrane Transport Proteins, metabolism | Myocardial Reperfusion Injury, metabolism | Myocytes, Cardiac, metabolism | Nitric Oxide Synthase Type II, antagonists and inhibitors | Mitochondrial Membrane Transport Proteins, antagonists and inhibitors | Nitric Oxide, metabolism | Quinones, therapeutic use | Membrane Potential, Mitochondrial, drug effects | L-Lactate Dehydrogenase, metabolism | Mitochondria, Heart, metabolism | Myocardial Reperfusion Injury, pathology | Atractyloside, pharmacology | Mitochondria, Heart, pathology | Quinones, pharmacology | Mitochondria, Heart, drug effects | Cardiovascular Agents, pharmacology | Chalcone, analogs and derivatives | Lactate dehydrogenase | Mitochondrial DNA | Index Medicus
Journal Article
Journal Article
Circulation Research: Journal of the American Heart Association, ISSN 0009-7330, 12/2003, Volume 93, Issue 12, pp. 1258 - 1266
ABSTRACT—Aldosterone has been suggested to elicit vessel contraction via a nongenomic mechanism. We tested this proposal in microdissected, perfused rabbit... 
Steroid | Smooth muscle | Kidney | Endothelium | endothelium | ACTIVATION | CARDIAC & CARDIOVASCULAR SYSTEMS | smooth muscle | INJURY | ENDOTHELIAL NITRIC-OXIDE | MINERALOCORTICOID RECEPTOR | SYNTHASE | kidney | 11-BETA-HYDROXYSTEROID DEHYDROGENASE | PERIPHERAL VASCULAR DISEASE | SMOOTH-MUSCLE-CELLS | CORTICOSTEROIDS | HYPERTENSION | HEMATOLOGY | DEPENDENT CA2+ CHANNEL | steroid | Arterioles - physiology | Endothelium, Vascular - cytology | Receptors, Mineralocorticoid - genetics | Kidney - blood supply | Calcium - metabolism | Humans | Protein-Serine-Threonine Kinases | Endothelium, Vascular - drug effects | Male | Aorta - metabolism | Phosphatidylinositol 3-Kinases - antagonists & inhibitors | RNA, Messenger - metabolism | 11-beta-Hydroxysteroid Dehydrogenase Type 2 - genetics | Chromones - pharmacology | Rabbits | Enzyme Inhibitors - pharmacology | Rats | Potassium - pharmacology | Arterioles - drug effects | Benzoquinones | Rats, Sprague-Dawley | Vasoconstriction - drug effects | Arterioles - metabolism | Endothelium, Vascular - metabolism | 11-beta-Hydroxysteroid Dehydrogenase Type 2 - metabolism | Heart Ventricles - metabolism | Nitric Oxide Synthase - metabolism | Heart Ventricles - drug effects | Receptors, Mineralocorticoid - metabolism | Nitric Oxide Synthase - antagonists & inhibitors | Phosphatidylinositol 3-Kinases - metabolism | Nitroprusside - pharmacology | Dose-Response Relationship, Drug | Lactams, Macrocyclic | Spironolactone - pharmacology | Nitric Oxide Donors - pharmacology | Quinones - pharmacology | RNA, Messenger - drug effects | NG-Nitroarginine Methyl Ester - pharmacology | Proto-Oncogene Proteins - metabolism | Aorta - drug effects | RNA, Messenger - genetics | Cells, Cultured | Morpholines - pharmacology | Aldosterone - pharmacology | Gene Expression Regulation - drug effects | Proto-Oncogene Proteins c-akt | Animals | In Vitro Techniques | Dactinomycin - pharmacology | Index Medicus
Journal Article
Biochemical Journal, ISSN 0264-6021, 1995, Volume 312, Issue 2, pp. 637 - 641
The G-protein-coupled central cannabinoid receptor (CB1) has been shown to be functionally associated with several biological responses including inhibition of... 
PATHWAYS | CELLS | INHIBITION | PHOSPHORYLATION | MAP KINASE | BIOCHEMISTRY & MOLECULAR BIOLOGY | INVOLVEMENT | GENE-EXPRESSION | MEDIATED SIGNAL-TRANSDUCTION | Analgesics - pharmacology | Tetradecanoylphorbol Acetate - pharmacology | Humans | Rifabutin - analogs & derivatives | Recombinant Proteins - biosynthesis | Virulence Factors, Bordetella - pharmacology | Immediate-Early Proteins | Lactams, Macrocyclic | Cyclohexanols - metabolism | Transfection | Piperidines - pharmacology | Early Growth Response Protein 1 | Cyclohexanols - pharmacology | Quinones - pharmacology | CHO Cells | Pyrazoles - pharmacology | Recombinant Proteins - metabolism | Cell Line | Cricetinae | GTP-Binding Proteins - physiology | Receptors, Drug - physiology | 8-Bromo Cyclic Adenosine Monophosphate - pharmacology | Enzyme Inhibitors - pharmacology | Pertussis Toxin | Transcription Factors - biosynthesis | Benzoquinones | 1-Methyl-3-isobutylxanthine - pharmacology | Cannabinoids - pharmacology | Animals | Receptors, Drug - drug effects | Rimonabant | Recombinant Proteins - drug effects | Receptors, Cannabinoid | Adenylate Cyclase Toxin | Bucladesine - pharmacology | Enzyme Activation | Kinetics | DNA-Binding Proteins - biosynthesis | Receptors, Drug - biosynthesis | Calcium-Calmodulin-Dependent Protein Kinases - metabolism | Index Medicus
Journal Article
Journal Article
Journal of Ethnopharmacology, ISSN 0378-8741, 01/2012, Volume 139, Issue 2, pp. 381 - 387
Journal Article