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Alzheimer's & Dementia: The Journal of the Alzheimer's Association, ISSN 1552-5260, 2015, Volume 11, Issue 12, pp. 1407 - 1416
Journal Article
Neuron, ISSN 0896-6273, 03/2018, Volume 97, Issue 5, pp. 1023 - 1031.e7
Mutations in ( ) have been linked to increased Alzheimer’s disease (AD) risk. Neurobiological functions of TREM2 and its pathophysiological ligands remain... 
TREM2 | Alzheimer’s disease | neuroinflammation | R47H | microglia | Alzheimer's disease | RESPONSES | VARIANTS | CHEMOTAXIS | ALZHEIMERS-DISEASE | IMPAIRS | PROLIFERATION | MODEL | EXPRESSION | NEUROSCIENCES | DEFICIENCY | BRAIN | Cell culture | Phosphorylation | Myeloid cells | Pathogenesis | Secretion | Lipids | Depolarization | DAP12 protein | Proteins | β-Amyloid | Syk protein | Ligands | Mutation | Alzheimers disease | Cell migration | Apoptosis
Journal Article
The Journal of Biological Chemistry, ISSN 0021-9258, 8/2018, Volume 293, Issue 32, pp. 12620 - 12633
Triggering receptor expressed on myeloid cells 2 (TREM2) is an orphan immune receptor expressed on cells of myeloid lineage such as macrophages and microglia.... 
myeloid cell | R47H TREM2 | Molecular Bases of Disease | gene knockout | antibody | genetics | neuroinflammation | neurodegeneration | Alzheimer's disease | microglia
Journal Article
Neurobiology of aging, ISSN 0197-4580, 12/2013, Volume 34, Issue 12, pp. 2889.e11 - 2889.e13
Recent studies have identified the R47H variant in TREM2 as an Alzheimer’s disease (AD) risk factor with estimated odds ratio ranging from 2.9–5.1. The Cache... 
TREM2 | Alzheimer’s disease | R47H | human | rare variant
Journal Article
JOURNAL OF BIOLOGICAL CHEMISTRY, ISSN 0021-9258, 08/2018, Volume 293, Issue 32, pp. 12620 - 12633
Triggering receptor expressed on myeloid cells 2 (TREM2) is an orphan immune receptor expressed on cells of myeloid lineage such as macrophages and microglia.... 
antibody | MACROPHAGES | BIOCHEMISTRY & MOLECULAR BIOLOGY | neurodegeneration | DAP12 | myeloid cell | R47H TREM2 | gene knockout | BINDS | genetics | neuroinflammation | MOUSE MODEL | TREM2 DEFICIENCY | LIGAND | Alzheimer's disease | microglia | EXPRESSION | PROGRESSION
Journal Article
Human Pathology, ISSN 0046-8177, 02/2018, Volume 72, pp. 91 - 99
Triggering receptor expressed on myeloid cells 2 (TREM2) is a member of the immunoglobulin superfamily and associates with TYRO protein tyrosine kinase–binding... 
Protein expression | TREM2 | Prognosis | Gastric cancer | mRNA expression | EFFICACY | STATISTICS | ALZHEIMERS-DISEASE | RISK | CELL-PROLIFERATION | PATHOLOGY | OVEREXPRESSION | PATHWAY | R47H | Polymerase chain reaction | Proteins | Liver cancer | Antigens | Chemotherapy | Digestive system | Medical prognosis | Classification | Aging | Kinases | Stomach cancer | Tumors
Journal Article
Molecular Neurodegeneration, ISSN 1750-1326, 12/2016, Volume 11, Issue 1
Journal Article
Molecular neurodegeneration, ISSN 1750-1326, 12/2018, Volume 13, Issue 1, p. 66
Alzheimer's disease (AD) is the leading cause of dementia. The two histopathological markers of AD are amyloid plaques composed of the amyloid- (A) peptide,... 
Gliosis | Alzheimer’s disease | Neurodegeneration | ApoE | TREM2 | Alzheimer's disease | Microglia | INFLAMMATORY RESPONSES | MYELOID CELLS 2 | R47H VARIANT | TAU PATHOLOGY | NEUROSCIENCES | APOLIPOPROTEIN-E | RISK-FACTOR | AMYLOID-BETA | MOUSE MODEL | UP-REGULATION | TRANSGENIC MICE
Journal Article
Amyotrophic Lateral Sclerosis and Frontotemporal Degeneration, ISSN 2167-8421, 07/2018, Volume 19, Issue 5-6, pp. 407 - 412
Activation of the TREM2 receptor on microglia stimulates phagocytosis and decreases the microglial proinflammatory response. Mutations in exon 2 of the TREM2... 
ALS | TREM2 | compound heterozygosity | FTD | CRITERIA | DIAGNOSIS | DEMENTIA | ALZHEIMERS-DISEASE | R47H VARIANT | CLINICAL NEUROLOGY | RISK-FACTOR | MUTATIONS | CODING VARIANTS
Journal Article
JOURNAL OF BIOLOGICAL CHEMISTRY, ISSN 0021-9258, 08/2018, Volume 293, Issue 32, pp. 12634 - 12646
Journal Article