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Biochemical Engineering Journal, ISSN 1369-703X, 01/2015, Volume 93, pp. 108 - 114
•Viral envelope proteins can enhance cellular secretion of non-enveloped virus.•Enhanced secretion of rAAV2 by VSVG was via exosome-mediated pathway.•Secreted... 
Animal cell culture | Recombinant DNA | rAAV secretion | Virus envelope | Protein | Biomedical | RAAV secretion | SYSTEM | CELLS | GENE DELIVERY | TRANSDUCTION | DIRECTED EVOLUTION | LENTIVIRAL VECTORS | ADENOASSOCIATED VIRUS TYPE-2 | ENGINEERING, CHEMICAL | IN-VITRO | BIOTECHNOLOGY & APPLIED MICROBIOLOGY | IMMUNE-RESPONSES | EFFICIENT | Proteins | Gene expression | Cells
Journal Article
Molecular Therapy, ISSN 1525-0016, 06/2017, Volume 25, Issue 6, pp. 1387 - 1394
Alpha-1 antitrypsin deficiency is a monogenic disorder resulting in emphysema due principally to the unopposed effects of neutrophil elastase. We previously... 
alpha-1 antitrypsin | clinical trial | rAAV | AAT | AAV | Tregs | gene therapy | A1AT | PD-1 | exhausted T cells | MEDICINE, RESEARCH & EXPERIMENTAL | CELLS | HEPATOCYTES | CLINICAL-TRIAL | TRANSFECTION | VECTOR | RESPONSES | TRANSGENE EXPRESSION | BIOTECHNOLOGY & APPLIED MICROBIOLOGY | LIVER | GENETICS & HEREDITY | ACCUMULATION | SECRETION | Immunohistochemistry | T-Lymphocyte Subsets - immunology | Dependovirus - genetics | Genetic Therapy | T-Lymphocytes, Regulatory - metabolism | Genetic Vectors - administration & dosage | Humans | Muscles - pathology | T-Lymphocytes, Regulatory - immunology | Time Factors | Epitopes, T-Lymphocyte - immunology | Muscles - metabolism | Transgenes | Neutrophils - metabolism | alpha 1-Antitrypsin Deficiency - genetics | Gene Expression | alpha 1-Antitrypsin - genetics | alpha 1-Antitrypsin Deficiency - therapy | Genetic Vectors - immunology | Neutrophils - enzymology | Dependovirus - immunology | Immunophenotyping | Genetic Vectors - genetics | alpha 1-Antitrypsin Deficiency - metabolism | Capsid - immunology | Biopsy | T-Lymphocyte Subsets - metabolism | Biomarkers | alpha 1-Antitrypsin - metabolism | Flow cytometry | Lung diseases | Neutrophils | Cytotoxicity | Histology | Lymphocytes T | Patients | Proteins | Lymphocytes | Degranulation | Elastase | Mutation | Gene therapy | Emphysema | Original
Journal Article
The Journal of Gene Medicine, ISSN 1099-498X, 06/2006, Volume 8, Issue 6, pp. 730 - 735
Journal Article
Journal Article
International journal of obesity (2005), ISSN 0307-0565, 2011, Volume 35, Issue 5, pp. 629 - 641
Objective:Reduction of melanocortin signaling in the brain results in obesity. However, where in the brain reduced melanocortin signaling mediates this effect... 
rAAV | AgRP | meal size | hypothalamus | melanocortin receptors | RECOMBINANT ADENOASSOCIATED VIRUS | SYMPATHETIC-NERVOUS-SYSTEM | FOOD-INTAKE | NEUROPEPTIDE-Y | AGOUTI-RELATED PROTEIN | NUTRITION & DIETETICS | ENERGY-EXPENDITURE | PARAVENTRICULAR NUCLEUS | MESSENGER-RNA | ENDOCRINOLOGY & METABOLISM | LEPTIN SECRETION | TRANSGENIC MICE | Cell Line | Hypothalamic Area, Lateral - metabolism | Receptors, Melanocortin - antagonists & inhibitors | Rats, Wistar | Hypothalamus - physiology | Nucleus Accumbens - metabolism | Rats | Male | Obesity - physiopathology | Ventromedial Hypothalamic Nucleus - metabolism | Receptors, Melanocortin - physiology | Agouti-Related Protein - metabolism | Eating - physiology | Obesity - metabolism | Animals | Hypothalamus - metabolism | Body Weight - physiology | Energy Metabolism - physiology | Midline Thalamic Nuclei - metabolism | Obesity | Brain | Physiological aspects | Development and progression | Cellular signal transduction | Research | Intermedin | Neuropeptide Y | Temperature | Body temperature | Hypothalamus (lateral) | Proopiomelanocortin | Hypothalamus | Paraventricular nucleus | Gene expression | Insulin | Nucleus accumbens | Energy balance | Hypothalamus (ventromedial) | SOCS-3 protein | Food intake | Temperature effects | Leptin | adipose tissues | Melanocortin receptors | Locomotor activity
Journal Article
FASEB journal : official publication of the Federation of American Societies for Experimental Biology, ISSN 0892-6638, 02/2019, Volume 33, Issue 2, pp. 2472 - 2483
Hepatitis B virus (HBV) infection and bile acid (BA) metabolism are interdependent: infection modifies the expression of the BA nuclear receptor farnesoid X... 
agonist | mouse model | rAAV-HBV | bile acids | HBx
Journal Article
FASEB JOURNAL, ISSN 0892-6638, 02/2019, Volume 33, Issue 2, pp. 2472 - 2483
Hepatitis B virus (HBV) infection and bile acid (BA) metabolism are interdependent: infection modifies the expression of the BA nuclear receptor farnesoid X... 
HEPARG CELLS | mouse model | rAAV-HBV | CLOSED-CIRCULAR DNA | BIOCHEMISTRY & MOLECULAR BIOLOGY | TRANSCRIPTION | agonist | CELL BIOLOGY | CCCDNA | REPLICATION | bile acids | FEEDBACK-REGULATION | BIOLOGY | EPIGENETIC REGULATION | MICE | HBV | BILE-ACIDS | HBx
Journal Article
International Journal of Neuropsychopharmacology, ISSN 1461-1457, 2016, Volume 19, Issue 5, p. pyv123
Journal Article
The Journal of Gene Medicine, ISSN 1099-498X, 10/2005, Volume 7, Issue 10, pp. 1311 - 1321
Journal Article