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1. Full Text Cooperation of breast cancer proteins PALB2 and piccolo BRCA2 in stimulating homologous recombination
by Masson, Jean-Yves and Cai, Hong and Coulombe, Yan and Stasiak, Andrzej and Dion-Côté, Anne-Marie and Launay, Hélène and Xia, Bing and Buisson, Rémi and Stasiak, Alicja Z
Nature structural & molecular biology, ISSN 1545-9993, 10/2010, Volume 17, Issue 10, pp. 1247 - 1254
Biochemistry & Molecular Biology | Biophysics | Life Sciences & Biomedicine | Science & Technology | Cell Biology | Recombination, Genetic - physiology | DNA, Neoplasm - metabolism | Humans | Neoplasm Proteins - physiology | DNA Repair - physiology | Molecular Sequence Data | Structure-Activity Relationship | DNA Breaks, Double-Stranded | BRCA2 Protein - physiology | Breast Neoplasms - metabolism | Base Sequence | Tumor Suppressor Proteins - chemistry | Tumor Suppressor Proteins - genetics | Female | Protein Interaction Domains and Motifs | Nuclear Proteins - genetics | Nucleic Acid Conformation | Fanconi Anemia Complementation Group N Protein | Peptide Fragments - metabolism | Neoplasm Proteins - chemistry | Nuclear Proteins - chemistry | Poly(ADP-ribose) Polymerase Inhibitors | Protein Interaction Mapping | Tumor Suppressor Proteins - physiology | Peptide Fragments - chemistry | Apoptosis Regulatory Proteins | Models, Biological | Rad51 Recombinase - chemistry | Rad51 Recombinase - physiology | BRCA2 Protein - chemistry | Nuclear Proteins - physiology | Poly (ADP-Ribose) Polymerase-1 | Breast cancer | Genetic aspects | Research | BRCA mutations | Ovarian cancer | Proteins | Mutation | Molecular biology | Prostate cancer | Index Medicus | RAD51 | homologous recombination | BRCA2 | PALB2
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2. Full Text RecA: Regulation and Mechanism of a Molecular Search Engine
by Bell, Jason C and Kowalczykowski, Stephen C
Trends in biochemical sciences (Amsterdam. Regular ed.), ISSN 0968-0004, 06/2016, Volume 41, Issue 6, pp. 491 - 507
homology search | self-assembly | total internal reflection fluorescence (TIRF) | single molecule imaging | RAD51 | recombination | Förster resonance energy transfer (FRET) | Recombination | Self-assembly | Homology search | Single molecule imaging | Total internal reflection fluorescence (TIRF) | DNA, Bacterial - metabolism | Humans | Homologous Recombination | DNA, Bacterial - chemistry | DNA, Single-Stranded - genetics | Escherichia coli - metabolism | Rec A Recombinases - genetics | Rad51 Recombinase - metabolism | Rec A Recombinases - metabolism | Recombinational DNA Repair | Rad51 Recombinase - genetics | DNA, Single-Stranded - metabolism | Models, Molecular | Escherichia coli Proteins - metabolism | DNA, Single-Stranded - chemistry | Sequence Homology, Amino Acid | BRCA2 Protein - metabolism | DNA, Bacterial - genetics | Escherichia coli - genetics | Rad51 Recombinase - chemistry | Escherichia coli Proteins - genetics | Protein Binding | Rec A Recombinases - chemistry | BRCA2 Protein - chemistry | DNA Damage | Escherichia coli Proteins - chemistry | Gene Expression Regulation, Bacterial | BRCA2 Protein - genetics | Proteins | Online information services | Information services | Search and rescue operations | Internet/Web search services | Online services | Molecular biology | Chromosomes | Index Medicus | Single-molecule imaging | Förster Resonance Energy Transfer (FRET)
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3. Full Text Novel insights into RAD51 activity and regulation during homologous recombination and DNA replication1
by Godin, Stephen K and Sullivan, Meghan R and Bernstein, Kara A
Biochemistry and cell biology, ISSN 0829-8211, 2016, Volume 94, Issue 5, pp. 407 - 418
DNA replication | réplication d’ADN | RAD51 | homologous recombination | recombinaison homologue | Rad51 paralogues | complexe Shu | Shu complex | paralogues de Rad51 | Homologous recombination
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4. Full Text Smarcal1-Mediated Fork Reversal Triggers Mre11-Dependent Degradation of Nascent DNA in the Absence of Brca2 and Stable Rad51 Nucleofilaments
by Kolinjivadi, Arun Mouli and Sannino, Vincenzo and De Antoni, Anna and Zadorozhny, Karina and Kilkenny, Mairi and Técher, Hervé and Baldi, Giorgio and Shen, Rong and Ciccia, Alberto and Pellegrini, Luca and Krejci, Lumir and Costanzo, Vincenzo
Molecular cell, ISSN 1097-2765, 09/2017, Volume 67, Issue 5, pp. 867 - 881.e7
Rad51 | Mre11 | DNA replication | Brca2 | Xenopus laevis | fork protection | Biochemistry & Molecular Biology | Life Sciences & Biomedicine | Science & Technology | Cell Biology | Proteins | Physiological aspects | Genomics | Index Medicus
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5. Full Text RI-1: A chemical inhibitor of RAD51 that disrupts Homologous recombination in human cells
by Budke, Brian and Logan, Hillary L and Kalin, Jay H and Zelivianskaia, Anna S and McGuire, William Cameron and Miller, Luke L and Stark, Jeremy M and Kozikowski, Alan P and Bishop, Douglas K and Connell, Philip P
Nucleic acids research, ISSN 0305-1048, 08/2012, Volume 40, Issue 15, pp. 7347 - 7357
Life Sciences & Biomedicine | Biochemistry & Molecular Biology | Science & Technology | Rad51 Recombinase - metabolism | Pyrroles - metabolism | Antibiotics, Antineoplastic - pharmacology | Enzyme Inhibitors - metabolism | Homologous Recombination - drug effects | Cross-Linking Reagents - pharmacology | Humans | Enzyme Inhibitors - pharmacology | Morpholines - pharmacology | Morpholines - metabolism | Rad51 Recombinase - antagonists & inhibitors | Morpholines - chemistry | Protein Subunits - metabolism | Mitomycin - pharmacology | Pyrroles - pharmacology | Enzyme Inhibitors - chemistry | Rad51 Recombinase - chemistry | Cell Line, Tumor | Pyrroles - chemistry | Cysteine - metabolism | DNA Damage | Index Medicus | Drugs | Rad51 protein | Cysteine | homologous recombination | Filaments | DNA damage | replication protein A | genomics | Tumor cell lines | Gene conversion | DNA repair | Monomers | Genome Integrity, Repair and
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6. Full Text RAD52 inactivation is synthetically lethal with deficiencies in BRCA1 and PALB2 in addition to BRCA2 through RAD51-mediated homologous recombination
by Lok, B.H and Carley, A.C and Tchang, B and Powell, S.N
Oncogene, ISSN 0950-9232, 07/2013, Volume 32, Issue 30, pp. 3552 - 3558
RAD52 | RAD51 | BRCA1 | Synthetic lethality | BRCA2 | PALB2 | Biochemistry & Molecular Biology | Oncology | Genetics & Heredity | Life Sciences & Biomedicine | Science & Technology | Cell Biology | Cell Survival - drug effects | DNA Repair - drug effects | Rad51 Recombinase - genetics | Humans | RNA, Small Interfering - pharmacology | Gene Silencing | Genes, Lethal - physiology | Cell Survival - genetics | DNA Repair - genetics | Rad52 DNA Repair and Recombination Protein - genetics | Rad52 DNA Repair and Recombination Protein - physiology | Gene Knockdown Techniques | Homologous Recombination - physiology | Genes, BRCA1 - physiology | Genes, BRCA2 - physiology | Genes, Lethal - genetics | Tumor Suppressor Proteins - genetics | Rad51 Recombinase - physiology | Cell Line, Tumor | Homologous Recombination - genetics | Gene Expression Regulation, Neoplastic - drug effects | Nuclear Proteins - genetics | Fanconi Anemia Complementation Group N Protein | Physiological aspects | Research | Genetic recombination | BRCA mutations | Rad51 proteins | Epigenetics | Genetic engineering | Gene therapy | Cancer therapies | Index Medicus | synthetic lethality
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7. Full Text Fanconi-Anemia-Associated Mutations Destabilize RAD51 Filaments and Impair Replication Fork Protection
by Zadorozhny, Karina and Sannino, Vincenzo and Beláň, Ondrej and Mlčoušková, Jarmila and Špírek, Mário and Costanzo, Vincenzo and Krejčí, Lumír
Cell reports (Cambridge), ISSN 2211-1247, 10/2017, Volume 21, Issue 2, pp. 333 - 340
replication | RAD51 | recombination | Fanconi anemia | Life Sciences & Biomedicine | Science & Technology | Cell Biology | Rad51 Recombinase - metabolism | Xenopus | Animals | Rad51 Recombinase - genetics | Adenosine Triphosphate - metabolism | Humans | Protein Binding | DNA Replication | Fanconi Anemia - genetics | Mutation | Protein Stability | MRE11 Homologue Protein - metabolism | Index Medicus
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8. Full Text Smarcal1-Mediated Fork Reversal Triggers Mre11-Dependent Degradation of Nascent DNA in the Absence of Brca2 and Stable Rad51 Nucleofilaments
by Kolinjivadi, Arun Mouli and Sannino, Vincenzo and De Antoni, Anna and Zadorozhny, Karina and Kilkenny, Mairi and Técher, Hervé and Baldi, Giorgio and Shen, Rong and Ciccia, Alberto and Pellegrini, Luca and Krejci, Lumir and Costanzo, Vincenzo
Molecular cell, 09/2017, Volume 67, Issue 5, p. 867
Genomic Instability | Xenopus Proteins - genetics | Humans | Male | DNA-Binding Proteins - metabolism | MRE11 Homologue Protein | Time Factors | Endodeoxyribonucleases - metabolism | DNA - biosynthesis | Female | Xenopus laevis - genetics | Exodeoxyribonucleases - genetics | Binding Sites | DNA Helicases - genetics | Rad51 Recombinase - metabolism | Rad51 Recombinase - genetics | DNA Replication | Saccharomyces cerevisiae Proteins - genetics | DNA-Binding Proteins - genetics | DNA - genetics | DNA Helicases - metabolism | Endodeoxyribonucleases - genetics | Animals | BRCA2 Protein - metabolism | Replication Origin | Xenopus laevis - metabolism | Exodeoxyribonucleases - metabolism | Saccharomyces cerevisiae Proteins - metabolism | Protein Binding | Xenopus Proteins - metabolism | Mutation | DNA Polymerase III - metabolism | BRCA2 Protein - genetics | DNA Polymerase I - metabolism
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9. Full Text A novel small molecule RAD51 inactivator overcomes imatinib‐resistance in chronic myeloid leukaemia
by Zhu, Jiewen and Zhou, Longen and Wu, Guikai and Konig, Heiko and Lin, Xiaoqin and Li, Guideng and Qiu, Xiao‐Long and Chen, Chi‐Fen and Hu, Chun‐Mei and Goldblatt, Erin and Bhatia, Ravi and Chamberlin, A. Richard and Chen, Phang‐Lang and Lee, Wen‐Hwa
EMBO molecular medicine, ISSN 1757-4676, 03/2013, Volume 5, Issue 3, pp. 353 - 365
small molecule | cancer | CML | RAD51 | inhibitor | Inhibitor | Small molecule | Cancer | Life Sciences & Biomedicine | Medicine, Research & Experimental | Science & Technology | Research & Experimental Medicine | Homologous Recombination - drug effects | Apoptosis - drug effects | Neoplastic Stem Cells - drug effects | Humans | Leukemia, Myelogenous, Chronic, BCR-ABL Positive - drug therapy | Proteasome Inhibitors - metabolism | RNA Interference | Time Factors | Neoplastic Stem Cells - pathology | Binding Sites | Rad51 Recombinase - metabolism | Tetrahydroisoquinolines - pharmacology | Pyrimidines - pharmacology | Piperazines - pharmacology | Drug Resistance, Neoplasm - genetics | Fusion Proteins, bcr-abl - antagonists & inhibitors | Rad51 Recombinase - chemistry | Cell Line, Tumor | Mice, Inbred NOD | Mice | Molecular Docking Simulation | Protein Processing, Post-Translational | Mutation | Proteasome Endopeptidase Complex - metabolism | Protein-Tyrosine Kinases - antagonists & inhibitors | Protein Multimerization | Leukemia, Myelogenous, Chronic, BCR-ABL Positive - genetics | Rad51 Recombinase - antagonists & inhibitors | Antineoplastic Agents - metabolism | Dose-Response Relationship, Drug | Indoles - metabolism | Protein-Tyrosine Kinases - genetics | Transfection | Leukemia, Myelogenous, Chronic, BCR-ABL Positive - pathology | Female | Indoles - pharmacology | Antineoplastic Agents - pharmacology | Benzamides - pharmacology | Gene Expression Regulation, Neoplastic - drug effects | Leukemia, Myelogenous, Chronic, BCR-ABL Positive - enzymology | Proteasome Inhibitors - pharmacology | Rad51 Recombinase - genetics | Mice, SCID | Imatinib Mesylate | Fusion Proteins, bcr-abl - genetics | Animals | Tumor Burden - drug effects | Tetrahydroisoquinolines - metabolism | Cell Proliferation - drug effects | Protein Kinase Inhibitors - pharmacology | Antimitotic agents | Care and treatment | Invisibility | Nuclear radiation | Proteolysis | Analysis | Drug resistance | Antineoplastic agents | Cell proliferation | BCR protein | Leukemia | DNA damage | Homologous recombination | Recombinase | Kinases | Cancer therapies | Experiments | Rad51 protein | Ionizing radiation | Granulocytes | Cell cycle | Bone marrow | Deoxyribonucleic acid--DNA | CD34 antigen | Medical research | Imatinib | Cell survival | Breast cancer | Chronic myeloid leukemia | Progenitor cells | Survival analysis | Stem cells | Apoptosis | Index Medicus
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10. Full Text RAD51 as a potential surrogate marker for DNA repair capacity in solid malignancies
by Gachechiladze, Mariam and Škarda, Josef and Soltermann, Alex and Joerger, Markus
International journal of cancer, ISSN 0020-7136, 10/2017, Volume 141, Issue 7, pp. 1286 - 1294
“BRCAness,” chemotherapy | radiotherapy | RAD51 | prognosis | Life Sciences & Biomedicine | Oncology | Science & Technology | Neoplasms - metabolism | Rad51 Recombinase - metabolism | Cell Proliferation - genetics | Rad51 Recombinase - genetics | Recombinational DNA Repair - genetics | Humans | Radiation Tolerance - genetics | Male | DNA Repair - genetics | DNA, Neoplasm - drug effects | Poly(ADP-ribose) Polymerase Inhibitors - therapeutic use | Neoplasms - drug therapy | Polymorphism, Genetic | Drug Resistance, Neoplasm - genetics | Neoplasms - genetics | Biomarkers, Tumor - metabolism | Genes, BRCA2 | Female | Neoplasms - radiotherapy | Biomarkers, Tumor - genetics | Genes, BRCA1 | DNA, Neoplasm - radiation effects | Precision Medicine | Medical research | Chemotherapy | DNA | Medicine, Experimental | DNA repair | Sugars | Cancer | Monosaccharides | Drugs | Genetic variability | DNA damage | Homologous recombination | Clinical trials | Cytotoxicity | Homology | Radioresistance | Proteins | Rad51 protein | Ribose | Damage | Repair | Deoxyribonucleic acid--DNA | Adenosine diphosphate | Poly(ADP-ribose) polymerase | Radiation therapy | Gene expression | Biomarkers | Protein expression | Immunoreactivity | Solid tumors | Tumors | Index Medicus
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